Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer

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2000 • 8,734 citations

Metastasis to bone: causes, consequences and therapeutic opportunities

2002 • 2,661 citations

The emerging role of lysophosphatidic acid in cancer

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Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

2002 • 908 citations

The bioactive phospholipid lysophosphatidic acid is released from activated platelets

1993 • 653 citations

Lysophosphatidic Acid as a Potential Biomarker for Ovarian and Other Gynecologic Cancers

1998 • 642 citations

Integrin activation controls metastasis in human breast cancer

2001 • 566 citations

Identification of p2y9/GPR23 as a Novel G Protein-coupled Receptor for Lysophosphatidic Acid, Structurally Distant from the Edg Family

2003 • 553 citations

Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist

2002 • 545 citations

Characterization of a Novel Subtype of Human G Protein-coupled Receptor for Lysophosphatidic Acid

1998 • 535 citations

Molecular Cloning and Characterization of a Novel Human G-protein-coupled Receptor, EDG7, for Lysophosphatidic Acid

1999 • 517 citations

Cancer and Bone*

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Serum Lysophosphatidic Acid Is Produced through Diverse Phospholipase Pathways

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Lysophospholipids activate ovarian and breast cancer cells

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Lysophosphatidic Acid and Autotaxin Stimulate Cell Motility of Neoplastic and Non-neoplastic Cells through LPA1

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Lysophosphatidic acid is a bioactive mediator in ovarian cancer

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Interleukin-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivo.

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Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species

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Lysophosphatidic Acid Induction of Vascular Endothelial Growth Factor Expression in Human Ovarian Cancer Cells

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Molecular Cloning of the Human Edg2 Protein and Its Identification as a Functional Cellular Receptor for Lysophosphatidic Acid

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Platelet and osteoclast β ₃ integrins are critical for bone metastasis

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Autotaxin Is Released from Adipocytes, Catalyzes Lysophosphatidic Acid Synthesis, and Activates Preadipocyte Proliferation

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Integrin αvβ3 expression confers on tumor cells a greater propensity to metastasize to bone

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Expression of interleukin 8 and not parathyroid hormone-related protein by human breast cancer cells correlates with bone metastasis in vivo.

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Mechanisms for Lysophosphatidic Acid-induced Cytokine Production in Ovarian Cancer Cells

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Identification of the molecular species of lysophosphatidic acid produced when platelets are stimulated by thrombin

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Early Detection of Bone Metastases in a Murine Model Using Fluorescent Human Breast Cancer Cells: Application to the Use of the Bisphosphonate Zoledronic Acid in the Treatment of Osteolytic Lesions

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Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer.

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Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells.

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Development of Our Current Understanding of Bioactive Lysophospholipids

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Inhibition of tumor cell-induced platelet aggregation and lung metastasis by the oral GpIIb/IIIa antagonist XV454

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Metastatic bone disease: Clinical and therapeutic aspects

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Dual mechanisms for lysophospholipid induction of proliferation of human breast carcinoma cells.

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Angiostatin Inhibits Bone Metastasis Formation in Nude Mice through a Direct Anti-osteoclastic Activity

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Platelets and Cancer: Implications for Antiangiogenic Therapy

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A simple and highly sensitive radioenzymatic assay for lysophosphatidic acid quantification

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Lysophosphatidic acid-induced aggregation of human and feline platelets: Structure-activity relationship

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Sphingosine 1-Phosphate Stimulates Fibronectin Matrix Assembly Through a Rho-Dependent Signal Pathway

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The effect of platelets on invasiveness and protease production of human mammary tumor cells

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Tumour progression and angiogenesis in bone metastasis from breast cancer: new approaches to an old problem

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Cytokines and Bone Remodeling

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Manipulating the environment of cancer cells in bone: a novel therapeutic approach

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The Role of Bisphosphonates in Breast Cancer Management: Review Article

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Thrombospondin (TSP1) mediates in vitro proliferation of human MG‐63 osteoblastic cells induced by α‐thrombin

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Differential stimulation of signaling pathways initiated by Edg-2 in response to lysophosphatidic acid or sphingosine-1-phosphate

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