Dendritic-cell control of pathogen-driven T-cell polarization

Dendritic cells and the control of immunity

1998 • 14,345 citations

Innate Immune Recognition

2002 • 8,157 citations

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

2001 • 5,893 citations

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Toll-like receptors: critical proteins linking innate and acquired immunity

2001 • 4,673 citations

Interleukin-12 and the regulation of innate resistance and adaptive immunity

2003 • 3,689 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Approaching the Asymptote? Evolution and Revolution in Immunology

1989 • 3,079 citations

Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

2002 • 2,438 citations

Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP

2002 • 2,037 citations

Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens

2001 • 1,989 citations

Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation

1999 • 1,912 citations

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

2002 • 1,733 citations

Host Defense Mechanisms Triggered by Microbial Lipoproteins Through Toll-Like Receptors

1999 • 1,679 citations

Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2

2003 • 1,593 citations

CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

1998 • 1,546 citations

The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens

1999 • 1,381 citations

Toll-like receptors control activation of adaptive immune responses

2001 • 1,374 citations

Natural versus adaptive regulatory T cells

2003 • 1,363 citations

Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins

2002 • 1,309 citations

Induction of tolerance by IL-10-treated dendritic cells.

1997 • 1,263 citations

Cutting Edge: Recognition of Gram-Positive Bacterial Cell Wall Components by the Innate Immune System Occurs Via Toll-Like Receptor 2

1999 • 1,252 citations

Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling

2002 • 1,228 citations

The Enigmatic Plasmacytoid T Cells Develop into Dendritic Cells with Interleukin (IL)-3 and CD40-Ligand

1997 • 1,224 citations

Discrimination of bacterial lipoproteins by Toll-like receptor 6

2001 • 1,222 citations

Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen

2001 • 1,212 citations

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction

2003 • 1,203 citations

Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells

2000 • 1,175 citations

Lipopolysaccharide-enhanced, Toll-like Receptor 4–dependent T Helper Cell Type 2 Responses to Inhaled Antigen

2002 • 1,172 citations

Mycobacteria Target DC-SIGN to Suppress Dendritic Cell Function

2002 • 1,037 citations

Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology

2001 • 1,017 citations

Distinct dendritic cell subsets differentially regulate the class of immune responseinvivo

1999 • 1,013 citations

CD8α+ and CD8α− Subclasses of Dendritic Cells Direct the Development of Distinct T Helper Cells In Vivo

1999 • 998 citations

T-cell priming by type-1and type-2 polarized dendritic cells: the concept of a third signal

1999 • 957 citations

Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity

2000 • 867 citations

IRF3 Mediates a TLR3/TLR4-Specific Antiviral Gene Program

2002 • 844 citations

CD4 and CD8 Expression by Dendritic Cell Subtypes in Mouse Thymus and Spleen

2000 • 812 citations

Characterization of Dendritic Cells that Induce Tolerance and T Regulatory 1 Cell Differentiation In Vivo

2003 • 811 citations

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

2002 • 803 citations

Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12

2001 • 798 citations

Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells

2001 • 792 citations

Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells.

1996 • 788 citations

Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni.

1991 • 777 citations

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.

1995 • 768 citations

Impaired response to interferon-α/β and lethal viral disease in human STAT1 deficiency

2003 • 763 citations

The Plasticity of Dendritic Cell Responses to Pathogens and Their Components

2001 • 760 citations

An innate sense of danger

1998 • 752 citations

Characterization of human blood dendritic cell subsets

2002 • 739 citations

Maturation, Activation, and Protection of Dendritic Cells Induced by Double-stranded RNA

1999 • 727 citations

Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells.

1995 • 699 citations

Toll-like Receptor 2 (TLR2) and TLR4 Differentially Activate Human Dendritic Cells

2001 • 693 citations

Pathogen-specific T Regulatory 1 Cells Induced in the Respiratory Tract by a Bacterial Molecule that Stimulates Interleukin 10 Production by Dendritic Cells

2002 • 632 citations

DC-SIGN Is the Major Mycobacterium tuberculosis Receptor on Human Dendritic Cells

2002 • 620 citations

A Novel Host-Parasite Lipid Cross-talk

2002 • 587 citations

Cutting Edge: Preferentially the R-Stereoisomer of the Mycoplasmal Lipopeptide Macrophage-Activating Lipopeptide-2 Activates Immune Cells Through a Toll-Like Receptor 2- and MyD88-Dependent Signaling Pathway

2000 • 584 citations

Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7

2003 • 578 citations

Flexibility of Mouse Classical and Plasmacytoid-derived Dendritic Cells in Directing T Helper Type 1 and 2 Cell Development

2003 • 561 citations

CD40 Triggering of Heterodimeric IL-12 p70 Production by Dendritic Cells In Vivo Requires a Microbial Priming Signal

2000 • 558 citations

Toll‐like receptor expression in murine DC subsets: lack of TLR7 expression by CD8α⁺ DC correlates with unresponsiveness to imidazoquinolines

2003 • 544 citations

Development of Th1-Inducing Capacity in Myeloid Dendritic Cells Requires Environmental Instruction

2000 • 514 citations

Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation

2000 • 513 citations

Microbial Compounds Selectively Induce Th1 Cell-Promoting or Th2 Cell-Promoting Dendritic Cells In Vitro with Diverse Th Cell-Polarizing Signals

2002 • 507 citations

Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses

2002 • 495 citations

Lipopolysaccharides from Distinct Pathogens Induce Different Classes of Immune Responses In Vivo

2001 • 485 citations

The Dendritic Cell Populations of Mouse Lymph Nodes

2001 • 461 citations

Interferon-α and Interleukin-12 Are Induced Differentially by Toll-like Receptor 7 Ligands in Human Blood Dendritic Cell Subsets

2002 • 461 citations

Evasion of innate immunity by parasitic protozoa

2002 • 429 citations

High-level IL-12 production by human dendritic cells requires two signals

1998 • 424 citations

Unique Functions of CD11b+, CD8α+, and Double-Negative Peyer’s Patch Dendritic Cells

2001 • 408 citations

Prostaglandin E2 Induces the Final Maturation of IL-12-Deficient CD1a+CD83+ Dendritic Cells: The Levels of IL-12 Are Determined During the Final Dendritic Cell Maturation and Are Resistant to Further Modulation

1998 • 379 citations

Inhibition of dendritic cell maturation by herpes simplex virus

1999 • 369 citations

The C‐type lectin DC‐SIGN (CD209) is an antigen‐uptake receptor for Candida albicans on dendritic cells

2003 • 365 citations

CCR5 provides a signal for microbial induced production of IL-12 by CD8α+ dendritic cells

2000 • 340 citations

Yersinia V–Antigen Exploits Toll-like Receptor 2 and CD14 for Interleukin 10–mediated Immunosuppression

2002 • 336 citations

A Filarial Nematode-Secreted Product Signals Dendritic Cells to Acquire a Phenotype That Drives Development of Th2 Cells

2000 • 335 citations

IL-12 and IFN-γ in host defense against mycobacteria and salmonella in mice and men

1999 • 333 citations

Regulatory Dendritic Cells Protect Mice from Murine Acute Graft-versus-Host Disease and Leukemia Relapse

2003 • 326 citations

Human Dendritic Cells Require Exogenous Interleukin-12–Inducing Factors to Direct the Development of Naive T-Helper Cells Toward the Th1 Phenotype

1997 • 302 citations

Mice Lacking Bioactive IL-12 Can Generate Protective, Antigen-Specific Cellular Responses to Mycobacterial Infection Only if the IL-12 p40 Subunit Is Present

2002 • 300 citations

CD8− Dendritic Cell Activation Status Plays an Integral Role in Influencing Th2 Response Development

2001 • 287 citations

Accumulation of Immature Langerhans Cells in Human Lymph Nodes Draining Chronically Inflamed Skin

2002 • 274 citations

Hepatitis C Virus Core and Nonstructural Protein 3 Proteins Induce Pro- and Anti-inflammatory Cytokines and Inhibit Dendritic Cell Differentiation

2003 • 254 citations

Histamine Polarizes Human Dendritic Cells into Th2 Cell-Promoting Effector Dendritic Cells

2001 • 248 citations

OX40 Costimulation Enhances Interleukin-4 (IL-4) Expression at Priming and Promotes the Differentiation of Naive Human CD4+ T Cells Into High IL-4–Producing Effectors

1998 • 247 citations

B7/CD28-Dependent CD4+CD25+ Regulatory T Cells Are Essential Components of the Memory-Protective Immunity to Candida albicans

2002 • 236 citations

Human cytomegalovirus inhibits maturation and impairs function of monocyte-derived dendritic cells

2002 • 232 citations

Mucosal CD8α⁺ DC, with a plasmacytoid phenotype, induce differentiation and support function of T cells with regulatory properties

2003 • 231 citations

Microbial Recognition Via Toll-Like Receptor-Dependent and -Independent Pathways Determines the Cytokine Response of Murine Dendritic Cell Subsets to CD40 Triggering

2002 • 231 citations

Cytokines Regulate the Capacity of CD8α+ and CD8α− Dendritic Cells to Prime Th1/Th2 Cells In Vivo

2001 • 222 citations

How dendritic cells and microbes interact to elicit or subvert protective immune responses

2002 • 221 citations

Lacto-N-fucopentaose III Found on Schitosoma mansoni Egg Antigens Functions as Adjuvant for Proteins by Inducing Th2-Type Response

2001 • 212 citations

The other side of the coin: The protective role of the TH2 cytokines

2001 • 202 citations

Endotoxin can induce MyD88-deficient dendritic cells to support Th2 cell differentiation

2002 • 199 citations

LFA-1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production.

1998 • 197 citations

Helper T cells regulate type-2 innate immunity in vivo

2002 • 195 citations

Induction of CD4+ T cell alloantigen-specific hyporesponsiveness by IL-10 and TGF-beta.

1999 • 195 citations

OX40 Costimulation Enhances Interleukin-4 (IL-4) Expression at Priming and Promotes the Differentiation of Naive Human CD4+ T Cells Into High IL-4–Producing Effectors

1998 • 181 citations

The Role of Dendritic Cells, B Cells, and M Cells in Gut-Oriented Immune Responses

2001 • 171 citations

Selective Suppression of IL-12 Production by Chemoattractants

2000 • 169 citations

Induction of IL-4-producing CD4+ T cells by antigenic peptides altered for TCR binding.

1997 • 163 citations

Cutting Edge: LFA-1 Interaction with ICAM-1 and ICAM-2 Regulates Th2 Cytokine Production

1998 • 160 citations

CD40 Ligation Conditions Dendritic Cell Antigen-Presenting Function Through Sustained Activation of NF-κB

2002 • 157 citations

Induction of CD4+ T Cell Alloantigen-Specific Hyporesponsiveness by IL-10 and TGF-β

1999 • 154 citations

Mice Lacking IL-12 Develop Polarized Th1 Cells During Viral Infection

1998 • 149 citations

Maturation of Human Monocyte-Derived Dendritic Cells Studied by Microarray Hybridization

2000 • 144 citations

On the Role of Dendritic Cells in Peripheral T Cell Tolerance and Modulation of Autoimmunity

2002 • 140 citations

Transcriptional reprogramming of dendritic cells by differentiation stimuli

2001 • 135 citations

IFN‐α enhances CD40 ligand‐mediated activation of immature monocyte‐derived dendritic cells

2002 • 129 citations

Differential Induction of Interleukin-10 and Interleukin-12 in Dendritic Cells by Microbial Toll-Like Receptor Activators and Skewing of T-Cell Cytokine Profiles

2003 • 128 citations

Cell activation by Porphyromonas gingivalis lipid A molecule through Toll-like receptor 4- and myeloid differentiation factor 88-dependent signaling pathway

2002 • 127 citations

The ability of murine dendritic cell subsets to direct T helper cell differentiation is dependent on microbial signals

2002 • 120 citations

Immune escape through C-type lectins on dendritic cells

2002 • 118 citations

Intercellular Adhesion Molecule-1/LFA-1 Ligation Favors Human Th1 Development

2002 • 118 citations

Malaria, monocytes, macrophages and myeloid dendritic cells: sticking of infected erythrocytes switches off host cells

2002 • 98 citations

Double-Stranded RNA-Exposed Human Keratinocytes Promote Th1 Responses by Inducing a Type-1 Polarized Phenotype in Dendritic Cells: Role of Keratinocyte-Derived Tumor Necrosis Factor α, Type I Interferons, and Interleukin-18

2003 • 92 citations

Analysis of Immunomodulatory Activities of Aqueous Humor from Eyes of Mice with Experimental Autoimmune Uveitis

2000 • 88 citations

Cell-type and Donor-specific Transcriptional Responses to Interferon-α

2002 • 80 citations

Synthetic mycoplasma-derived lipopeptide MALP-2 induces maturation and function of dendritic cells

2003 • 65 citations

A Simple, Conservative Explanation of the H‐2 Restriction of Interactions Between Lymphocytes

1977 • 55 citations

CTL-Mediated Killing of IntracellularMycobacterium tuberculosisIs Independent of Target Cell Nuclear Apoptosis

2000 • 43 citations

Conditioning of Dendritic Cells by Pathogen-Derived Stimuli

2001 • 10 citations