Role of NFAT Proteins in IL13 Gene Transcription in Mast Cells

Interleukin-13: Central Mediator of Allergic Asthma

1998 • 2,642 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy

1998 • 2,570 citations

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

1997 • 2,317 citations

Transcriptional regulation by calcium, calcineurin, and NFAT

2003 • 1,893 citations

Requirement for IL-13 Independently of IL-4 in Experimental Asthma

1998 • 1,869 citations

Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription

2000 • 1,658 citations

An early haematopoietic defect in mice lacking the transcription factor GATA-2

1994 • 1,412 citations

Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1

1991 • 1,321 citations

NFAT Signaling

2002 • 1,316 citations

IMMUNOLOGIC BASIS OF ANTIGEN-INDUCED AIRWAY HYPERRESPONSIVENESS

1999 • 1,047 citations

Linkage Analysis of IL4 and Other Chromosome 5q31.1 Markers and Total Serum Immunoglobulin E Concentrations

1994 • 1,025 citations

Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells

1989 • 931 citations

Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1.

1996 • 763 citations

Generic Signals and Specific Outcomes

1999 • 732 citations

Modulation of Chromatin Structure Regulates Cytokine Gene Expression during T Cell Differentiation

1998 • 697 citations

Transcriptional Mechanisms Underlying Lymphocyte Tolerance

2002 • 658 citations

Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells.

1983 • 654 citations

IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1

1999 • 651 citations

Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum

1998 • 639 citations

Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis

1995 • 619 citations

The erythroid-specific transcription factor eryf1: A new finger protein

1989 • 608 citations

Targeted Deletion of a High-Affinity GATA-binding Site in the GATA-1 Promoter Leads to Selective Loss of the Eosinophil Lineage In Vivo

2002 • 581 citations

The transcription factor NF-ATc is essential for cardiac valve formation

1998 • 580 citations

Transcription Factor GATA-2 Is Required for Proliferation/Survival of Early Hematopoietic Cells and Mast Cell Formation, But Not for Erythroid and Myeloid Terminal Differentiation

1997 • 543 citations

TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes

2002 • 517 citations

Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA

1998 • 510 citations

Transcription Factor GATA-2 Is Required for Proliferation/Survival of Early Hematopoietic Cells and Mast Cell Formation, But Not for Erythroid and Myeloid Terminal Differentiation

1997 • 503 citations

Concerted Dephosphorylation of the Transcription Factor NFAT1 Induces a Conformational Switch that Regulates Transcriptional Activity

2000 • 453 citations

NFATc1 and NFATc2 Together Control Both T and B Cell Activation and Differentiation

2001 • 397 citations

Development of hematopoietic cells lacking transcription factor GATA-1

1995 • 362 citations

GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling

2003 • 340 citations

Rescue of Cyclin D1 Deficiency by Knockin Cyclin E

1999 • 340 citations

Inhibition of Allergic Inflammation in a Murine Model of Asthma by Expression of a Dominant-Negative Mutant of GATA-3

1999 • 333 citations

Neoplastic transformation of mast cells by Abelson-MuLV: abrogation of IL-3 dependence by a nonautocrine mechanism

1985 • 330 citations

N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation

2000 • 322 citations

Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun

2000 • 316 citations

Critical Roles for Transcription Factor GATA-3 in Thymocyte Development

2003 • 299 citations

Delayed Lymphoid Repopulation with Defects in IL-4–Driven Responses Produced by Inactivation of NF-ATc

1998 • 298 citations

Cooperative and Antagonistic Interplay between PU.1 and GATA-2 in the Specification of Myeloid Cell Fates

2002 • 268 citations

Rescue of erythroid development in gene targeted GATA–1− mouse embryonic stem cells

1992 • 258 citations

Dynamics of GATA transcription factor expression during erythroid differentiation

1993 • 238 citations

Autoregulation of NFATc1/A Expression Facilitates Effector T Cells to Escape from Rapid Apoptosis

2002 • 194 citations

Functional redundancy of the muscle-specific transcription factors Myf5 and myogenin

1996 • 157 citations

Regulation of the Murine Nfatc1 Gene by NFATc2

2002 • 124 citations

A 3′ Enhancer in the IL-4 Gene Regulates Cytokine Production by Th2 Cells and Mast Cells

2002 • 117 citations

GATA factor transgenes under GATA-1 locus control rescue germline GATA-1 mutant deficiencies

2000 • 113 citations

NFAT1 and NFAT2 are positive regulators of IL-4 gene transcription

2002 • 112 citations

MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells

2000 • 105 citations

Drosophila engrailed can substitute for mouse Engrailed1 function in mid-hindbrain, but not limb development

1998 • 98 citations

Cooperative interaction between GATA5 and NF-ATc regulates endothelial-endocardial differentiation of cardiogenic cells

2002 • 96 citations

Calcineurin-GATA-6 pathway is involved in smooth muscle–specific transcription

2002 • 94 citations

In vivoimmunological function of mast cells derived from embryonic stem cells: An approach for the rapid analysis of even embryonic lethal mutations in adult micein vivo

2000 • 91 citations

Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31

1996 • 90 citations

Myogenin can substitute for Myf5 in promoting myogenesis but less efficiently

1997 • 90 citations

Sustained NFAT Signaling Promotes a Th1-Like Pattern of Gene Expression in Primary Murine CD4+ T Cells

2002 • 90 citations

An Intron Transcriptional Enhancer Element Regulates IL-4 Gene Locus Accessibility in Mast Cells

2000 • 72 citations

Calcineurin-GATA4 Pathway Is Involved in β-Adrenergic Agonist-responsive Endothelin-1 Transcription in Cardiac Myocytes

2001 • 70 citations

Mechanisms of Transcription in Eosinophils: GATA-1, but not GATA-2, Transactivates the Promoter of the Eosinophil Granule Major Basic Protein Gene

1998 • 66 citations

Regulation of IL‐4 production in mast cells: a paradigm for cell‐type‐specific gene expression

2001 • 63 citations

Structure of NFAT Bound to DNA as a Monomer

2003 • 32 citations

Nuclear Factor of Activated T Cells 2 Transactivation in Mast Cells

2003 • 17 citations