Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

Green Fluorescent Protein as a Marker for Gene Expression

1994 • 6,572 citations

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

A C. elegans mutant that lives twice as long as wild type

1993 • 3,250 citations

Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.

1991 • 3,108 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

1997 • 2,174 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1997 • 1,905 citations

2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

1994 • 1,472 citations

daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

1997 • 1,468 citations

Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

1997 • 1,448 citations

Signalling through the lipid products of phosphoinositide-3-OH kinase

1997 • 1,314 citations

Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

1996 • 1,277 citations

Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5

1993 • 1,269 citations

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

1997 • 1,190 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt

1997 • 1,051 citations

Insulin Action, Diabetogenes, and the Cause of Type II Diabetes

1994 • 914 citations

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

1996 • 870 citations

Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos

1997 • 663 citations

Phosphatidylinositol 3‐kinase

1994 • 649 citations

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase

1996 • 631 citations

Genes that regulate both development and longevity in Caenorhabditis elegans.

1995 • 579 citations

The PH domain: a common piece in the structural pathcwork of signalling proteins

1993 • 536 citations

Phosphoinositide kinases

1996 • 529 citations

Control of C. elegans Larval Development by Neuronal Expression of a TGF-β Homolog

1996 • 516 citations

A conserved RNA-binding protein that regulates sexual fates in the C. elegans hermaphrodite germ line

1997 • 504 citations

A Specific Product of Phosphatidylinositol 3-Kinase Directly Activates the Protein Kinase Akt through Its Pleckstrin Homology Domain

1997 • 481 citations

Genetic and Environmental Regulation of Dauer Larva Development

1997 • 446 citations

The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans.

1995 • 442 citations

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

1997 • 436 citations

A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results

1983 • 427 citations

Control of Larval Development by Chemosensory Neurons in Caenorhabditis elegans

1991 • 400 citations

daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans.

1994 • 375 citations

Insulin signal transduction through protein kinase cascades.

1998 • 364 citations

Chemosensory Neurons Function in Parallel to Mediate a Pheromone Response in C. elegans

1996 • 311 citations

The DAF-3 Smad protein antagonizes TGF-β-related receptor signaling in the Caenorhabditis elegansdauer pathway

1997 • 197 citations

Protein Kinase B/Akt Mediates Effects of Insulin on Hepatic Insulin-like Growth Factor-binding Protein-1 Gene Expression through a Conserved Insulin Response Sequence

1998 • 164 citations

The Eukaryotic Protein Kinase Superfamily

1995 • 143 citations

Analysis of hepatocyte nuclear factor-3β protein domains required for transcriptional activation and nuclear targeting

1995 • 127 citations

Chapter 4 Genetic Mapping with Polymorphic Sequence-Tagged Sites

1995 • 59 citations