Sphingosine-1-Phosphate Inhibits Nuclear Factor κB Activation and Germ Cell Apoptosis in the Human Testis Independently of Its Receptors

Cellular survival: a play in three Akts

1999 • 4,229 citations

Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

2002 • 4,097 citations

AP-1 as a regulator of cell life and death

2002 • 2,752 citations

Sphingosine-1-phosphate: an enigmatic signalling lipid

2003 • 2,022 citations

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine -1-phosphate therapy

2000 • 581 citations

Proliferation and differentiation of spermatogonial stem cells

2001 • 498 citations

Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival

1998 • 468 citations

Germ cell suicide: new insights into apoptosis during spermatogenesis

2000 • 449 citations

The Rel/NF-κB signal transduction pathway: introduction

1999 • 436 citations

Compartmentalization of ceramide signaling: physical foundations and biological effects

2000 • 421 citations

GONADAL DAMAGE FROM CHEMOTHERAPY AND RADIOTHERAPY

1998 • 406 citations

Spermatogenesis

1998 • 395 citations

The morphology and kinetics of spermatogonial degeneration in normal adult rats: An analysis using a simplified classification of the germinal epithelium

1978 • 366 citations

Sphingosine Kinase Interacts with TRAF2 and Dissects Tumor Necrosis Factor-α Signaling

2002 • 291 citations

Signaling and biological actions of sphingosine 1-phosphate

2003 • 272 citations

Sphingosine 1-Phosphate Inhibits Activation of Caspases that Cleave Poly(ADP-ribose) Polymerase and Lamins during Fas- and Ceramide-mediated Apoptosis in Jurkat T Lymphocytes

1998 • 265 citations

Prospects for Fertility after Chemotherapy or Radiation for Neoplastic Disease

1986 • 218 citations

Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress

1998 • 209 citations

Sphingosine‐1‐Phosphate in Cell Growth and Cell Death^a

1998 • 202 citations

Sphingosine 1-Phosphate-induced Cell Proliferation, Survival, and Related Signaling Events Mediated by G Protein-coupled Receptors Edg3 and Edg5

2000 • 196 citations

The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways

1998 • 195 citations

EDG‐1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration

2001 • 167 citations

Oxidized LDL-Induced Smooth Muscle Cell Proliferation Involves the EGF Receptor/PI-3 Kinase/Akt and the Sphingolipid Signaling Pathways

2002 • 120 citations

The modulation of sperm function by fertilization promoting peptide

1998 • 109 citations

Akt Activation Induced by Lysophosphatidic Acid and Sphingosine-1-phosphate Requires Both Mitogen-Activated Protein Kinase Kinase and p38 Mitogen-Activated Protein Kinase and Is Cell-Line Specific

2002 • 107 citations

Mechanism for Biphasic Rel A· NF-κB1 Nuclear Translocation in Tumor Necrosis Factor α-stimulated Hepatocytes

1997 • 103 citations

EDG1 Receptor Stimulation Leads to Cardiac Hypertrophy in Rat Neonatal Myocytes

2001 • 96 citations

N-Acetyl-<scp>l</scp>-Cysteine Inhibits Apoptosis in Human Male Germ Cellsin Vitro¹

1998 • 92 citations

Nuclear Factor-κB Activation in Human Testicular Apoptosis

2002 • 86 citations

Mitogen-activated Protein Kinases and Activator Protein 1 Are Required for Proliferation and Cardiomyocyte Differentiation of P19 Embryonal Carcinoma Cells

2002 • 82 citations

Involvement of Phospholipase D in Sphingosine 1-Phosphate-induced Activation of Phosphatidylinositol 3-Kinase and Akt in Chinese Hamster Ovary Cells Overexpressing EDG3

2001 • 75 citations

Protection from Radiation-Induced Male Germ Cell Loss by Sphingosine-1-Phosphate1

2004 • 70 citations

Sphingosine-1-phosphate inhibits human keratinocyte proliferation via Akt/protein kinase B inactivation

2003 • 68 citations

N-Acetyl-L-Cysteine Inhibits Apoptosis in Human Male Germ Cells in Vitro

1998 • 49 citations

Sphingosine-1-Phosphate in Inhibition of Male Germ Cell Apoptosis in the Human Testis

2003 • 48 citations

Signal transduction and the regulation of apoptosis: roles of ceramide.

1998 • 43 citations

Sphingolipid Regulation of Female Gonadal Cell Apoptosis

2000 • 39 citations

Sphingosine-1-phosphate stimulates smooth muscle cell migration through gαi- and pi3-kinase-dependent p38mapk activation

2003 • 33 citations

Sphingosine-1-phosphate promotes mouse melanocyte survival via ERK and Akt activation

2003 • 30 citations

Sphingolipids as differential regulators of cellular signalling processes

1997 • 27 citations

Differential regulation of ERK1/2 and p38MAPK by components of the Rho signaling pathway during Sphingosine-1-Phosphate-Induced smooth muscle cell migration1

2004 • 25 citations

Activator protein-1 in human male germ cell apoptosis

2004 • 23 citations

Chemical Anoxia Delays Germ Cell Apoptosis in the Human Testis1

2003 • 17 citations

Regulation of the stress response by ceramide

1997 • 15 citations

Differential regulation of ERK1/2 and p38MAPK by components of the rho signaling pathway during sphingosine-1-phosphate-induced smooth muscle cell migration

2003 • 4 citations