New Perspectives into the Molecular Pathogenesis and Treatment of Type 2 Diabetes

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

THE GLUCOSE FATTY-ACID CYCLE ITS ROLE IN INSULIN SENSITIVITY AND THE METABOLIC DISTURBANCES OF DIABETES MELLITUS

1963 • 5,061 citations

The hormone resistin links obesity to diabetes

2001 • 4,720 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

Obesity and insulin resistance

2000 • 3,076 citations

15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

1995 • 2,857 citations

Prevalence of Diabetes, Impaired Fasting Glucose, and Impaired Glucose Tolerance in U.S. Adults: The Third National Health and Nutrition Examination Survey, 1988–1994

1998 • 2,780 citations

Cellular mechanisms of insulin resistance

2000 • 2,692 citations

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

1996 • 2,561 citations

Obesity and the Regulation of Energy Balance

2001 • 2,387 citations

The coregulator exchange in transcriptional functions of nuclear receptors

2000 • 2,219 citations

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

2000 • 2,178 citations

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat.

1996 • 2,130 citations

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

1997 • 2,105 citations

PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development

1999 • 1,904 citations

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

Mechanism of free fatty acid-induced insulin resistance in humans.

1996 • 1,507 citations

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

2000 • 1,487 citations

PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance

1999 • 1,339 citations

Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity

1999 • 1,300 citations

Insulin resistance and cardiovascular disease

2000 • 1,280 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Quantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by¹³C Nuclear Magnetic Resonance Spectroscopy

1990 • 1,226 citations

Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction

2000 • 1,213 citations

A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

1998 • 1,173 citations

Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

1999 • 1,151 citations

Regional adiposity and morbidity.

1994 • 1,135 citations

Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells

2000 • 1,132 citations

Insulin resistance differentially affects the PI 3-kinase– and MAP kinase–mediated signaling in human muscle

2000 • 1,119 citations

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

Slow Glucose Removal Rate and Hyperinsulinemia Precede the Development of Type II Diabetes in the Offspring of Diabetic Parents

1990 • 1,051 citations

Mechanisms of fatty acid-induced inhibition of glucose uptake.

1994 • 1,049 citations

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

1999 • 1,040 citations

Thiazolidinediones in the Treatment of Insulin Resistance and Type II Diabetes

1996 • 1,004 citations

Signaling pathways in insulin action: molecular targets of insulin resistance

2000 • 932 citations

Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.

1999 • 891 citations

Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice

2000 • 805 citations

Insulin Degradation: Progress and Potential*

1998 • 772 citations

The role of TNFα and TNF receptors in obesity and insulin resistance

1999 • 771 citations

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

1999 • 771 citations

Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.

1998 • 768 citations

Evidence for 5′AMP-Activated Protein Kinase Mediation of the Effect of Muscle Contraction on Glucose Transport

1998 • 749 citations

Obesity in the new millennium

2000 • 707 citations

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

2000 • 669 citations

Direct antidiabetic effect of leptin through triglyceride depletion of tissues

1997 • 664 citations

Gestational Diabetes Mellitus

1986 • 646 citations

CAP defines a second signalling pathway required for insulin-stimulated glucose transport

2000 • 646 citations

Free Fatty Acids and Pathogenesis of Type 2 Diabetes Mellitus

2000 • 623 citations

Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

2001 • 606 citations

A genome–wide search for human non–insulin–dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2

1996 • 601 citations

Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat.

1998 • 554 citations

Regulation of gene expression by insulin

1996 • 543 citations

ADD1/SREBP-1c Is Required in the Activation of Hepatic Lipogenic Gene Expression by Glucose

1999 • 540 citations

Signaling Mechanisms That Regulate Glucose Transport

1999 • 525 citations

Dealing with energy demand: the AMP-activated protein kinase

1999 • 516 citations

Effects of an Engineered Human Anti–TNF-α Antibody (CDP571) on Insulin Sensitivity and Glycemic Control in Patients With NIDDM

1996 • 505 citations

Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes

1999 • 483 citations

Discovery of a Small Molecule Insulin Mimetic with Antidiabetic Activity in Mice

1999 • 452 citations

Regulation of fatty acid homeostasis in cells: Novel role of leptin

1999 • 442 citations

Mechanism of Insulin Resistance in A-ZIP/F-1 Fatless Mice

2000 • 439 citations

Molecular Basis of Insulin-stimulated GLUT4 Vesicle Trafficking

1999 • 417 citations

Improved insulin-sensitivity in mice heterozygous for PPAR-γ deficiency

2000 • 401 citations

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase

1999 • 396 citations

Lack of Suppression of Glucagon Contributes to Postprandial Hyperglycemia in Subjects with Type 2 Diabetes Mellitus¹

2000 • 373 citations

Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat.

1996 • 373 citations

Interactions between insulin resistance and insulin secretion in the development of glucose intolerance

2000 • 361 citations

Alterations in the Expression and Cellular Localization of Protein Kinase C Isozymes ε and θ Are Associated With Insulin Resistance in Skeletal Muscle of the High-Fat–Fed Rat

1997 • 315 citations

A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance

2000 • 295 citations

Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance.

2000 • 294 citations

New Insights Into the Role and Mechanism of Glycogen Synthase Activation by Insulin

1997 • 293 citations

Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs.

1996 • 290 citations

Evolution of β-Cell Dysfunction in the Male Zucker Diabetic Fatty Rat

1995 • 283 citations

Maturity-onset diabetes of the young: clinical heterogeneity explained by genetic heterogeneity

1998 • 281 citations

TNF-alpha and insulin resistance: summary and future prospects.

1998 • 280 citations

PPARγ and the Treatment of Insulin Resistance

2000 • 279 citations

Targeted Disruption of the Tumor Necrosis Factor-α Gene: Metabolic Consequences in Obese and Nonobese Mice

1997 • 277 citations

Lack of Suppression of Glucagon Contributes to Postprandial Hyperglycemia in Subjects with Type 2 Diabetes Mellitus

2000 • 262 citations

Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation

1999 • 247 citations

Differential activation of peroxisome proliferator-activated receptor-gamma by troglitazone and rosiglitazone.

2000 • 227 citations

Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction

2000 • 220 citations

Thiazolidinediones and insulin resistance: Peroxisome proliferatoractivated receptor γ activation stimulates expression of the CAP gene

1998 • 197 citations

Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1.

2000 • 184 citations

Synip

1999 • 183 citations

Obesity and diabetes in TNF-alpha receptor- deficient mice.

1998 • 168 citations

Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice

2000 • 166 citations

Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes

1997 • 155 citations

Membrane-permeant Esters of Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 149 citations

Insulin-stimulated Tyrosine Phosphorylation of Caveolin Is Specific for the Differentiated Adipocyte Phenotype in 3T3-L1 Cells

1997 • 143 citations

Perinuclear Localization and Insulin Responsiveness of GLUT4 Requires Cytoskeletal Integrity in 3T3-L1 Adipocytes

2000 • 128 citations

The Activation of Glycogen Synthase by Insulin Switches from Kinase Inhibition to Phosphatase Activation during Adipogenesis in 3T3-L1 Cells

1998 • 124 citations

Maturity-onset diabetes of the young

1994 • 121 citations

Regulation of insulin gene transcription

2000 • 117 citations

NIDDM Genes in Mice: Deleterious Synergism by Both Parental Genomes Contributes to Diabetogenic Thresholds

1998 • 116 citations

13C/31P NMR studies on the mechanism of insulin resistance in obesity.

1998 • 114 citations

Two Naturally Occurring Insulin Receptor Tyrosine Kinase Domain Mutants Provide Evidence That Phosphoinositide 3-Kinase Activation Alone Is Not Sufficient for the Mediation of Insulin's Metabolic and Mitogenic Effects

1997 • 92 citations

Insulin receptor-associated protein tyrosine phosphatase(s): role in insulin action.

1998 • 88 citations

A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes.

1998 • 85 citations

A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin

1995 • 83 citations

Overexpression of Protein Targeting to Glycogen (PTG) in Rat Hepatocytes Causes Profound Activation of Glycogen Synthesis Independent of Normal Hormone- and Substrate-mediated Regulatory Mechanisms

1998 • 81 citations

Untitled

1998 • 78 citations

Glucocorticoids and insulin: complex interaction on brown adipose tissue

1995 • 63 citations

The Regulation of Glycogen Synthase by Protein Phosphatase 1 in 3T3-L1 Adipocytes

1997 • 63 citations

Glucagon-like Peptide 2

1999 • 55 citations

Syndromes Associated with Insulin Resistance and Acanthosis Nigricans

1998 • 47 citations

Searching for Type 2 Diabetes Genes in the Post-genome Era

2000 • 44 citations

Role of the Src Homology 2 (SH2) Domain and C-Terminus Tyrosine Phosphorylation Sites of SH2-Containing Inositol Phosphatase (SHIP) in the Regulation of Insulin-Induced Mitogenesis1

1999 • 22 citations

Asp905Tyr Polymorphism of the Gene for the Skeletal Muscle-Specific Glycogen-Targeting Subunit of Protein Phosphatase 1 in NIDDM

1998 • 17 citations

Thiazolidinediones and insulin resistance

2002 • 2 citations

Deleted Work

1955 • 0 citations