3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

1996 • 1,277 citations

Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme

1989 • 1,244 citations

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

1997 • 1,190 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

The I.M.A.G.E. Consortium: An Integrated Molecular Analysis of Genomes and Their Expression

1996 • 1,132 citations

Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt

1997 • 1,051 citations

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1997 • 1,050 citations

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1994 • 978 citations

Phosphoinositide 3-kinases: A conserved family of signal transducers

1997 • 944 citations

A Retroviral Oncogene, akt , Encoding a Serine-Threonine Kinase Containing an SH2-Like Region

1991 • 900 citations

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1992 • 885 citations

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA.

1996 • 785 citations

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.

1992 • 732 citations

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

1997 • 699 citations

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase

1996 • 631 citations

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.

1991 • 537 citations

Protein sequence alignments: a strategy for the hierarchical analysis of residue conservation

1993 • 534 citations

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

1997 • 534 citations

The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

1996 • 492 citations

Molecular cloning and characterisation of a novel putative protein‐serine kinase related to the cAMP‐dependent and protein kinase C families

1991 • 485 citations

PH Domains: Diverse Sequences with a Common Fold Recruit Signaling Molecules to the Cell Surface

1996 • 464 citations

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

1997 • 436 citations

Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades

1997 • 435 citations

Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase.

1995 • 358 citations

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

1991 • 344 citations

The Drosophila insulin receptor is required for normal growth.

1996 • 337 citations

Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

1996 • 328 citations

The pleckstrin homology domain: An intriguing multifunctional protein module

1996 • 285 citations

PDK1, one of the missing links in insulin signal transduction?¹

1997 • 246 citations

Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase

1994 • 204 citations

The muscle pattern of a segment of Drosophila may be determined by neurons and not by contributing myoblasts

1986 • 157 citations

Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells.

1996 • 134 citations

Flexible protein sequence patterns

1990 • 120 citations

Sex determination in the germ line of Drosophila depends on genetic signals and inductive somatic factors*

1989 • 92 citations

Signaling Pathway Involved in the Activation of Heart 6-Phosphofructo-2-kinase by Insulin

1996 • 67 citations

How do germ cells choose their sex? Drosophila as a paradigm

1992 • 59 citations

Developmental Regulation of Expression and Activity of Multiple Forms of the Drosophila RAC Protein Kinase

1995 • 58 citations

The SH2-like Akt homology (AH) domain of c-akt is present in multiple copies in the genome of vertebrate and invertebrate eucaryotes. Cloning and characterization of the Drosophila melanogaster c-akt homolog Dakt1.

1994 • 51 citations

Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3.

1996 • 24 citations