Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue

The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM

1988 • 2,463 citations

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

1997 • 2,190 citations

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Pathophysiology of insulin resistance in human disease

1995 • 1,239 citations

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

Lipotoxicity in the Pathogenesis of Obesity-Dependent NIDDM: Genetic and Clinical Implications

1995 • 1,026 citations

Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle.

1994 • 683 citations

Non-Insulin-Dependent Diabetes Mellitus — A Genetically Programmed Failure of the Beta Cell to Compensate for Insulin Resistance

1996 • 607 citations

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

1996 • 596 citations

Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles

1997 • 549 citations

Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.

1987 • 399 citations

Exocytosis of Insulin Promotes Insulin Gene Transcription via the Insulin Receptor/PI-3 Kinase/p70 s6 Kinase and CaM Kinase Pathways

1998 • 284 citations

GENETICS OF NON-INSULIN-DEPENDENT (TYPE-II) DIABETES MELLITUS

1996 • 220 citations

Hypoglycemic effect of insulin-like growth factor-1 in mice lacking insulin receptors.

1997 • 156 citations

Diabetes Mellitus: A Fundamental and Clinical Text

1997 • 130 citations

Oxotremorine-m potentiation of glucose-induced insulin release from rat islets involves M3 muscarinic receptors

1995 • 121 citations

Effects of Hypophysectomy on Amino Acid Metabolism and Gluconeogenesis in the Perfused Rat Liver

1973 • 92 citations

Expression of a dominant-negative mutant human insulin receptor in the muscle of transgenic mice.

1994 • 57 citations

Lack of insulin receptors affects the formation of white adipose tissue in mice. A morphometric and ultrastructural analysis

1998 • 42 citations

The insulin receptor.

1989 • 16 citations

Expression of the gene encoding the tyrosine kinase-deficient human insulin receptor in transgenic mice

1994 • 8 citations

Hyperinsulinemia but No Diabetes in Transgenic Mice Homozygously Expressing the Tyrosine Kinase-Deficient Human Insulin Receptor

1997 • 6 citations