Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Williams Textbook of Endocrinology

2016 • 3,772 citations

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

1998 • 969 citations

The IRS-Signaling System: A Network of Docking Proteins That Mediate Insulin and Cytokine Action

1998 • 369 citations

The role of PI 3-kinase in insulin action

1998 • 224 citations

Differential Signaling by Insulin Receptor Substrate 1 (IRS-1) and IRS-2 in IRS-1-Deficient Cells

1997 • 212 citations

Insulin Receptor Substrate 3 Is Not Essential for Growth or Glucose Homeostasis

1999 • 191 citations

Evidence That IRS-2 Phosphorylation Is Required for Insulin Action in Hepatocytes

1998 • 169 citations

Interaction of Insulin Receptor Substrate-2 (IRS-2) with the Insulin and Insulin-like Growth Factor I Receptors

1996 • 133 citations

The IRS-2 Gene on Murine Chromosome 8 Encodes a Unique Signaling Adapter for Insulin and Cytokine Action

1997 • 130 citations

Characterization of Insulin Receptor Substrate 4 in Human Embryonic Kidney 293 Cells

1998 • 112 citations

Chronic hypoglycemia and diabetes impair counterregulation induced by localized 2-deoxy-glucose perfusion of the ventromedial hypothalamus in rats.

1999 • 82 citations

Discrete expression of insulin receptor substrate-4 mRNA in adult rat brain

1999 • 76 citations

Tyr624 and Tyr628 in Insulin Receptor Substrate-2 Mediate Its Association with the Insulin Receptor

1997 • 75 citations

Different Subcellular Distribution and Regulation of Expression of Insulin Receptor Substrate (IRS)-3 from Those of IRS-1 and IRS-2

1998 • 72 citations

Cloning, Tissue Expression, and Chromosomal Location of the Mouse Insulin Receptor Substrate 4 Gene*

1999 • 69 citations

Insulin receptors and signal transduction proteins in the hypothalamo-hypophyseal system: a review on morphological findings and functional implications.

1998 • 64 citations

Association of Insulin Receptor Substrate 3 with SH2 Domain-Containing Proteins in Rat Adipocytes

1998 • 28 citations

Activation of PI 3-kinase in 3T3-L1 adipocytes by association with insulin receptor substrate-1

1994 • 18 citations