A Role for AMP-Activated Protein Kinase in Contraction- and Hypoxia-Regulated Glucose Transport in Skeletal Muscle

Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase

1996 • 1,222 citations

A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

1998 • 1,173 citations

Exercise, Glucose Transport, and Insulin Sensitivity

1998 • 1,066 citations

AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle

1997 • 1,025 citations

AMP-activated protein kinase, a metabolic master switch: possible roles in Type 2 diabetes

1999 • 1,009 citations

Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise

1996 • 794 citations

Evidence for 5′AMP-Activated Protein Kinase Mediation of the Effect of Muscle Contraction on Glucose Transport

1998 • 749 citations

Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle

2000 • 720 citations

5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle.

1999 • 719 citations

Malonyl-CoA, fuel sensing, and insulin resistance

1999 • 655 citations

Mammalian AMP-activated Protein Kinase Subfamily

1996 • 631 citations

Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding

2000 • 605 citations

The regulation of AMP-activated protein kinase by phosphorylation

2000 • 582 citations

Glucose repression in yeast

1999 • 573 citations

Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR

1999 • 548 citations

Signaling Mechanisms That Regulate Glucose Transport

1999 • 525 citations

Dealing with energy demand: the AMP-activated protein kinase

1999 • 516 citations

Chronic activation of 5′-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle

1999 • 506 citations

Contraction stimulates translocation of glucose transporter GLUT4 in skeletal muscle through a mechanism distinct from that of insulin.

1995 • 499 citations

Tissue distribution of the AMP‐activated protein kinase, and lack of activation by cyclic‐AMP‐dependent protein kinase, studied using a specific and sensitive peptide assay

1989 • 437 citations

Characterization of the Role of AMP-Activated Protein Kinase in the Regulation of Glucose-Activated Gene Expression Using Constitutively Active and Dominant Negative Forms of the Kinase

2000 • 410 citations

Contraction-induced Changes in Acetyl-CoA Carboxylase and 5′-AMP-activated Kinase in Skeletal Muscle

1997 • 404 citations

Functional Domains of the α1 Catalytic Subunit of the AMP-activated Protein Kinase

1998 • 354 citations

AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge

1999 • 347 citations

Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle

1998 • 330 citations

Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport

1998 • 329 citations

The Effects of Wortmannin on Rat Skeletal Muscle

1995 • 320 citations

Effect of AMPK activation on muscle glucose metabolism in conscious rats

1999 • 311 citations

Stimulation of glucose transport in skeletal muscle by hypoxia

1991 • 299 citations

Electrical stimulation inactivates muscle acetyl-CoA carboxylase and increases AMP-activated protein kinase

1997 • 237 citations

Identification of a Novel AMP-activated Protein Kinase β Subunit Isoform That Is Highly Expressed in Skeletal Muscle

1998 • 233 citations

Use of a novel impermeable biotinylated photolabeling reagent to assess insulin- and hypoxia-stimulated cell surface GLUT4 content in skeletal muscle from type 2 diabetic patients.

2000 • 211 citations

Identification and Characterization of an Exercise-sensitive Pool of Glucose Transporters in Skeletal Muscle

1995 • 198 citations

Calcium stimulates glucose transport in skeletal muscle by a pathway independent of contraction

1991 • 192 citations

Increased expression of GLUT-4 and hexokinase in rat epitrochlearis muscles exposed to AICAR in vitro

2000 • 154 citations

Insulin, but Not Contraction, Activates Akt/PKB in Isolated Rat Skeletal Muscle

1998 • 153 citations

Activation of glycogen phosphorylase and glycogenolysis in rat skeletal muscle by AICAR — an activator of AMP‐activated protein kinase

1996 • 143 citations

Expression of the AMP‐activated protein kinase β1 and β2 subunits in skeletal muscle

1999 • 131 citations

The regulation of AMP-activated protein kinase by phosphorylation

2000 • 128 citations

Hypoxia Stimulates Glucose Transport in Insulin-Resistant Human Skeletal Muscle

1995 • 118 citations

Hypoglycaemic effect of AICAriboside in mice

1996 • 96 citations

Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding

2000 • 95 citations

AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge

1999 • 93 citations

Regulation of glucose utilization in yeast

1998 • 86 citations

A role for the serine/threonine kinase, Akt, in insulin-stimulated glucose uptake

1997 • 67 citations

Random Mutagenesis Screen for Dominant Behavioral Mutations in Mice

1997 • 66 citations

Contraction-induced increase in muscle insulin sensitivity: requirement for a serum factor

1994 • 64 citations

Hypoxia and contractions do not utilize the same signaling mechanism in stimulating skeletal muscle glucose transport

1998 • 58 citations

An Overview of Muscle Glucose Uptake during Exercise

1998 • 49 citations

Interactions between effects of W-7, insulin, and hypoxia on glucose transport in skeletal muscle

1994 • 42 citations

Intramuscular Mechanisms Regulating Fatty Acid Oxidation during Exercise

1998 • 39 citations

Mechanisms associated with hypoxia‐ and contraction‐mediated glucose transport in muscle are fibre‐dependent

1999 • 18 citations

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