Hierarchical Interactions Control CD4 Gene Expression during Thymocyte Development

Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

1997 • 2,205 citations

Multilineage gene expression precedes commitment in the hemopoietic system.

1997 • 757 citations

Molecular and Cellular Events of T Cell Development

1989 • 466 citations

Transcription from the RAG1 Locus Marks the Earliest Lymphocyte Progenitors in Bone Marrow

2002 • 460 citations

Myeloid or Lymphoid Promiscuity as a Critical Step in Hematopoietic Lineage Commitment

2002 • 428 citations

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

1994 • 418 citations

CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus

1991 • 343 citations

THE REGULATION OF CD4 AND CD8 CORECEPTOR GENE EXPRESSION DURING T CELL DEVELOPMENT

1999 • 245 citations

Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: A new perspective on thymic commitment and selection

1995 • 207 citations

A positive look at double-negative thymocytes

2002 • 201 citations

Unexpectedly Complex Regulation of CD4/CD8 Coreceptor Expression Supports a Revised Model for CD4+CD8+ Thymocyte Differentiation

1996 • 199 citations

Cis-acting sequences regulating expression of the human α-globin cluster lie within constitutively open chromatin

1992 • 162 citations

A transcriptional silencer controls the developmental expression of the CD4 gene.

1994 • 156 citations

New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision

2002 • 154 citations

c-Myb is essential for early T cell development

1999 • 153 citations

Requirement for TNF-α and IL-1α in Fetal Thymocyte Commitment and Differentiation

1995 • 135 citations

Promoter specificity mediates the independent regulation of neighboring genes.

1996 • 115 citations

Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation

2002 • 106 citations

A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13.

1996 • 98 citations

Post-Transcriptional Regulation of Early T Cell Development by T Cell Receptor Signals

1992 • 83 citations

CD4 is expressed on murine pluripotent hematopoietic stem cells

1992 • 81 citations

Locus control regions and epigenetic chromatin modifiers

2000 • 79 citations

Functional commitment to helper T cell lineage precedes positive selection and is independent of T cell receptor MHC specificity

1994 • 77 citations

A Region in the CD8 Gene Locus That Directs Expression to the Mature CD8 T Cell Subset in Transgenic Mice

1997 • 75 citations

L3T4 antigen expression by hemopoietic precursor cells.

1989 • 75 citations

Hierarchical Interactions of Control Elements Determine CD8α Gene Expression in Subsets of Thymocytes and Peripheral T Cells

1998 • 66 citations

A CD8 genomic fragment that directs subset-specific expression of CD8 in transgenic mice.

1997 • 63 citations

Combined Deletion of CD8 Locus cis-Regulatory Elements Affects Initiation but Not Maintenance of CD8 Expression

2002 • 61 citations

Specific expression of the human CD4 gene in mature CD4+ CD8- and immature CD4+ CD8+ T cells and in macrophages of transgenic mice.

1994 • 56 citations

Positive selection of CD4+ and CD8+ T cells

1996 • 55 citations

T cell fate specification and αβ/γδ lineage commitment

2001 • 51 citations

Variegated Expression of CD8α Resulting from In Situ Deletion of Regulatory Sequences

2002 • 49 citations

Characterization of an intronless CD4 minigene expressed in mature CD4 and CD8 T cells, but not expressed in immature thymocytes.

1996 • 46 citations

Asymmetric Redundancy in CD4 Silencer Function

1996 • 42 citations

Positive selection induces CD4 promoter and enhancer function

1997 • 37 citations

A Potential Role for Elf-1 in CD4 Promoter Function

1999 • 31 citations

Position-dependent variegation of a CD4 minigene with targeted expression to mature CD4+ T cells.

1997 • 31 citations

Early Intrathymic Precursor Cells Acquire a CD4low Phenotype

1998 • 28 citations

Thymocytes control the CD4 gene differently from mature T lymphocytes

1997 • 22 citations

Precise arrangement of factor-binding sites is required for murine CD4 promoter function

2000 • 12 citations

Controlling CD4 gene expression during T cell lineage commitment

2002 • 8 citations