Genetic Regulation of Commitment to Interleukin 4 Production by a CD4+ T Cell–intrinsic Mechanism

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

1995 • 5,291 citations

Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.

1989 • 5,285 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Precision mapping of quantitative trait loci.

1994 • 3,191 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

1997 • 2,317 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Stochastic mechanisms in gene expression

1997 • 1,860 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function

1997 • 1,326 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1996 • 1,277 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

Disruption of the murine IL-4 gene blocks Th2 cytokine responses

1993 • 1,197 citations

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1996 • 1,182 citations

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

1996 • 991 citations

Statistical Genomics: Linkage, Mapping, and QTL Analysis

1997 • 798 citations

Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.

1992 • 762 citations

The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4

1996 • 677 citations

Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations.

1995 • 554 citations

T cell genetic background determines default T helper phenotype development in vitro.

1995 • 466 citations

Reversibility of T helper 1 and 2 populations is lost after long-term stimulation.

1996 • 437 citations

Constructing polycompetitor cDNAs for quantitative PCR

1993 • 323 citations

IL-4 Rapidly Produced by Vβ4 Vα8 CD4+ T Cells Instructs Th2 Development and Susceptibility to Leishmania major in BALB/c Mice

1997 • 315 citations

Flow cytometric determination of cytokines in activated murine T helper lymphocytes: Expression of interleukin‐10 in interferon‐γ and in interleukin‐4‐expressing cells

1994 • 305 citations

Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor.

1990 • 292 citations

Independent and Epigenetic Regulation of the Interleukin-4 Alleles in CD4 ⁺ T Cells

1998 • 250 citations

Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses.

1996 • 204 citations

Selective development of T helper (Th)2 cells induced by continuous administration of low dose soluble proteins to normal and beta(2)-microglobulin-deficient BALB/c mice.

1996 • 198 citations

Cytokine transcriptional events during helper T cell subset differentiation.

1996 • 174 citations

Heterogeneity of single cell cytokine gene expression in clonal T cell populations.

1994 • 173 citations

Regulation of IL-4 Expression by Activation of Individual Alleles

1998 • 170 citations

Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells.

1994 • 158 citations

Single cell analysis of cytokine gene coexpression during CD4+ T-cell phenotype development.

1995 • 146 citations

Serial Backcross Mapping of Multiple Loci Associated with Resistance to Leishmania major in Mice

1997 • 144 citations

A biometrical genome search in rats reveals the multigenic basis of blood pressure variation.

1995 • 115 citations

Coexpression of granulocyte-macrophage colony-stimulating factor, gamma interferon, and interleukins 3 and 4 is random in murine alloreactive T-lymphocyte clones.

1988 • 106 citations

T cell genetic background determines maintenance of IL-12 signaling: effects on BALB/c and B10.D2 T helper cell type 1 phenotype development.

1997 • 103 citations

Evidence for the stochastic acquisition of cytokine profile by CD4⁺ T cells activated in a T helper type 2‐like response in vivo

1995 • 98 citations

Resistance to Leishmania major is Linked to the H2 Region on Chromosome 17 and to Chromosome 9

1997 • 97 citations

A minority subpopulation of CD4+ T cells directs the development of naive CD4+ T cells into IL-4-secreting cells.

1994 • 82 citations

Monoclonal antibodies block murine IL-4 receptor function.

1990 • 70 citations

MAPPING OF GENES CONTROLLING LEISHMANIA MAJOR INFECTION IN CXS RECOMBINANT INBRED MICE

1993 • 58 citations

Visualization of antigen-specific T cell activation and cytokine expression in vivo.

1997 • 53 citations

Differential production of IL-12 in BALB/c and DBA/2 mice controls IL-4 versus IFN-γ synthesis in primed CD4 lymphocytes

1996 • 37 citations