Phosphoinositide-Regulated Kinases and Phosphoinositide Phosphatases

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

1999 • 3,529 citations

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 • 3,129 citations

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 3,053 citations

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 3,002 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1997 • 2,746 citations

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

1999 • 2,577 citations

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

1998 • 2,505 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

1999 • 1,830 citations

Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the α1A-voltage-dependent calcium channel

1997 • 1,571 citations

The PI3K–PDK1 connection: more than just a road to PKB

2000 • 1,563 citations

The extended protein kinase C superfamily

1998 • 1,544 citations

Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

1997 • 1,448 citations

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

2000 • 1,431 citations

Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation

2000 • 1,365 citations

Mechanisms and consequences of activation of protein kinase B/Akt

1998 • 1,305 citations

Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTEN

1998 • 1,215 citations

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

1997 • 1,190 citations

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

1998 • 1,180 citations

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

1998 • 1,097 citations

Phosphorylation and Regulation of Raf by Akt (Protein Kinase B)

1999 • 1,084 citations

Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

1998 • 1,050 citations

Role of Translocation in the Activation and Function of Protein Kinase B

1997 • 1,044 citations

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activationofCREB

1998 • 975 citations

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

1998 • 969 citations

Phosphoinositide 3-kinases: A conserved family of signal transducers

1997 • 944 citations

Mutation ofPten/Mmac1in mice causes neoplasia in multiple organ systems

1999 • 941 citations

ICOS co-stimulatory receptor is essential for T-cell activation and function

2001 • 902 citations

Phosphorylation and Activation of p70 ^s6k by PDK1

1998 • 835 citations

Essential Role of Phosphoinositide Metabolism in Synaptic Vesicle Recycling

1999 • 825 citations

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

1998 • 823 citations

Phosphorylation of the PTEN Tail Regulates Protein Stability and Function

2000 • 756 citations

Mechanism of activation and function of protein kinase B

1998 • 753 citations

Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction

1999 • 722 citations

Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B

1999 • 719 citations

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

1997 • 699 citations

Signal-dependent membrane targeting by pleckstrin homology (PH) domains

2000 • 692 citations

Serine/Threonine Protein Kinases and Apoptosis

2000 • 692 citations

Signalling through phosphoinositide 3-kinases: the lipids take centre stage

1999 • 689 citations

Ribosomal S6 Kinase Signaling and the Control of Translation

1999 • 679 citations

Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase γ

1997 • 671 citations

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.

1996 • 636 citations

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase

1996 • 631 citations

Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway

1998 • 612 citations

Multiple pathways control protein kinase C phosphorylation

2000 • 598 citations

Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2

1999 • 598 citations

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

1999 • 592 citations

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

1998 • 579 citations

The PH domain: a common piece in the structural pathcwork of signalling proteins

1993 • 536 citations

Akt/Protein Kinase B Is Regulated by Autophosphorylation at the Hypothetical PDK-2 Site

2000 • 524 citations

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

1998 • 487 citations

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

2000 • 487 citations

A Specific Product of Phosphatidylinositol 3-Kinase Directly Activates the Protein Kinase Akt through Its Pleckstrin Homology Domain

1997 • 481 citations

Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC

1998 • 479 citations

How do protein kinases recognize their substrates?

1996 • 470 citations

Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease

1997 • 465 citations

Membrane Localization of Phosphatidylinositol 3-Kinase Is Sufficient To Activate Multiple Signal-Transducing Kinase Pathways

1996 • 443 citations

Role of Glycogen Synthase Kinase-3β in Neuronal Apoptosis Induced by Trophic Withdrawal

2000 • 440 citations

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2

1999 • 440 citations

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

1997 • 436 citations

Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades

1997 • 435 citations

Global unfolding of a substrate protein by the Hsp100 chaperone ClpA

1999 • 427 citations

Cellular Signaling

2000 • 415 citations

Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities

2000 • 398 citations

Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase

1999 • 396 citations

Peptide and Protein Library Screening Defines Optimal Substrate Motifs for AKT/PKB

2000 • 389 citations

Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)

1998 • 383 citations

Two yeast forkhead genes regulate the cell cycle and pseudohyphal growth

2000 • 373 citations

The lipid phosphatase SHIP2 controls insulin sensitivity

2001 • 369 citations

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

1999 • 368 citations

Insulin-Induced Phosphorylation and Activation of Cyclic Nucleotide Phosphodiesterase 3B by the Serine-Threonine Kinase Akt

1999 • 365 citations

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

1998 • 365 citations

A Novel Positive Feedback Loop Mediated by the Docking Protein Gab1 and Phosphatidylinositol 3-Kinase in Epidermal Growth Factor Receptor Signaling

2000 • 350 citations

Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

1999 • 349 citations

Deficiency of PTEN in Jurkat T Cells Causes Constitutive Localization of Itk to the Plasma Membrane and Hyperresponsiveness to CD3 Stimulation

2000 • 345 citations

Stimulation of Matrix Metalloproteinase Production by Recombinant Extracellular Matrix Metalloproteinase Inducer from Transfected Chinese Hamster Ovary Cells

1997 • 341 citations

Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells.

1998 • 338 citations

Identification of Flow-dependent Endothelial Nitric-oxide Synthase Phosphorylation Sites by Mass Spectrometry and Regulation of Phosphorylation and Nitric Oxide Production by the Phosphatidylinositol 3-Kinase Inhibitor LY294002

1999 • 331 citations

Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

1996 • 328 citations

Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

1999 • 326 citations

Mutations of the human PTEN gene

2000 • 323 citations

The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

1999 • 312 citations

A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1

2000 • 302 citations

Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase‐3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin

1998 • 298 citations

Structure, function, and biology of SHIP proteins

2000 • 298 citations

Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

2000 • 297 citations

Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases

2000 • 291 citations

Akt/PKB localisation and 3′ phosphoinositide generation at sites of epithelial cell–matrix and cell–cell interaction

1999 • 288 citations

Epstein-Barr Virus LMP2A Transforms Epithelial Cells, Inhibits Cell Differentiation, and Activates Akt

2000 • 279 citations

Activation of protein kinase B β and γ isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B α

1998 • 275 citations

The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2

1998 • 265 citations

Mechanism of Protein Kinase B Activation by Cyclic AMP-Dependent Protein Kinase

1999 • 262 citations

PDK1, one of the missing links in insulin signal transduction?¹

1997 • 246 citations

How BAD phosphorylation is good for survival

1999 • 242 citations

The Role of Phosphatases in Inositol Signaling Reactions

1999 • 224 citations

PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27KIP1 through the ubiquitin E3 ligase SCFSKP2

2001 • 223 citations

Intracellular signalling: PDK1 – a kinase at the hub of things

1999 • 221 citations

Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism

1999 • 216 citations

Further evidence that 3‐phosphoinositide‐dependent protein kinase‐1 (PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms

2000 • 206 citations

Activation of β1 Integrin Signaling Stimulates Tyrosine Phosphorylation of p190 and Membrane-protrusive Activities at Invadopodia

1998 • 204 citations

A Human Protein Kinase Bγ with Regulatory Phosphorylation Sites in the Activation Loop and in the C-terminal Hydrophobic Domain

1999 • 198 citations

Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase.

1996 • 194 citations

The pleckstrin homology domains of protein kinase B and GRP1 (general receptor for phosphoinositides-1) are sensitive and selective probes for the cellular detection of phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 3,4,5-trisphosphate in vivo

1999 • 192 citations

The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway

1999 • 186 citations

Vac1p coordinates Rab and phosphatidylinositol 3-kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome

1999 • 186 citations

A 3-Phosphoinositide-dependent Protein Kinase-1 (PDK1) Docking Site Is Required for the Phosphorylation of Protein Kinase Cζ (PKCζ) and PKC-related Kinase 2 by PDK1

2000 • 185 citations

Akt Phosphorylation Site Found in Human Caspase-9 Is Absent in Mouse Caspase-9

1999 • 181 citations

Altered Expression Levels and Impaired Steps in the Pathway to Phosphatidylinositol 3-Kinase Activation via Insulin Receptor Substrates 1 and 2 in Zucker Fatty Rats

1998 • 171 citations

Chronic administration of neuropeptide Y into the lateral ventricle inhibits both the pituitary-testicular axis and growth hormone and insulin-like growth factor I secretion in intact adult male rats.

1996 • 168 citations

Expression of a constitutively activated form of protein kinase B (c-Akt) in 3T3-L1 preadipose cells causes spontaneous differentiation.

1996 • 163 citations

Phosphorylation at Conserved Carboxyl-terminal Hydrophobic Motif Regulates the Catalytic and Regulatory Domains of Protein Kinase C

1997 • 151 citations

Regulation of GRP1-catalyzed ADP Ribosylation Factor Guanine Nucleotide Exchange by Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 151 citations

Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN

1999 • 142 citations

Dual Regulation of Platelet Protein Kinase B

2000 • 141 citations

A Single Ring Is Sufficient for Productive Chaperonin-Mediated Folding In Vivo

1998 • 138 citations

Evidence That 3-Phosphoinositide-dependent Protein Kinase-1 Mediates Phosphorylation of p70 S6 Kinase in Vivoat Thr-412 as well as Thr-252

1999 • 138 citations

Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis

2000 • 138 citations

Effect of Phosphoinositide-Dependent Kinase 1 on Protein Kinase B Translocation and Its Subsequent Activation

2000 • 137 citations

Fibroblast growth factor (FGF) signaling through PI 3-kinase and Akt/PKB is required for embryoid body differentiation

2000 • 135 citations

The Isolation and Characterization of a cDNA Encoding Phospholipid-specific Inositol Polyphosphate 5-Phosphatase

2000 • 134 citations

Properties of Type II Inositol Polyphosphate 5-Phosphatase

1995 • 127 citations

Rho GTPase Control of Protein Kinase C-related Protein Kinase Activation by 3-Phosphoinositide-dependent Protein Kinase

2000 • 126 citations

Heregulin Induces Phosphorylation of BRCA1 through Phosphatidylinositol 3-Kinase/AKT in Breast Cancer Cells

1999 • 124 citations

Distinct Phosphatidylinositol 3-Kinase Lipid Products Accumulate upon Oxidative and Osmotic Stress and Lead to Different Cellular Responses

1999 • 117 citations

Domain Swapping Used To Investigate the Mechanism of Protein Kinase B Regulation by 3-Phosphoinositide-Dependent Protein Kinase 1 and Ser473 Kinase

1999 • 113 citations

Insulin-like Growth Factor I Stimulates Tyrosine Phosphorylation of p130Cas, Focal Adhesion Kinase, and Paxillin

1998 • 104 citations

The epidemiology of endocrine tumours.

2000 • 103 citations

Identification of Novel Pleckstrin Homology (PH) Domains Provides a Hypothesis for PH Domain Function

1993 • 99 citations

Enzymatic Activity of the Src Homology 2 Domain-containing Inositol Phosphatase Is Regulated by a Plasma Membrane Location

2000 • 97 citations

ERBB-2 overexpression confers PI 3′ kinase-dependent invasion capacity on human mammary epithelial cells

2000 • 95 citations

DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides

1999 • 95 citations

A Novel B Lymphocyte–Associated Adaptor Protein, Bam32, Regulates Antigen Receptor Signaling Downstream of Phosphatidylinositol 3-Kinase

2000 • 94 citations

Short Term Insulin Treatment Prevents the Diabetogenic Action of Streptozotocin in Rats¹

1997 • 91 citations

Oxidative Stress and Vanadate Induce Tyrosine Phosphorylation of Phosphoinositide-Dependent Kinase 1 (PDK1)

2000 • 83 citations

Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase

2000 • 76 citations

Mutations in the retinoblastoma-related gene RB2/p130 in primary nasopharyngeal carcinoma.

2000 • 74 citations

Changes in polyamine catabolism in HL-60 human promyelogenous leukaemic cells in response to etoposide-induced apoptosis

1998 • 70 citations

Induction of p21Waf1/Cip1 by TNFα requires NF-κB activity and antagonizes apoptosis in Ewing tumor cells

2000 • 68 citations

Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene

2000 • 65 citations

Identification of centaurin-α1 as a potential in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein that is functionally homologous to the yeast ADP-ribosylation factor (ARF) GTPase-activating protein, Gcs1

1999 • 62 citations

Induction of Akt-2 Correlates with Differentiation in Sol8 Muscle Cells

1998 • 50 citations

Peroxovanadate induces tyrosine phosphorylation of phosphoinositide‐dependent protein kinase‐1

2000 • 49 citations

Colipase Stabilizes the Lid Domain of Pancreatic Triglyceride Lipase

1997 • 47 citations

β1-Integrin and PTEN control the phosphorylation of protein kinase C

2000 • 43 citations

A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase

2000 • 42 citations

A Constitutively Active Version of the Ser/Thr Kinase Akt Induces Production of the obGene Product, Leptin, in 3T3-L1 Adipocytes

1997 • 36 citations

Insulin-Induced Translocation of Protein Kinase B to the Plasma Membrane in Rat Adipocytes

1998 • 31 citations

Comparison of different methods of intracerebral administration of radioiododeoxyuridine for glioma therapy using a rat model

2000 • 29 citations

Cloning of the Murine Interferon-Inducible Protein 10 (IP-10) Receptor and Its Specific Expression in Lymphoid Organs

1998 • 29 citations

Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase

2000 • 28 citations

Molecular characterization of Oryza sativa 16.9 kDa heat shock protein

1999 • 20 citations

Cell polarity: Scaffold proteins par excellence

2000 • 18 citations

Vessels vivified by Akt acting on NO synthase

1999 • 16 citations

A novel principle for conferring selectivity to poly(A)-binding proteins: interdependence of two ATP synthase β-subunit mRNA-binding proteins

2000 • 12 citations

Plant development: Making asymmetric flowers

1997 • 8 citations

Berkeley dispute festers over biotech deal

1999 • 8 citations

Molecular characterization of Oryza sativa 16·9 kDa heat shock protein

1999 • 7 citations

British drive for more women in science

1999 • 4 citations

Promega and Roche take up battle over PCR patents

2000 • 3 citations

Structure and mechanism in protein science (book review)

1999 • 3 citations

This Week in Science

1997 • 3 citations

Accidental contamination 'unlikely'

1995 • 3 citations

Basic internet facilities

1997 • 2 citations

Recalcitrant institutes face cuts in Japan

1998 • 2 citations

Pole positioned by pombe pore protein

1999 • 2 citations

Mexican Fires Charge Up U.S. Clouds

1998 • 1 citations

Challenge for unknowns Combinatorial libraries

1997 • 1 citations