Adipose Tissue Selective Insulin Receptor Knockout Protects against Obesity and Obesity-Related Glucose Intolerance

Obesity as a medical problem

2000 • 4,948 citations

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

2001 • 4,874 citations

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

1995 • 3,730 citations

The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

2001 • 2,534 citations

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

2000 • 2,178 citations

Deletion of a DNA Polymerase β Gene Segment in T Cells Using Cell Type-Specific Gene Targeting

1994 • 1,396 citations

Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase

1999 • 1,284 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction

2000 • 1,213 citations

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

2001 • 1,202 citations

A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

1998 • 1,173 citations

Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study

1992 • 1,156 citations

Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

1999 • 1,151 citations

Insulin Action, Diabetogenes, and the Cause of Type II Diabetes

1994 • 914 citations

Disruption of overlapping transcripts in the ROSA βgeo 26 gene trap strain leads to widespread expression of β-galactosidase in mouse embryos and hematopoietic cells

1997 • 851 citations

Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance

2000 • 733 citations

PATHOGENESIS OF TYPE 2 DIABETES: METABOLIC AND MOLECULAR IMPLICATIONS FOR IDENTIFYING DIABETES GENES

1997 • 701 citations

Hormonal Regulation of Adiponectin Gene Expression in 3T3-L1 Adipocytes

2002 • 665 citations

Targeted Disruption of the β3-Adrenergic Receptor Gene

1995 • 483 citations

Evidence That Glucose Metabolism Regulates Leptin Secretion from Cultured Rat Adipocytes*

1998 • 416 citations

Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart

1999 • 360 citations

In vitro insulin resistance of human adipocytes isolated from subjects with noninsulin-dependent diabetes mellitus.

1983 • 249 citations

Leptin Induces Insulin-like Signaling That Antagonizes cAMP Elevation by Glucagon in Hepatocytes

2000 • 243 citations

Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction.

2000 • 224 citations

A fat-specific enhancer is the primary determinant of gene expression for adipocyte P2 in vivo.

1990 • 217 citations

Brown adipose tissue–specific insulin receptor knockout shows diabetic phenotype without insulin resistance

2001 • 216 citations

Regulation of ob gene expression and leptin secretion by insulin and dexamethasone in rat adipocytes.

1999 • 203 citations

Selective interaction between leptin and insulin signaling pathways in a hepatic cell line

2000 • 189 citations

PATHOGENESIS OF TYPE 2 DIABETES

2001 • 177 citations

Lactate release from the subcutaneous tissue in lean and obese men.

1994 • 151 citations

Improved techniques for studies of adipocyte cellularity and metabolism

1977 • 139 citations

Determinations of adipose cell size and number in suspensions of isolated rat and human adipose cells

1978 • 125 citations

Amelioration of Insulin Resistance in Streptozotocin Diabetic Mice by Transgenic Overexpression of GLUT4 Driven by an Adipose-Specific Promoter¹

1997 • 89 citations

Insulin binding and hexose transport in rat adipocytes

1980 • 89 citations

Insulin-dependent regulation of the insulin-sensitivity of adipocytes

1978 • 86 citations

Transgenic GLUT-4 overexpression in fat enhances glucose metabolism: preferential effect on fatty acid synthesis

1995 • 82 citations

Gold thioglucose obesity syndrome.

1977 • 65 citations

Expression of Leptin (Ob) and Leptin Receptor (Ob-R) in Human Fibroblasts: Regulation of Leptin Secretion by Insulin

2001 • 63 citations

Time Dependence of Insulin Action in Muscle and Adipose Tissue in the Rat In Vivo: An Increasing Response in Adipose Tissue with Time

1985 • 51 citations

Knockout Mice Challenge Our Concepts of Glucose Homeostasis and the Pathogenesis of Diabetes Mellitus

2000 • 47 citations

From lipodystrophy syndromes to diabetes mellitus

2001 • 41 citations

Effects of cell size and animal age on glucose metabolism in pig adipose tissue

1981 • 40 citations

Increased OB gene expression leads to elevated plasma leptin concentrations in patients with chronic primary hyperinsulinemia.

1998 • 33 citations

Expression of glucose transporters (GLUT 1 and GLUT 4) in primary cultured rat adipocytes: Differential evolution with time and chronic insulin effect

1992 • 22 citations

The Pathogenesis of Type 1 Diabetes

2024 • 5 citations