IRS-2 pathways integrate female reproduction and energy homeostasis

Role of leptin in the neuroendocrine response to fasting

1996 • 3,106 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1997 • 1,905 citations

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

1995 • 1,630 citations

Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin

1996 • 1,505 citations

Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice

1996 • 1,097 citations

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

1979 • 1,089 citations

Signals from the reproductive system regulate the lifespan of C. elegans

1999 • 956 citations

Autonomous Control of Cell and Organ Size by CHICO, a Drosophila Homolog of Vertebrate IRS1–4

1999 • 838 citations

Modulation of Insulin Activities by Leptin

1996 • 733 citations

What’s in a Name? In Search of Leptin’s Physiologic Role¹

1998 • 527 citations

Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling

1999 • 526 citations

A Novel 160-kDa Phosphotyrosine Protein in Insulin-treated Embryonic Kidney Cells Is a New Member of the Insulin Receptor Substrate Family

1997 • 381 citations

The 60-kDa Phosphotyrosine Protein in Insulin-treated Adipocytes Is a New Member of the Insulin Receptor Substrate Family

1997 • 354 citations

An Insulin-like Signaling Pathway Affects Both Longevity and Reproduction in Caenorhabditis elegans

1998 • 347 citations

Model for the regulation of energy balance and adiposity by the central nervous system

1999 • 339 citations

Neuroendocrine Responses to Starvation and Weight Loss

1997 • 270 citations

INSULIN ACTION IN THE NORMAL AND POLYCYSTIC OVARY

1999 • 256 citations

Leptin stimulates glucose transport and glycogen synthesis in C 2 C 12 myotubes: evidence for a PI3-kinase mediated effect

1997 • 207 citations

Selective interaction between leptin and insulin signaling pathways in a hepatic cell line

2000 • 189 citations

Phenotype and genotype in polycystic ovary syndrome

2001 • 149 citations

Estradiol stimulates tyrosine phosphorylation of the insulin-like growth factor-1 receptor and insulin receptor substrate-1 in the uterus.

1996 • 125 citations

Food intake and serum insulin responses to intraventricular infusions of insulin and IGF-I

1991 • 120 citations

Requirement for Phosphatidylinositol-3′-Kinase in Cytokine-Mediated Germ Cell Survival during Fetal Oogenesis in the Mouse*

1999 • 115 citations

Leptin Signaling in the Hypothalamus of Normal Rats in Vivo**This work was supported in part by a Boston Obesity Nutrition Research Center Grant (to J.C.C.), NIH Grant DK-50411 (to R.J.S.), and NIH Diabetes and Endocrinology Center Grant DK-36836 (to R.J.S.).

1998 • 110 citations

Insulin receptors and signal transduction proteins in the hypothalamo-hypophyseal system: a review on morphological findings and functional implications.

1998 • 64 citations

Human Insulin Receptor Substrate-2 (IRS-2) Is a Primary Progesterone Response Gene

1999 • 56 citations

Insulin receptors in the pituitary gland: morphological evidence for influence on opioid peptide-synthesizing cells

1997 • 45 citations