Epigenetic gene silencing by Runx proteins

Translating the Histone Code

2001 • 9,488 citations

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

1994 • 4,563 citations

Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly

2001 • 1,685 citations

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.

1991 • 897 citations

Rb targets histone H3 methylation and HP1 to promoters

2001 • 892 citations

Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development

2002 • 712 citations

Sustained Loss of a Neoplastic Phenotype by Brief Inactivation of MYC

2002 • 639 citations

SELECTION OF THE T CELL REPERTOIRE

1999 • 507 citations

Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

1998 • 468 citations

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

1994 • 418 citations

Biallelic and Heterozygous Point Mutations in the Runt Domain of theAML1/PEBP2B Gene Associated With Myeloblastic Leukemias

1999 • 408 citations

Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis

2003 • 380 citations

A Mechanism of Repression by Acute Myeloid Leukemia-1, the Target of Multiple Chromosomal Translocations in Acute Leukemia

2000 • 246 citations

THE REGULATION OF CD4 AND CD8 CORECEPTOR GENE EXPRESSION DURING T CELL DEVELOPMENT

1999 • 245 citations

Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes

2002 • 244 citations

Beyond the Nucleosome: Epigenetic Aspects of Position–Effect Variegation in Drosophila

1998 • 221 citations

Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage

2001 • 172 citations

Expression of the Runt Domain-Encoding PEBP2α Genes in T cells during Thymic Development

1995 • 160 citations

A transcriptional silencer controls the developmental expression of the CD4 gene.

1994 • 156 citations

Heterochromatin protein 1 modifies mammalian PEV in a dose- and chromosomal-context- dependent manner

1999 • 124 citations

Evidence for Distinct CD4 Silencer Functions at Different Stages of Thymocyte Differentiation

2002 • 116 citations

Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation

2002 • 106 citations

Mechanisms of transcriptional regulation by Runt domain proteins

2000 • 81 citations

Locus control regions and epigenetic chromatin modifiers

2000 • 79 citations

SUV39H1 interacts with AML1 and abrogates AML1 transactivity. AML1 is methylated in vivo

2003 • 69 citations

Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment

2001 • 67 citations

Identification and characterization of a human CD4 silencer

1996 • 64 citations

Combined Deletion of CD8 Locus cis-Regulatory Elements Affects Initiation but Not Maintenance of CD8 Expression

2002 • 61 citations

Variegated Expression of CD8α Resulting from In Situ Deletion of Regulatory Sequences

2002 • 49 citations

Positive Selection of Immature αβ T Cells

1993 • 24 citations