An epigenetic view of helper T cell differentiation

Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing

2002 • 3,546 citations

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

2001 • 2,768 citations

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

2001 • 2,746 citations

Methylation-Induced Repression— Belts, Braces, and Chromatin

1999 • 1,823 citations

The lineage decisions of helper T cells

2002 • 1,678 citations

Histone Methyltransferase Activity of a Drosophila Polycomb Group Repressor Complex

2002 • 1,515 citations

Drosophila Enhancer of Zeste/ESC Complexes Have a Histone H3 Methyltransferase Activity that Marks Chromosomal Polycomb Sites

2002 • 1,494 citations

Looping and Interaction between Hypersensitive Sites in the Active β-globin Locus

2002 • 1,322 citations

NUCLEASE HYPERSENSITIVE SITES IN CHROMATIN

1988 • 1,233 citations

A Critical Role for Dnmt1 and DNA Methylation in T Cell Development, Function, and Survival

2001 • 1,215 citations

Histone and chromatin cross-talk

2003 • 1,187 citations

Distinct Effects of T-bet in T _H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells

2002 • 1,169 citations

Cellular Memory and the Histone Code

2002 • 1,137 citations

The Histone Variant H3.3 Marks Active Chromatin by Replication-Independent Nucleosome Assembly

2002 • 1,088 citations

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

1997 • 1,022 citations

A histone H3 methyltransferase controls DNA methylation in Neurospora crassa

2001 • 997 citations

T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

2002 • 985 citations

Establishment and Maintenance of a Heterochromatin Domain

2002 • 895 citations

Helper T Cell Differentiation Is Controlled by the Cell Cycle

1998 • 862 citations

Role of T-bet in Commitment of T _H 1 Cells Before IL-12-Dependent Selection

2001 • 813 citations

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1998 • 800 citations

Identification of a Coordinate Regulator of Interleukins 4, 13, and 5 by Cross-Species Sequence Comparisons

2000 • 793 citations

Transitions in Distinct Histone H3 Methylation Patterns at the Heterochromatin Domain Boundaries

2001 • 746 citations

T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells

2001 • 743 citations

Rapid and Phosphoinositol-Dependent Binding of the SWI/SNF-like BAF Complex to Chromatin after T Lymphocyte Receptor Signaling

1998 • 719 citations

Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development

2002 • 712 citations

Subnuclear Compartmentalization of Immunoglobulin Loci During Lymphocyte Development

2002 • 708 citations

Stat6-Independent GATA-3 Autoactivation Directs IL-4-Independent Th2 Development and Commitment

2000 • 697 citations

Modulation of Chromatin Structure Regulates Cytokine Gene Expression during T Cell Differentiation

1998 • 697 citations

The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4

1996 • 677 citations

Long-range chromatin regulatory interactions in vivo

2002 • 651 citations

Lineage commitment in the immune system: the T helper lymphocyte grows up

2000 • 627 citations

Correlation Between Histone Lysine Methylation and Developmental Changes at the Chicken β-Globin Locus

2001 • 582 citations

A computational analysis of whole-genome expression data reveals chromosomal domains of gene expression

2000 • 532 citations

TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes

2002 • 517 citations

Early Transcription and Silencing of Cytokine Genes Underlie Polarization of T Helper Cell Subsets

2001 • 498 citations

Interphase chromosomes in Arabidopsis are organized as well defined chromocenters from which euchromatin loops emanate

2002 • 446 citations

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

1994 • 418 citations

NFATc1 and NFATc2 Together Control Both T and B Cell Activation and Differentiation

2001 • 397 citations

Gata-3 Induces T Helper Cell Type 2 (Th2) Cytokine Expression and Chromatin Remodeling in Committed Th1 Cells

2000 • 390 citations

Genomic strategies to identify mammalian regulatory sequences

2001 • 389 citations

Memory and flexibility of cytokine gene expression as separable properties of human TH1 and TH2 lymphocytes

2002 • 353 citations

Regulation of Chromatin Remodeling by Inositol Polyphosphates

2003 • 349 citations

Polycomb, Epigenomes, and Control of Cell Identity

2003 • 343 citations

Modulation of ATP-Dependent Chromatin-Remodeling Complexes by Inositol Polyphosphates

2003 • 336 citations

Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation

1998 • 332 citations

Th2 Lineage Commitment and Efficient IL-4 Production Involves Extended Demethylation of the IL-4 Gene

2002 • 328 citations

Cutting Edge: Changes in Histone Acetylation at the IL-4 and IFN-γ Loci Accompany Th1/Th2 Differentiation

2002 • 326 citations

Inhibitory Function of Two NFAT Family Members in Lymphoid Homeostasis and Th2 Development

1998 • 325 citations

Large clusters of co-expressed genes in the Drosophila genome

2002 • 322 citations

Hlx is induced by and genetically interacts with T-bet to promote heritable TH1 gene induction

2002 • 304 citations

Modulation of Heterochromatin Protein 1 Dynamics in Primary Mammalian Cells

2003 • 289 citations

Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype.

1994 • 282 citations

Cell-Type-Restricted Binding of the Transcription Factor NFAT to a Distal IL-4 Enhancer In Vivo

2000 • 270 citations

Pax5/BSAP Maintains the Identity of B Cells in Late B Lymphopoiesis

2001 • 246 citations

Transcriptional Regulation of Mammalian Genes in Vivo

1997 • 244 citations

Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes

2002 • 244 citations

Regulation of IL-4 Gene Expression by Distal Regulatory Elements and GATA-3 at the Chromatin Level

2001 • 234 citations

Gene Silencing Quantitatively Controls the Function of a Developmental trans-Activator

2002 • 204 citations

Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4.

1993 • 201 citations

Deletion of a coordinate regulator of type 2 cytokine expression in mice

2001 • 196 citations

Identification of a Conserved GATA3 Response Element Upstream Proximal from the Interleukin-13 Gene Locus

2002 • 194 citations

Instruction for Cytokine Expression in T Helper Lymphocytes in Relation to Proliferation and Cell Cycle Progression

1999 • 190 citations

Cytokine Coexpression During Human Th1/Th2 Cell Differentiation: Direct Evidence for Coordinated Expression of Th2 Cytokines

2002 • 183 citations

Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage

2001 • 172 citations

Establishment of transcriptional competence in early and late S phase

2002 • 172 citations

Chromatin Structure and Gene Regulation in the Immune System

2002 • 163 citations

Transcriptional control of B-cell development

2002 • 161 citations

NFATc2 and NFATc3 regulate TH2 differentiation and modulate TCR-responsiveness of naïve TH cells

2001 • 158 citations

A transcriptional silencer controls the developmental expression of the CD4 gene.

1994 • 156 citations

Cutting Edge: Chromatin Remodeling at the IL-4/IL-13 Intergenic Regulatory Region for Th2-Specific Cytokine Gene Cluster

2000 • 152 citations

Activation by locus control regions?

1999 • 144 citations

Coordinate Regulation of the IL-4, IL-13, and IL-5 Cytokine Cluster in Th2 Clones Revealed by Allelic Expression Patterns

2000 • 139 citations

ROG, Repressor of GATA, Regulates the Expression of Cytokine Genes

2000 • 139 citations

Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region.

1998 • 139 citations

The Potency of TCR Signaling Differentially Regulates NFATc/p Activity and Early IL-4 Transcription in Naive CD4+ T Cells

2002 • 136 citations

The Roles of Nuclear Factor of Activated T Cells and Ying-Yang 1 in Activation-induced Expression of the Interferon-γ Promoter in T Cells

1998 • 128 citations

T helper cell differentiation: on again, off again

2002 • 121 citations

A 3′ Enhancer in the IL-4 Gene Regulates Cytokine Production by Th2 Cells and Mast Cells

2002 • 117 citations

Evidence for Distinct CD4 Silencer Functions at Different Stages of Thymocyte Differentiation

2002 • 116 citations

Regulation of Th2 Cell Differentiation by mel-18, a Mammalian Polycomb Group Gene

2001 • 115 citations

In Vivo Priming of Cd4 T Cells That Produce Interleukin (Il)-2 but Not IL-4 or Interferon (Ifn)-γ, and Can Subsequently Differentiate into IL-4–Or IFN-γ–Secreting Cells

2001 • 113 citations

Multiple Developmental Stage–Specific Enhancers Regulate CD8 Expression in Developing Thymocytes and in Thymus-Independent T Cells

1998 • 107 citations

Friend of GATA-1 Represses GATA-3–dependent Activity in CD4+ T Cells

2001 • 86 citations

In TH2 cells theIl4gene has a series of accessibility states associated with distinctive probabilities of IL-4 production

2002 • 82 citations

Cutting Edge: Identification of an Alternative GATA-3 Promoter Directing Tissue-Specific Gene Expression in Mouse and Human

2002 • 82 citations

T cell differentiation: a mechanistic view

2000 • 77 citations

A Region in the CD8 Gene Locus That Directs Expression to the Mature CD8 T Cell Subset in Transgenic Mice

1997 • 75 citations

Cell Division Is Not a “Clock” Measuring Acquisition of Competence to Produce IFN-γ or IL-4

2001 • 74 citations

A New Regulatory Region of the IL-2 Locus That Confers Position-Independent Transgene Expression

2001 • 73 citations

Regulation of IL‐4 production in mast cells: a paradigm for cell‐type‐specific gene expression

2001 • 63 citations

X-chromosome inactivation and the search for chromosome-wide silencers

2002 • 62 citations

Friend of GATA Is Expressed in Naive Th Cells and Functions As a Repressor of GATA-3-Mediated Th2 Cell Development

2002 • 53 citations

Yin-Yang 1 Activates Interleukin-4 Gene Expression in T Cells

2001 • 50 citations

Hierarchical Interactions Control CD4 Gene Expression during Thymocyte Development

2003 • 44 citations

The Human IL-3 Locus Is Regulated Cooperatively by Two NFAT-Dependent Enhancers That Have Distinct Tissue-Specific Activities

2002 • 39 citations

Intergenic Transcription Occurs throughout the Human IL-4/IL-13 Gene Cluster

1999 • 27 citations

Molecular regulation of CC-chemokine receptor 3 expression in human T helper 2 cells

2001 • 26 citations