Lysophosphatidic acid production and action: Validated targets in cancer?

The Hallmarks of Cancer

2000 • 27,569 citations

The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited

2003 • 4,433 citations

Use of proteomic patterns in serum to identify ovarian cancer

2002 • 3,227 citations

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

1999 • 1,484 citations

The emerging role of lysophosphatidic acid in cancer

2003 • 1,086 citations

Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

2002 • 908 citations

Malignant effusions and immunogenic tumour-derived exosomes

2002 • 904 citations

Identification of Human Plasma Lysophospholipase D, a Lysophosphatidic Acid-producing Enzyme, as Autotaxin, a Multifunctional Phosphodiesterase

2002 • 723 citations

Role of LBPA and Alix in Multivesicular Liposome Formation and Endosome Organization

2004 • 671 citations

Proton-sensing G-protein-coupled receptors

2003 • 667 citations

Lysophosphatidic Acid as a Potential Biomarker for Ovarian and Other Gynecologic Cancers

1998 • 642 citations

Identification of p2y9/GPR23 as a Novel G Protein-coupled Receptor for Lysophosphatidic Acid, Structurally Distant from the Edg Family

2003 • 553 citations

Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist

2002 • 545 citations

Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid

1999 • 536 citations

Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells

1995 • 523 citations

Molecular Cloning and Characterization of a Novel Human G-protein-coupled Receptor, EDG7, for Lysophosphatidic Acid

1999 • 517 citations

Serum Lysophosphatidic Acid Is Produced through Diverse Phospholipase Pathways

2002 • 413 citations

Lysophosphatidic acid mediates the rapid activation of platelets and endothelial cells by mildly oxidized low density lipoprotein and accumulates in human atherosclerotic lesions

1999 • 411 citations

Modulation of Membrane Curvature by Phosphatidic Acid and Lysophosphatidic Acid

2003 • 373 citations

Mammalian non-pancreatic phospholipases A2

1993 • 355 citations

TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells

2003 • 342 citations

Lysophosphatidylcholine as a Ligand for the Immunoregulatory Receptor G2A

2001 • 329 citations

Gene Expression Patterns in Ovarian Carcinomas

2003 • 320 citations

Lysophospholipids activate ovarian and breast cancer cells

1995 • 289 citations

Lysophosphatidic acid is a bioactive mediator in ovarian cancer

2002 • 271 citations

E-cadherin induces mesenchymal-to-epithelial transition in human ovarian surface epithelium

1999 • 258 citations

Multiple Mechanisms Linked to Platelet Activation Result in Lysophosphatidic Acid and Sphingosine 1-Phosphate Generation in Blood

2002 • 254 citations

Markedly Elevated Levels of Vascular Endothelial Growth Factor in Malignant Ascites

1999 • 247 citations

Lysophosphatidic Acid Induction of Vascular Endothelial Growth Factor Expression in Human Ovarian Cancer Cells

2001 • 245 citations

Sphingosylphosphorylcholine and Lysophosphatidylcholine Are Ligands for the G Protein-coupled Receptor GPR4

2001 • 242 citations

Electrospray Ionization Mass Spectrometry Analysis of Lysophospholipids in Human Ascitic Fluids: Comparison of the Lysophospholipid Contents in Malignant vs Nonmalignant Ascitic Fluids

2001 • 234 citations

Autotaxin Is Released from Adipocytes, Catalyzes Lysophosphatidic Acid Synthesis, and Activates Preadipocyte Proliferation

2003 • 225 citations

Biomarker Amplification by Serum Carrier Protein Binding

2003 • 211 citations

Lysophosphatidic Acid Induces Neointima Formation Through PPARγ Activation

2004 • 202 citations

cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases.

1994 • 202 citations

Lysophosphatidic acids induce proliferation of cultured vascular smooth muscle cells from rat aorta

1994 • 195 citations

Mechanisms for Lysophosphatidic Acid-induced Cytokine Production in Ovarian Cancer Cells

2004 • 191 citations

Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells

2000 • 188 citations

Identification of the molecular species of lysophosphatidic acid produced when platelets are stimulated by thrombin

1989 • 185 citations

Molecular mechanisms of lysophosphatidic acid action

2003 • 181 citations

Lysophospholipids and their G protein-coupled receptors in inflammation and immunity

2002 • 179 citations

Malignant effusions contain lysophosphatidic acid (LPA)-like activity

1998 • 178 citations

Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells.

2002 • 163 citations

Evaluation of Plasma Lysophospholipids for Diagnostic Significance Using Electrospray Ionization Mass Spectrometry (ESI‐MS) Analyses

2000 • 159 citations

Identification of human renal cell carcinoma associated genes by suppression subtractive hybridization

2001 • 149 citations

Gelsolin Binding and Cellular Presentation of Lysophosphatidic Acid

2000 • 128 citations

Lysophosphatidic acid, a growth factor-like lipid, in the saliva

2002 • 123 citations

Identification of a Phosphothionate Analogue of Lysophosphatidic Acid (LPA) as a Selective Agonist of the LPA3 Receptor

2003 • 121 citations

Lipid phosphate phosphatases regulate signal transduction through glycerolipids and sphingolipids

2002 • 119 citations

Lysophospholipids Increase Interleukin-8 Expression in Ovarian Cancer Cells

2001 • 116 citations

Phorbol 12-Myristate 13-Acetate Stimulates Lysophosphatidic Acid Secretion from Ovarian and Cervical Cancer Cells but Not from Breast or Leukemia Cells

1998 • 113 citations

Role for 18:1 Lysophosphatidic Acid as an Autocrine Mediator in Prostate Cancer Cells

2002 • 108 citations

In vivo roles of lysophospholipid receptors revealed by gene targeting studies in mice

2002 • 108 citations

The biologically active phospholipid, lysophosphatidic acid, induces phosphatidylcholine breakdown in fibroblasts via activation of phospholipase D. Comparison with the response to endothelin

1992 • 107 citations

Biochemical and Molecular Characterization of Two Phosphatidic Acid-selective Phospholipase A1s, mPA-PLA1α and mPA-PLA1β

2003 • 105 citations

Increased Production of Bioactive Lysophosphatidic Acid by Serum Lysophospholipase D in Human Pregnancy1

2002 • 105 citations

Abnormal serum lysophospholipids in multiple myeloma patients

1999 • 93 citations

Oxidized low density lipoprotein-mediated activation of phospholipase D in smooth muscle cells: a possible role in cell proliferation and atherogenesis.

1995 • 89 citations

The Significance of Plasma Lysophospholipids in Patients with Renal Failure on Hemodialysis.

1998 • 85 citations

ADP-ribosylation-factor-regulated phospholipase D activity localizes to secretory vesicles and mobilizes to the plasma membrane following N-formylmethionyl-leucyl-phenylalanine stimulation of human neutrophils

1997 • 84 citations

Lipid Phosphate Phosphatases Regulate Lysophosphatidic Acid Production and Signaling in Platelets

2003 • 83 citations

A novel laminin‐induced lysophosphatidic acid autocrine loop in the migration of ovarian cancer cells

2003 • 81 citations

Selective blockade of lysophosphatidic acid LPA₃receptors reduces murine renal ischemia-reperfusion injury

2003 • 73 citations

Unfolding the Pathophysiological Role of Bioactive Lysophospholipids

2003 • 73 citations

Synergistic Induction of Tumor Antigens by Wnt-1 Signaling and Retinoic Acid Revealed by Gene Expression Profiling

2002 • 72 citations

Fatty Acid Composition of Lysophosphatidic Acid and Lysophosphatidylinositol in Plasma from Patients with Ovarian Cancer and Other Gynecological Diseases

2001 • 72 citations

Bmp-2 downstream targets in mesenchymal development identified by subtractive cloning from recombinant mesenchymal progenitors (C3H10T½)

1998 • 71 citations

Quantitative analysis of acyl-lysophosphatidic acid in plasma using negative ionization tandem mass spectrometry

2003 • 70 citations

Lysophosphatidic acid signaling: how a small lipid does big things

2003 • 69 citations

The G Protein-Coupled Receptor GPR4 Suppresses ERK Activation in a Ligand-Independent Manner

2003 • 69 citations

Secretion of a lysophospholipase D activity by adipocytes: involvement in lysophosphatidic acid synthesis

2002 • 68 citations

Microarray analysis identifies Autotaxin, a tumour cell motility and angiogenic factor with lysophospholipase D activity, as a specific target of cell transformation by v-Jun

2003 • 66 citations

Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid

2004 • 66 citations

Induction of protein growth factor systems in the ovaries of transgenic mice overexpressing human type 2 lysophosphatidic acid G protein-coupled receptor (LPA2)

2004 • 62 citations

Role of phospholipase D in agonist-stimulated lysophosphatidic acid synthesis by ovarian cancer cells

2003 • 59 citations

Enantioselective Responses to a Phosphorothioate Analogue of Lysophosphatidic Acid with LPA₃Receptor-Selective Agonist Activity

2003 • 58 citations

Increased formation of lysophosphatidic acids by lysophospholipase D in serum of hypercholesterolemic rabbits

2002 • 50 citations

Structure–activity relationships of lysophosphatidic acid analogs

2002 • 46 citations

Synthesis of Chiral (α,α-Difluoroalkyl)phosphonate Analogues of (Lyso)phosphatidic Acid via Hydrolytic Kinetic Resolution

2002 • 39 citations

A Real-Time Fluorogenic Phospholipase A2 Assay for Biochemical and Cellular Activity Measurements

2002 • 37 citations

Competitive Fluorescence Polarization Assays for the Detection of Phosphoinositide Kinase and Phosphatase Activity

2003 • 36 citations

Regulation of secretory type-II phospholipase A2 and of lysophosphatidic acid synthesis

1998 • 28 citations

Inducible Expression of a Constitutively Active Mutant of Mitogen-activated Protein Kinase Kinase 7 Specifically Activates c-JUN NH2-terminal Protein Kinase, Alters Expression of at Least Nine Genes, and Inhibits Cell Proliferation

2002 • 27 citations

Activation of mTOR signaling by novel fluoromethylene phosphonate analogues of phosphatidic acid

2004 • 24 citations

Lack of significant differences in the corrected activity of lysophospholipase D, producer of phospholipid mediator lysophosphatidic acid, in incubated serum from women with and without ovarian tumors

2001 • 21 citations

Modulators of lysophosphatidic acid signalling

2003 • 20 citations

Phospholipase D and phosphatidic acid enhance the hydrolysis of phospholipids in vesicles and in cell membranes by human secreted phospholipase A2

1998 • 19 citations

Upregulation of endothelin-1 production by lysophosphatidic acid in rat aortic endothelial cells

1998 • 18 citations

A Gonadotropin-Releasing Hormone-Responsive Phosphatase Hydrolyses Lysophosphatidic Acid within the Plasma Membrane of Ovarian Cancer Cells

2000 • 17 citations

Ovarian Expression, Cellular Localization, and Hormonal Regulation of Rat Secretory Phospholipase A2: Increased Expression by Interleukin-1 and by Gonadotropins1

1997 • 16 citations