Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

1996 • 1,277 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

2001 • 1,202 citations

A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

1998 • 1,173 citations

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

Inducible Gene Targeting in Mice Using the Cre/loxSystem

1998 • 756 citations

Identification of a novel gene encoding an insulin-responsive glucose transporter protein

1989 • 601 citations

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

1996 • 596 citations

Protein Kinase B/Akt Participates in GLUT4 Translocation by Insulin in L6 Myoblasts

1999 • 590 citations

Mechanism of Insulin Resistance in A-ZIP/F-1 Fatless Mice

2000 • 439 citations

Potential Role of Protein Kinase B in Insulin-induced Glucose Transport, Glycogen Synthesis, and Protein Synthesis

1998 • 369 citations

Requirement of Atypical Protein Kinase Cλ for Insulin Stimulation of Glucose Uptake but Not for Akt Activation in 3T3-L1 Adipocytes

1998 • 365 citations

Pathophysiology and Pharmacological Treatment of Insulin Resistance*

2000 • 354 citations

Construction and Characterization of a Conditionally Active Version of the Serine/Threonine Kinase Akt

1998 • 318 citations

A Role for Protein Kinase Bβ/Akt2 in Insulin-Stimulated GLUT4 Translocation in Adipocytes

1999 • 316 citations

Insights into insulin resistance and type 2 diabetes from knockout mouse models

2000 • 252 citations

Insulin Increases the Association of Akt-2 with Glut4-containing Vesicles

1998 • 242 citations

Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction

2000 • 220 citations

Targeted Mutagenesis of the POU-Domain GeneBrn4/Pou3f4Causes Developmental Defects in the Inner Ear

1999 • 176 citations

Insulin, but Not Contraction, Activates Akt/PKB in Isolated Rat Skeletal Muscle

1998 • 153 citations

The Insulin-Sensitive Glucose Transporter

1992 • 135 citations

The direct and indirect effects of insulin on hepatic glucose production in vivo

1998 • 130 citations

Activation of Protein Kinase B/Akt Is Sufficient to Repress the Glucocorticoid and cAMP Induction of Phosphoenolpyruvate Carboxykinase Gene

1998 • 127 citations

Dominant Negative Forms of Akt (Protein Kinase B) and Atypical Protein Kinase Cλ Do Not Prevent Insulin Inhibition of Phosphoenolpyruvate Carboxykinase Gene Transcription

1999 • 101 citations

Assessment of the Roles of Mitogen-activated Protein Kinase, Phosphatidylinositol 3-Kinase, Protein Kinase B, and Protein Kinase C in Insulin Inhibition of cAMP-induced Phosphoenolpyruvate Carboxykinase Gene Transcription

1998 • 83 citations

Differentiation-dependent Suppression of Platelet-derived Growth Factor Signaling in Cultured Adipocytes

1999 • 60 citations

Mapping of AKT3, encoding a member of the Akt/protein kinase B family, to human and rodent chromosomes by fluorescence in situ hybridization

2000 • 59 citations

Activation of protein kinase B/cAkt in hepatocytes is sufficient for the induction of expression of the gene encoding glucokinase

2000 • 44 citations

Chromosome mapping of the mouse <i>Akt</i><i>2</i> gene and <i>Akt</i><i>2</i> pseudogene

1996 • 5 citations

Book Reviews

1997 • 1 citations

JIM BENETT, ROBERT BRAIN, KATE BYCROFT et al., Empires of Physics.. A Guide to the Exhibition. Cambridge, Whipple Museum of the History of Science, 1993, 110 pp., fig.

1993 • 1 citations

Sisters find a slick way to stick

2000 • 1 citations