Acetylation inactivates the transcriptional repressor BCL6

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

2000 • 3,355 citations

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

1996 • 2,873 citations

hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

2001 • 2,550 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

2001 • 2,042 citations

Histone Acetyltransferases

2001 • 1,745 citations

Clonal selection and learning in the antibody system

1996 • 1,710 citations

Acetylation of Histones and Transcription-Related Factors

2000 • 1,702 citations

DNA damage activates p53 through a phosphorylation–acetylation cascade

1998 • 1,194 citations

Histone Deacetylase Inhibitors: Inducers of Differentiation or Apoptosis of Transformed Cells

2000 • 1,158 citations

p300/CBP proteins: HATs for transcriptional bridges and scaffolds

2001 • 1,046 citations

Control of Inflammation, Cytokine Expression, and Germinal Center Formation by BCL-6

1997 • 921 citations

p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.

1991 • 915 citations

BCL-6 Represses Genes that Function in Lymphocyte Differentiation, Inflammation, and Cell Cycle Control

2000 • 862 citations

The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation

1997 • 815 citations

Deacetylation of p53 modulates its effect on cell growth and apoptosis

2000 • 794 citations

Sir2 links chromatin silencing, metabolism, and aging

2000 • 725 citations

Acetylation of p53 Activates Transcription through Recruitment of Coactivators/Histone Acetyltransferases

2001 • 704 citations

Regulation of activity of the transcription factor GATA-1 by acetylation

1998 • 686 citations

Alterations of a Zinc Finger-Encoding Gene, BCL-6 , in Diffuse Large-Cell Lymphoma

1993 • 680 citations

Regulation of E2F1 activity by acetylation

2000 • 654 citations

Histone deacetylases, transcriptional control, and cancer

2000 • 622 citations

BCL-6 protein is expressed in germinal-center B cells

1995 • 582 citations

BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci

1998 • 539 citations

Mutation ofBCL-6Gene in Normal B Cells by the Process of Somatic Hypermutation of Ig Genes

1998 • 536 citations

The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila.

1994 • 466 citations

LAZ3, a novel zinc–finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas

1993 • 444 citations

BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor.

1996 • 434 citations

Histone deacetylases: silencers for hire

2000 • 429 citations

Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma.

1995 • 359 citations

Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma

1997 • 351 citations

Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein

1997 • 343 citations

Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the Gcn5p acetyltransferase

1998 • 318 citations

The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT

1998 • 314 citations

Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas.

1993 • 293 citations

Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor

1998 • 287 citations

Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma.

1995 • 285 citations

BCL-6 gene product, a 92- to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts

1995 • 284 citations

Acetylation control of the retinoblastoma tumour-suppressor protein

2001 • 280 citations

BCL-6 expression during B-cell activation

1996 • 262 citations

The LAZ3(BCL-6) oncoprotein recruits a SMRT/mSIN3A/histone deacetylase containing complex to mediate transcriptional repression

1998 • 229 citations

Suppression of Signal Transducer and Activator of Transcription 3–Dependent B Lymphocyte Terminal Differentiation by Bcl-6

2000 • 219 citations

Transcriptional repression by the proto-oncogene BCL-6.

1996 • 196 citations

Transcriptional Repression of Stat6-Dependent Interleukin-4-Induced Genes by BCL-6: Specific Regulation of Iɛ Transcription and Immunoglobulin E Switching

1999 • 188 citations

Components of the SMRT Corepressor Complex Exhibit Distinctive Interactions with the POZ Domain Oncoproteins PLZF, PLZF-RARα, and BCL-6

1998 • 163 citations

Disrupted p53 function as predictor of treatment failure and poor prognosis in B- and T-cell non-Hodgkin's lymphoma.

1999 • 75 citations

A Short Mutational Hot Spot in the First Intron of BCL-6 Is Associated with Increased BCL-6 Expression and with Longer Overall Survival in Large B-Cell Lymphomas

2002 • 50 citations

A new functional domain of Bcl6 family that recruits histone deacetylases

2001 • 44 citations

Multiple Domains Participate in Distance-Independent LAZ3/BCL6-Mediated Transcriptional Repression

1996 • 44 citations