Signalling through IGF-I and insulin receptors: where is the specificity?

Cell Signaling by Receptor Tyrosine Kinases

2010 • 7,477 citations

Cell Signaling by Receptor Tyrosine Kinases

2000 • 3,570 citations

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

Normal growth and development in the absence of hepatic insulin-like growth factor I

1999 • 1,430 citations

A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

1998 • 1,173 citations

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

1997 • 929 citations

Insulin Receptor Isoform A, a Newly Recognized, High-Affinity Insulin-Like Growth Factor II Receptor in Fetal and Cancer Cells

1999 • 865 citations

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

1996 • 596 citations

Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling

1999 • 526 citations

Multiple Signaling Pathways of the Insulin-Like Growth Factor 1 Receptor in Protection from Apoptosis

1999 • 499 citations

Mouse Mutants Lacking the Type 2 IGF Receptor (IGF2R) Are Rescued from Perinatal Lethality inIgf2andIgf1rNull Backgrounds

1996 • 479 citations

Role of insulin-like growth factor binding proteins in controlling IGF actions

1998 • 401 citations

Growth-Promoting Interaction of IGF-II with the Insulin Receptor during Mouse Embryonic Development

1997 • 391 citations

Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes

2001 • 367 citations

Transcriptional control of liver regeneration

1996 • 353 citations

IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase.

1993 • 323 citations

Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3′-kinase is essential for male fertility

2000 • 313 citations

Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality.

1996 • 287 citations

Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR

2000 • 273 citations

Identification of Domains of the Insulin-Like Growth Factor I Receptor That Are Required for Protection from Apoptosis

1997 • 258 citations

Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3).

1993 • 247 citations

Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos

1998 • 225 citations

Differential signalling potential of insulin- and IGF-1-receptor cytoplasmic domains.

1989 • 225 citations

14-3-3 (ϵ) Interacts with the Insulin-like Growth Factor I Receptor and Insulin Receptor Substrate I in a Phosphoserine-dependent Manner

1997 • 196 citations

Insulin Receptor Substrate-2 Binds to the Insulin Receptor through Its Phosphotyrosine-binding Domain and through a Newly Identified Domain Comprising Amino Acids 591–786

1996 • 194 citations

Identification of insulin receptor tyrosine residues autophosphorylated in vitro.

1987 • 182 citations

Evidence That IRS-2 Phosphorylation Is Required for Insulin Action in Hepatocytes

1998 • 169 citations

Insulin and Insulin-like Growth Factor I Receptors Utilize Different G Protein Signaling Components

2001 • 161 citations

Hypoglycemic effect of insulin-like growth factor-1 in mice lacking insulin receptors.

1997 • 156 citations

The Two PDGF Receptors Maintain Conserved Signaling In Vivo despite Divergent Embryological Functions

2001 • 147 citations

Essential role of tyrosine residues 1131, 1135, and 1136 of the insulin-like growth factor-I (IGF-I) receptor in IGF-I action.

1994 • 145 citations

Coupling Met to Specific Pathways Results in Distinct Developmental Outcomes

2001 • 144 citations

Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue

1998 • 143 citations

Grb10 Interacts Differentially with the Insulin Receptor, Insulin-like Growth Factor I Receptor, and Epidermal Growth Factor Receptor via the Grb10 Src Homology 2 (SH2) Domain and a Second Novel Domain Located between the Pleckstrin Homology and SH2 Domains

1998 • 140 citations

Ligand-binding properties of the two isoforms of the human insulin receptor.

1993 • 140 citations

Interaction of Insulin Receptor Substrate-2 (IRS-2) with the Insulin and Insulin-like Growth Factor I Receptors

1996 • 133 citations

Growth and Differentiation Signals by the Insulin-like Growth Factor 1 Receptor in Hemopoietic Cells Are Mediated through Different Pathways

1999 • 126 citations

Direct activation of the phosphatidylinositol 3'-kinase by the insulin receptor.

1994 • 126 citations

Insulin-like Growth Factor-I Stimulates Tyrosine Phosphorylation of Endogenous c-Crk

1995 • 112 citations

The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts.

1997 • 101 citations

14-3-3 Proteins interact with the insulin-like growth factor receptor but not the insulin receptor1

1997 • 99 citations

Insulin Regulation of Gene Expression through the Forkhead Transcription Factor Foxo1 (Fkhr) Requires Kinases Distinct from Akt

2001 • 81 citations

Binding properties of chimeric insulin receptors containing the cysteine-rich domain of either the insulin-like growth factor I receptor or the insulin receptor related receptor

1991 • 76 citations

Mechanism of Insulin and IGF‐I

1995 • 67 citations

Differences in Signaling Properties of the Cytoplasmic Domains of the Insulin Receptor and Insulin-like Growth Factor Receptor in 3T3-L1 Adipocytes

1999 • 63 citations

Role of the carboxyl-terminal domains of the insulin and insulin-like growth factor I receptors in receptor function.

1994 • 60 citations

A PDZ Domain Protein Interacts with the C-terminal Tail of the Insulin-like Growth Factor-1 Receptor but Not with the Insulin Receptor

2001 • 59 citations

Substrate Specificities of the Insulin and Insulin-like Growth Factor 1 Receptor Tyrosine Kinase Catalytic Domains

1995 • 54 citations

Essential role of tyrosine residues 1131, 1135, and 1136 of the insulin- like growth factor-I (IGF-I) receptor in IGF-I action

1994 • 50 citations

Interaction of Insulin Receptor Substrate 3 with Insulin Receptor, Insulin Receptor-related Receptor, Insulin-like Growth Factor-1 Receptor, and Downstream Signaling Proteins

1999 • 47 citations

Differential Signaling of Insulin and IGF-1 Receptors to Glycogen Synthesis in Murine Hepatocytes

1999 • 46 citations

Interaction of MAD2 with the Carboxyl Terminus of the Insulin Receptor but Not with the IGFIR EVIDENCE FOR RELEASE FROM THE INSULIN RECEPTOR AFTER ACTIVATION

1997 • 45 citations

The Differential Effects of pp120 (Ceacam 1) on the Mitogenic Action of Insulin and Insulin-Like Growth Factor 1 Are Regulated by the Nonconserved Tyrosine 1316 in the Insulin Receptor

2000 • 42 citations

Insulin receptor autophosphorylation. II. Determination of autophosphorylation sites by chemical sequence analysis and identification of the juxtamembrane sites

1993 • 41 citations

Differential Phosphorylation of pp120 by Insulin and Insulin-like Growth Factor-1 Receptors: Role for the C-Terminal Domain of the β-Subunit

1997 • 40 citations

Genetics of Type 2 Diabetes Insight from Targeted Mouse Mutants

2001 • 40 citations

Differential Signaling to Glycogen Synthesis by the Intracellular Domain of the Insulin versus the Insulin-like Growth Factor-1 Receptor

1997 • 36 citations

Increased IGFR activity and glucose transport in cultured skeletal muscle from insulin receptor null mice

2001 • 34 citations

IGF‐1 receptor as an alternative receptor for metabolic signaling in insulin receptor‐deficient muscle cells

2001 • 33 citations

Mitogenic and Metabolic Effects of Type I IGF Receptor Overexpression in Insulin Receptor-Deficient Hepatocytes

2001 • 17 citations

Localization of Specific Amino Acids Contributing to Insulin Specificity of the Insulin Receptor

1995 • 8 citations