Antigen Presentation and T Cell Stimulation by Dendritic Cells

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

Toll-like receptors in the induction of the innate immune response

2000 • 3,052 citations

Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells

1998 • 2,916 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

1995 • 2,531 citations

Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria

2001 • 2,472 citations

DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T Cells

2000 • 2,384 citations

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

1999 • 2,380 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

1997 • 2,257 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes

1998 • 2,078 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation

1999 • 1,912 citations

Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo

2001 • 1,845 citations

Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon

1999 • 1,754 citations

Innate Immunity

2000 • 1,715 citations

Identification of DC-SIGN, a Novel Dendritic Cell–Specific ICAM-3 Receptor that Supports Primary Immune Responses

2000 • 1,665 citations

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

2000 • 1,632 citations

Natural adjuvants: Endogenous activators of dendritic cells

1999 • 1,611 citations

HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine

2000 • 1,594 citations

Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells

2000 • 1,577 citations

Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming

2001 • 1,538 citations

Corpse clearance defines the meaning of cell death

2000 • 1,528 citations

Proteomic Analysis of Dendritic Cell-Derived Exosomes: A Secreted Subcellular Compartment Distinct from Apoptotic Vesicles

2001 • 1,492 citations

A receptor for phosphatidylserine-specific clearance of apoptotic cells

2000 • 1,480 citations

Antigen-Specific Inhibition of Effector T Cell Function in Humans after Injection of Immature Dendritic Cells

2001 • 1,384 citations

Consequences of Cell Death

2000 • 1,382 citations

The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens

1999 • 1,381 citations

Activation of human dendritic cells through CD40 cross-linking.

1994 • 1,351 citations

Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway

2000 • 1,299 citations

Cd8+ but Not Cd8− Dendritic Cells Cross-Prime Cytotoxic T Cells in Vivo

2000 • 1,286 citations

Vaccination with Mage-3a1 Peptide–Pulsed Mature, Monocyte-Derived Dendritic Cells Expands Specific Cytotoxic T Cells and Induces Regression of Some Metastases in Advanced Stage IV Melanoma

1999 • 1,260 citations

Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes

1998 • 1,226 citations

The Enigmatic Plasmacytoid T Cells Develop into Dendritic Cells with Interleukin (IL)-3 and CD40-Ligand

1997 • 1,224 citations

Danger signals: SOS to the immune system

2001 • 1,198 citations

Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

1994 • 1,185 citations

Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells

2000 • 1,175 citations

Phagocytosis and clearance of apoptotic cells is mediated by MER

2001 • 1,153 citations

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells

1997 • 1,143 citations

CD91 Is a Common Receptor for Heat Shock Proteins gp96, hsp90, hsp70, and Calreticulin

2001 • 1,118 citations

Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity

1995 • 1,097 citations

Differential Expression and Regulation of Toll-Like Receptors (TLR) in Human Leukocytes: Selective Expression of TLR3 in Dendritic Cells

2000 • 1,060 citations

Distinct dendritic cell subsets differentially regulate the class of immune responseinvivo

1999 • 1,013 citations

Molecular Characterization of Dendritic Cell-Derived Exosomes

1999 • 1,005 citations

CD8α+ and CD8α− Subclasses of Dendritic Cells Direct the Development of Distinct T Helper Cells In Vivo

1999 • 998 citations

The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing

1995 • 959 citations

T-cell priming by type-1and type-2 polarized dendritic cells: the concept of a third signal

1999 • 957 citations

Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay.

1976 • 951 citations

Langerin, a Novel C-Type Lectin Specific to Langerhans Cells, Is an Endocytic Receptor that Induces the Formation of Birbeck Granules

2000 • 934 citations

Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo.

1996 • 922 citations

A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes

2000 • 908 citations

Fcγ Receptor–mediated Induction of Dendritic Cell Maturation and Major Histocompatibility Complex Class I–restricted Antigen Presentation after Immune Complex Internalization

1999 • 898 citations

The Duration of Antigenic Stimulation Determines the Fate of Naive and Effector T Cells

1998 • 890 citations

A Phagosome-to-Cytosol Pathway for Exogenous Antigens Presented on MHC Class I Molecules

1995 • 882 citations

TRANCE (Tumor Necrosis Factor [TNF]-related Activation-induced Cytokine), a New TNF Family Member Predominantly Expressed in T cells, Is a Dendritic Cell–specific Survival Factor

1997 • 869 citations

Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity

2000 • 867 citations

B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells

2001 • 850 citations

Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines.

1996 • 849 citations

Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules.

1997 • 837 citations

Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking

1998 • 832 citations

Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization

2000 • 804 citations

Endocytosed HSP60s Use Toll-like Receptor 2 (TLR2) and TLR4 to Activate the Toll/Interleukin-1 Receptor Signaling Pathway in Innate Immune Cells

2001 • 800 citations

4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

1997 • 777 citations

Neonatal Tolerance Revisited: Turning on Newborn T Cells with Dendritic Cells

1996 • 770 citations

Developmental regulation of MHC class II transport in mouse dendritic cells

1997 • 754 citations

Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity.

1996 • 746 citations

Induction of a CD8+ Cytotoxic T Lymphocyte Response by Cross-priming Requires Cognate CD4+ T Cell Help

1997 • 729 citations

Maturation, Activation, and Protection of Dendritic Cells Induced by Double-stranded RNA

1999 • 727 citations

Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance

2000 • 723 citations

THE CD1 SYSTEM: Antigen-Presenting Molecules for T Cell Recognition of Lipids and Glycolipids

1999 • 711 citations

Dendritic Cell Survival and Maturation Are Regulated by Different Signaling Pathways

1998 • 685 citations

Freshly Isolated Peyer's Patch, but Not Spleen, Dendritic Cells Produce Interleukin 10 and Induce the Differentiation of T Helper Type 2 Cells

1999 • 656 citations

A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis.

1996 • 653 citations

Regression of human metastatic renal cell carcinoma after vaccination with tumor cell–dendritic cell hybrids

2000 • 652 citations

Efficient Presentation of Phagocytosed Cellular Fragments on the Major Histocompatibility Complex Class II Products of Dendritic Cells

1998 • 649 citations

CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells

1999 • 638 citations

Immunotherapy of Hormone-Refractory Prostate Cancer With Antigen-Loaded Dendritic Cells

2000 • 627 citations

The Natural Killer T (NKT) Cell Ligand α-Galactosylceramide Demonstrates Its Immunopotentiating Effect by Inducing Interleukin (IL)-12 Production by Dendritic Cells and IL-12 Receptor Expression on NKT Cells

1999 • 624 citations

Dendritic cell lineage, plasticity and cross-regulation

2001 • 613 citations

Regulation of Toll-Like Receptors in Human Monocytes and Dendritic Cells

2001 • 604 citations

Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages.

1993 • 592 citations

Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen

1999 • 586 citations

Cutting Edge: Intravenous Soluble Antigen Is Presented to CD4 T Cells by CD8− Dendritic Cells, but Cross-Presented to CD8 T Cells by CD8+ Dendritic Cells

2001 • 584 citations

The Human Toll Signaling Pathway: Divergence of Nuclear Factor κB and JNK/SAPK Activation Upstream of Tumor Necrosis Factor Receptor–associated Factor 6 (TRAF6)

1998 • 581 citations

Predominant Role for Directly Transfected Dendritic Cells in Antigen Presentation to CD8+ T Cells after Gene Gun Immunization

1998 • 569 citations

Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells

1999 • 564 citations

Cutting Edge: Heat Shock Protein (HSP) 60 Activates the Innate Immune Response: CD14 Is an Essential Receptor for HSP60 Activation of Mononuclear Cells

2000 • 561 citations

In Vivo Detection of Dendritic Cell Antigen Presentation to CD4+ T Cells

1997 • 560 citations

The Dendritic Cell Receptor for Endocytosis, Dec-205, Can Recycle and Enhance Antigen Presentation via Major Histocompatibility Complex Class II–Positive Lysosomal Compartments

2000 • 546 citations

Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy

2001 • 535 citations

Understanding dendritic cell and T‐lymphocyte traffic through the analysis of chemokine receptor expression

2000 • 526 citations

Cathepsin S Required for Normal MHC Class II Peptide Loading and Germinal Center Development

1999 • 519 citations

Accessory factors in clathrin-dependent synaptic vesicle endocytosis

2000 • 513 citations

Tumor necrosis factor-α

1991 • 508 citations

Endotoxin-Induced Maturation of MyD88-Deficient Dendritic Cells

2001 • 505 citations

Differentiation of T Regulatory Cells by Immature Dendritic Cells

2001 • 500 citations

DC-SIGN–ICAM-2 interaction mediates dendritic cell trafficking

2000 • 498 citations

Dendritic Cells Discriminate between Yeasts and Hyphae of the Fungus Candida albicans

2000 • 498 citations

Transport of Peptide-MHC Class II Complexes in Developing Dendritic Cells

2000 • 483 citations

Resting Respiratory Tract Dendritic Cells Preferentially Stimulate T Helper Cell Type 2 (Th2) Responses and Require Obligatory Cytokine Signals for Induction of Th1 Immunity

1998 • 480 citations

Dendritic cells as a tool to induce anergic and regulatory T cells

2001 • 478 citations

Phagocytosis of antigens by Langerhans cells in vitro.

1993 • 474 citations

Murine CD1d-Restricted T Cell Recognition of Cellular Lipids

2000 • 467 citations

Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells

1999 • 466 citations

CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy

1999 • 463 citations

Targeted Expression of Major Histocompatibility Complex (MHC) Class II Molecules Demonstrates that Dendritic Cells Can Induce Negative but Not Positive Selection of Thymocytes In Vivo

1997 • 459 citations

Sensing Pathogens and Tuning Immune Responses

2001 • 458 citations

Murine dendritic cells pulsed with whole tumor lysates mediate potent antitumor immune responsesin vitroandin vivo

1998 • 457 citations

Tumor-specific killer cells in paraneoplastic cerebellar degeneration

1998 • 449 citations

Uptake of Pneumocystis carinii mediated by the macrophage mannose receptor

1991 • 444 citations

The PI3 kinase, p38 SAP kinase, and NF-κB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte–derived dendritic cells

2000 • 440 citations

Developmental Control of Endocytosis in Dendritic Cells by Cdc42

2000 • 440 citations

A Novel Inhibitory Receptor (ILT3) Expressed on Monocytes, Macrophages, and Dendritic Cells Involved in Antigen Processing

1997 • 426 citations

Processing of Some Antigens by the Standard Proteasome but Not by the Immunoproteasome Results in Poor Presentation by Dendritic Cells

2000 • 418 citations

Expression and function of OX40 ligand on human dendritic cells.

1997 • 416 citations

Class I MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages

1995 • 416 citations

Receptor-Mediated Uptake of Antigen/Heat Shock Protein Complexes Results in Major Histocompatibility Complex Class I Antigen Presentation via Two Distinct Processing Pathways

1999 • 413 citations

The Formation of Immunogenic Major Histocompatibility Complex Class II–Peptide Ligands in Lysosomal Compartments of Dendritic Cells Is Regulated by Inflammatory Stimuli

2000 • 412 citations

Impaired Invariant Chain Degradation and Antigen Presentation and Diminished Collagen-Induced Arthritis in Cathepsin S Null Mice

1999 • 408 citations

Cutting Edge: Receptor-Mediated Endocytosis of Heat Shock Proteins by Professional Antigen-Presenting Cells

1999 • 399 citations

Idiotype Vaccination Using Dendritic Cells After Autologous Peripheral Blood Stem Cell Transplantation for Multiple Myeloma—A Feasibility Study

1999 • 398 citations

Expression and function of CCR5 and CXCR4 on human Langerhans cells and macrophages: Implications for HIV primary infection

1997 • 398 citations

Recognizing death: the phagocytosis of apoptotic cells

1998 • 381 citations

TGF-beta 1 prevents the noncognate maturation of human dendritic Langerhans cells.

1999 • 379 citations

Developmental Regulation of Invariant Chain Proteolysis Controls MHC Class II Trafficking in Mouse Dendritic Cells

1998 • 378 citations

COSTIMULATORY MOLECULE-DEFICIENT DENDRITIC CELL PROGENITORS (MHC CLASS II+, CD80dim, CD86-) PROLONG CARDIAC ALLOGRAFT SURVIVAL IN NONIMMUNOSUPPRESSED RECIPIENTS12

1996 • 378 citations

Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice

2001 • 376 citations

The cell biology of antigen presentation in dendritic cells

2001 • 375 citations

The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor

2000 • 375 citations

αvβ5 integrin recruits the CrkII–Dock180–Rac1 complex for phagocytosis of apoptotic cells

2000 • 375 citations

Invariant Chain Structure and MHC Class II Function

1996 • 374 citations

Microbial Lipopeptides Stimulate Dendritic Cell Maturation Via Toll-Like Receptor 2

2001 • 360 citations

Induction of cytotoxic T cell responses and tumor immunity against unrelated tumors using telomerase reverse transcriptase RNA transfected dendritic cells.

2000 • 355 citations

Bystander apoptosis triggers dendritic cell maturation and antigen-presenting function.

1998 • 353 citations

Cross-Presentation of Glycoprotein 96–Associated Antigens on Major Histocompatibility Complex Class I Molecules Requires Receptor-Mediated Endocytosis

1999 • 352 citations

Constitutive macropinocytosis allows TAP‐dependent major histocompatibility compex class I presentation of exogenous soluble antigen by bone marrow‐derived dendritic cells

1997 • 351 citations

The Mannose Receptor Delivers Lipoglycan Antigens to Endosomes for Presentation to T Cells by CD1b Molecules

1997 • 339 citations

Phase I study in melanoma patients of a vaccine with peptide-pulsed dendritic cells generatedin vitro from CD34+ hematopoietic progenitor cells

2000 • 337 citations

Trance, a Tumor Necrosis Factor Family Member, Enhances the Longevity and Adjuvant Properties of Dendritic Cells in Vivo

2000 • 335 citations

The nature of the MHC class I peptide loading complex

1999 • 332 citations

Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion.

1996 • 330 citations

Antigen Presentation by Dendritic Cells after Immunization with DNA Encoding a Major Histocompatibility Complex Class II–restricted Viral Epitope

1997 • 326 citations

Dendritic Cells as Sensors of Infection

2001 • 324 citations

Induction of antitumor immunity using bone marrow-generated dendritic cells.

1996 • 323 citations

CD4+ T Cell Help Impairs CD8+ T Cell Deletion Induced by Cross-presentation of Self-Antigens and Favors Autoimmunity

1997 • 320 citations

Dendritic Cells Induce Autoimmune Diabetes and Maintain Disease via De Novo Formation of Local Lymphoid Tissue

1998 • 315 citations

The Adenylate Cyclase Toxin of Bordetella pertussis Binds to Target Cells via the αMβ2 Integrin (Cd11b/Cd18)

2001 • 314 citations

MHC Class I-Related Neonatal Fc Receptor for IgG Is Functionally Expressed in Monocytes, Intestinal Macrophages, and Dendritic Cells

2001 • 310 citations

The endocytic activity of dendritic cells.

1995 • 308 citations

TGF-β1 Prevents the Noncognate Maturation of Human Dendritic Langerhans Cells

1999 • 303 citations

Major histocompatibility complex class I presentation of peptides derived from soluble exogenous antigen by a subset of cells engaged in phagocytosis.

1995 • 300 citations

Cutting Edge: Bystander Apoptosis Triggers Dendritic Cell Maturation and Antigen-Presenting Function

1998 • 295 citations

Mechanisms of Exogenous Antigen Presentation by MHC Class I Molecules in Vitro and in Vivo: Implications for Generating CD8+ T Cell Responses to Infectious Agents, Tumors, Transplants, and Vaccines

1999 • 293 citations

High Levels of a Major Histocompatibility Complex II–Self Peptide Complex on Dendritic Cells from the T Cell Areas of Lymph Nodes

1997 • 292 citations

Cross-Priming of Naive Cd8 T Cells against Melanoma Antigens Using Dendritic Cells Loaded with Killed Allogeneic Melanoma Cells

2000 • 292 citations

Dendritic cells: On the move from bench to bedside

2001 • 291 citations

Recycling MHC class I molecules and endosomal peptide loading

1999 • 290 citations

The Role of Toll-like Receptors (TLRs) in Bacteria-induced Maturation of Murine Dendritic Cells (DCs)

2001 • 281 citations

Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen‐specific T cells

1993 • 276 citations

Rac is required for constitutive macropinocytosis by dendritic cells but does not control its downregulation

2000 • 275 citations

Inverse relationship of melanocyte differentiation antigen expression in melanoma tissues and CD8+ cytotoxic-T-cell responses: Evidence for immunoselection of antigen-loss variantsin vivo

1996 • 274 citations

Dendritic cells, but not macrophages, produce IL-12 immediately followingLeishmania donovani infection

1998 • 271 citations

Distinct Subsets of CD1d-restricted T Cells Recognize Self-antigens Loaded in Different Cellular Compartments

1999 • 269 citations

Dendritic Cells

1999 • 269 citations

Therapy of murine tumors with p53 wild-type and mutant sequence peptide-based vaccines.

1996 • 262 citations

The selective engulfment of apoptotic bodies by dendritic cells is mediated by the αvβ3 integrin and requires intracellular and extracellular calcium

1997 • 262 citations

Bacteria-induced neo-biosynthesis, stabilization, and surface expression of functional class I molecules in mouse dendritic cells

1998 • 262 citations

Human CD8 + T Cell Responses to EBV EBNA1: HLA Class I Presentation of the (Gly-Ala)–Containing Protein Requires Exogenous Processing

1997 • 261 citations

Cell-Associated Ovalbumin Is Cross-Presented Much More Efficiently than Soluble Ovalbumin In Vivo

2001 • 260 citations

Immunotherapy with Dendritic Cells Directed against Tumor Antigens Shared with Normal Host Cells Results in Severe Autoimmune Disease

2000 • 258 citations

Salmonella-Induced Apoptosis of Infected Macrophages Results in Presentation of a Bacteria-Encoded Antigen after Uptake by Bystander Dendritic Cells

2000 • 248 citations

CELLULAR AND HUMORAL IMMUNE RESPONSES IN PATIENTS WITH METASTATIC RENAL CELL CARCINOMA AFTER VACCINATION WITH ANTIGEN PULSED DENDRITIC CELLS

1999 • 245 citations

Dendritic Cells Derived In Vitro From Acute Myelogenous Leukemia Cells Stimulate Autologous, Antileukemic T-Cell Responses

1999 • 241 citations

Dendritic Cells Capture Killed Tumor Cells and Present Their Antigens to Elicit Tumor-Specific Immune Responses

2000 • 237 citations

Proteases involved in MHC dass II antigen presentation

1999 • 235 citations

Type I (CD64) and type II (CD32) Fc gamma receptor-mediated phagocytosis by human blood dendritic cells.

1996 • 235 citations

Presence of IgE antibodies to bovine serum albumin in a patient developing anaphylaxis after vaccination with human peptide-pulsed dendritic cells

2000 • 234 citations

FAS Engagement Induces the Maturation of Dendritic Cells (Dcs), the Release of Interleukin (Il)-1β, and the Production of Interferon γ in the Absence of IL-12 during Dc–T Cell Cognate Interaction

2000 • 230 citations

Compartmentalization of Bacterial Antigens: Differential Effects on Priming of CD8 T Cells and Protective Immunity

1998 • 228 citations

Tumor necrosis factor alpha maintains the viability of murine epidermal Langerhans cells in culture, but in contrast to granulocyte/macrophage colony-stimulating factor, without inducing their functional maturation.

1990 • 227 citations

Cathepsin S Controls the Trafficking and Maturation of Mhc Class II Molecules in Dendritic Cells

1999 • 227 citations

Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses

2000 • 227 citations

In Vivo Cross-Priming of MHC Class I–Restricted Antigens Requires the TAP Transporter

1996 • 225 citations

CD8+ T Cell-Dependent Elimination of Dendritic Cells In Vivo Limits the Induction of Antitumor Immunity

2000 • 222 citations

Generation of tumor-specific T-lymphocytes by cross-priming with human dendritic cells ingesting apoptotic tumor cells.

2000 • 222 citations

The interface between innate and acquired immunity: glycolipid antigen presentation by CD1d-expressing dendritic cells to NKT cells induces the differentiation of antigen-specific cytotoxic T lymphocytes

2000 • 222 citations

Human Monocyte–Derived Dendritic Cells Induce Naive T Cell Differentiation into T Helper Cell Type 2 (Th2) or Th1/Th2 Effectors

2000 • 222 citations

Heat Shock Protein-chaperoned Peptides but Not Free Peptides Introduced into the Cytosol Are Presented Efficiently by Major Histocompatibility Complex I Molecules

2001 • 218 citations

OmpA targets dendritic cells, induces their maturation and delivers antigen into the MHC class I presentation pathway

2000 • 214 citations

Expression of the Serpin Serine Protease Inhibitor 6 Protects Dendritic Cells from Cytotoxic T Lymphocyte–Induced Apoptosis

2001 • 205 citations

Dendritic cells require maturation via CD40 to generate protective antitumor immunity.

1998 • 204 citations

Cd40-Independent Pathways of T Cell Help for Priming of Cd8+ Cytotoxic T Lymphocytes

2000 • 201 citations

Separate Pathways for Antigen Presentation by CD1 Molecules

1999 • 200 citations

Activation of antitumor cytotoxic T lymphocytes by fusions of human dendritic cells and breast carcinoma cells

2000 • 199 citations

Characterization of sheep afferent lymph dendritic cells and their role in antigen carriage.

1989 • 196 citations

Immature Dendritic Cells Acquire Cd8+Cytotoxic T Lymphocyte Priming Capacity upon Activation by T Helper Cell–Independent or–Dependent Stimuli

2000 • 195 citations

Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins.

1990 • 193 citations

Involvement of caveolae in the uptake of respiratory syncytial virus antigen by dendritic cells

1999 • 193 citations

Impaired immune responses and altered peptide repertoire in tapasin-deficient mice

2000 • 192 citations

Phase II prostate cancer vaccine trial: Report of a study involving 37 patients with disease recurrence following primary treatment

1999 • 191 citations

Extracellular antigen processing and presentation by immature dendritic cells

1999 • 190 citations

Plasmacytoid Dendritic Cells Are Highly Susceptible to Human Immunodeficiency Virus Type 1 Infection and Release Infectious Virus

2001 • 190 citations

Cytokines Regulate Proteolysis in Major Histocompatibility Complex Class II–Dependent Antigen Presentation by Dendritic Cells

2001 • 186 citations

Dendritic Cells Infiltrating Tumors Cotransduced with Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf) and Cd40 Ligand Genes Take up and Present Endogenous Tumor-Associated Antigens, and Prime Naive Mice for a Cytotoxic T Lymphocyte Response

1999 • 184 citations

CD40 signaling in human dendritic cells is initiated within membrane rafts

2000 • 183 citations

Are dendritic cells the key to liver transplant tolerance?

1999 • 180 citations

Viral vectors for dendritic cell-based immunotherapy

2001 • 180 citations

Cutting Edge: Dendritic Cells Are Sufficient to Cross-Present Self-Antigens to CD8 T Cells In Vivo

2001 • 180 citations

Phase 1 Study in Patients With Metastatic Melanoma of Immunization With Dendritic Cells Presenting Epitopes Derived From the Melanoma-Associated Antigens MART-1 and gp100

2000 • 179 citations

Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L.

1996 • 174 citations

The Mouse Cd1d-Restricted Repertoire Is Dominated by a Few Autoreactive T Cell Receptor Families

2001 • 174 citations

Dendritic cells up-regulate immunoproteasomes and the proteasome regulator PA28 during maturation

1999 • 170 citations

Immune selection after antigen-specific immunotherapy of melanoma

1999 • 162 citations

GADD45γ Mediates the Activation of the p38 and JNK MAP Kinase Pathways and Cytokine Production in Effector TH1 Cells

2001 • 161 citations

Antigen-pulsed CD8α+ Dendritic Cells Generate an Immune Response after Subcutaneous Injection without Homing to the Draining Lymph Node

1999 • 161 citations

Expression of multilectin receptors and comparative FITC–dextran uptake by human dendritic cells

2000 • 158 citations

A Subset of Human Dendritic Cells Expresses IgA Fc Receptor (CD89), Which Mediates Internalization and Activation Upon Cross-Linking by IgA Complexes

2001 • 157 citations

Generation of antimelanoma cytotoxic T lymphocytes from healthy donors after presentation of melanoma-associated antigen-derived epitopes by dendritic cells in vitro.

1995 • 157 citations

Antigen processing in the endocytic compartment

2001 • 156 citations

Cutting Edge: Dendritic Cells Require Maturation via CD40 to Generate Protective Antitumor Immunity

1998 • 155 citations

Parasitism of Epidermal Langerhans Cells in Experimental Cutaneous Leishmaniasis withLeishmania major

1993 • 153 citations

Depressed Langerhans cell migration and reduced contact hypersensitivity response in mice lacking TNF receptor p75.

1997 • 152 citations

Dendritic cells acquire the MAGE-3 human tumor antigen from apoptotic cells and induce a class I-restricted T cell response

2000 • 152 citations

The Granzyme B Inhibitor, Protease Inhibitor 9, Is Mainly Expressed by Dendritic Cells and at Immune-Privileged Sites

2001 • 151 citations

MHC Class II Expression Is Regulated in Dendritic Cells Independently of Invariant Chain Degradation

2001 • 151 citations

Activation of human epidermal Langerhans cells by engagement of the high affinity receptor for IgE, Fc epsilon RI.

1995 • 150 citations

CC chemokine receptor-7 on dendritic cells is induced after interaction with apoptotic tumor cells: critical role in migration from the tumor site to draining lymph nodes.

2000 • 148 citations

The αβ T Cell Response to Self-Glycolipids Shows a Novel Mechanism of CD1b Loading and a Requirement for Complex Oligosaccharides

2000 • 146 citations

CD8+ T Cells Mediate CD40-independent Maturation of Dendritic Cells In Vivo

1999 • 145 citations

Role of Ox40 Signals in Coordinating Cd4 T Cell Selection, Migration, and Cytokine Differentiation in T Helper (Th)1 and Th2 Cells

2000 • 143 citations

Mechanism of Measles Virus–Induced Suppression of Inflammatory Immune Responses

2001 • 140 citations

Bone Marrow–Derived Antigen-Presenting Cells Are Required for the Generation of Cytotoxic T Lymphocyte Responses to Viruses and Use Transporter Associated with Antigen Presentation (Tap)-Dependent and -Independent Pathways of Antigen Presentation

2000 • 138 citations

Antigen-specific T lymphocytes regulate lipopolysaccharide-induced apoptosis of dendritic cells in vivo.

1998 • 133 citations

Augmentation of dendritic cells in murine organ donors by Flt3 ligand alters the balance between transplant tolerance and immunity.

1997 • 132 citations

CpG DNA Induces Maturation of Dendritic Cells with Distinct Effects on Nascent and Recycling MHC-II Antigen-Processing Mechanisms

2000 • 129 citations

Antigen-unspecific B Cells and Lymphoid Dendritic Cells Both Show Extensive Surface Expression of Processed Antigen–Major Histocompatibility Complex Class II Complexes after Soluble Protein Exposure In Vivo or In Vitro

1997 • 128 citations

The B Subunit of Shiga Toxin Fused to a Tumor Antigen Elicits CTL and Targets Dendritic Cells to Allow MHC Class I-Restricted Presentation of Peptides Derived from Exogenous Antigens

2000 • 128 citations

Dendritic cells break tolerance and induce protective immunity against a melanocyte differentiation antigen in an autologous melanoma model.

2000 • 127 citations

Preoperative Mobilization of Circulating Dendritic Cells by Flt3 Ligand Administration to Patients With Metastatic Colon Cancer

2000 • 127 citations

Intrathymic presentation of circulating non-MHC antigens by medullary dendritic cells. An antigen-dependent microenvironment for T cell differentiation.

1986 • 126 citations

Analysis of Adjuvant Function by Direct Visualization of Antigen Presentation In Vivo: Endotoxin Promotes Accumulation of Antigen-Bearing Dendritic Cells in the T Cell Areas of Lymphoid Tissue

1999 • 126 citations

Differential Role for p38 Mitogen-Activated Protein Kinase in Regulating CD40-Induced Gene Expression in Dendritic Cells and B Cells

1999 • 126 citations

Dendritic cells are the most efficient in presenting endogenous naturally processed self-epitopes to class II-restricted T cells.

1995 • 125 citations

Dendritic Cells Are Resistant to Apoptosis Through the Fas (CD95/APO-1) Pathway

1999 • 124 citations

Dendritic cells and the replication of HIV-1

1996 • 122 citations

Class I-restricted presentation of exogenous antigen acquired by Fcγ receptor-mediated endocytosis is regulated in dendritic cells

2000 • 121 citations

Intersection of Group I CD1 Molecules and Mycobacteria in Different Intracellular Compartments of Dendritic Cells

2000 • 118 citations

Dendritic Cells Cross-Present Latency Gene Products from Epstein-Barr Virus–Transformed B Cells and Expand Tumor-Reactive Cd8+ Killer T Cells

2001 • 118 citations

Mycoplasma fermentansLipoprotein M161Ag-Induced Cell Activation Is Mediated by Toll-Like Receptor 2: Role of N-Terminal Hydrophobic Portion in its Multiple Functions

2001 • 117 citations

Bacterial Lipopolysaccharide, TNF-α, and Calcium Ionophore Under Serum-Free Conditions Promote Rapid Dendritic Cell-Like Differentiation in CD14+ Monocytes Through Distinct Pathways That Activate NF-κB

2000 • 117 citations

Human acute myeloblastic leukemia cells differentiatein vitro into mature dendritic cells and induce the differentiation of cytotoxic T cells against autologous leukemias

1999 • 116 citations

CD1c molecules broadly survey the endocytic system

2000 • 115 citations

Murine dendritic cells internalizeLeishmania major promastigotes, produce IL-12 p40 and stimulate primary T cell proliferationin vitro

1999 • 115 citations

Molecular Cloning and Functional Characterization of a Human Scavenger Receptor with C-Type Lectin (SRCL), a Novel Member of a Scavenger Receptor Family

2001 • 113 citations

Binding and Uptake of Agalactosyl IgG by Mannose Receptor on Macrophages and Dendritic Cells

1999 • 111 citations

Cutting Edge: Antigen-Specific T Lymphocytes Regulate Lipopolysaccharide-Induced Apoptosis of Dendritic Cells In Vivo

1998 • 110 citations

Prevention of Peripheral Tolerance by a Dendritic Cell Growth Factor: Flt3 Ligand as an Adjuvant

1998 • 110 citations

A Pilot Clinical Trial of HIV Antigen-Pulsed Allogeneic and Autologous Dendritic Cell Therapy in HIV-Infected Patients

1998 • 109 citations

Antigen Loading of MHC Class I Molecules in the Endocytic Tract

2001 • 108 citations

Histoplasma capsulatumYeasts Are Phagocytosed Via Very Late Antigen-5, Killed, and Processed for Antigen Presentation by Human Dendritic Cells

2001 • 107 citations

Rapid Extracellular Degradation of Synthetic Class I Peptides by Human Dendritic Cells

1998 • 106 citations

Dendritic cells generated from blood precursors of chronic myelogenous leukemia patients carry the philadelphia translocation and can induce a CML-specific primary cytotoxic T-cell response

1997 • 104 citations

Requirements for Bone Marrow–Derived Antigen-Presenting Cells in Priming Cytotoxic T Cell Responses to Intracellular Pathogens

2000 • 99 citations

Identification and analysis of a novel member of the ubiquitin family expressed in dendritic cells and mature B cells

1997 • 99 citations

Efficient nonviral transfection of dendritic cells and their use for in vivo immunization

2000 • 98 citations

Incoming Human Cytomegalovirus pp65 (UL83) Contained in Apoptotic Infected Fibroblasts Is Cross-Presented to CD8⁺T Cells by Dendritic Cells

2000 • 97 citations

Human Cd1b and Cd1c Isoforms Survey Different Intracellular Compartments for the Presentation of Microbial Lipid Antigens

2000 • 92 citations

Characterization of CD1e, a Third Type of CD1 Molecule Expressed in Dendritic Cells

2000 • 92 citations

Maturation of dendritic cells leads to up-regulation of cellular FLICE-inhibitory protein and concomitant down-regulation of death ligand–mediated apoptosis

2000 • 92 citations

Dendritic cell presentation of antigens from apoptotic cells in a proinflammatory context: Role of opsonizing anti-?2-glycoprotein I antibodies

1999 • 90 citations

The impact of the non‐classical MHC proteins HLA‐DM and HLA‐DO on loading of MHC class II molecules

1999 • 90 citations

Dendritic cell maturation is induced by mycoplasma infection but not by necrotic cells

2000 • 90 citations

Apoptotic cells overexpress vinculin and induce vinculin-specific cytotoxic T-cell cross-priming

2001 • 89 citations

Dead or alive: immunogenicity of human melanoma cells when presented by dendritic cells.

2000 • 85 citations

Influences of Transporter Associated with Antigen Processing (TAP) on the Repertoire of Peptides Associated with the Endoplasmic Reticulum–resident Stress Protein gp96

1997 • 85 citations

Protective Antiviral Cytotoxic T Cell Memory Is Most Efficiently Maintained by Restimulation Via Dendritic Cells

1999 • 83 citations

Rapid Peptide Turnover and Inefficient Presentation of Exogenous Antigen Critically Limit the Activation of Self-Reactive CTL by Dendritic Cells

2001 • 83 citations

Membrane and soluble Fc gamma RII/III modulate the antigen-presenting capacity of murine dendritic epidermal Langerhans cells for IgG-complexed antigens.

1995 • 82 citations

Mobilization of MHC class I molecules from late endosomes to the cell surface following activation of CD34-derived human Langerhans cells

2001 • 80 citations

CTL priming by CD8+ and CD8– dendritic cellsin vivo

1999 • 76 citations

Dendritic Cell Maturation Overrules H-2d–Mediated Natural Killer T (Nkt) Cell Inhibition

2001 • 76 citations

Induction of peripheral CD8⁺ T‐cell tolerance by cross‐presentation of self antigens

1998 • 76 citations

Perforin-independent regulation of dendritic cell homeostasis by CD8+ T cellsin vivo: implications for adaptive immunotherapy

2001 • 71 citations

Enumeration of Antigen-Presenting Cells in Mice Infected with Sendai Virus

1999 • 70 citations

CD1d on Myeloid Dendritic Cells Stimulates Cytokine Secretion from and Cytolytic Activity of Vα24JαQ T Cells: A Feedback Mechanism for Immune Regulation

2000 • 69 citations

MHC class II and CD40 play opposing roles in dendritic cell survival

2000 • 65 citations

Presentation of self and microbial lipids by CD1 molecules

2001 • 62 citations

CD1a Molecules Traffic Through the Early Recycling Endosomal Pathway in Human Langerhans Cells11Presented in part at the 6th International Workshop on Langerhans Cells, New York, NY, U.S.A., 8–10 October 1999 (J Invest Dermatol 114:228 2000).

2001 • 61 citations

Dendritic cell maturation and antigen presentation in the absence of invariant chain

1998 • 57 citations

Langerhans Cells Phagocytose Vaginal Epithelial Cells Undergoing Apoptosis during the Murine Estrous Cycle1

1991 • 53 citations

Processing of bacterial antigens for peptide presentation on MHC class I molecules

1999 • 51 citations

Presentation of Epstein-Barr virus latency antigens to CD8+, interferon-γ-secreting, T lymphocytes

1999 • 50 citations

Exogenous antigen targeted to FcγRI on myeloid cells is presented in association with MHC class I

2001 • 49 citations

CD1 and lipid antigens: intracellular pathways for antigen presentation

2001 • 49 citations

Third Keystone Symposium on Cellular Immunology and the Immunotherapy of Cancer Antigen Processing and Presentation Autologous Human Dendriphages Pulsed with Synthetic or Natural Tumor Peptides Elicit Tumor-Specific CTLs In Vitro

1998 • 44 citations

The efficiency of antigen delivery from macrophage phagosomes into cytoplasm for MHC class I-restricted antigen presentation

1997 • 42 citations

Differential susceptibility to CD95 (Apo-1/Fas) and MHC class II-induced apoptosis during murine dendritic cell development

2000 • 40 citations

Invariant Chain Controls H2-M Proteolysis in Mouse Splenocytes and Dendritic Cells

2000 • 36 citations

Cutting Edge: Resistance to Apoptosis and Continuous Proliferation of Dendritic Cells Deficient for TNF Receptor-1

2000 • 35 citations

Colocalization of FcγRI-Targeted Antigen With Class I MHC: Implications for Antigen Processing

2001 • 34 citations

Immunotherapy of cancer. Generation of CEA specific CTL using CEA peptide pulsed dendritic cells.

1997 • 34 citations

Dendritic cell-based immunotherapy of cancer

2000 • 31 citations

The mode of protein antigen administration determines preferential presentation of peptide-class II complexes by lymph node dendritic or B cells

1997 • 25 citations

Immunotherapy of Cancer

1997 • 24 citations

Intrathymic deletion of MHC class I-restricted cytotoxic T cell precursors by constitutive cross-presentation of exogenous antigen

1999 • 22 citations

Modulation of MHC class II transport and lysosome distribution by macrophage-colony stimulating factor in human dendritic cells derived from monocytes

2001 • 21 citations

Tumor-Dendritic Cell Fusion Technology and Immunotherapy Strategies

2001 • 21 citations

Antigen‐presenting Function of the Mouse CD1 Moleculea

1996 • 12 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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