Reduction of Protein Tyrosine Phosphatase 1B Increases Insulin-Dependent Signaling in ob/ob Mice
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A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding
1976 • 225,752 citations
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
1976 • 200,127 citations
Role of Insulin Resistance in Human Disease
1988 • 12,099 citations
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
1995 • 5,143 citations
Banting lecture 1988. Role of insulin resistance in human disease
1988 • 3,751 citations
Obesity and insulin resistance
2000 • 3,076 citations
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
1995 • 2,106 citations
Disruption of IRS-2 causes type 2 diabetes in mice
1998 • 1,766 citations
Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice
2000 • 1,218 citations
Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor
1996 • 1,074 citations
Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats.
1987 • 792 citations
New Perspectives into the Molecular Pathogenesis and Treatment of Type 2 Diabetes
2001 • 695 citations
The Effects of Rosiglitazone on Insulin Sensitivity, Lipolysis, and Hepatic and Skeletal Muscle Triglyceride Content in Patients With Type 2 Diabetes
2002 • 634 citations
Resistin and obesity-associated insulin resistance
2002 • 524 citations
Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.
2000 • 519 citations
Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo.
1999 • 499 citations
Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2
2000 • 499 citations
A review of issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides
1999 • 441 citations
Protein-tyrosine Phosphatase 1B Is a Negative Regulator of Insulin- and Insulin-like Growth Factor-I-stimulated Signaling
1996 • 424 citations
PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice
2002 • 407 citations
Insulin signal transduction through protein kinase cascades.
1998 • 364 citations
Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse.
1997 • 301 citations
Protein Tyrosine Phosphatase 1B Interacts With the Activated Insulin Receptor
1996 • 293 citations
Contrasting Effects of IRS-1 Versus IRS-2 Gene Disruption on Carbohydrate and Lipid Metabolism in Vivo
2000 • 291 citations
Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes.
1997 • 282 citations
Inhibition of GSK-3 Selectively Reduces Glucose-6-Phosphatase and Phosphoenolpyruvate Carboxykinase Gene Expression
2001 • 215 citations
Cellular mechanisms of insulin resistance in humans
1999 • 176 citations
Pioglitazone: mechanism of action.
2001 • 173 citations
Evidence That IRS-2 Phosphorylation Is Required for Insulin Action in Hepatocytes
1998 • 169 citations
Protein Tyrosine Phosphatase 1B Reduction Regulates Adiposity and Expression of Genes Involved in Lipogenesis
2002 • 158 citations
Phosphatidylinositol 3-Kinase, but Not p70/p85 Ribosomal S6 Protein Kinase, Is Required for the Regulation of Phosphoenolpyruvate Carboxykinase (PEPCK) Gene Expression by Insulin
1995 • 148 citations
The role of lipids in the pathogenesis of muscle insulin resistance and beta cell failure in type II diabetes and obesity
2001 • 130 citations
Triglycerides, fatty acids and insulin resistance - hyperinsulinemia
2001 • 117 citations
Integration of biochemical and physiologic effects of insulin on glucose metabolism
2001 • 102 citations
Dynamics of Protein-tyrosine Phosphatases in Rat Adipocytes
2000 • 91 citations
Hyperinsulinemia induces a reversible impairment ininsulin receptor function leading to diabetes in the sand rat model ofnon-insulin-dependent diabetes mellitus.
1994 • 88 citations
Inhibitory effect of hyperglycemia on insulin-induced Akt/protein kinase B activation in skeletal muscle
2001 • 62 citations
Defective Insulin Receptor Function in Down-Regulated HepG2 Cells*
1990 • 41 citations
Insulin signal transduction through protein kinase cascades
1998 • 39 citations
Effect of Streptozocin-Induced Diabetes on Insulin-Receptor Tyrosine Kinase Activity in Obese Zucker Rats
1990 • 38 citations
Insulin-Sensitive Tyrosine Kinase Is Increased in Livers of Adult Obese Zucker Rats:Correction with Prolonged Fasting
1988 • 21 citations
Correction of hyperglycaemia reduces insulin resistance and serum soluble E‐selectin levels in patients with Type 2 diabetes mellitus
2001 • 16 citations
Effect of streptozocin-induced diabetes on insulin-receptor tyrosine kinase activity in obese Zucker rats
1990 • 14 citations
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