TEC FAMILY KINASES IN T LYMPHOCYTE DEVELOPMENT AND FUNCTION

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

Regulation of Phosphoinositide-Specific Phospholipase C

2001 • 1,604 citations

Positive and Negative Selection of T Cells

2003 • 1,547 citations

The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

1993 • 1,438 citations

Active and Inactive Protein Kinases: Structural Basis for Regulation

1996 • 1,361 citations

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

1993 • 1,338 citations

NFAT Signaling

2002 • 1,316 citations

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

2000 • 890 citations

Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID Mice

1993 • 868 citations

T-cell development and the CD4–CD8 lineage decision

2002 • 738 citations

Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

2002 • 685 citations

Colocalization of X-Linked Agammaglobulinemia and X-Linked Immunodeficiency Genes

1993 • 631 citations

Signal Transduction Mediated by the T Cell Antigen Receptor: The Role of Adapter Proteins

2002 • 565 citations

Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase.

1996 • 560 citations

T Helper Cell Fate Specified by Kinase-Mediated Interaction of T-bet with GATA-3

2005 • 505 citations

A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.

1996 • 494 citations

Potassium and Calcium Channels in Lymphocytes

1995 • 488 citations

Binding of G protein beta gamma-subunits to pleckstrin homology domains.

1994 • 479 citations

A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains

1997 • 458 citations

Activation of BTK by a Phosphorylation Mechanism Initiated by SRC Family Kinases

1996 • 445 citations

Immunodeficiency in Protein Kinase Cβ-Deficient Mice

1996 • 444 citations

Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

1998 • 436 citations

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

1998 • 420 citations

Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation

1998 • 410 citations

Requirement for Tec Kinases Rlk and Itk in T Cell Receptor Signaling and Immunity

1999 • 399 citations

SHIP Modulates Immune Receptor Responses by Regulating Membrane Association of Btk

1998 • 397 citations

Structures of Src-family tyrosine kinases

1997 • 377 citations

Deficiency of PTEN in Jurkat T Cells Causes Constitutive Localization of Itk to the Plasma Membrane and Hyperresponsiveness to CD3 Stimulation

2000 • 345 citations

T Cell Receptor–initiated Calcium Release Is Uncoupled from Capacitative Calcium Entry in Itk-deficient T Cells

1998 • 336 citations

LFA-1–mediated Adhesion Is Regulated by Cytoskeletal Restraint and by a Ca2+-dependent Protease, Calpain

1998 • 324 citations

The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C.

1994 • 322 citations

Regulation of Btk Function by a Major Autophosphorylation Site Within the SH3 Domain

1996 • 321 citations

Protein Kinase C θ Affects Ca2+ Mobilization and NFAT Activation in Primary Mouse T Cells

2003 • 320 citations

Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk

1995 • 313 citations

Impaired NFATc Translocation and Failure of Th2 Development in Itk-Deficient CD4+ T Cells

1999 • 307 citations

The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species

2001 • 304 citations

Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells.

1994 • 299 citations

A LAT Mutation That Inhibits T Cell Development Yet Induces Lymphoproliferation

2002 • 278 citations

Biochemical Interactions Integrating Itk with the T Cell Receptor-initiated Signaling Cascade

2000 • 278 citations

Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A

2002 • 274 citations

Regulatory intramolecular association in a tyrosine kinase of the Tec family

1997 • 274 citations

Phosphoinositides, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membrane

2001 • 273 citations

Induction of T Helper Type 2 Immunity by a Point Mutation in the LAT Adaptor

2002 • 265 citations

itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2.

1992 • 254 citations

Interaction of SLP adaptors with the SH2 domain of Tec family kinases

1999 • 245 citations

Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia

1997 • 240 citations

Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase.

1994 • 240 citations

THE WISKOTT-ALDRICH SYNDROME PROTEIN (WASP): Roles in Signaling and Cytoskeletal Organization

1999 • 240 citations

CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line.

1994 • 232 citations

Integrins and T Cell–Mediated Immunity

2004 • 232 citations

The Store-Operated Calcium Current ICRAC: Nonlinear Activation by InsP3 and Dissociation from Calcium Release

1997 • 231 citations

Signaling network of the Btk family kinases

2000 • 230 citations

Differential Roles of ERK and p38 MAP Kinase Pathways in Positive and Negative Selection of T Lymphocytes

1998 • 217 citations

Vav1 Transduces T Cell Receptor Signals to the Activation of Phospholipase C-γ1 via Phosphoinositide 3-Kinase-dependent and -independent Pathways

2002 • 214 citations

BTK Regulates PtdIns-4,5-P2 Synthesis

2003 • 214 citations

The B Cell Antigen Receptor Controls Integrin Activity through Btk and PLCγ2

2003 • 212 citations

Cyclophilin A Regulates TCR Signal Strength in CD4+ T Cells via a Proline-Directed Conformational Switch in Itk

2004 • 212 citations

Gα12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF

2003 • 208 citations

Severe B Cell Deficiency in Mice Lacking the Tec Kinase Family Members Tec and Btk

2000 • 206 citations

Mutation of the Pleckstrin Homology Domain of Bruton's Tyrosine Kinase in Immunodeficiency Impaired Inositol 1,3,4,5-Tetrakisphosphate Binding Capacity

1996 • 203 citations

Protein Kinase C θ Is Critical for the Development of In Vivo T Helper (Th)2 Cell But Not Th1 Cell Responses

2004 • 202 citations

Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate

1999 • 202 citations

Identification of the SH2 Domain Binding Protein of Bruton’s Tyrosine Kinase as BLNK—Functional Significance of Btk-SH2 Domain in B-Cell Antigen Receptor-Coupled Calcium Signaling

1999 • 199 citations

Fyn and PTP-PEST–mediated Regulation of Wiskott-Aldrich Syndrome Protein (WASp) Tyrosine Phosphorylation Is Required for Coupling T Cell Antigen Receptor Engagement to WASp Effector Function and T Cell Activation

2004 • 197 citations

Identification of Itk/Tsk Src Homology 3 Domain Ligands

1996 • 193 citations

Phosphatidylinositol 3-kinase-γ activates Bruton’s tyrosine kinase in concert with Src family kinases

1997 • 192 citations

Activation of bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain

1995 • 191 citations

Vav1 Controls Integrin Clustering and MHC/Peptide-Specific Cell Adhesion to Antigen-Presenting Cells

2002 • 190 citations

Direct stimulation of Bruton's tyrosine kinase by Gq-protein α-subunit

1997 • 186 citations

CD28 as a Molecular Amplifier Extending TCR Ligation and Signaling Capabilities

2001 • 183 citations

BAP-135, a target for Bruton’s tyrosine kinase in response to B cell receptor engagement

1997 • 182 citations

Btk function in B cell development and response

1998 • 181 citations

Fundamental Immunology

2004 • 180 citations

Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase

1997 • 178 citations

Mutation of Tec family kinases alters T helper cell differentiation

2001 • 174 citations

Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction.

1994 • 172 citations

Lck Phosphorylates the Activation Loop Tyrosine of the Itk Kinase Domain and Activates Itk Kinase Activity

1997 • 169 citations

Signaling through Itk Promotes T Helper 2 Differentiation via Negative Regulation of T-bet

2004 • 164 citations

p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation.

1995 • 164 citations

Transforming Growth Factor β Blocks Tec Kinase Phosphorylation, Ca2+ Influx, and NFATc Translocation Causing Inhibition of T Cell Differentiation

2003 • 163 citations

NK T Cell Precursors Exhibit Differential Cytokine Regulation and Require Itk for Efficient Maturation

2002 • 161 citations

Expression of the chlI, chlD, and chlH Genes from the Cyanobacterium Synechocystis PCC6803 in Escherichia coli and Demonstration That the Three Cognate Proteins Are Required for Magnesium-protoporphyrin Chelatase Activity

1996 • 160 citations

Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain

2001 • 157 citations

BTKbase, mutation database for X-linked agammaglobulinemia (XLA)

1998 • 155 citations

New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision

2002 • 154 citations

Src Family Protein Tyrosine Kinases Induce Autoactivation of Bruton's Tyrosine Kinase

1995 • 151 citations

Attenuation of Immunological Symptoms of Allergic Asthma in Mice Lacking the Tyrosine Kinase ITK

2003 • 149 citations

Tec family of protein-tyrosine kinases: an overview of their structure and function

1999 • 147 citations

Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk.

1993 • 144 citations

PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization

2001 • 143 citations

A novel protein-tyrosine kinase, tec, is preferentially expressed in liver.

1990 • 139 citations

Kinase-Independent Functions for Itk in TCR-Induced Regulation of Vav and the Actin Cytoskeleton

2005 • 134 citations

Pleckstrin Homology Domains Interact with Filamentous Actin

1999 • 133 citations

Tec Family Kinases Modulate Thresholds for Thymocyte Development and Selection

2000 • 131 citations

Structure and Expression of Novel Protein-Tyrosine Kinases, EMB and EMT, in Hematopoietic Cells

1993 • 131 citations

Itk Functions to Control Actin Polymerization at the Immune Synapse through Localized Activation of Cdc42 and WASP

2003 • 131 citations

Transphosphorylation of Bruton's Tyrosine Kinase on Tyrosine 551 Is Critical for B Cell Antigen Receptor Function

1997 • 129 citations

Phosphorylation of two regulatory tyrosine residues in the activation of Bruton’s tyrosine kinase via alternative receptors

1997 • 129 citations

Activation of Tsk and Btk tyrosine kinases by G protein beta gamma subunits.

1995 • 127 citations

Bruton's Tyrosine Kinase as an Inhibitor of the Fas/CD95 Death-inducing Signaling Complex

1999 • 124 citations

Structural characterization of a proline-driven conformational switch within the Itk SH2 domain

2002 • 122 citations

Vav1: a key signal transducer downstream of the TCR

2003 • 120 citations

Redistribution of Bruton's tyrosine kinase by activation of phosphatidylinositol 3-kinase and Rho-family GTPases

2000 • 120 citations

Tyrosine phosphorylation of the Wiskott‐Aldrich Syndrome protein by Lyn and Btk is regulated by CDC42

1998 • 111 citations

Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways.

1996 • 109 citations

Involvement of Wiskott-Aldrich Syndrome Protein in B-Cell Cytoplasmic Tyrosine Kinase Pathway

1999 • 108 citations

Tec Kinases Mediate Sustained Calcium Influx via Site-specific Tyrosine Phosphorylation of the Phospholipase Cγ Src Homology 2-Src Homology 3 Linker

2004 • 106 citations

The Role of Tec Protein-tyrosine Kinase in T Cell Signaling

1999 • 106 citations

Regulation of Btk by Src Family Tyrosine Kinases

1996 • 106 citations

Selective Itk Inhibitors Block T-Cell Activation and Murine Lung Inflammation

2004 • 105 citations

A novel function for the Tec family tyrosine kinase Itk in activation of β1 integrins by the T-cell receptor

2001 • 104 citations

The Tec29 Tyrosine Kinase Is Required during Drosophila Embryogenesis and Interacts with Src64 in Ring Canal Development

1998 • 104 citations

Tec/Bmx non-receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Galpha 12/13

1998 • 104 citations

Tec family kinases in lymphocyte signaling and function

2000 • 103 citations

Itk/Emt/Tsk Activation in Response to CD3 Cross-linking in Jurkat T Cells Requires ZAP-70 and Lat and Is Independent of Membrane Recruitment

1999 • 101 citations

Activation and interaction with protein kinase C of a cytoplasmic tyrosine kinase, Itk/Tsk/Emt, on Fc epsilon RI cross-linking on mast cells.

1995 • 100 citations

Crystal Structure of Bruton's Tyrosine Kinase Domain Suggests a Novel Pathway for Activation and Provides Insights into the Molecular Basis of X-linked Agammaglobulinemia

2001 • 99 citations

Ribp, a Novel Rlk/Txk- and Itk-Binding Adaptor Protein That Regulates T Cell Activation

1999 • 99 citations

Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK

1997 • 97 citations

Requirement for Tec Kinases in Chemokine-Induced Migration and Activation of Cdc42 and Rac

2004 • 97 citations

Beyond calcium: new signaling pathways for Tec family kinases

2002 • 96 citations

Stem cell factor induces phosphatidylinositol 3′-kinase–dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells

2000 • 96 citations

Expression and Function of Tec, Itk, and Btk in Lymphocytes: Evidence for a Unique Role for Tec

2004 • 93 citations

The EMT/ITK/TSK (EMT) tyrosine kinase is activated during TCR signaling: LCK is required for optimal activation of EMT.

1996 • 92 citations

Txk, a Nonreceptor Tyrosine Kinase of the Tec Family, Is Expressed in T Helper Type 1 Cells and Regulates Interferon γ Production in Human T Lymphocytes

1999 • 92 citations

Identification of Rlk, a Novel Protein Tyrosine Kinase with Predominant Expression in the T Cell Lineage

1995 • 92 citations

Imaging immune cell interactions and functions: SMACs and the Immunological Synapse

2003 • 90 citations

Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain.

1995 • 90 citations

Characterization of the Pleckstrin Homology Domain of Btk as an Inositol Polyphosphate and Phosphoinositide Binding Domain

1997 • 89 citations

The SH3 domain of Itk/Emt binds to proline-rich sequences in the cytoplasmic domain of the T cell costimulatory receptor CD28.

1997 • 88 citations

Protein Tyrosine Phosphatase CD148-Mediated Inhibition of T-Cell Receptor Signal Transduction Is Associated with Reduced LAT and Phospholipase Cγ1 Phosphorylation

2001 • 87 citations

TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12

1994 • 86 citations

rlk/TXK Encodes Two Forms of a Novel Cysteine String Tyrosine Kinase Activated by Src Family Kinases

1999 • 86 citations

A specific intermolecular association between the regulatory domains of a tec family kinase

2000 • 85 citations

On the brink of becoming a T cell

2002 • 84 citations

Identification, cloning, and characterization of a novel human T-cell- specific tyrosine kinase located at the hematopoietin complex on chromosome 5q

1993 • 82 citations

Chemotactic Factor-Induced Recruitment and Activation of Tec Family Kinases in Human Neutrophils. II. Effects of LFM-A13, a Specific Btk Inhibitor

2003 • 81 citations

Regulation of CXC Chemokine Receptor 4-mediated Migration by the Tec Family Tyrosine Kinase ITK

2004 • 81 citations

The inducible expression of the tumor suppressor gene PTEN promotes apoptosis and decreases cell size by inhibiting the PI3K/Akt pathway in Jurkat T cells.

2002 • 81 citations

The Wiskott–Aldrich syndrome protein: forging the link between actin and cell activation

2003 • 80 citations

TCR/CD3-Induced Activation and Binding of Emt/Itk to Linker of Activated T Cell Complexes: Requirement for the Src Homology 2 Domain

2000 • 80 citations

Itk Phosphorylation Sites Are Required for Functional Activity in Primary T Cells

2003 • 79 citations

Functions of Bruton's tyrosine kinase in mast and B cells

1999 • 79 citations

The role of Tec family kinases in T cell development and function

2003 • 79 citations

Tec Kinase Signaling in T Cells Is Regulated by Phosphatidylinositol 3-Kinase and the Tec Pleckstrin Homology Domain

2001 • 78 citations

Functional LCK Is Required for Optimal CD28-mediated Activation of the TEC Family Tyrosine Kinase EMT/ITK

1996 • 77 citations

Analysis of CD28 cytoplasmic tail tyrosine residues as regulators and substrates for the protein tyrosine kinases, EMT and LCK.

1997 • 76 citations

Bruton’s tyrosine kinase (BTK) as a dual-function regulator of apoptosis

1998 • 74 citations

Solution Structure of the SH3 Domain from Bruton's Tyrosine Kinase^,

1998 • 74 citations

Chemotactic Factor-induced Recruitment and Activation of Tec Family Kinases in Human Neutrophils

2002 • 73 citations

Defective Fas Ligand Expression and Activation-Induced Cell Death in the Absence of IL-2-Inducible T Cell Kinase

2002 • 73 citations

Inducible T Cell Tyrosine Kinase Regulates Actin-Dependent Cytoskeletal Events Induced by the T Cell Antigen Receptor

2003 • 72 citations

Reconstitution of Btk Signaling by the Atypical Tec Family Tyrosine Kinases Bmx and Txk

1999 • 69 citations

Diacylglycerol's affair with protein kinase C turns 25

2004 • 68 citations

Positive feedback regulation of PLCγ1/Ca²⁺ signaling by PKCθ in restimulated T cells via a Tec kinase‐dependent pathway

2004 • 66 citations

Emt/Itk Associates with Activated TCR Complexes: Role of the Pleckstrin Homology Domain

1999 • 66 citations

Transcriptional Regulation of the Carcinoembryonic Antigen Gene

1995 • 66 citations

The Transcription FactorBrightAssociates with Bruton’s Tyrosine Kinase, the Defective Protein in Immunodeficiency Disease

2000 • 65 citations

Membrane Raft-Dependent Regulation of Phospholipase Cγ-1 Activation in T Lymphocytes

2001 • 64 citations

p130Cas Couples the Tyrosine Kinase Bmx/Etk with Regulation of the Actin Cytoskeleton and Cell Migration

2003 • 64 citations

The Absence of Itk Inhibits Positive Selection Without Changing Lineage Commitment

2002 • 63 citations

Cutting Edge: Selective Requirement for the Wiskott-Aldrich Syndrome Protein in Cytokine, but Not Chemokine, Secretion by CD4+ T Cells

2004 • 63 citations

Identification of Highly Expressed Genes in Peripheral Blood T Cells from Patients with Atopic Dermatitis

2002 • 63 citations

A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC Gamma 2 in B cells

2001 • 62 citations

Crystal Structures of Interleukin-2 Tyrosine Kinase and Their Implications for the Design of Selective Inhibitors

2004 • 60 citations

Regulated association between the tyrosine kinase Emt/Itk/Tsk and phospholipase-C gamma 1 in human T lymphocytes.

1999 • 60 citations

SHIP Family Inositol Phosphatases Interact with and Negatively Regulate the Tec Tyrosine Kinase

2004 • 58 citations

Tec protein‐tyrosine kinase is an effector molecule of Lyn proteni‐tyroenie kinase

1996 • 58 citations

A Role for the Tec Family Tyrosine Kinase Txk in T Cell Activation and Thymocyte Selection

1999 • 58 citations

Resting Lymphocyte Kinase (Rlk/Txk) Targets Lymphoid Adaptor SLP-76 in the Cooperative Activation of Interleukin-2 Transcription in T-cells

2000 • 58 citations

The SH3 domain of Bruton's tyrosine kinase displays altered ligand binding properties when auto‐phosphorylatedin vitro

1999 • 56 citations

Interaction between G Proteins and Tyrosine Kinases upon T Cell Receptor·CD3-mediated Signaling

1995 • 55 citations

Txk, a Member of Nonreceptor Tyrosine Kinase of Tec Family, Acts as a Th1 Cell-Specific Transcription Factor and Regulates IFN-γ Gene Transcription

2002 • 55 citations

Antiviral immune responses in Itk-deficient mice

1997 • 55 citations

An SH3-binding Site Conserved in Bruton's Tyrosine Kinase and Related Tyrosine Kinases Mediates Specific Protein Interactions in Vitro and in Vivo

1995 • 55 citations

Itk Negatively Regulates Induction of T Cell Proliferation by CD28 Costimulation

1997 • 52 citations

Defective immunoglobulin class switching in Vav-deficient mice is attributable to compromised T cell help

1999 • 49 citations

A novel human tyrosine kinase gene inducible in T cells by interleukin 2

1993 • 48 citations

Differential regulation of NFAT and SRF by the B cell receptor via a PLC -Ca2+-dependent pathway

2003 • 48 citations

Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk.

2001 • 47 citations

Phosphorylation of the Linker for Activation of T-Cells by Itk Promotes Recruitment of Vav

2002 • 45 citations

Tec and Jak2 Kinases Cooperate to Mediate Cytokine-Driven Activation of c-fos Transcription

1998 • 45 citations

Phosphatidylinositol 3-Kinase Is Required for CD28 But Not CD3 Regulation of the TEC Family Tyrosine Kinase EMT/ITK/TSK: Functional and Physical Interaction of EMT with Phosphatidylinositol 3-Kinase

1998 • 44 citations

The Solution Structure and Intramolecular Associations of the Tec Kinase Src Homology 3 Domain

2002 • 44 citations

Competing modes of self‐association in the regulatory domains of Bruton's tyrosine kinase: Intramolecular contact versus asymmetric homodimerization

2002 • 44 citations

Intermolecular interactions between the SH3 domain and the proline‐rich TH region of Bruton's tyrosine kinase

2001 • 44 citations

The SH3 domain of Bruton's tyrosine kinase displays altered ligand binding properties when auto-phosphorylatedin vitro

1999 • 44 citations

Activation and Association of the Tec Tyrosine Kinase with the Human Prolactin Receptor: Mapping of a Tec/Vav1-Receptor Binding Site

2001 • 43 citations

Murine txk: a protein tyrosine kinase gene regulated by T cell activation.

1995 • 43 citations

CD2 singnaling in T cells involves tyrosine phosphorylation and activation of the Tec family kinase, EMT/ITK/TSK

1996 • 42 citations

Crystal Structure and NMR Studies of the Apo SH2 Domains of ZAP-70: Two Bikes Rather than a Tandem

2002 • 42 citations

Pleckstrin Homology Domains of Tec Family Protein Kinases

1999 • 41 citations

Ligand Specificity Modulated by Prolyl Imide Bond Cis/Trans Isomerization in the Itk SH2 Domain: A Quantitative NMR Study

2003 • 41 citations

Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases

2003 • 41 citations

The proline rich region of the Tec homology domain of ITK regulates its activity

2002 • 41 citations

Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway

1999 • 41 citations

The role of G-proteins versus protein tyrosine kinases in the regulation of lymphocyte activation

1992 • 39 citations

Regulated Association Between the Tyrosine Kinase Emt/Itk/Tsk and Phospholipase-Cγ1 in Human T Lymphocytes

1999 • 38 citations

Differential Roles of Lck and Itk in T Cell Response to Antigen Recognition Revealed by Calcium Imaging and Electron Microscopy

2001 • 37 citations

Itk, a T cell-specific tyrosine kinase, is required for CD2-mediated interleukin-2 promoter activation in the human T cell line Jurkat.

1997 • 36 citations

Determinants of Intra versus Intermolecular Self-association Within the Regulatory Domains of Rlk and Itk

2003 • 33 citations

Nuclear localization of the tyrosine kinase Itk and interaction of its SH3 domain with karyopherin α (Rch1α)

2001 • 33 citations

Characterization of Itk Tyrosine Kinase: Contribution of Noncatalytic Domains to Enzymatic Activity

2001 • 33 citations

Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: Intramolecular contact versus asymmetric homodimerization

2002 • 33 citations

Mediation by the Protein-tyrosine Kinase Tec of Signaling between the B Cell Antigen Receptor and Dok-1

2000 • 31 citations

Efficient CD28 signalling leads to increases in the kinase activities of the TEC family tyrosine kinase EMT/ITK/TSK and the SRC family tyrosine kinase LCK

1998 • 26 citations

The SH3 domain of Tec kinase is essential for its targeting to activated CD28 costimulatory molecule

2004 • 25 citations

The Tec family of tyrosine kinases in T cells, amplifiers of T cell receptor signals

2002 • 25 citations

Solution structure of the human BTK SH3 domain complexed with a proline-rich peptide from p120cbl.

2000 • 23 citations

Deletion of Src Homology 3 Domain Results in Constitutive Activation of Tec Protein‐Tyrosine Kinase

1996 • 20 citations

Interaction between Btk TH and SH3 domain

2002 • 20 citations

CD2-mediated activation of the Tec-family tyrosine kinase ITK is controlled by proline-rich stretch-4 of the CD2 cytoplasmic tail

1998 • 18 citations

Role of the PHTH Module in Protein Substrate Recognition by Bruton's Agammaglobulinemia Tyrosine Kinase

2001 • 16 citations

Both proline‐rich sequences in the TH region of Bruton's tyrosine kinase stabilize intermolecular interactions with the SH3 domain

2001 • 15 citations

Evidence of Autophosphorylation in Txk: Y91 Is an Autophosphorylation Site.

2002 • 14 citations

Tec Kinase Migrates to the T Cell-APC Interface Independently of Its Pleckstrin Homology Domain

2004 • 14 citations

Splice variants of the mouse <i>Tec</i> gene are differentially expressed in vivo

1999 • 13 citations

Th1‐dominant shift of T cell cytokine production, and subsequent reduction of serum immunoglobulin E response by administration in vivo of plasmid expressing Txk/Rlk, a member of Tec family tyrosine kinases, in a mouse model

2004 • 12 citations

The murine form of TXK, a novel TEC kinase expressed in thymus maps to Chromosome 5

1995 • 11 citations

Functional analysis of the T-cell-restricted protein tyrosine kinase Txk

1998 • 8 citations