Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle

The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function

2017 • 8,063 citations

The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous Catheterization

1981 • 1,728 citations

Quantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by¹³C Nuclear Magnetic Resonance Spectroscopy

1990 • 1,226 citations

A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

1998 • 1,173 citations

Insulin Action, Diabetogenes, and the Cause of Type II Diabetes

1994 • 914 citations

Impaired Glucose Transport as a Cause of Decreased Insulin-Stimulated Muscle Glycogen Synthesis in Type 2 Diabetes

1999 • 666 citations

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

1996 • 596 citations

Hepatic and peripheral insulin resistance: A common feature of Type 2 (non-insulin-dependent) and Type 1 (insulin-dependent) diabetes mellitus

1982 • 540 citations

Muscle Glucose Metabolism following Exercise in the Rat

1982 • 504 citations

Mechanism of Insulin Resistance in A-ZIP/F-1 Fatless Mice

2000 • 439 citations

Evidence Against Altered Expression of GLUT1 or GLUT4 in Skeletal Muscle of Patients With Obesity or NIDDM

1990 • 322 citations

Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality.

1996 • 287 citations

Evidence from transgenic mice that glucose transport is rate-limiting for glycogen deposition and glycolysis in skeletal muscle

1993 • 281 citations

Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat.

1992 • 263 citations

Relative contribution of glycogen synthesis and glycolysis to insulin-mediated glucose uptake. A dose-response euglycemic clamp study in normal and diabetic rats.

1990 • 258 citations

The contribution of insulin-dependent and insulin-independent glucose uptake to intravenous glucose tolerance in healthy human subjects

1994 • 231 citations

Role of glucose transporters in the cellular insulin resistance of type II non-insulin-dependent diabetes mellitus.

1988 • 169 citations

Insulin Induces the Translocation of GLUT4 From a Unique Intracellular Organelle to Transverse Tubules in Rat Skeletal Muscle

1992 • 164 citations

Glucose Metabolism in Rat Skeletal Muscle at Rest: Effect of Starvation, Diabetes, Ketone Bodies and Free Fatty Acids

1974 • 129 citations

Glucose Transport and NIDDM

1992 • 111 citations

Hyperinsulinemia increases the amount of GLUT4 mRNA in white adipose tissue and decreases that of muscles : a clue for increased fat depot and insulin resistance

1990 • 109 citations

Plasma Free Fatty Acids Decrease Insulin-Stimulated Skeletal Muscle Glucose Uptake by Suppressing Glycolysis in Conscious Rats

1996 • 98 citations

A Comparison of the Relative Effects of Obesity and Non-insulin-dependent Diabetes Mellitus on In Vivo Insulin-stimulated Glucose Utilization

1984 • 87 citations

Transgenic GLUT-4 overexpression in fat enhances glucose metabolism: preferential effect on fatty acid synthesis

1995 • 82 citations

Insulin Resistance in Skeletal Muscles in Patients With NIDDM

1992 • 73 citations

Metabolic consequences of hyperinsulinaemia imposed on normal rats on glucose handling by white adipose tissue, muscles and liver

1990 • 67 citations

Fasting Does Not Impaird Insulin-Stimulated Glucose Uptake But Alters Intracellular Glucose Metabolism in Conscious Rats

1993 • 66 citations

Adrenalectomy reverses insulin resistance in muscle from obese (ob/ob) mice

1984 • 59 citations

Molecular mechanisms of insulin action in normal and insulin-resistant states

2009 • 40 citations

Effect of IGF-I on Phosphatidylinositol 3-Kinase in Soleus Muscle of Lean and Insulin-Resistant Obese Mice

1996 • 17 citations