Contrasting Effects of IRS-1 Versus IRS-2 Gene Disruption on Carbohydrate and Lipid Metabolism in Vivo

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

The insulin signaling system.

1994 • 1,733 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

1999 • 1,256 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

Role of IRS-2 in insulin and cytokine signalling

1995 • 843 citations

PATHOGENESIS OF TYPE 2 DIABETES: METABOLIC AND MOLECULAR IMPLICATIONS FOR IDENTIFYING DIABETES GENES

1997 • 701 citations

What if Minkowski Had Been Ageusic? An Alternative Angle on Diabetes

1992 • 664 citations

Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling

1999 • 526 citations

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2

2000 • 499 citations

Mechanism of Insulin Resistance in A-ZIP/F-1 Fatless Mice

2000 • 439 citations

Type 2 Diabetes: When Insulin Secretion Fails to Compensate for Insulin Resistance

1998 • 415 citations

EFFECT OF EPINEPHRINE ON RAT DIAPHRAGM

1950 • 389 citations

A Novel 160-kDa Phosphotyrosine Protein in Insulin-treated Embryonic Kidney Cells Is a New Member of the Insulin Receptor Substrate Family

1997 • 381 citations

The IRS-Signaling System: A Network of Docking Proteins That Mediate Insulin and Cytokine Action

1998 • 369 citations

The 60-kDa Phosphotyrosine Protein in Insulin-treated Adipocytes Is a New Member of the Insulin Receptor Substrate Family

1997 • 354 citations

Insulin Signalling and Insulin Actions in the Muscles and Livers of Insulin-Resistant, Insulin Receptor Substrate 1-Deficient Mice

1996 • 289 citations

Insulin Receptor Substrate 3 Is Not Essential for Growth or Glucose Homeostasis

1999 • 191 citations

Evidence That IRS-2 Phosphorylation Is Required for Insulin Action in Hepatocytes

1998 • 169 citations

Insulin Receptor Substrate-2 Is Not Necessary for Insulin- and Exercise-stimulated Glucose Transport in Skeletal Muscle

1999 • 106 citations

New concepts in extracellular signaling for insulin action: the single gateway hypothesis.

1997 • 100 citations

Dose-response relationship of insulin to glucose fluxes in the awake and unrestrained mouse

1999 • 14 citations