The four Rs of RNA-directed evolution

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

The nuclear RNase III Drosha initiates microRNA processing

2003 • 4,966 citations

Ontogeny and Phylogeny

1977 • 3,887 citations

RNA interference

2002 • 3,369 citations

RNAi

2000 • 2,596 citations

Mechanisms of Alternative Pre-Messenger RNA Splicing

2003 • 2,547 citations

Selfish DNA: the ultimate parasite

1980 • 2,095 citations

The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes

2003 • 2,079 citations

A microRNA in a Multiple-Turnover RNAi Enzyme Complex

2002 • 2,052 citations

Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi

2002 • 2,040 citations

Gene Regulation for Higher Cells: A Theory

1969 • 2,022 citations

Transposable Elements: Targets for Early Nutritional Effects on Epigenetic Gene Regulation

2003 • 1,970 citations

Fetal origins of adult disease: strength of effects and biological basis

2002 • 1,965 citations

Searching for genetic determinants in the new millennium

2000 • 1,878 citations

Role of MicroRNAs in Plant and Animal Development

2003 • 1,765 citations

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

2002 • 1,566 citations

Whole-Genome Shotgun Assembly and Analysis of the Genome of Fugu rubripes

2002 • 1,560 citations

Drosophila Enhancer of Zeste/ESC Complexes Have a Histone H3 Methyltransferase Activity that Marks Chromosomal Polycomb Sites

2002 • 1,494 citations

Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation

2002 • 1,426 citations

Single-Stranded Antisense siRNAs Guide Target RNA Cleavage in RNAi

2002 • 1,422 citations

RNA Editing by Adenosine Deaminases That Act on RNA

2002 • 1,203 citations

Vertebrate MicroRNA Genes

2003 • 1,190 citations

Epigenetic reprogramming in mouse primordial germ cells

2002 • 1,159 citations

Arabidopsis SGS2 and SGS3 Genes Are Required for Posttranscriptional Gene Silencing and Natural Virus Resistance

2000 • 1,082 citations

ARGONAUTE4 Control of Locus-Specific siRNA Accumulation and DNA and Histone Methylation

2003 • 1,041 citations

The non-coding Air RNA is required for silencing autosomal imprinted genes

2002 • 1,040 citations

Two classes of short interfering RNA in RNA silencing

2002 • 1,022 citations

The antiquity of RNA-based evolution

2002 • 1,000 citations

Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice.

1998 • 964 citations

Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains

2003 • 961 citations

Establishment and Maintenance of a Heterochromatin Domain

2002 • 895 citations

New microRNAs from mouse and human

2003 • 881 citations

The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis

2002 • 874 citations

Maternal epigenetics and methyl supplements affectagoutigene expression inA^vy/amice

1998 • 851 citations

Non‐coding RNAs: the architects of eukaryotic complexity

2001 • 815 citations

7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes

2001 • 680 citations

The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription

2001 • 670 citations

Widespread occurrence of antisense transcription in the human genome

2003 • 655 citations

Transgenerational inheritance of epigenetic states at the murine Axin ^Fu allele occurs after maternal and paternal transmission

2003 • 621 citations

Analysis of a piwi-Related Gene Implicates Small RNAs in Genome Rearrangement in Tetrahymena

2002 • 594 citations

Origin of a substantial fraction of human regulatory sequences from transposable elements

2003 • 575 citations

EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans

2000 • 546 citations

Metastable epialleles in mammals

2002 • 496 citations

SURVEY AND SUMMARY Transcription by RNA polymerases I and III

2000 • 491 citations

Evidence that siRNAs Function as Guides, Not Primers, in the Drosophila and Human RNAi Pathways

2002 • 473 citations

The Fate of dsRNA in the Nucleus

2001 • 470 citations

A micrococcal nuclease homologue in RNAi effector complexes

2003 • 451 citations

An Alu Transposition Model for the Origin and Expansion of Human Segmental Duplications

2003 • 432 citations

Male Germ Cell Gene Expression

2002 • 411 citations

mRNA of placental origin is readily detectable in maternal plasma

2003 • 391 citations

RNAi Related Mechanisms Affect Both Transcriptional and Posttranscriptional Transgene Silencing in Drosophila

2002 • 383 citations

Numerous microRNPs in neuronal cells containing novel microRNAs

2003 • 378 citations

Chromodomains are protein–RNA interaction modules

2000 • 374 citations

Retrotransposons as epigenetic mediators of phenotypic variation in mammals

2001 • 339 citations

Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene

2003 • 335 citations

Quality Control of mRNA Function

2001 • 326 citations

Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and Broad-Complex gene activity

2003 • 316 citations

RNA interference machinery regulates chromosome dynamics during mitosis and meiosis in fission yeast

2002 • 315 citations

Hairpin RNAs and Retrotransposon LTRs Effect RNAi and Chromatin-Based Gene Silencing

2003 • 314 citations

The Role of the Placenta in Fetal Programming—A Review

2002 • 291 citations

Prader-Willi and Angelman syndromes: Sister imprinted disorders

2000 • 291 citations

Genomewide view of gene silencing by small interfering RNAs

2003 • 287 citations

Germline development in vertebrates and invertebrates

1999 • 274 citations

Disruption of Imprinted X Inactivation by Parent-of-Origin Effects at Tsix

2000 • 271 citations

RNA-directed DNA methylation.

2000 • 258 citations

Antisense Transcripts With FANTOM2 Clone Set and Their Implications for Gene Regulation

2003 • 254 citations

U1 snRNA associates with TFIIH and regulates transcriptional initiation

2002 • 253 citations

Absence of transitive and systemic pathways allows cell-specific and isoform-specific RNAi in Drosophila

2003 • 246 citations

Antisense transcripts in the human genome

2002 • 242 citations

General transcription factors bind promoters repressed by Polycomb group proteins

2001 • 240 citations

Telomere dysfunction and the initiation of genome instability

2003 • 212 citations

The rox1 and rox2 RNAs Are Essential Components of the Compensasome, which Mediates Dosage Compensation in Drosophila

1999 • 202 citations

Nuclear antisense RNA induces extensive adenosine modifications and nuclear retention of target transcripts

1997 • 196 citations

Impact of Alternative Initiation, Splicing, and Termination on the Diversity of the mRNA Transcripts Encoded by the Mouse Transcriptome

2003 • 189 citations

Programmed DNA Deletion As an RNA-Guided System of Genome Defense

2003 • 185 citations

Pdd1p, A Novel Chromodomain-Containing Protein, Links Heterochromatin Assembly and DNA Elimination in Tetrahymena

1996 • 183 citations

The balance sheet for transcription: an analysis of nuclear RNA metabolism in mammalian cells

2000 • 169 citations

Distinct RNA motifs are important for coactivation of steroid hormone receptors by steroid receptor RNA activator (SRA)

2002 • 164 citations

A Low Number Wins the GeneSweep Pool

2003 • 150 citations

Transcription through Intergenic Chromosomal Memory Elements of the Drosophila Bithorax Complex Correlates with an Epigenetic Switch

2002 • 147 citations

Posttranscriptional Gene Silencing Is Not Compromised in the Arabidopsis CARPEL FACTORY (DICER-LIKE1) Mutant, a Homolog of Dicer-1 from Drosophila

2003 • 146 citations

Identification of Putative Noncoding RNAs Among the RIKEN Mouse Full-Length cDNA Collection

2003 • 145 citations

Mechanisms of Retroviral Recombination

2001 • 143 citations

The contribution of RNAs and retroposition to evolutionary novelties.

2003 • 138 citations

The Role of RNA Editing by ADARs in RNAi

2002 • 138 citations

Post-transcriptional Regulation of Thyroid Hormone Receptor Expression by cis-Acting Sequences and a Naturally Occurring Antisense RNA

2000 • 135 citations

The non-coding RNAs as riboregulators

2001 • 134 citations

Species Differences in TSIX/Tsix Reveal the Roles of These Genes in X-Chromosome Inactivation

2002 • 130 citations

Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis

2003 • 126 citations

RNAi: Mammalian oocytes do it without RNA-dependent RNA polymerase

2003 • 125 citations

Discovery of Imprinted Transcripts in the Mouse Transcriptome Using Large-Scale Expression Profiling

2003 • 106 citations

Role of Antisense RNA in Coordinating Cardiac Myosin Heavy Chain Gene Switching

2003 • 99 citations

RNA processing and the evolution of eukaryotes

1999 • 97 citations

Transcription defines the embryonic domains of cis-regulatory activity at the Drosophila bithorax complex

2002 • 94 citations

Family-centered approaches to understanding and preventing coronary heart disease

2003 • 91 citations

Molecular Basis of the Pleiotropic Phenotype of Mice Carrying the hypervariable yellow (Ahvy) Mutation at the agouti Locus

1996 • 79 citations

Antisense-mediated redirection of mRNA splicing

2003 • 53 citations

The AROM Gene, Spliced mRNAs Encoding New DNA/RNA-binding Proteins Are Transcribed from the Opposite Strand of the Melanin-concentrating Hormone Gene in Mammals

2000 • 47 citations

RNA binding and intramolecular interactions modulate the regulation of gene expression by nuclear factor 110

2003 • 45 citations

RNA editing, introns and evolution

1996 • 45 citations

Rewriting the information in DNA: RNA editing in kinetoplastids and myxomycetes

2002 • 33 citations

Deleted Work

1955 • 0 citations