Distinct and Overlapping Functions of Insulin and IGF-I Receptors

Cell Signaling by Receptor Tyrosine Kinases

2010 • 7,477 citations

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

Cell Signaling by Receptor Tyrosine Kinases

2000 • 3,570 citations

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 3,053 citations

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

Polycystic Ovary Syndrome

1995 • 2,450 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 2,349 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

2000 • 2,178 citations

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

1997 • 2,174 citations

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1997 • 1,905 citations

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

Insulin-Like Growth Factors I and II. Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations*

1989 • 1,796 citations

Parental imprinting of the mouse insulin-like growth factor II gene

1991 • 1,773 citations

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting

1990 • 1,650 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

1997 • 1,554 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

1997 • 1,468 citations

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

2000 • 1,431 citations

Normal growth and development in the absence of hepatic insulin-like growth factor I

1999 • 1,430 citations

Scatter factor/hepatocyte growth factor is essential for liver development

1995 • 1,398 citations

Molecular and Cellular Aspects of the Insulin-Like Growth Factor I Receptor

1995 • 1,361 citations

Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase

1999 • 1,284 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction

2000 • 1,213 citations

A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

1998 • 1,173 citations

Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

1999 • 1,151 citations

Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor

1982 • 1,138 citations

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

1997 • 1,107 citations

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

1999 • 1,102 citations

Intrauterine Growth Retardation and Postnatal Growth Failure Associated with Deletion of the Insulin-Like Growth Factor I Gene

1996 • 1,094 citations

The Syndromes of Insulin Resistance and Acanthosis Nigricans

1976 • 1,086 citations

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1994 • 1,071 citations

Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor

1995 • 1,039 citations

The Insulin-Like Growth Factor-Binding Protein (IGFBP) Superfamily*

1999 • 1,008 citations

Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice

1999 • 938 citations

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

1997 • 929 citations

Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma

1993 • 884 citations

Insulin Receptor Isoform A, a Newly Recognized, High-Affinity Insulin-Like Growth Factor II Receptor in Fetal and Cancer Cells

1999 • 865 citations

Insulin-like growth factor II receptor as a multifunctional binding protein

1987 • 858 citations

Role of IRS-2 in insulin and cytokine signalling

1995 • 843 citations

Autonomous Control of Cell and Organ Size by CHICO, a Drosophila Homolog of Vertebrate IRS1–4

1999 • 838 citations

IGF-I is required for normal embryonic growth in mice.

1993 • 810 citations

Growth Hormone and Bone*

1998 • 807 citations

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

1997 • 806 citations

A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse)

1997 • 784 citations

Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome

1996 • 767 citations

Disruption of imprinting caused by deletion of the H19 gene region in mice

1995 • 765 citations

The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo

1989 • 760 citations

Roles of Growth Hormone and Insulin-like Growth Factor 1 in Mouse Postnatal Growth

2001 • 747 citations

REGULATION OF PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP) GENE EXPRESSION

1997 • 726 citations

Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B

1999 • 719 citations

Cryptorchidism in mice mutant for Insl3

1999 • 719 citations

The IRS-signalling system: A network of docking proteins that mediate insulin action

1998 • 693 citations

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1996 • 674 citations

Cellular Localization of Somatomedin (Insulin-Like Growth Factor) Messenger RNA in the Human Fetus

1987 • 663 citations

Targeted Disruption of the Insl3 Gene Causes Bilateral Cryptorchidism

1999 • 658 citations

Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons

1995 • 629 citations

Effects of an Igf1 gene null mutation on mouse reproduction.

1996 • 615 citations

Mutations in the glucokinase gene of the fetus result in reduced birth weight

1998 • 602 citations

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

1996 • 596 citations

Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality.

1994 • 593 citations

Mechanism of the Stimulatory Effect of Growth Hormone on Longitudinal Bone Growth*

1987 • 580 citations

Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles

1997 • 549 citations

Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma

1993 • 546 citations

Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues.

1986 • 531 citations

Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling

1999 • 526 citations

Growth Hormone Stimulates Longitudinal Bone Growth Directly

1982 • 524 citations

Untitled

1998 • 523 citations

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

2000 • 519 citations

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2

2000 • 499 citations

An ultrastructural analysis of the developing embryonic pancreas

1972 • 495 citations

Insulin Receptors in the Liver: Specific Binding of [ ¹²⁵ I]Insulin to the Plasma Membrane and Its Relation to Insulin Bioactivity

1971 • 494 citations

Adaptations of glucose and fatty acid metabolism during perinatal period and suckling-weaning transition

1992 • 481 citations

Mouse Mutants Lacking the Type 2 IGF Receptor (IGF2R) Are Rescued from Perinatal Lethality inIgf2andIgf1rNull Backgrounds

1996 • 479 citations

Regulation of embryonic growth and lysosomal targeting by the imprintedIgf2/Mpr gene

1994 • 471 citations

Insulin Stimulates Phosphorylation of the Forkhead Transcription Factor FKHR on Serine 253 through a Wortmannin-sensitive Pathway

1999 • 470 citations

Growth Hormone (GH) Insensitivity Due to Primary GH Receptor Deficiency

1994 • 466 citations

IRS-2 pathways integrate female reproduction and energy homeostasis

2000 • 459 citations

Discovery of a Small Molecule Insulin Mimetic with Antidiabetic Activity in Mice

1999 • 452 citations

The C. elegans PTEN Homolog, DAF-18, Acts in the Insulin Receptor-like Metabolic Signaling Pathway

1998 • 440 citations

Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2

1997 • 419 citations

Tissue Distribution of Insulin-Like Growth Factor I and II Messenger Ribonucleic Acid in the Adult Rat*

1987 • 418 citations

Role of insulin-like growth factor binding proteins in controlling IGF actions

1998 • 401 citations

Growth-Promoting Interaction of IGF-II with the Insulin Receptor during Mouse Embryonic Development

1997 • 391 citations

A Novel 160-kDa Phosphotyrosine Protein in Insulin-treated Embryonic Kidney Cells Is a New Member of the Insulin Receptor Substrate Family

1997 • 381 citations

daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans.

1994 • 375 citations

The lipid phosphatase SHIP2 controls insulin sensitivity

2001 • 369 citations

Cell Nonautonomy of C. elegans daf-2 Function in the Regulation of Diapause and Life Span

1998 • 362 citations

DNA excision in liver by an albumin-Cre transgene occurs progressively with age

2000 • 360 citations

The 60-kDa Phosphotyrosine Protein in Insulin-treated Adipocytes Is a New Member of the Insulin Receptor Substrate Family

1997 • 354 citations

Cloning and Characterization of Three Human Forkhead Genes That Comprise an FKHR-like Gene Subfamily

1998 • 350 citations

Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith–Wiedemann and Simpson–Golabi–Behmel syndromes

1997 • 349 citations

Structure of the human insulin receptor gene and characterization of its promoter.

1989 • 349 citations

An Insulin-like Signaling Pathway Affects Both Longevity and Reproduction in Caenorhabditis elegans

1998 • 347 citations

Genetics of mouse growth.

1998 • 342 citations

Regulation of Glucose-6-phosphatase Gene Expression by Protein Kinase Bα and the Forkhead Transcription Factor FKHR

2000 • 339 citations

The Drosophila insulin receptor is required for normal growth.

1996 • 337 citations

Hepatocyte nuclear factor 3/fork head or "winged helix" proteins: a family of transcription factors of diverse biologic function.

1993 • 329 citations

Autoregulatory Mechanisms in Protein-tyrosine Kinases

1998 • 319 citations

Lilly Lecture: Molecular Mechanisms of Insulin Resistance: Lessons From Patients With Mutations in the Insulin-Receptor Gene

1992 • 319 citations

Alternative splicing of human insulin receptor messenger RNA

1989 • 312 citations

Tissue-Specific Expression of Two Alternatively Spliced Insulin Receptor mRNAs in Man

1989 • 308 citations

Two Mutant Alleles of the Insulin Receptor Gene in a Patient with Extreme Insulin Resistance

1988 • 308 citations

Chemical Composition of Newly Born Mammals

1950 • 306 citations

Effects of an Igf1 gene null mutation on mouse reproduction

1996 • 302 citations

Single-Chain Antibody-Mediated Intracellular Retention of ErbB-2 Impairs Neu Differentiation Factor and Epidermal Growth Factor Signaling

1995 • 300 citations

Mutations in the Insulin Receptor Gene

1992 • 294 citations

Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling

1999 • 289 citations

Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality.

1996 • 287 citations

Cloning of a cDNA for a novel insulin-like peptide of the testicular Leydig cells.

1993 • 282 citations

Insulin receptor activation by IGF-II in breast cancers: evidence for a new autocrine/paracrine mechanism

1999 • 280 citations

Transgenic knockouts reveal a critical requirement for pancreatic β cell glucokinase in maintaining glucose homeostasis

1995 • 277 citations

Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR

2000 • 273 citations

Phenotypic alterations in insulin-deficient mutant mice

1997 • 272 citations

Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene

1991 • 262 citations

Role of Gab1 in Heart, Placenta, and Skin Development and Growth Factor- and Cytokine-Induced Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Activation

2000 • 258 citations

Transient neonatal diabetes: widening the understanding of the etiopathogenesis of diabetes.

2000 • 257 citations

RNA-Mediated Gene Duplication: the Rat Preproinsulin I Gene Is a Functional Retroposon

1985 • 256 citations

Pancreatic β-Cell-specific Targeted Disruption of Glucokinase Gene

1995 • 235 citations

Insulin-like growth factor II stimulates cell proliferation through the insulin receptor

1997 • 234 citations

Phosphoenolpyruvate Carboxykinase Is Necessary for the Integration of Hepatic Energy Metabolism

2000 • 232 citations

Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis

2000 • 227 citations

Primary Structure of a Putative Receptor for a Ligand of the Insulin Family

1989 • 224 citations

Onset of cell-specific gene expression in the developing mouse pancreas.

1992 • 224 citations

Acquisition of increased hormone sensitivity during in vitro adipocyte development.

1977 • 221 citations

Allele specific inactivation of insulin 1 and 2, in the mouse yolk sac, indicates imprinting

1994 • 219 citations

Embryogenesis of the Human Pancreatic Islets: A Light and Electron Microscopic Study

1972 • 214 citations

Apoptosis in the Pancreatic Islet Cells of the Neonatal Rat Is Associated with a Reduced Expression of Insulin-Like Growth Factor II that May Act as a Survival Factor*

1998 • 210 citations

An imprinted locus associated with transient neonatal diabetes mellitus

2000 • 210 citations

Insulin-like Growth Factor-II Is an Autocrine Survival Factor for Differentiating Myoblasts

1996 • 205 citations

Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cells

1990 • 199 citations

The DAF-3 Smad protein antagonizes TGF-β-related receptor signaling in the Caenorhabditis elegansdauer pathway

1997 • 197 citations

Rat insulin-like growth factor II gene

1986 • 192 citations

Insulin Receptor Substrate 3 Is Not Essential for Growth or Glucose Homeostasis

1999 • 191 citations

Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele

1997 • 189 citations

Hormones in male sexual development

2000 • 185 citations

Five mutant alleles of the insulin receptor gene in patients with genetic forms of insulin resistance.

1990 • 183 citations

Epigenotype-phenotype correlations in Beckwith-Wiedemann syndrome

2000 • 181 citations

An infant with deletion of the distal long arm of chromosome 15 (q26.1→qter) and loss of insulin‐like growth factor 1 receptor gene

1991 • 179 citations

Early pattern of differentiation in the human pancreas.

2000 • 176 citations

DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells

2000 • 169 citations

Evidence That IRS-2 Phosphorylation Is Required for Insulin Action in Hepatocytes

1998 • 169 citations

Hypoglycemic effect of insulin-like growth factor-1 in mice lacking insulin receptors.

1997 • 156 citations

A mutation in the insulin receptor gene that impairs transport of the receptor to the plasma membrane and causes insulin-resistant diabetes.

1989 • 155 citations

RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon.

1985 • 153 citations

Mouse Leydig insulin-like (Ley I-L) gene: Structure and expression during testis and ovary development

1997 • 151 citations

Identification of INSL5, a New Member of the Insulin Superfamily

1999 • 143 citations

Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue

1998 • 143 citations

Ligand-binding properties of the two isoforms of the human insulin receptor.

1993 • 140 citations

Metabolic and endocrine findings in appropriate and small for gestational age fetuses

1991 • 133 citations

Overexpression of Insulin-Like Growth Factor-II in Transgenic Mice Is Associated with Pancreatic Islet Cell Hyperplasia*

1999 • 132 citations

Homozygous deletion of the human insulin receptor gene results in leprechaunism

1993 • 127 citations

Growth and Differentiation Signals by the Insulin-like Growth Factor 1 Receptor in Hemopoietic Cells Are Mediated through Different Pathways

1999 • 126 citations

Factors Affecting the Secretion of Insulin and Glucagon by the Rat Fetus

1974 • 126 citations

Expression, Characterization, and Crystallization of the Catalytic Core of the Human Insulin Receptor Protein-tyrosine Kinase Domain

1995 • 126 citations

Isolation of a Drosophila genomic sequence homologous to the kinase domain of the human insulin receptor and detection of the phosphorylated Drosophila receptor with an anti-peptide antibody.

1986 • 123 citations

Alternatively spliced variants of the insulin receptor protein. Expression in normal and diabetic human tissues.

1992 • 121 citations

Identification of INSL6, a New Member of the Insulin Family That Is Expressed in the Testis of the Human and Rat1

2000 • 117 citations

Regulation of insulin gene transcription

2000 • 117 citations

Effects of Insulin-Like Growth Factor I (IGF-I) Therapy on Body Composition and Insulin Resistance in IGF-I Gene Deletion

2000 • 116 citations

Genetic control of size inDrosophila

2000 • 116 citations

Molecular Genetics of Maturity-onset Diabetes of the Young

1999 • 113 citations

Altered expression of insulin receptor types A and B in the skeletal muscle of non-insulin-dependent diabetes mellitus patients.

1991 • 109 citations

Preserved Pancreatic β-Cell Development and Function in Mice Lacking the Insulin Receptor-Related Receptor

2001 • 108 citations

Insulin Receptor Substrate 3 (IRS-3) and IRS-4 Impair IRS-1- and IRS-2-Mediated Signaling

2001 • 107 citations

Transdominant inhibition of tyrosine kinase activity in mutant insulin/insulin-like growth factor I hybrid receptors.

1991 • 103 citations

Cloning of a New Member of the Insulin Gene Superfamily (INSL4) Expressed in Human Placenta

1995 • 101 citations

Pancreas development and diabetes

1999 • 100 citations

Homozygous nonsense mutation in the insulin receptor gene in infant with leprechaunism

1993 • 100 citations

The insulin receptor-related receptor. Tissue expression, ligand binding specificity, and signaling capabilities.

1992 • 99 citations

Growth factors in preimplantation mammalian embryos.

1993 • 98 citations

The Drosophila Insulin Receptor Contains a Novel Carboxyl-terminal Extension Likely to Play an Important Role in Signal Transduction

1995 • 98 citations

Evidence That Insulin is Imprinted in the Human Yolk Sac

2001 • 97 citations

Glucokinase Mutations, Insulin Secretion, and Diabetes Mellitus

1996 • 97 citations

Expression of liver carnitine palmitoyltransferase I and II genes during development in the rat

1994 • 95 citations

IGF-I deficient mice show reduced peripheral nerve conduction velocities and decreased axonal diameters and respond to exogenous IGF-I treatment

1999 • 94 citations

Hypoglycemia in Beckwith-Wiedemann syndrome

2000 • 92 citations

Insulin, insulin-like growth factors and glucose transporters: temporal patterns of gene expression in early murine and bovine embryos

1992 • 91 citations

Cloning, Tissue Expression, and Chromosomal Localization of the Mouse IRS-3 Gene

1997 • 89 citations

Congenital Absence of the Pancreas and Intrauterine Growth Retardation

1979 • 89 citations

The Drosophila Insulin Receptor Activates Multiple Signaling Pathways but Requires Insulin Receptor Substrate Proteins for DNA Synthesis

1996 • 88 citations

Overexpression of insulin-like growth factor-II induces accelerated myoblast differentiation

1996 • 87 citations

Cloning of Two Novel Mammalian Paralogs of Relaxin/Insulin Family Proteins and Their Expression in Testis and Kidney

1999 • 86 citations

THE INFANT OF THE DIABETIC MOTHER

1996 • 86 citations

Developmental changes in mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene expression in rat liver, intestine and kidney

1993 • 85 citations

The 60 kDa Insulin Receptor Substrate Functions Like an IRS Protein (pp60^IRS3) in Adipose Cells

1997 • 83 citations

Increased expression of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of noninsulin-dependent diabetes mellitus subjects.

1996 • 83 citations

Increased and Persistent Circulating Insulin-Like Growth Factor II in Neonatal Transgenic Mice Suppresses Developmental Apoptosis in the Pancreatic Islets*

2000 • 80 citations

Discrete expression of insulin receptor substrate-4 mRNA in adult rat brain

1999 • 76 citations

Genetic modifiers of the insulin resistance phenotype in mice.

2000 • 76 citations

Carbohydrate metabolism in primary growth hormone resistance (Laron syndrome) before and during insulin-like growth factor-I treatment

1995 • 75 citations

Ring chromosome 15 involving deletion of the insulin-like growth factor 1 receptor gene in a patient with features of Silver-Russell syndrome

1993 • 74 citations

A Mutation in the Tyrosine Kinase Domain of the Insulin Receptor Associated with Insulin Resistance in an Obese Woman*

1991 • 74 citations

A direct growth effect of growth hormone in rat hindlimb shown by arterial infusion

1986 • 70 citations

Long-Term Effect of Recombinant Human Insulin-Like Growth Factor I on Metabolic and Growth Control in a Patient with Leprechaunism

1998 • 69 citations

A homozygous kinase-defective mutation in the insulin receptor gene in a patient with leprechaunism

1997 • 68 citations

Mechanism of Insulin and IGF‐I

1995 • 67 citations

Multiple endosomal recycling pathways in rat adipose cells

1998 • 65 citations

Ontogenetic appearance of immunoreactive endocrine cells in rat pancreatic islets

1982 • 62 citations

Polyhormonal aspect of the endocrine cells of the human fetal pancreas

1999 • 61 citations

Withers, D. J. et al. Disruption of IRS-2 causes type 2 diabetes in mice. Nature 391, 900-904

1998 • 61 citations

Hypoglycemia and Hyperinsulinism in Infants with Erythroblastosis Fetalis

1968 • 60 citations

Insulin effect during embryogenesis determines fetal growth: a possible molecular link between birth weight and susceptibility to type 2 diabetes.

2000 • 60 citations

Substitution of isoleucine for methionine at position 1153 in the beta-subunit of the human insulin receptor. A mutation that impairs receptor tyrosine kinase activity, receptor endocytosis, and insulin action.

1992 • 59 citations

Expression of insulin-receptor substrate-1 and -2 in ovaries from women with insulin resistance and from controls

2000 • 57 citations

Progressive Decline in Insulin Levels in Rabson-Mendenhall Syndrome¹

1999 • 57 citations

Congenital absence of islets of Langerhans.

1977 • 57 citations

Insulin receptor-related receptor is expressed in pancreatic beta-cells and stimulates tyrosine phosphorylation of insulin receptor substrate-1 and -2.

1999 • 56 citations

Extreme Insulin Resistance in Association with Abnormally High Binding Affinity of Insulin Receptors from a Patient with Leprechaunism: Evidence for a Defect Intrinsic to the Receptor

1982 • 56 citations

Insulin-like growth factor-I and diabetes. A review

1998 • 56 citations

Non-insulin-dependent diabetes mellitus and gestational diabetes mellitus: Same disease, another name?

1995 • 54 citations

Altered expression of the two naturally occurring human insulin receptor variants in isolated adipocytes of non-insulin-dependent diabetes mellitus patients

1991 • 53 citations

A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth.

1998 • 51 citations

The molecular basis of persistent hyperinsulinemic hypoglycemia of infancy and its pathologic substrates

2000 • 51 citations

Pancreatic Insulin-, Glucagon-, and Somatostatin-Positive Isle Cell Populations during the Perinatal Development of the Rat

1980 • 50 citations

Specific, High Affinity Relaxin-like Factor Receptors

1999 • 50 citations

Aging, life span, and senescence

1998 • 49 citations

Progressive Decline in Insulin Levels in Rabson-Mendenhall Syndrome

1999 • 49 citations

Insulin receptor isotype expression correlates with risk of non-insulin-dependent diabetes.

1993 • 49 citations

Substitution of arginine for histidine at position 209 in the alpha-subunit of the human insulin receptor. A mutation that impairs receptor dimerization and transport of receptors to the cell surface.

1991 • 48 citations

A Novel Human Insulin Receptor Gene Mutation Uniquely Inhibits Insulin Binding Without Impairing Posttranslational Processing

1994 • 48 citations

Differential Signaling of Insulin and IGF-1 Receptors to Glycogen Synthesis in Murine Hepatocytes

1999 • 46 citations

Insulin receptor-related receptor messenger ribonucleic acid is focally expressed in sympathetic and sensory neurons and renal distal tubule cells.

1993 • 45 citations

Effect of Intravenous Insulin-like Growth Factor I in Two Patients with Leprechaunism

1994 • 43 citations

GLUCOSE-INDUCED INCREASE OF PLASMA INSULIN IN THE RAT FOETUS IN UTERO

1974 • 42 citations

Lack of insulin receptors affects the formation of white adipose tissue in mice. A morphometric and ultrastructural analysis

1998 • 42 citations

SMAD Proteins Transactivate the Human ApoCIII Promoter by Interacting Physically and Functionally with Hepatocyte Nuclear Factor 4

2000 • 41 citations

Selective coexpression of insulin receptor-related receptor (IRR) and TRK in NGF-sensitive neurons

1994 • 41 citations

Molecular defects of the insulin receptor gene

1995 • 40 citations

Genetics of Type 2 Diabetes Insight from Targeted Mouse Mutants

2001 • 40 citations

Homozygosity for a null allele of the insulin receptor gene in a patient with leprechaunism

1995 • 40 citations

Relative expression of insulin receptor isoforms does not differ in lean, obese, and noninsulin-dependent diabetes mellitus subjects.

1993 • 38 citations

Glucose Kinetics in Leprechaunism: Accelerated Fasting due to Insulin Resistance*

1980 • 38 citations

Insulin receptor gene expression during development: developmental regulation of insulin receptor mRNA abundance in embryonic rat liver and yolk sac, developmental regulation of insulin receptor gene splicing, and comparison to abundance of insulin-like growth factor 1 receptor mRNA.

1992 • 37 citations

Tissue-specific expression of the rat insulin receptor-related receptor gene.

1992 • 36 citations

Identification, Chromosomal Mapping, and Partial Characterization of MouseIns16:A New Member of the Insulin Family

2000 • 33 citations

Characterization of the Endogenous Insulin Receptor-related Receptor in Neuroblastomas

1995 • 32 citations

Homozygous nonsense mutation in the insulin receptor gene of a patient with severe congenital insulin resistance: leprechaunism and the role of the insulin‐like growth factor receptor

1996 • 30 citations

Expression of insulin receptor spliced variants and their functional correlates in muscle from patients with non-insulin-dependent diabetes mellitus.

1993 • 29 citations

Genetic abnormalities in polycystic ovary syndrome.

1999 • 29 citations

Synthesis and Accumulation of Proinsulin and Insulin during Development of the Embryonic Rat Pancreas*

1979 • 28 citations

Insulin receptor-related receptor expression in non-A intercalated cells in the kidney

1997 • 28 citations

Evidence That Two Naturally Occurring Human Insulin Receptor α-Subunit Variants Are Immunologically Distinct

1992 • 28 citations

Cutaneous Manifestations of Leprechaunism

1981 • 27 citations

Expression of a cDNA encoding the human insulin receptor-related receptor.

1994 • 27 citations

Influences of IGF-I gene disruption on the cellular profile of the diaphragm

2000 • 25 citations

Biological actions of IGFs in mammalian development

1994 • 25 citations

Ultrastructural Localization of Insulin-like Growth Factor-2 (IGF-2) to the Secretory Granules of Insulin Cells: A Study in Normal and Diabetic (GK) Rats

1997 • 24 citations

Insulin receptor-related receptor messenger ribonucleic acid: quantitative distribution and localization to subpopulations of epithelial cells in stomach and kidney.

1995 • 24 citations

The ratio of mouse insulin I:insulin II does not reflect that of the corresponding preproinsulin mRNAs

1992 • 23 citations

Primitive Islets Contain Two Populations of Cells with Differing Glucagon Immunoreactivity

1981 • 23 citations

HYPOGLYCEMIA AND RH ERYTHROBLASTOSIS FETALIS

1967 • 22 citations

Intramolecular subunit interactions between insulin and insulin-like growth factor 1 .alpha..beta. half-receptors induced by ligand and manganese/magnesium-ATP binding

1992 • 22 citations

Insulin receptor-related receptor messenger ribonucleic acid in the stomach is focally expressed in the enterochromaffin-like cells.

1995 • 21 citations

Insulin-like growth factor II in human fetal pancreas and its co-localization with the major islet hormones: comparison with adult pancreas

2000 • 21 citations

The Carboxyl Terminal Extension of the Drosophila Insulin Receptor Homologue Binds IRS-1 and Influences Cell Survival

1999 • 21 citations

Major Circadian Variations of Glucose Homeostasis in a Patient with Rabson-Mendenhall Syndrome and Primary Insulin Resistance Due to a Mutation(Cys284 → Tyr) in the Insulin Receptor α-Subunit

1997 • 21 citations

Two aberrant splicings caused by mutations in the insulin receptor gene in cultured lymphocytes from a patient with Rabson-Mendenhall's syndrome.

1998 • 21 citations

A TrkB/insulin receptor-related receptor chimeric receptor induces PC12 cell differentiation and exhibits prolonged activation of mitogen-activated protein kinase.

1999 • 21 citations

Expression of insulin receptor-related receptor in the rat brain examined by in situ hybridization and immunohistochemistry

1996 • 19 citations

Replacements of Leucine 87 in Human Insulin Receptor Alter Affinity for Insulin

1995 • 19 citations

Constitutionally Short Stature: Analysis of the Insulin-Like Growth Factor-I Gene and the Human Growth Hormone Gene Cluster

1991 • 19 citations

Characterization of a Hybrid Receptor Formed by Dimerization of the Insulin Receptor-Related Receptor (IRR) with the Insulin Receptor (IR): Coexpression of cDNAs Encoding Human IRR and Human IR in NIH-3T3 Cells

1996 • 18 citations

Mitogenic and Metabolic Effects of Type I IGF Receptor Overexpression in Insulin Receptor-Deficient Hepatocytes

2001 • 17 citations

Insulin-Like Growth Factor-I Gene Analysis in Subjects with Constitutionally Variant Stature

1990 • 17 citations

Expression of insulin receptor spliced variants and their functional correlates in muscle from patients with non-insulin-dependent diabetes mellitus

1993 • 16 citations

Expression of insulin receptor-related receptor rnRNA in the rat brain is highly restricted to forebrain cholinergic neurons

1995 • 16 citations

Low Prevalence of Insulin-Like Growth Factor-I Gene Mutations in Human Growth Disorders*

1990 • 16 citations

Tissue-specific expression of the rat insulin receptor-related receptor gene

1992 • 16 citations

REGULATION OF GLUCOSE-6-PHOSPHATASE GENE EXPRESSION BY PROTEIN KINASE B AND THE FORKHEAD TRANSCRIPTION FACTOR FKHR

2001 • 15 citations

Influence of the weaning diet on the changes of glucose metabolism and of insulin sensitivity

1993 • 14 citations

Insulin receptor mRNA splicing and altered metabolic control in aged and mildly insulin-deficient rats

1997 • 13 citations

Insulin/Insulin-Like Growth Factor I Hybrid Receptors Overexpression Is Not an Early Defect in Insulin-Resistant Subjects

2000 • 12 citations

Expression of the two insulin receptor isoforms is not altered in the skeletal muscle and liver of diabetic rats

1998 • 11 citations

[Physiopathological approach and antenatal diagnosis of diabetes mellitus insulin resistant: apropos of a case with leprechaunism].

1994 • 4 citations