Sphingosine 1‐phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma

Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

1998 • 1,003 citations

Cytokines in symptomatic asthma airways

1992 • 750 citations

Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex.

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Airway remodeling in asthma

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Sphingosine 1-phosphate signalling in mammalian cells

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Characterization of a Novel Subtype of Human G Protein-coupled Receptor for Lysophosphatidic Acid

1998 • 535 citations

Molecular Cloning and Characterization of a Novel Human G-protein-coupled Receptor, EDG7, for Lysophosphatidic Acid

1999 • 517 citations

Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival

1998 • 468 citations

Sphingosine 1-phosphate signalling in mammalian cells

2000 • 458 citations

Tumor necrosis factor-α induces adhesion molecule expression through the sphingosine kinase pathway

1998 • 404 citations

Tumor Necrosis Factor (TNF)-α Inhibits Insulin Signaling through Stimulation of the p55 TNF Receptor and Activation of Sphingomyelinase

1996 • 404 citations

National asthma education program expert panel report. Guidelines for the diagnosis and management of asthma

1991 • 397 citations

Sphingosine 1-Phosphate Stimulates Cell Migration through a Gi-coupled Cell Surface Receptor

1999 • 371 citations

Differential Coupling of the Sphingosine 1-Phosphate Receptors Edg-1, Edg-3, and H218/Edg-5 to the Gi, Gq, and G12 Families of Heterotrimeric G Proteins

1999 • 329 citations

A human airway smooth muscle cell line that retains physiological responsiveness

1989 • 321 citations

Increased MCP-1, RANTES, and MIP-1alpha in bronchoalveolar lavage fluid of allergic asthmatic patients.

1996 • 298 citations

EDG1 Is a Functional Sphingosine-1-phosphate Receptor That Is Linked via a Gi/o to Multiple Signaling Pathways, Including Phospholipase C Activation, Ca2+Mobilization, Ras-Mitogen-activated Protein Kinase Activation, and Adenylate Cyclase Inhibition

1998 • 279 citations

Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction.

1995 • 264 citations

Differential Pharmacological Properties and Signal Transduction of the Sphingosine 1-Phosphate Receptors EDG-1, EDG-3, and EDG-5

1999 • 255 citations

Identification of cDNAs encoding two G protein‐coupled receptors for lysosphingolipids¹

1997 • 247 citations

Human airway smooth muscle cells express and release RANTES in response to T helper 1 cytokines: regulation by T helper 2 cytokines and corticosteroids.

1997 • 242 citations

T lymphocytes adhere to airway smooth muscle cells via integrins and CD44 and induce smooth muscle cell DNA synthesis.

1994 • 235 citations

Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3

2000 • 231 citations

Differential Regulation of Sphingomyelinase and Ceramidase Activities by Growth Factors and Cytokines

1995 • 222 citations

Comparison of Intrinsic Activities of the Putative Sphingosine 1-Phosphate Receptor Subtypes to Regulate Several Signaling Pathways in Their cDNA-transfected Chinese Hamster Ovary Cells

1999 • 219 citations

Sphingosine 1-Phosphate-induced Cell Proliferation, Survival, and Related Signaling Events Mediated by G Protein-coupled Receptors Edg3 and Edg5

2000 • 196 citations

The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways

1998 • 195 citations

Sphingosine 1-Phosphate-induced Cell Rounding and Neurite Retraction Are Mediated by the G Protein-coupled Receptor H218

1999 • 183 citations

Enzymatic Measurement of Sphingosine 1-Phosphate

1999 • 182 citations

Induction of cyclo‐oxygenase‐2 by cytokines in human cultured airway smooth muscle cells: novel inflammatory role of this cell type

1997 • 179 citations

The Balance between Sphingosine and Sphingosine-1-Phosphate Is Decisive for Mast Cell Activation after Fc∈ Receptor I Triggering

1999 • 175 citations

Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6

2000 • 174 citations

The Inducible G Protein-coupled Receptor edg-1 Signals via the Gi/Mitogen-activated Protein Kinase Pathway

1996 • 167 citations

Involvement of a Pertussis Toxin-sensitive G Protein in the Mitogenic Signaling Pathways of Sphingosine 1-Phosphate

1995 • 161 citations

Histamine stimulates proliferation of airway smooth muscle and induces c-fos expression

1990 • 158 citations

Edg-6 as a Putative Sphingosine 1-Phosphate Receptor Coupling to Ca2+ Signaling Pathway

2000 • 154 citations

Airway smooth muscle cells: contributing to and regulating airway mucosal inflammation?

2000 • 146 citations

Airway remodeling and persistent airway obstruction in asthma

1999 • 145 citations

MAPK superfamily activation in human airway smooth muscle: mitogenesis requires prolonged p42/p44 activation

1999 • 136 citations

Synthetic functions of airway smooth muscle in asthma

1997 • 131 citations

Sphingomyelin‐Derived Lipids Differentially Regulate the Extracellular Signal‐Regulated Kinase 2 (ERK‐2) and c‐Jun N‐Terminal Kinase (JNK) Signal Cascades in Airway Smooth Muscle

1996 • 126 citations

Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation

1999 • 125 citations

Eosinophil recruitment following allergen challenge is associated with the release of the chemokine RANTES into asthmatic airways.

1996 • 119 citations

Tumor Necrosis Factor- α –Induced Secretion of RANTES and Interleukin-6 from Human Airway Smooth-Muscle Cells

2000 • 117 citations

alpha-Thrombin increases cytosolic calcium and induces human airway smooth muscle cell proliferation.

1995 • 103 citations

Mechanisms of Acute Desensitization of the β₂AR–Adenylyl Cyclase Pathway in Human Airway Smooth Muscle

1998 • 97 citations

Mechanisms underlying TNF-α effects on agonist-mediated calcium homeostasis in human airway smooth muscle cells

1997 • 88 citations

TGF-beta 1 modulates human airway smooth-muscle cell proliferation induced by mitogens.

1997 • 87 citations

Sphingosine‐1‐phosphate modulates growth and adhesion of ovarian cancer cells

1999 • 87 citations

Synergistic stimulation of airway smooth muscle cell mitogenesis.

2000 • 86 citations

Cellular and Molecular Mechanisms Regulating Airway Smooth Muscle Proliferation and Cell Adhesion Molecule Expression

1998 • 86 citations

Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle

1999 • 83 citations

Cytokines induce airway smooth muscle cell hyperresponsiveness to contractile agonists

1998 • 83 citations

Tumor Necrosis Factor- α Enhances mRNA Expression and Secretion of Interleukin-6 in Cultured Human Airway Smooth Muscle Cells

2000 • 75 citations

Involvement of Focal Adhesion Kinase in Inhibition of Motility of Human Breast Cancer Cells by Sphingosine 1-Phosphate

1999 • 70 citations

Kinetics of the development and recovery of the lung from IgE-mediated inflammation: dissociation of pulmonary eosinophilia, lung injury, and eosinophil-active cytokines.

1997 • 68 citations

Pulmonary inflammation after segmental ragweed challenge in allergic asthmatic and nonasthmatic subjects.

1995 • 65 citations

Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle

1999 • 56 citations

Involvement of pertussis toxin‐sensitive GTP‐binding proteins in sphingosine 1‐phosphate‐induced activation of phospholipase CCa²⁺ system in HL60 leukemia cells

1996 • 53 citations

Inflammatory and Contractile Agents Sensitize Specific Adenylyl Cyclase Isoforms in Human Airway Smooth Muscle

1999 • 51 citations

Ca²⁺ increase and Ca²⁺‐influx in human tracheal smooth muscle cells: role of Ca²⁺ pools controlled by sarco‐endoplasmic reticulum Ca²⁺‐ATPase 2 isoform

1995 • 46 citations

EGF activates ErbB-2 and stimulates phosphatidylinositol 3-kinase in human airway smooth muscle cells

1999 • 38 citations

Activation of K-p21ras and N-p21ras, but Not H-p21ras, Is Necessary for Mitogen-Induced Human Airway Smooth-Muscle Proliferation

1999 • 37 citations

Airway Smooth Muscle in Asthma

2000 • 35 citations

IL-1β RELEASE FROM CULTURED BRONCHIAL EPITHELIAL CELLS AND BRONCHOALVEOLAR LAVAGE CELLS FROM ALLERGIC AND NORMAL HUMANS FOLLOWING SEGMENTAL CHALLENGE WITH RAGWEED

1996 • 33 citations

Deciphering the Homeokinetic Code of Airway Smooth Muscle

2000 • 17 citations