A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting

Establishment in culture of pluripotential cells from mouse embryos

1981 • 8,424 citations

Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.

1981 • 5,629 citations

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1987 • 2,368 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

Insulin-Like Growth Factors I and II. Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations*

1989 • 1,796 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines

1984 • 1,518 citations

Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination

1985 • 978 citations

Teratocarcinomas and embryonic stem cells : a practical approach

1987 • 878 citations

Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector

1986 • 761 citations

The pIC plasmid and phage vectors with versatile cloning sites for recombinant selection by insertional inactivation

1984 • 718 citations

Experimental Approaches to Mammalian Embryonic Development

1987 • 596 citations

Germ-line transmission of a disrupted β2microglobulin gene produced by homologous recombination in embryonic stem cells

1989 • 355 citations

Germ-Line Transmission of a c- abl Mutation Produced by Targeted Gene Disruption in ES Cells

1989 • 285 citations

Teratocarcinomas and Embryonic Stem Cells: A Practical Approach

1988 • 263 citations

Expression of the insulin-like growth factor II gene in the choroid plexus and the leptomeninges of the adult rat central nervous system.

1988 • 262 citations

Insulin-Like Growth Factors/Somatomedins: Structure, Secretion, Biological Actions and Physiological Role

1986 • 240 citations

Targeted mutation of the Hprt gene in mouse embryonic stem cells.

1988 • 226 citations

Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination.

1989 • 216 citations

Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells

1989 • 200 citations

Pattern of the insulin-like growth factor II gene expression during rat embryogenesis

1988 • 199 citations

Rat insulin-like growth factor II gene

1986 • 192 citations

Recombinant fragment assay for gene targetting based on the polymerase chain reaction

1988 • 192 citations

Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination

1989 • 166 citations

The gene structure of the insulin-like growth factor family

1989 • 143 citations

FETAL GROWTH CONTROL: THE ROLE OF INSULIN AND RELATED PEPTIDES

1984 • 129 citations

Growth Factors in Early Embryogenesis

1989 • 119 citations

Targeting of Nonexpressed Genes in Embryonic Stem Cells Via Homologous Recombination

1989 • 109 citations

A promoter of the rat insulin-like growth factor II gene consists of minimal control elements

1988 • 88 citations

Peptide hormones as prohormones

1986 • 44 citations

A new leader exon identified in the rat insulin-like growth factor II gene

1987 • 44 citations

Peptide hormones as prohormones

1990 • 21 citations