A Grb2-associated docking protein in EGF- and insulin-receptor signalling

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.

1994 • 886 citations

Role of IRS-2 in insulin and cytokine signalling

1995 • 843 citations

Two Binding Orientations for Peptides to the Src SH3 Domain: Development of a General Model for SH3-Ligand Interactions

1994 • 800 citations

Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors.

1995 • 633 citations

The Function of GRB2 in Linking the Insulin Receptor to Ras Signaling Pathways

1993 • 629 citations

The GTPase dynamin binds to and is activated by a subset of SH3 domains

1993 • 557 citations

The PH domain: a common piece in the structural pathcwork of signalling proteins

1993 • 536 citations

ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor.

1994 • 520 citations

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1.

1993 • 452 citations

Phosphotyrosine-Dependent Interaction of SHC and Insulin Receptor Substrate 1 with the NPEY Motif of the Insulin Receptor via a Novel Non-SH2 Domain

1995 • 368 citations

Association of insulin receptor substrate-1 with integrins

1994 • 362 citations

Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites.

1994 • 313 citations

Binding of the Ras Activator Son of Sevenless to Insulin Receptor Substrate-1 Signaling Complexes

1993 • 298 citations

The New Elements of Insulin Signaling: Insulin Receptor Substrate-1 and Proteins With SH2 Domains

1993 • 221 citations

Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells.

1993 • 207 citations

The GRB2/Sem‐5 adaptor protein

1994 • 182 citations

pGSTag--a versatile bacterial expression plasmid for enzymatic labeling of recombinant proteins.

1992 • 136 citations

Binding of Vav to Grb2 through dimerization of Src homology 3 domains.

1994 • 112 citations

Insulin receptor substrate-1 (IRS1) and Shc compete for a limited pool of Grb2 in mediating insulin downstream signaling.

1994 • 109 citations

Direct Association of Grb2 with the p85 Subunit of Phosphatidylinositol 3-Kinase

1995 • 100 citations

Human Skeletal Muscle Insulin Receptor Substrate-1: Characterization of the cDNA, Gene, and Chromosomal Localization

1993 • 100 citations

Association between GRB2/Sos and Insulin Receptor Substrate 1 Is Not Sufficient for Activation of Extracellular Signal-Regulated Kinases by Interleukin-4: Implications for Ras Activation by Insulin

1995 • 67 citations

Insulin Receptor Substrate 1 Rescues Insulin Action in CHO Cells Expressing Mutant Insulin Receptors That Lack a Juxtamembrane NPXY Motif

1995 • 27 citations