REGULATION OF TH2 DIFFERENTIATION ANDIl4LOCUS ACCESSIBILITY

MicroRNAs

2004 • 33,206 citations

The functions of animal microRNAs

2004 • 10,392 citations

Translating the Histone Code

2001 • 9,488 citations

MicroRNAs: small RNAs with a big role in gene regulation

2004 • 6,733 citations

Combinatorial microRNA target predictions

2005 • 4,543 citations

Human MicroRNA Targets

2004 • 3,702 citations

Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1

2004 • 3,675 citations

Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing

2002 • 3,546 citations

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

MicroRNAs Modulate Hematopoietic Lineage Differentiation

2003 • 3,241 citations

Epigenetic Reprogramming in Mammalian Development

2001 • 2,978 citations

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

2001 • 2,746 citations

The Microprocessor complex mediates the genesis of microRNAs

2004 • 2,625 citations

Processing of primary microRNAs by the Microprocessor complex

2004 • 2,617 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

2001 • 2,550 citations

Mechanisms of gene silencing by double-stranded RNA

2004 • 2,439 citations

RNA silencing in plants

2004 • 2,393 citations

The ENCODE (ENCyclopedia Of DNA Elements) Project

2004 • 2,327 citations

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

1997 • 2,317 citations

The microRNA Registry

2003 • 2,203 citations

Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi

2002 • 2,040 citations

Dicer is essential for mouse development

2003 • 1,896 citations

Transcriptional regulation by calcium, calcineurin, and NFAT

2003 • 1,893 citations

Human Argonaute2 Mediates RNA Cleavage Targeted by miRNAs and siRNAs

2004 • 1,887 citations

Antigen Presentation and T Cell Stimulation by Dendritic Cells

2002 • 1,860 citations

Identification of hundreds of conserved and nonconserved human microRNAs

2005 • 1,825 citations

Histone Acetyltransferases

2001 • 1,745 citations

The lineage decisions of helper T cells

2002 • 1,678 citations

Histone Methyltransferase Activity of a Drosophila Polycomb Group Repressor Complex

2002 • 1,515 citations

Genomic Maps and Comparative Analysis of Histone Modifications in Human and Mouse

2005 • 1,497 citations

Drosophila Enhancer of Zeste/ESC Complexes Have a Histone H3 Methyltransferase Activity that Marks Chromosomal Polycomb Sites

2002 • 1,494 citations

Cooperation between Complexes that Regulate Chromatin Structure and Transcription

2002 • 1,474 citations

Dendritic-cell control of pathogen-driven T-cell polarization

2003 • 1,413 citations

Toll-like receptors control activation of adaptive immune responses

2001 • 1,374 citations

Looping and Interaction between Hypersensitive Sites in the Active β-globin Locus

2002 • 1,322 citations

NFAT Signaling

2002 • 1,316 citations

Ribo-gnome: The Big World of Small RNAs

2005 • 1,276 citations

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing

2005 • 1,253 citations

RNAi-Mediated Targeting of Heterochromatin by the RITS Complex

2004 • 1,219 citations

A Critical Role for Dnmt1 and DNA Methylation in T Cell Development, Function, and Survival

2001 • 1,215 citations

Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1–polarizing program in dendritic cells

2005 • 1,142 citations

Acetylation: a regulatory modification to rival phosphorylation?

2000 • 1,136 citations

Unbiased Mapping of Transcription Factor Binding Sites along Human Chromosomes 21 and 22 Points to Widespread Regulation of Noncoding RNAs

2004 • 1,079 citations

Unlocking the potential of the human genome with RNA interference

2004 • 1,066 citations

Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast

2002 • 1,050 citations

Epigenetic Regulation of Cellular Memory by the Polycomb and Trithorax Group Proteins

2004 • 1,049 citations

Arginine Methylation

2005 • 1,048 citations

Heterochromatin and Epigenetic Control of Gene Expression

2003 • 1,039 citations

Molecular Mechanisms RegulatinG Th1 Immune Responses

2003 • 1,005 citations

Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains

2003 • 961 citations

Small Interfering RNA-Induced Transcriptional Gene Silencing in Human Cells

2004 • 916 citations

Establishment and Maintenance of a Heterochromatin Domain

2002 • 895 citations

Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells

2004 • 890 citations

Histone methylation in transcriptional control

2002 • 887 citations

The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3

2004 • 872 citations

Helper T Cell Differentiation Is Controlled by the Cell Cycle

1998 • 862 citations

Involvement of MicroRNA in AU-Rich Element-Mediated mRNA Instability

2005 • 848 citations

Induction and suppression of RNA silencing: insights from viral infections

2005 • 832 citations

Chromatin Compaction by a Polycomb Group Protein Complex

2004 • 815 citations

Role of T-bet in Commitment of T _H 1 Cells Before IL-12-Dependent Selection

2001 • 813 citations

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1998 • 800 citations

Histone Deimination Antagonizes Arginine Methylation

2004 • 796 citations

Identification of a Coordinate Regulator of Interleukins 4, 13, and 5 by Cross-Species Sequence Comparisons

2000 • 793 citations

Association of Transcriptionally Silent Genes with Ikaros Complexes at Centromeric Heterochromatin

1997 • 792 citations

Histone H3 lysine 4 methylation patterns in higher eukaryotic genes

2003 • 772 citations

Characterization of Dicer-deficient murine embryonic stem cells

2005 • 763 citations

Transcription and Processing of Human microRNA Precursors

2004 • 752 citations

Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity

2003 • 706 citations

Stat6-Independent GATA-3 Autoactivation Directs IL-4-Independent Th2 Development and Commitment

2000 • 697 citations

Modulation of Chromatin Structure Regulates Cytokine Gene Expression during T Cell Differentiation

1998 • 697 citations

Histone H3 Lysine 9 Methylation and HP1γ Are Associated with Transcription Elongation through Mammalian Chromatin

2005 • 690 citations

The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4

1996 • 677 citations

Long-range chromatin regulatory interactions in vivo

2002 • 651 citations

The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb

2005 • 639 citations

An epigenetic road map for histone lysine methylation

2003 • 631 citations

Binary switches and modification cassettes in histone biology and beyond

2003 • 628 citations

Conditional deletion of Gata3 shows its essential function in TH1-TH2 responses

2004 • 625 citations

Aberrant T cell differentiation in the absence of Dicer

2005 • 620 citations

Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function

2003 • 598 citations

RNA meets chromatin

2005 • 595 citations

The β-globin nuclear compartment in development and erythroid differentiation

2003 • 547 citations

TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes

2002 • 517 citations

T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer

2005 • 504 citations

Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation

2005 • 504 citations

Immunoglobulin E Production in the Absence of Interleukin-4-Secreting CD1-Dependent Cells

1997 • 501 citations

Early Transcription and Silencing of Cytokine Genes Underlie Polarization of T Helper Cell Subsets

2001 • 498 citations

A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation

2001 • 497 citations

Proximity among Distant Regulatory Elements at the β-Globin Locus Requires GATA-1 and FOG-1

2005 • 492 citations

Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family

2001 • 487 citations

Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27

2004 • 485 citations

Dicer is essential for formation of the heterochromatin structure in vertebrate cells

2004 • 484 citations

Analysis of Type 2 Immunity In Vivo with a Bicistronic IL-4 Reporter

2001 • 460 citations

Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process

2003 • 458 citations

Active chromatin domains are defined by acetylation islands revealed by genome-wide mapping

2005 • 445 citations

The nervous system and innate immunity: the neuropeptide connection

2005 • 436 citations

REGULATION OF LYMPHOID DEVELOPMENT, DIFFERENTIATION, AND FUNCTION BY THE NOTCH PATHWAY

2005 • 434 citations

An epigenetic view of helper T cell differentiation

2003 • 429 citations

MicroRNA profiling of the murine hematopoietic system.

2005 • 428 citations

siRNA and miRNA: an insight into RISCs

2005 • 427 citations

Ubiquitination of Histone H2B by Rad6 Is Required for Efficient Dot1-mediated Methylation of Histone H3 Lysine 79

2002 • 424 citations

Long-range intrachromosomal interactions in the T helper type 2 cytokine locus

2004 • 421 citations

NFATc1 and NFATc2 Together Control Both T and B Cell Activation and Differentiation

2001 • 397 citations

RITS acts in cis to promote RNA interference–mediated transcriptional and post-transcriptional silencing

2004 • 395 citations

Interleukin 2 plays a central role in Th2 differentiation

2004 • 393 citations

Gata-3 Induces T Helper Cell Type 2 (Th2) Cytokine Expression and Chromatin Remodeling in Committed Th1 Cells

2000 • 390 citations

Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma

2000 • 387 citations

Acetylation inactivates the transcriptional repressor BCL6

2002 • 383 citations

Position-effect protection and enhancer blocking by the chicken β-globin insulator are separable activities

2002 • 380 citations

An Enhanced Immune Response in Mice Lacking the Transcription Factor NFAT1

1996 • 375 citations

Induction of DNA methylation and gene silencing by short interfering RNAs in human cells

2004 • 372 citations

Global and Hox-specific roles for the MLL1 methyltransferase

2005 • 357 citations

Stat5 Activation Plays a Critical Role in Th2 Differentiation

2003 • 357 citations

Memory and flexibility of cytokine gene expression as separable properties of human TH1 and TH2 lymphocytes

2002 • 353 citations

Polycomb, Epigenomes, and Control of Cell Identity

2003 • 343 citations

GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells

2004 • 339 citations

The Silent Revolution: RNA Interference as Basic Biology, Research Tool, and Therapeutic

2004 • 334 citations

Inhibition of Allergic Inflammation in a Murine Model of Asthma by Expression of a Dominant-Negative Mutant of GATA-3

1999 • 333 citations

Th2 Lineage Commitment and Efficient IL-4 Production Involves Extended Demethylation of the IL-4 Gene

2002 • 328 citations

Cutting Edge: Changes in Histone Acetylation at the IL-4 and IFN-γ Loci Accompany Th1/Th2 Differentiation

2002 • 326 citations

Inhibitory Function of Two NFAT Family Members in Lymphoid Homeostasis and Th2 Development

1998 • 325 citations

TEC FAMILY KINASES IN T LYMPHOCYTE DEVELOPMENT AND FUNCTION

2004 • 325 citations

Histone H2B Ubiquitylation Is Associated with Elongating RNA Polymerase II

2005 • 324 citations

RNAi-Independent Heterochromatin Nucleation by the Stress-Activated ATF/CREB Family Proteins

2004 • 321 citations

RNA interference machinery regulates chromosome dynamics during mitosis and meiosis in fission yeast

2002 • 315 citations

Regulation of αβ/γδ T Cell Lineage Commitment and Peripheral T Cell Responses by Notch/RBP-J Signaling

2004 • 306 citations

Tails of Intrigue

2003 • 305 citations

Hlx is induced by and genetically interacts with T-bet to promote heritable TH1 gene induction

2002 • 304 citations

Histone variants meet their match

2005 • 294 citations

In search of antisense

2004 • 293 citations

The insulation of genes from external enhancers and silencing chromatin

2002 • 291 citations

Silence from within: Endogenous siRNAs and miRNAs

2005 • 289 citations

Delta1-Notch3 Interactions Bias the Functional Differentiation of Activated CD4+ T Cells

2003 • 289 citations

Notch signaling is an important regulator of type 2 immunity

2005 • 282 citations

Stat6 Is Necessary and Sufficient for IL-4’s Role in Th2 Differentiation and Cell Expansion

2001 • 281 citations

Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21.

2005 • 275 citations

Cell-Type-Restricted Binding of the Transcription Factor NFAT to a Distal IL-4 Enhancer In Vivo

2000 • 270 citations

GATA-3 Suppresses Th1 Development by Downregulation of Stat4 and Not through Effects on IL-12Rβ2 Chain or T-bet

2003 • 266 citations

Do protein motifs read the histone code?

2005 • 258 citations

Signaling pathways in Th2 development

2004 • 258 citations

Independent and Epigenetic Regulation of the Interleukin-4 Alleles in CD4 ⁺ T Cells

1998 • 250 citations

Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes

2002 • 244 citations

Histone H2B Ubiquitylation Controls Processive Methylation but Not Monomethylation by Dot1 and Set1

2005 • 240 citations

Regulation of IL-4 Gene Expression by Distal Regulatory Elements and GATA-3 at the Chromatin Level

2001 • 234 citations

Intergenic transcription through a Polycomb group response element counteracts silencing

2005 • 233 citations

Transcript imaging of the development of human T helper cells using oligonucleotide arrays

2000 • 230 citations

Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3.

1998 • 228 citations

Regulation of the Th2 Cytokine Locus by a Locus Control Region

2003 • 222 citations

Division of labor in Polycomb group repression

2004 • 219 citations

The Role of the RNAi Machinery in Heterochromatin Formation

2005 • 208 citations

Beta 2-microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses.

1996 • 207 citations

Transforming Growth Factor-β Stimulates p300-dependent RUNX3 Acetylation, Which Inhibits Ubiquitination-mediated Degradation

2004 • 204 citations

Gene Silencing Quantitatively Controls the Function of a Developmental trans-Activator

2002 • 204 citations

Common logic of transcription factor and microRNA action

2004 • 199 citations

Endotoxin can induce MyD88-deficient dendritic cells to support Th2 cell differentiation

2002 • 199 citations

Transcription factor YY1 functions as a PcG protein in vivo

2003 • 198 citations

Deletion of a coordinate regulator of type 2 cytokine expression in mice

2001 • 196 citations

Identification of a Conserved GATA3 Response Element Upstream Proximal from the Interleukin-13 Gene Locus

2002 • 194 citations

Th2-Specific Chromatin Remodeling and Enhancer Activity in the Th2 Cytokine Locus Control Region

2004 • 188 citations

Antigen receptor loci poised for V(D)J rearrangement are broadly associated with BRG1 and flanked by peaks of histone H3 dimethylated at lysine 4

2003 • 186 citations

Looping, Linking, and Chromatin Activity

2000 • 183 citations

Identifying gene regulatory elements by genome-wide recovery of DNase hypersensitive sites

2004 • 181 citations

A role for the immunological synapse in lineage commitment of CD4 lymphocytes

2004 • 180 citations

Multiple interactions between regulatory regions are required to stabilize an active chromatin hub

2004 • 178 citations

Chromatin remodeling complexes: strength in diversity, precision through specialization

2005 • 177 citations

Regulation of IL4 gene expression by T cells and therapeutic perspectives

2003 • 168 citations

Chromatin Structure and Gene Regulation in the Immune System

2002 • 163 citations

Cutting Edge: Differential Responsiveness of the IL-5 and IL-4 Genes to Transcription Factor GATA-3

1998 • 162 citations

Inhibition of Th2 Differentiation and GATA-3 Expression by BCL-6

2003 • 161 citations

Essential Role of GATA3 for the Maintenance of Type 2 Helper T (Th2) Cytokine Production and Chromatin Remodeling at the Th2 Cytokine Gene Loci

2004 • 160 citations

Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells.

1994 • 158 citations

NFATc2 and NFATc3 regulate TH2 differentiation and modulate TCR-responsiveness of naïve TH cells

2001 • 158 citations

IL-4 production by T cells from naive donors. IL-2 is required for IL-4 production.

1990 • 155 citations

EZH2 and Histone 3 Trimethyl Lysine 27 Associated with Il4 and Il13 Gene Silencing in TH1 Cells

2005 • 153 citations

The Cell Type-Specific Expression of the Murine IL-13 Gene Is Regulated by GATA-3

2001 • 152 citations

Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions

2004 • 152 citations

Cutting Edge: Chromatin Remodeling at the IL-4/IL-13 Intergenic Regulatory Region for Th2-Specific Cytokine Gene Cluster

2000 • 152 citations

Down-regulation of TDT transcription in CD4⁺CD8⁺thymocytes by Ikaros proteins in direct competition with an Ets activator

2001 • 151 citations

Transcription through Intergenic Chromosomal Memory Elements of the Drosophila Bithorax Complex Correlates with an Epigenetic Switch

2002 • 147 citations

Active recruitment of DNA methyltransferases regulates interleukin 4 in thymocytes and T cells

2003 • 145 citations

Recently activated naive CD4 T cells can help resting B cells, and can produce sufficient autocrine IL-4 to drive differentiation to secretion of T helper 2-type cytokines.

1995 • 144 citations

RNA interference and heterochromatin in the fission yeast Schizosaccharomyces pombe

2005 • 139 citations

Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region.

1998 • 139 citations

A Distal Enhancer in the Interferon-γ (IFN-γ) Locus Revealed by Genome Sequence Comparison

2004 • 137 citations

DNA methylation and the expanding epigenetics of T cell lineage commitment

2005 • 136 citations

Gene Microarrays Reveal Extensive Differential Gene Expression in Both CD4+ and CD8+ Type 1 and Type 2 T Cells

2001 • 135 citations

Dynamic assembly of silent chromatin during thymocyte maturation

2004 • 132 citations

The Role of Brg1, a Catalytic Subunit of Mammalian Chromatin-remodeling Complexes, in T Cell Development

2003 • 129 citations

The Roles of Nuclear Factor of Activated T Cells and Ying-Yang 1 in Activation-induced Expression of the Interferon-γ Promoter in T Cells

1998 • 128 citations

Arginine Methylation of NIP45 Modulates Cytokine Gene Expression in Effector T Lymphocytes

2004 • 127 citations

Nuclear repositioning marks the selective exclusion of lineage‐inappropriate transcription factor loci during T helper cell differentiation

2004 • 125 citations

DNA Methylation Is a Nonredundant Repressor of the Th2 Effector Program

2004 • 123 citations

Conventional, Naive CD4+ T Cells Provide an Initial Source of IL-4 During Th2 Differentiation

2000 • 122 citations

A 3′ Enhancer in the IL-4 Gene Regulates Cytokine Production by Th2 Cells and Mast Cells

2002 • 117 citations

Regulation of Th2 Cell Differentiation by mel-18, a Mammalian Polycomb Group Gene

2001 • 115 citations

Deletion of a conserved Il4 silencer impairs T helper type 1–mediated immunity

2004 • 114 citations

Transcription through theiab-7 cis-regulatory domain of the bithorax complex interferes with maintenance ofPolycomb-mediated silencing

2002 • 113 citations

The Role of mel-18, a Mammalian Polycomb Group Gene, during IL-7–Dependent Proliferation of Lymphocyte Precursors

1997 • 112 citations

Molecular Genetics of Allergic Diseases

2000 • 112 citations

Genetic Reprogramming of Primary Human T Cells Reveals Functional Plasticity in Th Cell Differentiation

2003 • 112 citations

DNA Methylation Changes at Human Th2 Cytokine Genes Coincide with DNase I Hypersensitive Site Formation During CD4+ T Cell Differentiation

2002 • 110 citations

Systematic identification of sense-antisense transcripts in mammalian cells

2003 • 104 citations

Genetic Regulation of Commitment to Interleukin 4 Production by a CD4+ T Cell–intrinsic Mechanism

1998 • 104 citations

Human naive CD4 T cells produce interleukin‐4 at priming and acquire a Th2 phenotype upon repetitive stimulations in neutral conditions

1995 • 104 citations

Beta 2-microglobulin-dependent T cells are dispensable for allergen-induced T helper 2 responses.

1996 • 103 citations

Epigenetic control in the immune response

2005 • 103 citations

AML1 Is Functionally Regulated through p300-mediated Acetylation on Specific Lysine Residues

2004 • 102 citations

Role of NFAT Proteins in IL13 Gene Transcription in Mast Cells

2004 • 98 citations

Structures of protein domains that create or recognize histone modifications

2004 • 97 citations

Chromatin landscape dynamics of theIl4–Il13locus during T helper 1 and 2 development

2004 • 96 citations

GATA-3 in Human T Cell Helper Type 2 Development

2004 • 94 citations

Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: A target for STAT6 but not GATA3

2004 • 94 citations

Stat5a regulates T helper cell differentiation by several distinct mechanisms

2001 • 92 citations

Rapid Expansion and IL-4 Expression by Leishmania-Specific Naive Helper T Cells In Vivo

2002 • 92 citations

GATA-3 transcriptional imprinting in Th2 lymphocytes: A mathematical model

2002 • 89 citations

Expression of Notch ligands, Jagged1, 2 and Delta1 in antigen presenting cells in mice

2002 • 86 citations

In TH2 cells theIl4gene has a series of accessibility states associated with distinctive probabilities of IL-4 production

2002 • 82 citations

Transcription activates repressed domains in theDrosophilabithorax complex

2002 • 80 citations

The four Rs of RNA-directed evolution

2003 • 77 citations

Interleukin-4 Receptor Alpha-Deficient BALB/c Mice Show an Unimpaired T Helper 2 Polarization in Response toLeishmania majorInfection

2000 • 77 citations

Probabilistic Regulation in TH2 Cells Accounts for Monoallelic Expression of IL-4 and IL-13

2005 • 77 citations

Early IL-4 Production Does Not Predict Susceptibility toLeishmania major

1996 • 76 citations

Bioinformatics for the 'bench biologist': how to find regulatory regions in genomic DNA

2004 • 76 citations

Comprehensive gene expression profile of human activated Th1- and Th2-polarized cells

2001 • 76 citations

Pinpointing IL‐4‐independent acquisition and IL‐4‐influenced maintenance of Th2 activity by CD4 T cells

2004 • 74 citations

An Intron Transcriptional Enhancer Element Regulates IL-4 Gene Locus Accessibility in Mast Cells

2000 • 72 citations

Long-range transcriptional regulation of cytokine gene expression

1998 • 71 citations

Histone deacetylation inhibits IL4 gene expression in T cells

2002 • 70 citations

A Critical Control Element for Interleukin-4 Memory Expression in T Helper Lymphocytes

2005 • 70 citations

Polycomb-group genes as regulators of mammalian lymphopoiesis

2001 • 69 citations

Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities☆

2004 • 69 citations

Probabilistic Regulation of IL-4 Production in Th2 Cells

2004 • 69 citations

An IL-4-independent and CD25-mediated function of c-maf in promoting the production of Th2 cytokines

2002 • 65 citations

Regulation of IL‐4 production in mast cells: a paradigm for cell‐type‐specific gene expression

2001 • 63 citations

Epigenetic gene silencing by Runx proteins

2004 • 63 citations

A closer look at long-range chromosomal interactions

2003 • 62 citations

The establishment and maintenance of lymphocyte identity through gene silencing

2003 • 60 citations

Kinetic analysis of genomewide gene expression reveals molecule circuitries that control T cell activation and Th1/2 differentiation

2004 • 57 citations

Stat5a Inhibits IL-12-Induced Th1 Cell Differentiation through the Induction of Suppressor of Cytokine Signaling 3 Expression

2005 • 56 citations

The IL-4 production capability of different strains of naive CD4+ T cells controls the direction of the Th cell response

2002 • 55 citations

Interleukin (IL)-4-independent Maintenance of Histone Modification of the IL-4 Gene Loci in Memory Th2 Cells

2004 • 55 citations

Th2 Cells: Orchestrating Barrier Immunity

2004 • 54 citations

Analysis of intergenic transcription in the human IL-4/IL-13 gene cluster

2004 • 53 citations

Up-Regulation of Hlx in Immature Th Cells Induces IFN-γ Expression

2004 • 51 citations

Yin-Yang 1 Activates Interleukin-4 Gene Expression in T Cells

2001 • 50 citations

The gene encoding interleukin-13: a susceptibility locus for asthma and related traits

2000 • 49 citations

Indispensable Role of Stat5a in Stat6-Independent Th2 Cell Differentiation and Allergic Airway Inflammation

2005 • 45 citations

Susceptibility to Infectious Diseases:Leishmaniaas a Paradigm

1999 • 44 citations

Hierarchical Interactions Control CD4 Gene Expression during Thymocyte Development

2003 • 44 citations

Centromeric Repositioning of Coreceptor Loci Predicts Their Stable Silencing and the CD4/CD8 Lineage Choice

2004 • 43 citations

Basal Chromatin Modification at the IL-4 Gene in Helper T Cells

2003 • 36 citations

Dynamic Repositioning of CD4 and CD8 Genes during T Cell Development

2004 • 33 citations

Small RNAs and Immunity

2004 • 32 citations

Chromatin-based regulation of cytokine transcription in Th2 cells and mast cells

2005 • 29 citations

Intergenic Transcription Occurs throughout the Human IL-4/IL-13 Gene Cluster

1999 • 27 citations

In this issue

2002 • 25 citations

A Leishmania major Response Locus Identified by Interval-specific Congenic Mapping of a T Helper Type 2 Cell Bias-controlling Quantitative Trait Locus

2004 • 24 citations

Nuclear factor of activated T cells and YY1 combine to repress IL-5 expression in a human T-cell line

1999 • 24 citations

An intron GATA‐binding site regulates chromatin accessibility and is essential for IL‐4 gene expression in mast cells

2005 • 22 citations

Potential roles for short RNAs in lymphocytes

2005 • 7 citations