In TH2 cells theIl4gene has a series of accessibility states associated with distinctive probabilities of IL-4 production

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions

1999 • 1,532 citations

Helper T Cell Differentiation Is Controlled by the Cell Cycle

1998 • 862 citations

Identification of a Coordinate Regulator of Interleukins 4, 13, and 5 by Cross-Species Sequence Comparisons

2000 • 793 citations

Modulation of Chromatin Structure Regulates Cytokine Gene Expression during T Cell Differentiation

1998 • 697 citations

Th2 Lineage Commitment and Efficient IL-4 Production Involves Extended Demethylation of the IL-4 Gene

2002 • 328 citations

Multicolour spectral karyotyping of mouse chromosomes

1996 • 313 citations

Receptor-directed focusing of lymphokine release by helper T cells

1988 • 284 citations

Stat6 Is Necessary and Sufficient for IL-4’s Role in Th2 Differentiation and Cell Expansion

2001 • 281 citations

Cell-Type-Restricted Binding of the Transcription Factor NFAT to a Distal IL-4 Enhancer In Vivo

2000 • 270 citations

Independent and Epigenetic Regulation of the Interleukin-4 Alleles in CD4 ⁺ T Cells

1998 • 250 citations

Regulation of IL-4 Gene Expression by Distal Regulatory Elements and GATA-3 at the Chromatin Level

2001 • 234 citations

Deletion of a coordinate regulator of type 2 cytokine expression in mice

2001 • 196 citations

Regulation of IL-4 Expression by Activation of Individual Alleles

1998 • 170 citations

Regulation of Expression of IL-4 Alleles

2001 • 147 citations

Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region.

1998 • 139 citations

A DNase I-hypersensitive site in the second intron of the murine IL-4 gene defines a mast cell-specific enhancer.

1992 • 78 citations

Kissing cousins: immunological and neurological synapses

2001 • 31 citations