Identification of Interactive Loci Linked to Insulin and Leptin in Mice With Genetic Insulin Resistance

MAPMAKER: An interactive computer package for constructing primary genetic linkage maps of experimental and natural populations

1987 • 6,762 citations

Pathogenesis of NIDDM: A Balanced Overview

1992 • 2,111 citations

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

1997 • 1,647 citations

Insulin Resistance and Insulin Secretory Dysfunction as Precursors of Non-Insulin-Dependent Diabetes Mellitus: Prospective Studies of Pima Indians

1993 • 1,516 citations

Resolution of quantitative traits into Mendelian factors by using a complete linkage map of restriction fragment length polymorphisms

1988 • 1,513 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Molecular Mechanisms and Clinical Pathophysiology of Maturity-Onset Diabetes of the Young

2001 • 1,127 citations

Diet-Induced Type II Diabetes in C57BL/6J Mice

1988 • 1,111 citations

Dual specificity phosphatases: a gene family for control of MAP kinase function

2000 • 791 citations

Inhibition of Stat1-mediated gene activation by PIAS1

1998 • 760 citations

Heritability of Type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance - a population-based twin study

1999 • 611 citations

Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles

1997 • 549 citations

Overview of QTL mapping software and introduction to Map Manager QT

1999 • 456 citations

Pathogenesis of Type 2 (non-insulin dependent) diabetes mellitus: a balanced overview

1992 • 435 citations

Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism.

2000 • 423 citations

Kelly West Lecture 1991 Challenges in Diabetes Epidemiology—From West to the Rest

1992 • 338 citations

Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice

1998 • 309 citations

Detection of Obesity QTLs on Mouse Chromosomes 1 and 7 by Selective DNA Pooling

1996 • 243 citations

Linkage Between Markers in the Vicinity of the Uncoupling Protein 2 Gene and Resting Metabolic Rate in Humans

1997 • 227 citations

GENETICS OF NON-INSULIN-DEPENDENT (TYPE-II) DIABETES MELLITUS

1996 • 220 citations

Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and Type II diabetes

2001 • 220 citations

Diet-induced type II diabetes in C57BL/6J mice

1988 • 210 citations

Chronic central leptin infusion enhances insulin-stimulated glucose metabolism and favors the expression of uncoupling proteins.

1998 • 197 citations

Genetic obesity unmasks nonlinear interactions between murine type 2 diabetes susceptibility loci.

2000 • 142 citations

Relation between leptin and the regulation of glucose metabolism

2000 • 140 citations

Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model.

1998 • 134 citations

Low Plasma Leptin in Response to Dietary Fat in Diabetes- and Obesity-Prone Mice

1997 • 125 citations

Impact of Genetic Background on Development of Hyperinsulinemia and Diabetes in Insulin Receptor/Insulin Receptor Substrate-1 Double Heterozygous Mice

2003 • 118 citations

Uncoupling Protein 3 Content Is Decreased in Skeletal Muscle of Patients With Type 2 Diabetes

2001 • 115 citations

Fasting and Leptin Modulate Adipose and Muscle Uncoupling Protein: Divergent Effects Between Messenger Ribonucleic Acid and Protein Expression¹

1999 • 108 citations

Putting the genes for type II diabetes on the map

2001 • 105 citations

Potential Role of Rab4 in the Regulation of Subcellular Localization of Glut4 in Adipocytes

1996 • 103 citations

UCP2, UCP3 and leptin gene expression: modulation by food restriction and leptin

1998 • 92 citations

Differential regulation of leptin expression and function in A/J vs. C57BL/6J mice during diet-induced obesity

2000 • 88 citations

Coincidence of genetic loci for plasma cholesterol levels and obesity in a multifactorial mouse model.

1993 • 84 citations

Genetic modifiers of the insulin resistance phenotype in mice.

2000 • 76 citations

Mice with targeted gene disruptions or gene insertions for diabetes research: problems, pitfalls, and potential solutions

2002 • 75 citations

Lilly Lecture: Syndromes of Insulin Resistance: From Patient to Gene and Back Again

1992 • 74 citations

Stat 5B, Activated by Insulin in a Jak-Independent Fashion, Plays a Role inGlucokinaseGene Transcription¹

2000 • 44 citations

A statistical and genetical study of diabetes: II. Heritability of liability

1972 • 43 citations

Gene-environment interaction: a significant diet-dependent obesity locus demonstrated in a congenic segment on mouse Chromosome 7 Mus castaneus. -->

1999 • 34 citations

Lilly Lecture: syndromes of insulin resistance. From patient to gene and back again

1992 • 30 citations

Low plasma leptin in response to dietary fat in diabetes- and obesity-prone mice

1997 • 27 citations

A comparison of tests for the k‐sample, non‐decreasing alternative

1995 • 26 citations

Downregulation of uncoupling protein 2 mRNA in white adipose tissue and uncoupling protein 3 mRNA in skeletal muscle during the early stages of leptin treatment.

1999 • 25 citations

Testing for Trend with Count Data

1998 • 25 citations

Assignment of the Protein Kinase C δ Polypeptide Gene (PRKCD) to Human Chromosome 3 and Mouse Chromosome 14

1994 • 22 citations

The molecular basis and clinical characteristics of Maternally Inherited Diabetes and Deafness (MIDD), a recently recognized diabetic subtype

2009 • 14 citations