Chromatin Structure and Gene Regulation in the Immune System

Translating the Histone Code

2001 • 9,488 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

1996 • 2,873 citations

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

2001 • 2,746 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

1997 • 2,317 citations

The Role of DNA Methylation in Mammalian Epigenetics

2001 • 1,956 citations

Chromosomal Subunits in Active Genes Have an Altered Conformation

1976 • 1,842 citations

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

1999 • 1,549 citations

Nuclear protein CBP is a coactivator for the transcription factor CREB

1994 • 1,447 citations

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

1999 • 1,139 citations

The molecular basis for metameric pattern in the Drosophila embryo

1987 • 1,028 citations

Helper T Cell Differentiation Is Controlled by the Cell Cycle

1998 • 862 citations

Role of T-bet in Commitment of T _H 1 Cells Before IL-12-Dependent Selection

2001 • 813 citations

Structure and Function of a Human TAF _II 250 Double Bromodomain Module

2000 • 808 citations

Identification of a Coordinate Regulator of Interleukins 4, 13, and 5 by Cross-Species Sequence Comparisons

2000 • 793 citations

Association of Transcriptionally Silent Genes with Ikaros Complexes at Centromeric Heterochromatin

1997 • 792 citations

Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.

1994 • 775 citations

Ordered Recruitment of Chromatin Modifying and General Transcription Factors to the IFN-β Promoter

2000 • 716 citations

ATP-dependent remodeling and acetylation as regulators of chromatin fluidity

1999 • 705 citations

Ordered Recruitment of Transcription and Chromatin Remodeling Factors to a Cell Cycle– and Developmentally Regulated Promoter

1999 • 703 citations

Modulation of Chromatin Structure Regulates Cytokine Gene Expression during T Cell Differentiation

1998 • 697 citations

Stat6-Independent GATA-3 Autoactivation Directs IL-4-Independent Th2 Development and Commitment

2000 • 697 citations

The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4

1996 • 677 citations

Lineage commitment in the immune system: the T helper lymphocyte grows up

2000 • 627 citations

A position-effect assay for boundaries of higher order chromosomal domains

1991 • 616 citations

Chromatin

1989 • 606 citations

Ikaros DNA-Binding Proteins Direct Formation of Chromatin Remodeling Complexes in Lymphocytes

1999 • 583 citations

Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken beta-globin chromosomal domain.

1994 • 539 citations

Early Transcription and Silencing of Cytokine Genes Underlie Polarization of T Helper Cell Subsets

2001 • 498 citations

Regulation of Interleukin 12 p40 Expression through an NF-κB Half-Site

1995 • 495 citations

Ikaros, an Early Lymphoid-Specific Transcription Factor and a Putative Mediator for T Cell Commitment

1992 • 458 citations

The chromatin structure of specific genes: I. Evidence for higher order domains of defined DNA sequence

1979 • 445 citations

Promoter targeting and chromatin remodeling by the SWI/SNF complex

2000 • 433 citations

Perturbation of Nuclear Architecture by Long-Distance Chromosome Interactions

1996 • 425 citations

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

1994 • 418 citations

The molecular basis of T helper 1 and T helper 2 cell differentiation

2000 • 400 citations

Dynamic Repositioning of Genes in the Nucleus of Lymphocytes Preparing for Cell Division

1999 • 393 citations

THE POLYCOMB AND TRITHORAX GROUP PROTEINS OF DROSOPHILA: Trans-Regulators of Homeotic Gene Function

1995 • 390 citations

Gata-3 Induces T Helper Cell Type 2 (Th2) Cytokine Expression and Chromatin Remodeling in Committed Th1 Cells

2000 • 390 citations

The chromatin structure of specific genes: II. Disruption of chromatin structure during gene activity

1979 • 389 citations

Insulators and Boundaries: Versatile Regulatory Elements in the Eukaryotic Genome

2001 • 386 citations

The Transcription Factor c-Maf Controls the Production of Interleukin-4 but Not Other Th2 Cytokines

1999 • 377 citations

Locus Control Region Function and Heterochromatin-Induced Position Effect Variegation

1996 • 373 citations

CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation

1998 • 357 citations

Structure and Function of the Interferon- Enhanceosome

1998 • 354 citations

Mechanisms of transcriptional memory

2001 • 354 citations

X-chromosome inactivation and cell memory

1992 • 329 citations

Heterochromatin Effects on the Frequency and Duration of LCR-Mediated Gene Transcription

1996 • 328 citations

Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human β-globin locus

2000 • 312 citations

Multiple Control Elements Mediate Activation of the Murine and Human Interleukin 12 p40 Promoters: Evidence of Functional Synergy between C/EBP and Rel Proteins

1997 • 310 citations

Genetic modification of heterochromatic association and nuclear organization in Drosophila

1996 • 306 citations

Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages

2000 • 301 citations

Cell-Type-Restricted Binding of the Transcription Factor NFAT to a Distal IL-4 Enhancer In Vivo

2000 • 270 citations

Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice

1997 • 266 citations

A role for mel-18, a Polycomb group-related vertebrate gene, during the anteroposterior specification of the axial skeleton

1996 • 256 citations

Transcriptional Regulation in Eukaryotes: Concepts, Strategies and Techniques

2000 • 253 citations

Independent and Epigenetic Regulation of the Interleukin-4 Alleles in CD4 ⁺ T Cells

1998 • 250 citations

Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding

2000 • 250 citations

Nuclear compartments and gene regulation

1999 • 248 citations

Transcriptional Regulation of Mammalian Genes in Vivo

1997 • 244 citations

Regulation of IL-4 Gene Expression by Distal Regulatory Elements and GATA-3 at the Chromatin Level

2001 • 234 citations

Monoallelic Expression of the Interleukin-2 Locus

1998 • 232 citations

Unfolding the mysteries of heterochromatin

1998 • 222 citations

LyF-1, a transcriptional regulator that interacts with a novel class of promoters for lymphocyte-specific genes.

1991 • 203 citations

Deletion of a coordinate regulator of type 2 cytokine expression in mice

2001 • 196 citations

Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects

1997 • 196 citations

Coordination of a Transcriptional Switch by HMGI(Y) Acetylation

2001 • 195 citations

Domain Organization at the Centromere and Neocentromere

2001 • 188 citations

Allelic exclusion of Ly49-family genes encoding class I MHC-specific receptors on NK cells

1995 • 188 citations

Rapid and Selective Remodeling of a Positioned Nucleosome during the Induction of IL-12 p40 Transcription

1999 • 184 citations

Regulation of IL-4 Expression by Activation of Individual Alleles

1998 • 170 citations

Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event

2001 • 164 citations

Silenced Chromatin Is Permissive to Activator Binding and PIC Recruitment

2001 • 159 citations

Control of lymphocyte development by the Ikaros gene family

1999 • 157 citations

A transcriptional silencer controls the developmental expression of the CD4 gene.

1994 • 156 citations

Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice

1995 • 155 citations

Cutting Edge: Chromatin Remodeling at the IL-4/IL-13 Intergenic Regulatory Region for Th2-Specific Cytokine Gene Cluster

2000 • 152 citations

Down-regulation of TDT transcription in CD4⁺CD8⁺thymocytes by Ikaros proteins in direct competition with an Ets activator

2001 • 151 citations

Binding of Ikaros to the lambda5 promoter silences transcription through a mechanism that does not require heterochromatin formation

2001 • 148 citations

Regulation of Expression of IL-4 Alleles

2001 • 147 citations

Activation by locus control regions?

1999 • 144 citations

Coordinate Regulation of the IL-4, IL-13, and IL-5 Cytokine Cluster in Th2 Clones Revealed by Allelic Expression Patterns

2000 • 139 citations

Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region.

1998 • 139 citations

NF-AT-Driven Interleukin-4 Transcription Potentiated by NIP45

1996 • 136 citations

T-cell subset-specific expression of the IL-4 gene is regulated by a silencer element and STAT6

1997 • 133 citations

Large-scale chromatin structure and function

1999 • 129 citations

Heterochromatin protein 1 modifies mammalian PEV in a dose- and chromosomal-context- dependent manner

1999 • 124 citations

Formation of stable transcription complexes as assayed by analysis of individual templates.

1988 • 118 citations

Transcription of the interleukin 4 gene is regulated by multiple promoter elements.

1993 • 103 citations

Lineage commitment in lymphopoiesis

2000 • 98 citations

Characterization of an Activation Protein-1-binding Site in the Murine Interleukin-12 p40 Promoter

2001 • 90 citations

Combinatorial regulation of transcription I: General aspects of transcriptional control

1995 • 86 citations

Identification of IL-4 promoter elements conferring Th2-restricted expression during T helper cell subset development.

1997 • 83 citations

Cell Division Is Not a “Clock” Measuring Acquisition of Competence to Produce IFN-γ or IL-4

2001 • 74 citations

mel-18 Negatively Regulates Cell Cycle Progression upon B Cell Antigen Receptor Stimulation through a Cascade Leading to c-myc/cdc25

1998 • 64 citations

Regulation of IL‐4 production in mast cells: a paradigm for cell‐type‐specific gene expression

2001 • 63 citations

Unequal Access

2000 • 63 citations

The IFN- Enhancer: A Paradigm for Understanding Activation and Repression of Inducible Gene Expression

1999 • 53 citations

Accessibility control of variable region gene assembly during T‐cell development

1998 • 48 citations

Developing a Virtual Reality User Interface (VRUI) for Geographic Information Retrieval on the Internet

1999 • 39 citations

Disrupting Il13 impairs production of IL-4 specified by the linked allele

2001 • 24 citations

Faithful Expression of the Human 5q31 Cytokine Cluster in Transgenic Mice

2000 • 23 citations

Bias in the Expression of IL-4 Alleles: The Use of T Cells from a GFP Knock-in Mouse

1999 • 9 citations

Regulation of Chromatin Accessibility for V(D)J Recombination

1999 • 5 citations

Cooperative Assembly of RNA Polymerase II Transcription Complexes

1998 • 5 citations