Sphingosine-1-phosphate inhibition of placental trophoblast differentiation through a Gi-coupled receptor response

The Pathology of the Human Placenta

1967 • 2,145 citations

Purification, Characterization, andin vitroDifferentiation of Cytotrophoblasts from Human Term Placentae*

1986 • 1,556 citations

G Protein Pathways

2002 • 1,222 citations

Lysophospholipid Receptors: Signaling and Biology

2004 • 752 citations

Sphingosine kinase, sphingosine-1-phosphate, and apoptosis

2002 • 527 citations

Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival

1998 • 468 citations

Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets

1995 • 435 citations

A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development

2000 • 401 citations

Epidermal Growth Factor Induces Differentiation and Secretion of Human Chorionic Gonadotropin and Placental Lactogen in Normal Human Placenta*

1987 • 329 citations

EDG1 Is a Functional Sphingosine-1-phosphate Receptor That Is Linked via a Gi/o to Multiple Signaling Pathways, Including Phospholipase C Activation, Ca2+Mobilization, Ras-Mitogen-activated Protein Kinase Activation, and Adenylate Cyclase Inhibition

1998 • 279 citations

Signaling and biological actions of sphingosine 1-phosphate

2003 • 272 citations

Stereological Investigation of Placental Morphology in Pregnancies Complicated by Pre-eclampsia with and without Intrauterine Growth Restriction

2003 • 272 citations

Pathology of the Human Placenta

2001 • 221 citations

Differences in Apoptotic Susceptibility of Cytotrophoblasts and Syncytiotrophoblasts in Normal Pregnancy to Those Complicated with Preeclampsia and Intrauterine Growth Restriction

2003 • 213 citations

The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways

1998 • 195 citations

Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts.

1994 • 188 citations

Proliferation of villous trophoblast of the human placenta in normal and abnormal pregnancies

1991 • 179 citations

Syncytial fusion of human trophoblast depends on caspase 8

2003 • 175 citations

The Inducible G Protein-coupled Receptor edg-1 Signals via the Gi/Mitogen-activated Protein Kinase Pathway

1996 • 167 citations

Downregulation of Placental Syncytin Expression and Abnormal Protein Localization in Pre-eclampsia

2001 • 165 citations

Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways

2003 • 155 citations

Epidermal growth factor inhibits cytokine-induced apoptosis of primary human trophoblasts

1996 • 147 citations

The Central Role of Human Chorionic Gonadotropin in the Formation of Human Placental Syncytium

2003 • 134 citations

Pathways of transduction engaged by sphingosine 1-phosphate through G protein-coupled receptors

2002 • 130 citations

Cyclic AMP-dependent protein kinases and human trophoblast cell differentiation in vitro

1998 • 124 citations

In vitro cultured human term cytotrophoblast: A model for normal primary epithelial cells demonstrating a spontaneous differentiation programme that requires EGF for extensive development of syncytium

1997 • 104 citations

Functional, long-term cultures of human term trophoblasts purified by column-elimination of CD9 expressing cells

1994 • 102 citations

Preparation and Functional Characterization of Villous Cytotrophoblasts Free of Syncytial Fragments

2002 • 87 citations

Novel clusters of receptors for sphingosine‐1‐phosphate, sphingosylphosphorylcholine, and (lyso)‐phosphatidic acid: New receptors for “Old” ligands

2004 • 83 citations

Sphingosine-1-phosphate Lyase Is Involved in the Differentiation of F9 Embryonal Carcinoma Cells to Primitive Endoderm

2003 • 75 citations

Sphingosine 1 phosphate induces the chemotaxis of human natural killer cells. Role for heterotrimeric G proteins and phosphoinositide 3 kinases

2002 • 70 citations

Transcriptional Regulation of the Human Chorionic Gonadotropin β Gene during Villous Trophoblast Differentiation

2004 • 61 citations

Placental trophoblasts resist infection by multiple human immunodeficiency virus (HIV) type 1 variants even with cytomegalovirus coinfection but support HIV replication after provirus transfection

1997 • 57 citations

Human and rat alveolar macrophages express multiple EDG receptors

2001 • 52 citations

Pathology of the Human Placenta, 4th Edition

2001 • 32 citations

Cyclic AMP- and differentiation-dependent regulation of the proximal alphaHCG gene promoter in term villous trophoblasts

1999 • 30 citations

Attachment of human placental‐type alkaline phosphatase via phosphatidylinositol to syncytiotrophoblast and tumour cell plasma membranes

1988 • 26 citations

PLATELETS AND INTRAUTERINE GROWTH RETARDATION IN PRE-ECLAMPSIA

1976 • 25 citations

Hypertension in Pregnancy and Size at Birth

1996 • 19 citations

The adverse effect on fetal hemogram by preeclampsia: marked anisocytosis with normocytic, normochromic erythrocythemia as well as thrombocytopenia

1994 • 11 citations

Analysis of human trophoblastic tissue in diagnosis of embryonic viral infections

1994 • 10 citations