Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

Insulin Action, Diabetogenes, and the Cause of Type II Diabetes

1994 • 914 citations

Role of IRS-2 in insulin and cytokine signalling

1995 • 843 citations

Altered striatal function in a mutant mouse lacking D1A dopamine receptors.

1994 • 350 citations

Lilly Lecture: Molecular Mechanisms of Insulin Resistance: Lessons From Patients With Mutations in the Insulin-Receptor Gene

1992 • 319 citations

Binding of insulin receptors to lectins: evidence for common carbohydrate determinants on several membrane receptors

1981 • 267 citations

Insulin-like growth factor I binding in hepatocytes from human liver, human hepatoma, and normal, regenerating, and fetal rat liver.

1988 • 252 citations

The contribution of insulin-dependent and insulin-independent glucose uptake to intravenous glucose tolerance in healthy human subjects

1994 • 231 citations

Substrate Phosphorylation Catalyzed by the Insulin Receptor Tyrosine Kinase

1989 • 132 citations

Homozygous deletion of the human insulin receptor gene results in leprechaunism

1993 • 127 citations

Genetic Analysis of Glucose Tolerance in Inbred Mouse Strains: Evidence for Polygenic Control

1988 • 109 citations

Homozygous nonsense mutation in the insulin receptor gene in infant with leprechaunism

1993 • 100 citations

Transmembrane signaling by the human insulin receptor kinase. Relationship between intramolecular beta subunit trans- and cis-autophosphorylation and substrate kinase activation.

1992 • 98 citations

Insulin, insulin-like growth factors and glucose transporters: temporal patterns of gene expression in early murine and bovine embryos

1992 • 91 citations

Targeted inactivation of the insulin receptor gene in mouse 3T3-L1 fibroblasts via homologous recombination.

1991 • 89 citations

Identification of a 190-kDa Protein as a Novel Substrate for the Insulin Receptor Kinase Functionally Similar to Insulin Receptor Substrate-1

1995 • 86 citations

Insulin and insulinlike growth factor 1 (IGF-1) receptors during central nervous system development: expression of two immunologically distinct IGF-1 receptor beta subunits.

1989 • 84 citations

Insulin receptors with defective tyrosine kinase inhibit normal receptor function at the level of substrate phosphorylation.

1988 • 82 citations

Purification and characterization of the receptor for insulin-like growth factor I

1986 • 77 citations

Cloning of cDNA for the alpha subunit of mouse insulin-like growth factor I receptor and the role of the receptor in metanephric development.

1993 • 63 citations

A mutation in the extracellular domain of the insulin receptor impairs the ability of insulin to stimulate receptor autophosphorylation.

1991 • 46 citations

Homozygosity for a null allele of the insulin receptor gene in a patient with leprechaunism

1995 • 40 citations

Evidence for hybrid rodent and human insulin receptors in transfected cells

1991 • 40 citations

Molecular defects of the insulin receptor gene

1995 • 40 citations