The Cross Talk Between Protein Kinase A– and RhoA-Mediated Signaling in Cancer Cells

Integrin Signaling

1999 • 3,705 citations

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1999 • 1,558 citations

RHO–GTPases and cancer

2002 • 1,355 citations

Bidirectional signaling between the cytoskeleton and integrins

1999 • 765 citations

An essential part for Rho–associated kinase in the transcellular invasion of tumor cells

1999 • 609 citations

Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes.

1996 • 560 citations

Ras Protein Farnesyltransferase: A Strategic Target for Anticancer Therapeutic Development

1999 • 538 citations

Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase.

1994 • 469 citations

Structure and Function of Cyclic Nucleotide-Dependent Protein Kinases

1994 • 442 citations

Rho family proteins and Ras transformation: the RHOad less traveled gets congested

1998 • 352 citations

FHL2, a novel tissue-specific coactivator of the androgen receptor

2000 • 330 citations

Role of Endothelial Nitric Oxide Synthase in Endothelial Cell Migration

1999 • 311 citations

Role of cyclic AMP receptor proteins in growth, differentiation, and suppression of malignancy: new approaches to therapy.

1990 • 281 citations

Protein Kinase A Anchoring

1997 • 272 citations

cAMP-induced Morphological Changes Are Counteracted by the Activated RhoA Small GTPase and the Rho Kinase ROKα

1998 • 267 citations

Terminal neuroendocrine differentiation of human prostate carcinoma cells in response to increased intracellular cyclic AMP.

1994 • 247 citations

Rho-Kinase Inhibitor Retards Migration and in Vivo Dissemination of Human Prostate Cancer Cells

2000 • 234 citations

A-kinase anchoring proteins: protein kinase A and beyond

2000 • 228 citations

Acquisition of neuroendocrine characteristics by prostate tumor cells is reversible: implications for prostate cancer progression.

1999 • 225 citations

AKAP signaling complexes at the cytoskeleton

2001 • 223 citations

Regulation of Integrin αvβ3-mediated Endothelial Cell Migration and Angiogenesis by Integrin α5β1 and Protein Kinase A

2000 • 214 citations

Role for G ₁₂ /G ₁₃ in Agonist-Induced Vascular Smooth Muscle Cell Contraction

2000 • 210 citations

Rhoa Function in Lamellae Formation and Migration Is Regulated by the α6β4 Integrin and Camp Metabolism

2000 • 208 citations

Elevation of Intracellular cAMP Inhibits RhoA Activation and Integrin-dependent Leukocyte Adhesion Induced by Chemoattractants

1997 • 205 citations

Expression of seven main Rho family members in gastric carcinoma

2004 • 180 citations

Small GTP-binding Protein Rho Stimulates the Actomyosin System, Leading to Invasion of Tumor Cells

1998 • 160 citations

Release of cAMP Gating by the α6β4 Integrin Stimulates Lamellae Formation and the Chemotactic Migration of Invasive Carcinoma Cells

1998 • 156 citations

Activated 3′,5′-Cyclic AMP-dependent Protein Kinase Is Sufficient to Induce Neuroendocrine-like Differentiation of the LNCaP Prostate Tumor Cell Line

2000 • 116 citations

Role of RhoA activation in the growth and morphology of a murine prostate tumor cell line

1999 • 108 citations

Regulation of Cytoskeleton Organization and Paxillin Dephosphorylation by cAMP

1996 • 105 citations

Inhibition of Rho Is Required for cAMP-induced Melanoma Cell Differentiation

1998 • 101 citations

Reversal of the Malignant Phenotype of Gastric Cancer Cells by Inhibition of RhoA Expression and Activity

2004 • 100 citations

Cyclic AMP induces transforming growth factor beta 2 gene expression and growth arrest in the human androgen-independent prostate carcinoma cell line PC-3.

1992 • 70 citations

Phase I clinical study with 8-chloro-cAMP and evaluation of immunological effects in cancer patients

1995 • 69 citations

Protein kinase A RIalpha antisense inhibition of PC3M prostate cancer cell growth: Bcl-2 hyperphosphorylation, Bax up-regulation, and Bad-hypophosphorylation.

2002 • 53 citations

Somatostatin Interferes with Thyrotropin-induced G1-S Transition Mediated by cAMP-dependent Protein Kinase and Phosphatidylinositol 3-Kinase

2000 • 47 citations

Identification of G protein-coupled receptors potently stimulating migration of human transitional-cell carcinoma cells

1997 • 38 citations

Colorimetric determination of inhibition of hematopoietic progenitor cells in soft agar

2000 • 36 citations

Involvement of small GTPases Rho and Rac in the invasion of rat ascites hepatoma cells.

1999 • 33 citations

Rho-like GTPases: their role in cell adhesion and invasion.

1999 • 33 citations

The effect of papaverine on morphologic differentiation, proliferation and invasive potential of human prostatic cancer LNCaP cells

1999 • 27 citations

Role of cyclic AMP and polypeptide growth regulators in growth inhibition by interferon in PC‐3 cells

1991 • 23 citations

Overexpression of rho effector rhotekin confers increased survival in gastric adenocarcinoma

2004 • 19 citations

Overexpression of Rho Effector Rhotekin Confers Increased Survival in Gastric Adenocarcinoma

2004 • 14 citations

Protein kinase C and adenylate cyclase as targets for growth inhibition of human gastric cancer cells

1993 • 13 citations