Signaling Mechanisms Responsible for Lysophosphatidic Acid-induced Urokinase Plasminogen Activator Expression in Ovarian Cancer Cells

Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment

1993 • 2,182 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

Lysophosphatidic Acid as a Potential Biomarker for Ovarian and Other Gynecologic Cancers

1998 • 642 citations

General mechanisms of metastasis

1997 • 610 citations

The ins and outs of lysophosphatidic acid signaling

2004 • 550 citations

Requirement for the lp _A1 lysophosphatidic acid receptor gene in normal suckling behavior

2000 • 468 citations

Molecular aspects of tumor cell invasion and metastasis

1993 • 463 citations

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1995 • 429 citations

The Plasminogen (Fibrinolytic) System

1999 • 424 citations

New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades

2001 • 397 citations

Stimulation of Membrane Ruffling and MAP Kinase Activation by Distinct Effectors of RAS

1996 • 377 citations

Increased expression of matrix metalloproteinases (MMP)-2, MMP-9, and the urokinase-type plasminogen activator is associated with progression from benign to advanced ovarian cancer.

2001 • 336 citations

Characterization of an ovarian cancer activating factor in ascites from ovarian cancer patients.

1995 • 325 citations

Characterization of lpa₂ (Edg4) and lpa₁/lpa₂ (Edg2/Edg4) Lysophosphatidic Acid Receptor Knockout Mice: Signaling Deficits without Obvious Phenotypic Abnormality Attributable to lpa₂

2002 • 315 citations

Enhanced Tumorigenicity and Invasion-Metastasis by Hepatocyte Growth Factor/Scatter Factor-Met Signalling in Human Cells Concomitant with Induction of the Urokinase Proteolysis Network

1996 • 312 citations

Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK–ERK independent mechanism

2001 • 311 citations

Lysophospholipid G Protein-coupled Receptors

2004 • 281 citations

Lysophosphatidic acid is a bioactive mediator in ovarian cancer

2002 • 271 citations

ralGDS family members interact with the effector loop of ras p21.

1994 • 260 citations

Lysophosphatidic Acid Induction of Vascular Endothelial Growth Factor Expression in Human Ovarian Cancer Cells

2001 • 245 citations

Lysophospholipid Growth Factors in the Initiation, Progression, Metastases, and Management of Ovarian Cancer

2000 • 243 citations

Lysophosphatidic acid promotes matrix metalloproteinase (MMP) activation and MMP-dependent invasion in ovarian cancer cells.

2001 • 241 citations

Apoptosis Signaling Pathway in T Cells Is Composed of ICE/Ced-3 Family Proteases and MAP Kinase Kinase 6b

1997 • 234 citations

Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex.

1993 • 209 citations

Mechanisms for Lysophosphatidic Acid-induced Cytokine Production in Ovarian Cancer Cells

2004 • 191 citations

Rac Mediates Cytoskeletal Rearrangements and Increased Cell Motility Induced by Urokinase-Type Plasminogen Activator Receptor Binding to Vitronectin

2001 • 186 citations

Direct Interaction between Ras and the Kinase Domain of Mitogen-activated Protein Kinase Kinase Kinase (MEKK1)

1995 • 177 citations

Proteolysis, Cell Adhesion, Chemotaxis, and Invasiveness Are Regulated by the u-PA-u-PAR-PAI-1 System

1999 • 175 citations

Constitutive and lysophosphatidic acid (LPA)-induced LPA production: role of phospholipase D and phospholipase A2.

2000 • 172 citations

Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists

2001 • 163 citations

Matrix Metalloproteinase System Deficiencies and Matrix Degradation

1999 • 150 citations

Lysophosphatidic acid induces urokinase secretion by ovarian cancer cells.

1999 • 147 citations

The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer.

2003 • 142 citations

Urokinase (uPA) and PAI-1 Predict Survival in Advanced Ovarian Cancer Patients (FIGO III) after Radical Surgery and Platinum-Based Chemotherapy

1994 • 140 citations

Lysophosphatidic acid as a novel cell survival/apoptotic factor

2002 • 134 citations

Urokinase Plasminogen Activator/Urokinase-specific Surface Receptor Expression and Matrix Invasion by Breast Cancer Cells Requires Constitutive p38α Mitogen-activated Protein Kinase Activity

2000 • 133 citations

Lysophosphatidic Acid Stimulates Ovarian Cancer Cell Migration via a Ras-MEK Kinase 1 Pathway

2004 • 124 citations

Role of urokinase (uPA) and its receptor (uPAR) in invasion and metastasis of hormone-dependent malignancies.

1998 • 118 citations

Lysophospholipids Increase Interleukin-8 Expression in Ovarian Cancer Cells

2001 • 116 citations

Src-Dependence and Pertussis-Toxin Sensitivity of Urokinase Receptor-Dependent Chemotaxis and Cytoskeleton Reorganization in Rat Smooth Muscle Cells

1999 • 109 citations

Lysophosphatidic Acid Receptor-Selective Effects on Jurkat T Cell Migration Through a Matrigel Model Basement Membrane

2001 • 96 citations

Expression of antisense uPAR and antisense uPA from a bicistronic adenoviral construct inhibits glioma cell invasion, tumor growth, and angiogenesis

2003 • 96 citations

Rac1-MKK3-p38-MAPKAPK2 Pathway Promotes Urokinase Plasminogen Activator mRNA Stability in Invasive Breast Cancer Cells

2002 • 88 citations

Insulin Activates Nuclear Factor κB in Mammalian Cells through a Raf-1-mediated Pathway

1995 • 85 citations

Up-regulation of urokinase-type plasminogen activator by insulin-like growth factor-I depends upon phosphatidylinositol-3 kinase and mitogen-activated protein kinase kinase.

2001 • 84 citations

Antisense inhibition of urokinase reduces spread of human ovarian cancer in mice

1995 • 83 citations

Lysophosphatidic acid: mitogen and motility factor

2003 • 82 citations

Association of urokinase-type plasminogen activator and its inhibitor with disease progression and prognosis in ovarian cancer.

2001 • 82 citations

Inhibition of Tumor Invasion by Genomic Down-regulation of Matriptase through Suppression of Activation of Receptor-bound Pro-urokinase

2004 • 81 citations

Inhibition of tumor invasion and metastasis by a novel lysophosphatidic acid (cyclic LPA)

1999 • 80 citations

The significance of urokinase-type plasminogen activator, its inhibitors, and its receptor in ascites of patients with epithelial ovarian cancer

1995 • 79 citations

Urokinase Stimulates Human Vascular Smooth Muscle Cell Migration via a Phosphatidylinositol 3-Kinase-Tyk2 Interaction

2000 • 77 citations

Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer

2003 • 76 citations

RalA requirement for v-Src- and v-Ras-induced tumorigenicity and overproduction of urokinase-type plasminogen activator: involvement of metalloproteases

1999 • 76 citations

Activation of the Urokinase Plasminogen Activator/Urokinase Plasminogen Activator Receptor System and Redistribution of E-Cadherin Are Associated with Hepatocyte Growth Factor-Induced Motility of Pancreas Tumor Cells Overexpressing Met

1998 • 72 citations

Involvement of a Mitogen-activated Protein Kinase Signaling Pathway in the Regulation of Urokinase Promoter Activity by c-Ha-ras

1995 • 72 citations

Suppression of Urokinase Expression and Invasiveness by Urinary Trypsin Inhibitor Is Mediated through Inhibition of Protein Kinase C- and MEK/ERK/c-Jun-dependent Signaling Pathways

2001 • 72 citations

Cooperation of Gq, Gi, and G12/13 in Protein Kinase D Activation and Phosphorylation Induced by Lysophosphatidic Acid

2003 • 66 citations

Lysophospholipid mediators of immunity and neoplasia

2002 • 65 citations

The Raf‐1 kinase associates with vimentin kinases and regulates the structure of vimentin filaments

2000 • 64 citations

Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cell line by overexpression of bikunin

2003 • 61 citations

Urokinase induces proliferation of human ovarian cancer cells: characterization of structural elements required for growth factor function

1998 • 60 citations

High‐affinity urokinase‐derived cyclic peptides inhibiting urokinase/urokinase receptor‐interaction: effects on tumor growth and spread

2002 • 59 citations

Role of phospholipase D in agonist-stimulated lysophosphatidic acid synthesis by ovarian cancer cells

2003 • 59 citations

Chemoattractant-stimulated NF-κB Activation Is Dependent on the Low Molecular Weight GTPase RhoA

2001 • 46 citations

The Ras-Raf pathway is activated in human immunodeficiency virus-infected monocytes and particpates in the activation of NF-kappa B

1996 • 45 citations

Dedifferentiation of serous ovarian cancer from cystic to solid tumors is associated with increased expression of mRNA for urokinase plasminogen activator (uPA), its receptor (uPAR) and its inhibitor (PAI-1)

2001 • 45 citations

Characterization of Raf-1 Activation in Mitosis

1999 • 45 citations

Heregulin regulation of urokinase plasminogen activator and its receptor: human breast epithelial cell invasion.

2001 • 42 citations

Plasminogen fragmentation and increased production of extracellular matrix-degrading proteinases are associated with serous epithelial ovarian cancer progression

2003 • 28 citations

Simultaneous up-regulation of urokinase-type plasminogen activator (uPA) and uPA receptor by hepatocyte growth factor/scatter factor in human glioma cells.

1999 • 28 citations

NF‐κB‐mediated regulation of urokinase gene expression by PMA and TNF‐α in human A549 cells

1996 • 22 citations

Rel transcription factors contribute to elevated urokinase expression in human ovarian carcinoma cells

1999 • 20 citations

Autocrine regulation of growth stimulation in human epithelial ovarian carcinoma by serine-proteinase-catalysed release of the urinary-type-plasminogen-activator N-terminal fragment

1999 • 14 citations

Co-localization of Urokinase and its Receptor on Established Human Umbilical Vein Endothelial Cell.

1999 • 5 citations

Selective Inhibition of G Protein-Mediated Pathways Using RGS Domains

2003 • 5 citations

Specific Keynote: Molecular Determinants of Angiogenesis in Ovarian Cancer

2003 • 4 citations