Mouse models of insulin resistance

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

1993 • 23,535 citations

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

Central nervous system control of food intake

2000 • 6,305 citations

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

Insulin signalling and the regulation of glucose and lipid metabolism

2001 • 4,995 citations

Cellular survival: a play in three Akts

1999 • 4,229 citations

Genetic Dissection of Complex Traits

1994 • 3,497 citations

A central role for JNK in obesity and insulin resistance

2002 • 3,225 citations

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

2000 • 2,178 citations

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

1997 • 2,174 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1997 • 1,905 citations

Transcriptional regulation of adipogenesis

2000 • 1,875 citations

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

2001 • 1,849 citations

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

2001 • 1,789 citations

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

Report of the task group on reference man

1979 • 1,754 citations

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting

1990 • 1,650 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

The PI3K–PDK1 connection: more than just a road to PKB

2000 • 1,563 citations

Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle

2002 • 1,540 citations

daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

1997 • 1,468 citations

Retinopathy and Nephropathy in Patients with Type 1 Diabetes Four Years after a Trial of Intensive Therapy

2000 • 1,468 citations

The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307

2000 • 1,423 citations

Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction

2003 • 1,399 citations

Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis

2001 • 1,329 citations

Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

2003 • 1,328 citations

Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase

1999 • 1,284 citations

Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

1996 • 1,277 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice

2000 • 1,218 citations

Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction

2000 • 1,213 citations

Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival

2001 • 1,204 citations

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

2001 • 1,202 citations

A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

1998 • 1,173 citations

Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

1999 • 1,151 citations

Unified nomenclature for the winged helix/forkhead transcription factors

2000 • 1,136 citations

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

1999 • 1,102 citations

Insulin receptors are widely distributed in the central nervous system of the rat

1978 • 1,092 citations

Direct control of the Forkhead transcription factor AFX by protein kinase B

1999 • 1,080 citations

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

Development of obesity in transgenic mice after genetic ablation of brown adipose tissue

1993 • 1,057 citations

Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

2001 • 1,013 citations

Phosphorylation of Ser307 in Insulin Receptor Substrate-1 Blocks Interactions with the Insulin Receptor and Inhibits Insulin Action

2002 • 973 citations

A Role for AMP-Activated Protein Kinase in Contraction- and Hypoxia-Regulated Glucose Transport in Skeletal Muscle

2001 • 935 citations

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

1996 • 870 citations

Insulin Receptor Isoform A, a Newly Recognized, High-Affinity Insulin-Like Growth Factor II Receptor in Fetal and Cancer Cells

1999 • 865 citations

Hypothalamic insulin signaling is required for inhibition of glucose production

2002 • 852 citations

Role of IRS-2 in insulin and cytokine signalling

1995 • 843 citations

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2

2003 • 808 citations

Adipose Tissue Selective Insulin Receptor Knockout Protects against Obesity and Obesity-Related Glucose Intolerance

2002 • 806 citations

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

1997 • 740 citations

Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance

2000 • 733 citations

A Lesson in Metabolic Regulation Inspired by the Glucokinase Glucose Sensor Paradigm

1996 • 728 citations

Prevention of fat-induced insulin resistance by salicylate

2001 • 713 citations

The Forkhead Transcription Factor Foxo1 Regulates Adipocyte Differentiation

2003 • 711 citations

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBβ

2003 • 708 citations

New Perspectives into the Molecular Pathogenesis and Treatment of Type 2 Diabetes

2001 • 695 citations

The IRS-signalling system: A network of docking proteins that mediate insulin action

1998 • 693 citations

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

1998 • 680 citations

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1996 • 674 citations

Impaired Glucose Transport as a Cause of Decreased Insulin-Stimulated Muscle Glycogen Synthesis in Type 2 Diabetes

1999 • 666 citations

Cellular Localization of Somatomedin (Insulin-Like Growth Factor) Messenger RNA in the Human Fetus

1987 • 663 citations

CAP defines a second signalling pathway required for insulin-stimulated glucose transport

2000 • 646 citations

The Function of GRB2 in Linking the Insulin Receptor to Ras Signaling Pathways

1993 • 629 citations

Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1

2002 • 616 citations

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

2002 • 614 citations

Dynamics of β-cell Mass in the Growing Rat Pancreas: Estimation With a Simple Mathematical Model

1995 • 607 citations

Non-Insulin-Dependent Diabetes Mellitus — A Genetically Programmed Failure of the Beta Cell to Compensate for Insulin Resistance

1996 • 607 citations

Hemodynamic actions of insulin

1994 • 606 citations

Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

2001 • 606 citations

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

1996 • 596 citations

Insulin/IGF-1 and TNF-α stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways

2001 • 577 citations

Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

2002 • 573 citations

The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

2001 • 570 citations

A Molecular Basis for Insulin Resistance

1997 • 550 citations

Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles

1997 • 549 citations

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth

2002 • 534 citations

Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues.

1986 • 531 citations

A Conserved Regulatory System for Aging

2001 • 526 citations

Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling

1999 • 526 citations

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

2000 • 519 citations

Distinct and Overlapping Functions of Insulin and IGF-I Receptors

2001 • 515 citations

Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα

2001 • 509 citations

Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo.

1999 • 499 citations

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2

2000 • 499 citations

Diabetes mellitus and genetically programmed defects in β-cell function

2001 • 484 citations

Adaptations of glucose and fatty acid metabolism during perinatal period and suckling-weaning transition

1992 • 481 citations

Mouse Mutants Lacking the Type 2 IGF Receptor (IGF2R) Are Rescued from Perinatal Lethality inIgf2andIgf1rNull Backgrounds

1996 • 479 citations

Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4

1995 • 478 citations

Insulin Stimulates Phosphorylation of the Forkhead Transcription Factor FKHR on Serine 253 through a Wortmannin-sensitive Pathway

1999 • 470 citations

Akt, a Pleckstrin Homology Domain Containing Kinase, Is Activated Primarily by Phosphorylation

1996 • 469 citations

Receptor-Mediated Transport of Insulin Across Endothelial Cells

1985 • 462 citations

IRS-2 pathways integrate female reproduction and energy homeostasis

2000 • 459 citations

Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice

2000 • 448 citations

Tumor Necrosis Factor α-induced Phosphorylation of Insulin Receptor Substrate-1 (IRS-1)

1995 • 426 citations

Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2

1997 • 419 citations

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

2002 • 407 citations

Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators

2002 • 406 citations

Role of insulin-like growth factor binding proteins in controlling IGF actions

1998 • 401 citations

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase

1999 • 396 citations

Growth-Promoting Interaction of IGF-II with the Insulin Receptor during Mouse Embryonic Development

1997 • 391 citations

Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans

1999 • 386 citations

A Novel 160-kDa Phosphotyrosine Protein in Insulin-treated Embryonic Kidney Cells Is a New Member of the Insulin Receptor Substrate Family

1997 • 381 citations

Islet β cell expression of constitutively active Akt1/PKBα induces striking hypertrophy, hyperplasia, and hyperinsulinemia

2001 • 381 citations

daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans.

1994 • 375 citations

Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression

2002 • 375 citations

β-cell–specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass

2002 • 370 citations

The lipid phosphatase SHIP2 controls insulin sensitivity

2001 • 369 citations

Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes

2001 • 367 citations

Insulin-Induced Phosphorylation and Activation of Cyclic Nucleotide Phosphodiesterase 3B by the Serine-Threonine Kinase Akt

1999 • 365 citations

Requirement of Atypical Protein Kinase Cλ for Insulin Stimulation of Glucose Uptake but Not for Akt Activation in 3T3-L1 Adipocytes

1998 • 365 citations

Cell Nonautonomy of C. elegans daf-2 Function in the Regulation of Diapause and Life Span

1998 • 362 citations

DNA excision in liver by an albumin-Cre transgene occurs progressively with age

2000 • 360 citations

Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart

1999 • 360 citations

GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes

1997 • 359 citations

The 60-kDa Phosphotyrosine Protein in Insulin-treated Adipocytes Is a New Member of the Insulin Receptor Substrate Family

1997 • 354 citations

Rapid tightening of blood glucose control leads to transient deterioration of retinopathy in insulin dependent diabetes mellitus: the Oslo study.

1985 • 353 citations

An Insulin-like Signaling Pathway Affects Both Longevity and Reproduction in Caenorhabditis elegans

1998 • 347 citations

Genetics of mouse growth.

1998 • 342 citations

Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle

2000 • 340 citations

The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance

2003 • 329 citations

Islet β cell expression of constitutively active Akt1/PKBα induces striking hypertrophy, hyperplasia, and hyperinsulinemia

2001 • 328 citations

Essential role of PDK1 in regulating cell size and development in mice

2002 • 322 citations

Lilly Lecture: Molecular Mechanisms of Insulin Resistance: Lessons From Patients With Mutations in the Insulin-Receptor Gene

1992 • 319 citations

Construction and Characterization of a Conditionally Active Version of the Serine/Threonine Kinase Akt

1998 • 318 citations

Two Mutant Alleles of the Insulin Receptor Gene in a Patient with Extreme Insulin Resistance

1988 • 308 citations

Chemical Composition of Newly Born Mammals

1950 • 306 citations

Insulin transport across capillaries is rate limiting for insulin action in dogs.

1989 • 299 citations

Contrasting Effects of IRS-1 Versus IRS-2 Gene Disruption on Carbohydrate and Lipid Metabolism in Vivo

2000 • 291 citations

Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α

2000 • 291 citations

Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality.

1996 • 287 citations

Exocytosis of Insulin Promotes Insulin Gene Transcription via the Insulin Receptor/PI-3 Kinase/p70 s6 Kinase and CaM Kinase Pathways

1998 • 284 citations

Birth weight, type 2 diabetes, and insulin resistance in Pima Indian children and young adults.

1999 • 279 citations

Transgenic knockouts reveal a critical requirement for pancreatic β cell glucokinase in maintaining glucose homeostasis

1995 • 277 citations

Altered function of insulin receptor substrate-1–deficient mouse islets and cultured β-cell lines

1999 • 276 citations

Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus

1982 • 276 citations

Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR

2000 • 273 citations

Phenotypic alterations in insulin-deficient mutant mice

1997 • 272 citations

Selective Insulin Signaling through A and B Insulin Receptors Regulates Transcription of Insulin and Glucokinase Genes in Pancreatic β Cells

2001 • 268 citations

Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c

2002 • 266 citations

CEACAM1 regulates insulin clearance in liver

2002 • 263 citations

Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene

1991 • 262 citations

Mouse models of insulin resistance

2002 • 254 citations

Insights into insulin resistance and type 2 diabetes from knockout mouse models

2000 • 252 citations

Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

2002 • 245 citations

Protein Kinase C Modulation of Insulin Receptor Substrate-1 Tyrosine Phosphorylation Requires Serine 612

1997 • 245 citations

Hepatocyte Growth Factor Overexpression in the Islet of Transgenic Mice Increases Beta Cell Proliferation, Enhances Islet Mass, and Induces Mild Hypoglycemia

2000 • 244 citations

Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice

1999 • 239 citations

Minimally invasive aortic banding in mice: effects of altered cardiomyocyte insulin signaling during pressure overload

2003 • 237 citations

Pancreatic β-Cell-specific Targeted Disruption of Glucokinase Gene

1995 • 235 citations

Phosphoenolpyruvate Carboxykinase Is Necessary for the Integration of Hepatic Energy Metabolism

2000 • 232 citations

The Insulin Receptor and Its Cellular Targets¹

2001 • 231 citations

Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis

2000 • 227 citations

Responses of GLUT4-Deficient Hearts to Ischemia Underscore the Importance of Glycolysis

2001 • 225 citations

Primary Structure of a Putative Receptor for a Ligand of the Insulin Family

1989 • 224 citations

Regulation of Phosphatidylinositol 3′-Kinase by Tyrosyl Phosphoproteins

1995 • 222 citations

Akt Signaling Mediates Postnatal Heart Growth in Response to Insulin and Nutritional Status

2002 • 221 citations

Brown adipose tissue–specific insulin receptor knockout shows diabetic phenotype without insulin resistance

2001 • 216 citations

Embryogenesis of the Human Pancreatic Islets: A Light and Electron Microscopic Study

1972 • 214 citations

Effects of Acute and Chronic Administration of the Melanocortin Agonist MTII in Mice With Diet-Induced Obesity

2002 • 210 citations

Targeted Expression of Placental Lactogen in the Beta Cells of Transgenic Mice Results in Beta Cell Proliferation, Islet Mass Augmentation, and Hypoglycemia

2000 • 209 citations

Insulin signaling is required for insulin’s direct and indirect action on hepatic glucose production

2003 • 207 citations

Regulation of insulin-like growth factor–dependent myoblast differentiation by Foxo forkhead transcription factors

2003 • 204 citations

Essential Role of Insulin Receptor Substrate 1 (IRS-1) and IRS-2 in Adipocyte Differentiation

2001 • 201 citations

Skeletal muscle blood flow independently modulates insulin-mediated glucose uptake

1994 • 200 citations

Reduction of Protein Tyrosine Phosphatase 1B Increases Insulin-Dependent Signaling in ob/ob Mice

2003 • 199 citations

Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss.

1988 • 195 citations

Insulin Receptor Substrate 3 Is Not Essential for Growth or Glucose Homeostasis

1999 • 191 citations

Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization

2003 • 189 citations

Defective insulin secretion in pancreatic β cells lacking type 1 IGF receptor

2002 • 188 citations

Insulin-induced cortical actin remodeling promotes GLUT4 insertion at muscle cell membrane ruffles

2001 • 187 citations

Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4

2001 • 187 citations

IRS proteins and beta-cell function.

2001 • 180 citations

Pdx1 restores β cell function in Irs2 knockout mice

2002 • 179 citations

Early pattern of differentiation in the human pancreas.

2000 • 176 citations

Transgenic mice overexpressing insulin-like growth factor-II in β cells develop type 2 diabetes

2000 • 174 citations

Evidence That IRS-2 Phosphorylation Is Required for Insulin Action in Hepatocytes

1998 • 169 citations

Roles of Insulin Receptor Substrate-1, Phosphatidylinositol 3-Kinase, and Release of Intracellular Ca2+ Stores in Insulin-stimulated Insulin Secretion in β-Cells

2000 • 164 citations

Signalling through IGF-I and insulin receptors: where is the specificity?

2002 • 163 citations

Evidence for a circulating islet cell growth factor in insulin-resistant states

2001 • 158 citations

Hypoglycemic effect of insulin-like growth factor-1 in mice lacking insulin receptors.

1997 • 156 citations

A Phosphatidylinositol 3-Kinase-independent Insulin Signaling Pathway to N-WASP/Arp2/3/F-actin Required for GLUT4 Glucose Transporter Recycling

2002 • 151 citations

Posttranscriptional Control of Adipocyte Differentiation through Activation of Phosphoinositide 3-Kinase

1998 • 150 citations

The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake.

1995 • 149 citations

Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue

1998 • 143 citations

Attenuation of insulin secretion by insulin-like growth factor 1 is mediated through activation of phosphodiesterase 3B

1997 • 141 citations

Role of Tissue-Specific Blood Flow and Tissue Recruitment in Insulin-Mediated Glucose Uptake of Human Skeletal Muscle

1998 • 139 citations

Transendothelial insulin transport is not saturable in vivo. No evidence for a receptor-mediated process.

1996 • 138 citations

Insulin: new roles for an ancient hormone

1999 • 133 citations

Metabolic and endocrine findings in appropriate and small for gestational age fetuses

1991 • 133 citations

Lipoatrophic diabetes in Irs1^−/−/Irs3^−/− double knockout mice

2002 • 129 citations

Homozygous deletion of the human insulin receptor gene results in leprechaunism

1993 • 127 citations

Insulin-Like Growth Factor-I at Physiological Concentrations Is a Potent Inhibitor of Insulin Secretion*

1990 • 127 citations

Factors Affecting the Secretion of Insulin and Glucagon by the Rat Fetus

1974 • 126 citations

Impact of Genetic Background on Development of Hyperinsulinemia and Diabetes in Insulin Receptor/Insulin Receptor Substrate-1 Double Heterozygous Mice

2003 • 118 citations

Phosphoinositide-Regulated Kinases and Phosphoinositide Phosphatases

2001 • 117 citations

Syntaxin 4 heterozygous knockout mice develop muscle insulin resistance

2001 • 117 citations

Absence of functional insulin receptor substrate-3 ( IRS-3 ) gene in humans

2002 • 113 citations

Molecular Genetics of Maturity-onset Diabetes of the Young

1999 • 113 citations

Preserved Pancreatic β-Cell Development and Function in Mice Lacking the Insulin Receptor-Related Receptor

2001 • 108 citations

Insulin Receptor Substrate-2 Is Not Necessary for Insulin- and Exercise-stimulated Glucose Transport in Skeletal Muscle

1999 • 106 citations

Homozygous nonsense mutation in the insulin receptor gene in infant with leprechaunism

1993 • 100 citations

Insulin-Stimulated Phosphorylation of Recombinant pp120/HA4, an Endogenous Substrate of the Insulin Receptor Tyrosine Kinase

1995 • 92 citations

Hypoglycemia in Beckwith-Wiedemann syndrome

2000 • 92 citations

Diabetes and Cardiovascular Diseases

2002 • 92 citations

Oxidative and non-oxidative glucose metabolism in non-obese Type 2 (non-insulin-dependent) diabetic patients

1988 • 91 citations

Cloning, Tissue Expression, and Chromosomal Localization of the Mouse IRS-3 Gene

1997 • 89 citations

The Effect of Oral Glucose on Serum Free Insulin-Like Growth Factor-I and -II in Healthy Adults*

1997 • 86 citations

THE INFANT OF THE DIABETIC MOTHER

1996 • 86 citations

Insulin receptor substrate-2 amino acid polymorphisms are not associated with random type 2 diabetes among Caucasians.

1998 • 85 citations

The 60 kDa Insulin Receptor Substrate Functions Like an IRS Protein (pp60^IRS3) in Adipose Cells

1997 • 83 citations

Effects of Knockout of the Protein Kinase C β Gene on Glucose Transport and Glucose Homeostasis1

1999 • 77 citations

Phosphatidylinositol 3-Kinase Suppresses Glucose-Stimulated Insulin Secretion by Affecting Post-Cytosolic [Ca2+] Elevation Signals

2002 • 77 citations

Genetic modifiers of the insulin resistance phenotype in mice.

2000 • 76 citations

Effects of Mutations in the Insulin-like Growth Factor Signaling System on Embryonic Pancreas Development and β-Cell Compensation to Insulin Resistance

2002 • 74 citations

A Link between Insulin Resistance and Hyperinsulinemia: Inhibitors of Phosphatidylinositol 3-Kinase Augment Glucose-Induced Insulin Secretion from Islets of Lean, But Not Obese, Rats¹

2000 • 69 citations

A homozygous kinase-defective mutation in the insulin receptor gene in a patient with leprechaunism

1997 • 68 citations

Quantitation of glycolysis and skeletal muscle glycogen synthesis in humans

1993 • 66 citations

THE GENETICIST'S APPROACH TO COMPLEX DISEASE

1996 • 63 citations

Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of their relation with alterations in insulin secretion and insulin sensitivity

1999 • 63 citations

Ontogenetic appearance of immunoreactive endocrine cells in rat pancreatic islets

1982 • 62 citations

Polyhormonal aspect of the endocrine cells of the human fetal pancreas

1999 • 61 citations

Hypoglycemia and Hyperinsulinism in Infants with Erythroblastosis Fetalis

1968 • 60 citations

Progressive Decline in Insulin Levels in Rabson-Mendenhall Syndrome¹

1999 • 57 citations

Extreme Insulin Resistance in Association with Abnormally High Binding Affinity of Insulin Receptors from a Patient with Leprechaunism: Evidence for a Defect Intrinsic to the Receptor

1982 • 56 citations

Identification of Interactive Loci Linked to Insulin and Leptin in Mice With Genetic Insulin Resistance

2003 • 56 citations

Insulin receptor-related receptor is expressed in pancreatic beta-cells and stimulates tyrosine phosphorylation of insulin receptor substrate-1 and -2.

1999 • 56 citations

Uptake of glucose carbon in muscle glycogen and adipose tissue triglycerides in vivo in humans

1992 • 55 citations

Non-insulin-dependent diabetes mellitus and gestational diabetes mellitus: Same disease, another name?

1995 • 54 citations

The molecular basis of persistent hyperinsulinemic hypoglycemia of infancy and its pathologic substrates

2000 • 51 citations

Effects of Wortmannin on Increased Glucose Transport by Insulin and Norepinephrine in Primary Culture of Brown Adipocytes

1994 • 50 citations

Effect of Insulin Therapy on Progression of Retinopathy in Noninsulin-dependent Diabetes Mellitus

1993 • 50 citations

Pancreatic Insulin-, Glucagon-, and Somatostatin-Positive Isle Cell Populations during the Perinatal Development of the Rat

1980 • 50 citations

Aging, life span, and senescence

1998 • 49 citations

A Novel Human Insulin Receptor Gene Mutation Uniquely Inhibits Insulin Binding Without Impairing Posttranslational Processing

1994 • 48 citations

Developmental Changes in Serum Levels of Free and Total Insulin-Like Growth Factor I (IGF-I), IGF-Binding Protein-1 and -3, and the Acid-Labile Subunit in Rats**This work was supported by grants from the Danish Health Research Council (Grants 9602012 and 9700592), the Aarhus University-Novo Nordisk Center for Research in Growth and Regeneration (Danish Health Research Council Grant 9600822), the Institute of Experimental Clinical Research, University of Aarhus, the Novo Foundation, the Nordic …

1998 • 48 citations

Interaction of Insulin Receptor Substrate 3 with Insulin Receptor, Insulin Receptor-related Receptor, Insulin-like Growth Factor-1 Receptor, and Downstream Signaling Proteins

1999 • 47 citations

Differential Signaling of Insulin and IGF-1 Receptors to Glycogen Synthesis in Murine Hepatocytes

1999 • 46 citations

Searching for Type 2 Diabetes Genes in the Post-genome Era

2000 • 44 citations

Effect of Intravenous Insulin-like Growth Factor I in Two Patients with Leprechaunism

1994 • 43 citations

GLUCOSE-INDUCED INCREASE OF PLASMA INSULIN IN THE RAT FOETUS IN UTERO

1974 • 42 citations

Exclusion of insulin receptor substrate 2 (IRS-2) as a major locus for early-onset autosomal dominant type 2 diabetes.

1999 • 41 citations

Genetics of Type 2 Diabetes Insight from Targeted Mouse Mutants

2001 • 40 citations

Homozygosity for a null allele of the insulin receptor gene in a patient with leprechaunism

1995 • 40 citations

Differential Phosphorylation of pp120 by Insulin and Insulin-like Growth Factor-1 Receptors: Role for the C-Terminal Domain of the β-Subunit

1997 • 40 citations

Glucose Kinetics in Leprechaunism: Accelerated Fasting due to Insulin Resistance*

1980 • 38 citations

Impaired Insulin Signaling in Skeletal Muscles from Transgenic Mice Expressing Kinase-deficient Insulin Receptors

1995 • 35 citations

Increased IGFR activity and glucose transport in cultured skeletal muscle from insulin receptor null mice

2001 • 34 citations

Impact of Genetic Background and Ablation of Insulin Receptor Substrate (IRS)-3 on IRS-2 Knock-out Mice

2003 • 31 citations

Homozygous nonsense mutation in the insulin receptor gene of a patient with severe congenital insulin resistance: leprechaunism and the role of the insulin‐like growth factor receptor

1996 • 30 citations

Synthesis and Accumulation of Proinsulin and Insulin during Development of the Embryonic Rat Pancreas*

1979 • 28 citations

Genetic manipulation of receptor expression and function

2000 • 25 citations

Primitive Islets Contain Two Populations of Cells with Differing Glucagon Immunoreactivity

1981 • 23 citations

HYPOGLYCEMIA AND RH ERYTHROBLASTOSIS FETALIS

1967 • 22 citations

Major Circadian Variations of Glucose Homeostasis in a Patient with Rabson-Mendenhall Syndrome and Primary Insulin Resistance Due to a Mutation(Cys284 → Tyr) in the Insulin Receptor α-Subunit

1997 • 21 citations

Mitogenic and Metabolic Effects of Type I IGF Receptor Overexpression in Insulin Receptor-Deficient Hepatocytes

2001 • 17 citations

Deleted Work

1955 • 0 citations