Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

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Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines

1984 • 1,518 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

A peroxidase-coupled method for the colorimetric determination of serum triglycerides.

1983 • 1,327 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

Insulin Action, Diabetogenes, and the Cause of Type II Diabetes

1994 • 914 citations

Insulin Resistance — Mechanisms, Syndromes, and Implications

1991 • 788 citations

Determination of blood glucose using 4-amino phenazone as oxygen acceptor.

1969 • 736 citations

Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4

1995 • 478 citations

Structure of the human insulin receptor gene and characterization of its promoter.

1989 • 349 citations

The Insulin-Like Growth Factor-I Receptor

1994 • 325 citations

Lilly Lecture: Molecular Mechanisms of Insulin Resistance: Lessons From Patients With Mutations in the Insulin-Receptor Gene

1992 • 319 citations

Control of adipocyte differentiation

1995 • 262 citations

The Insulin Receptor: A Multifunctional Protein

1990 • 149 citations

Substrate Phosphorylation Catalyzed by the Insulin Receptor Tyrosine Kinase

1989 • 132 citations

Homozygous deletion of the human insulin receptor gene results in leprechaunism

1993 • 127 citations

Homozygous nonsense mutation in the insulin receptor gene in infant with leprechaunism

1993 • 100 citations

Lilly lecture 1990. Molecular defects in diabetes mellitus

1991 • 55 citations

Homozygosity for a null allele of the insulin receptor gene in a patient with leprechaunism

1995 • 40 citations

Interaction of p85 subunit of PI 3‐kinase with insulin and IGF‐1 receptors analysed by using the two‐hybrid system

1995 • 35 citations

Characterization of the mouse insulin receptor gene promoter.

1989 • 28 citations

Transgenic approaches to the pathogenesis of NIDDM

1994 • 21 citations