Epigenetic control in the immune response

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

1997 • 2,317 citations

The lineage decisions of helper T cells

2002 • 1,678 citations

A Critical Role for Dnmt1 and DNA Methylation in T Cell Development, Function, and Survival

2001 • 1,215 citations

Distinct Effects of T-bet in T _H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells

2002 • 1,169 citations

Molecular Mechanisms RegulatinG Th1 Immune Responses

2003 • 1,005 citations

T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

2002 • 985 citations

Helper T Cell Differentiation Is Controlled by the Cell Cycle

1998 • 862 citations

Role of T-bet in Commitment of T _H 1 Cells Before IL-12-Dependent Selection

2001 • 813 citations

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1998 • 800 citations

Identification of a Coordinate Regulator of Interleukins 4, 13, and 5 by Cross-Species Sequence Comparisons

2000 • 793 citations

Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development

2002 • 712 citations

Modulation of Chromatin Structure Regulates Cytokine Gene Expression during T Cell Differentiation

1998 • 697 citations

Stat6-Independent GATA-3 Autoactivation Directs IL-4-Independent Th2 Development and Commitment

2000 • 697 citations

Conditional deletion of Gata3 shows its essential function in TH1-TH2 responses

2004 • 625 citations

TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes

2002 • 517 citations

Early Transcription and Silencing of Cytokine Genes Underlie Polarization of T Helper Cell Subsets

2001 • 498 citations

An epigenetic view of helper T cell differentiation

2003 • 429 citations

Long-range intrachromosomal interactions in the T helper type 2 cytokine locus

2004 • 421 citations

Gata-3 Induces T Helper Cell Type 2 (Th2) Cytokine Expression and Chromatin Remodeling in Committed Th1 Cells

2000 • 390 citations

Memory and flexibility of cytokine gene expression as separable properties of human TH1 and TH2 lymphocytes

2002 • 353 citations

GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells

2004 • 339 citations

Th2 Lineage Commitment and Efficient IL-4 Production Involves Extended Demethylation of the IL-4 Gene

2002 • 328 citations

Cutting Edge: Changes in Histone Acetylation at the IL-4 and IFN-γ Loci Accompany Th1/Th2 Differentiation

2002 • 326 citations

Hlx is induced by and genetically interacts with T-bet to promote heritable TH1 gene induction

2002 • 304 citations

Cell-Type-Restricted Binding of the Transcription Factor NFAT to a Distal IL-4 Enhancer In Vivo

2000 • 270 citations

Signaling pathways in Th2 development

2004 • 258 citations

Independent and Epigenetic Regulation of the Interleukin-4 Alleles in CD4 ⁺ T Cells

1998 • 250 citations

Transcription

2002 • 241 citations

Regulation of IL-4 Gene Expression by Distal Regulatory Elements and GATA-3 at the Chromatin Level

2001 • 234 citations

Regulation of the Th2 Cytokine Locus by a Locus Control Region

2003 • 222 citations

Gene Silencing Quantitatively Controls the Function of a Developmental trans-Activator

2002 • 204 citations

Identification of a Conserved GATA3 Response Element Upstream Proximal from the Interleukin-13 Gene Locus

2002 • 194 citations

Instruction for Cytokine Expression in T Helper Lymphocytes in Relation to Proliferation and Cell Cycle Progression

1999 • 190 citations

Th2-Specific Chromatin Remodeling and Enhancer Activity in the Th2 Cytokine Locus Control Region

2004 • 188 citations

Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage

2001 • 172 citations

Regulation of IL-4 Expression by Activation of Individual Alleles

1998 • 170 citations

Essential Role of GATA3 for the Maintenance of Type 2 Helper T (Th2) Cytokine Production and Chromatin Remodeling at the Th2 Cytokine Gene Loci

2004 • 160 citations

Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions

2004 • 152 citations

Cutting Edge: Chromatin Remodeling at the IL-4/IL-13 Intergenic Regulatory Region for Th2-Specific Cytokine Gene Cluster

2000 • 152 citations

Active recruitment of DNA methyltransferases regulates interleukin 4 in thymocytes and T cells

2003 • 145 citations

Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region.

1998 • 139 citations

A Distal Enhancer in the Interferon-γ (IFN-γ) Locus Revealed by Genome Sequence Comparison

2004 • 137 citations

Evolutionarily conserved sequence elements that positively regulate IFN-γ expression in T cells

2004 • 134 citations

Dynamic assembly of silent chromatin during thymocyte maturation

2004 • 132 citations

Nuclear repositioning marks the selective exclusion of lineage‐inappropriate transcription factor loci during T helper cell differentiation

2004 • 125 citations

DNA Methylation Is a Nonredundant Repressor of the Th2 Effector Program

2004 • 123 citations

Evidence for Distinct CD4 Silencer Functions at Different Stages of Thymocyte Differentiation

2002 • 116 citations

Deletion of a conserved Il4 silencer impairs T helper type 1–mediated immunity

2004 • 114 citations

Chromatin landscape dynamics of theIl4–Il13locus during T helper 1 and 2 development

2004 • 96 citations

Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: A target for STAT6 but not GATA3

2004 • 94 citations

A stepwise epigenetic process controls immunoglobulin allelic exclusion

2004 • 84 citations

Cutting Edge: The Differential Involvement of the N-Finger of GATA-3 in Chromatin Remodeling and Transactivation During Th2 Development

2002 • 69 citations

Cell cycle controlling the silencing and functioning of mammalian activators

2001 • 67 citations

Identification of cooperative monomeric Brachyury sites conferring T-bet responsiveness to the proximal IFN- promoter

2003 • 62 citations

Dynamic alterations in the conformation of the Ifng gene region during T helper cell differentiation

2003 • 59 citations

Up-Regulation of Hlx in Immature Th Cells Induces IFN-γ Expression

2004 • 51 citations

Centromeric Repositioning of Coreceptor Loci Predicts Their Stable Silencing and the CD4/CD8 Lineage Choice

2004 • 43 citations

The CD4⧸CD8 Lineage Choice: New Insights into Epigenetic Regulation during T Cell Development

2004 • 41 citations

Basal Chromatin Modification at the IL-4 Gene in Helper T Cells

2003 • 36 citations

Dynamic Repositioning of CD4 and CD8 Genes during T Cell Development

2004 • 33 citations

Immunity and the Animation of the Genome

2003 • 4 citations