Up-Regulation of Hlx in Immature Th Cells Induces IFN-γ Expression

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

2001 • 156,143 citations

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

2000 • 2,755 citations

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

1997 • 2,317 citations

Lymphokine Production by Human T Cells in Disease States

1994 • 1,351 citations

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1996 • 1,277 citations

IL-4 directs the development of Th2-like helper effectors.

1990 • 1,261 citations

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1996 • 1,182 citations

Distinct Effects of T-bet in T _H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells

2002 • 1,169 citations

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

1997 • 1,022 citations

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

1993 • 991 citations

T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

2002 • 985 citations

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

1990 • 954 citations

Identifying differences in mRNA expression by representational difference analysis of cDNA

1994 • 904 citations

Role of T-bet in Commitment of T _H 1 Cells Before IL-12-Dependent Selection

2001 • 813 citations

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1998 • 800 citations

Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 Cells

1997 • 783 citations

T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells

2001 • 743 citations

Stat6-Independent GATA-3 Autoactivation Directs IL-4-Independent Th2 Development and Commitment

2000 • 697 citations

The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4

1996 • 677 citations

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

1995 • 675 citations

Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene

1997 • 666 citations

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.

1995 • 446 citations

Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones.

1994 • 438 citations

Developmental commitment to the Th2 lineage by extinction of IL-12 signaling

1995 • 429 citations

Gata-3 Induces T Helper Cell Type 2 (Th2) Cytokine Expression and Chromatin Remodeling in Committed Th1 Cells

2000 • 390 citations

The Transcription Factor c-Maf Controls the Production of Interleukin-4 but Not Other Th2 Cytokines

1999 • 377 citations

Antiproliferative effect of IFN-gamma in immune regulation. III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-gamma.

1989 • 349 citations

Constructing polycompetitor cDNAs for quantitative PCR

1993 • 323 citations

Five mouse tubulin isotypes and their regulated expression during development.

1985 • 323 citations

Hlx is induced by and genetically interacts with T-bet to promote heritable TH1 gene induction

2002 • 304 citations

c-maf Promotes T Helper Cell Type 2 (Th2) and Attenuates Th1 Differentiation by Both Interleukin 4–dependent and –independent Mechanisms

1998 • 303 citations

Single Cell Analysis Reveals That IL-4 Receptor/Stat6 Signaling Is Not Required for the In Vivo or In Vitro Development of CD4+ Lymphocytes with a Th2 Cytokine Profile

2000 • 252 citations

GATA-3 Significantly Downregulates IFN-γ Production from Developing Th1 Cells in Addition to Inducing IL-4 and IL-5 Levels

1999 • 172 citations

A Signal Transducer and Activator of Transcription (Stat)4-independent Pathway for the Development of T Helper Type 1 Cells

1998 • 172 citations

IL‐12‐Deficient Mice Are Defective but Not Devoid of Type 1 Cytokine Responses

1996 • 115 citations

The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway

1999 • 111 citations

Novel murine homeo box gene on chromosome 1 expressed in specific hematopoietic lineages and during embryogenesis.

1991 • 108 citations