Arginine Methylation

Translating the Histone Code

2001 • 9,488 citations

Identification and characterization of a spinal muscular atrophy-determining gene

1995 • 3,722 citations

Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1

2004 • 3,675 citations

Regulation of chromatin structure by site-specific histone H3 methyltransferases

2000 • 2,709 citations

Regulation of Transcription by a Protein Methyltransferase

1999 • 1,169 citations

The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder

1999 • 1,052 citations

Human PAD4 Regulates Histone Arginine Methylation Levels via Demethylimination

2004 • 955 citations

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

2004 • 859 citations

Histone Deimination Antagonizes Arginine Methylation

2004 • 796 citations

Specificity in Signal Transduction

2004 • 795 citations

Methylation of Histone H4 at Arginine 3 Facilitating Transcriptional Activation by Nuclear Hormone Receptor

2001 • 758 citations

Arginine-Mediated RNA Recognition: the Arginine Fork

1991 • 757 citations

SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells

2004 • 710 citations

Measuring conformational dynamics of biomolecules by single molecule fluorescence spectroscopy.

2000 • 703 citations

Homocysteine Impairs the Nitric Oxide Synthase Pathway

2001 • 663 citations

Human SWI/SNF-Associated PRMT5 Methylates Histone H3 Arginine 8 and Negatively Regulates Expression of ST7 and NM23 Tumor Suppressor Genes

2004 • 553 citations

RNA and Protein Interactions Modulated by Protein Arginine Methylation

1998 • 499 citations

Ordered Cooperative Functions of PRMT1, p300, and CARM1 in Transcriptional Activation by p53

2004 • 497 citations

Arginine Methylation of STAT1 Modulates IFNα/β-Induced Transcription

2001 • 475 citations

Identifying and quantifying in vivo methylation sites by heavy methyl SILAC

2004 • 446 citations

Role of Protein Methylation in Regulation of Transcription

2005 • 441 citations

The Mammalian Immediate-early TIS21 Protein and the Leukemia-associated BTG1 Protein Interact with a Protein-arginine -Methyltransferase

1996 • 435 citations

Protein-RNA interactions: a structural analysis

2001 • 427 citations

State of the Arg

2001 • 425 citations

HIV-1 Tat transcriptional activity is regulated by acetylation

1999 • 411 citations

A Transcriptional Switch Mediated by Cofactor Methylation

2001 • 407 citations

The Methylosome, a 20S Complex Containing JBP1 and pICln, Produces Dimethylarginine-Modified Sm Proteins

2001 • 392 citations

Symmetrical dimethylation of arginine residues in spliceosomal Sm protein B/B′ and the Sm-like protein LSm4, and their interaction with the SMN protein

2001 • 361 citations

SMN, the Product of the Spinal Muscular Atrophy Gene, Binds Preferentially to Dimethylarginine-Containing Protein Targets

2001 • 358 citations

Nuclear Localization of Peptidylarginine Deiminase V and Histone Deimination in Granulocytes

2002 • 355 citations

PRMT5 (Janus Kinase-binding Protein 1) Catalyzes the Formation of Symmetric Dimethylarginine Residues in Proteins

2001 • 352 citations

A Proteomic Analysis of Arginine-methylated Protein Complexes

2003 • 352 citations

Structure of the Predominant Protein Arginine Methyltransferase PRMT1 and Analysis of Its Binding to Substrate Peptides

2003 • 344 citations

Arginine N-Methyltransferase 1 Is Required for Early Postimplantation Mouse Development, but Cells Deficient in the Enzyme Are Viable

2000 • 340 citations

Blocking NO synthesis: how, where and why?

2002 • 323 citations

The Novel Human Protein Arginine N-Methyltransferase PRMT6 Is a Nuclear Enzyme Displaying Unique Substrate Specificity

2002 • 322 citations

SMN tudor domain structure and its interaction with the Sm proteins.

2001 • 317 citations

Crystal structure of the conserved core of protein arginine methyltransferase PRMT3

2000 • 310 citations

Small Molecule Regulators of Protein Arginine Methyltransferases

2004 • 304 citations

In Vivo and In Vitro Arginine Methylation of RNA-Binding Proteins

1995 • 302 citations

PRMT 3, a Type I Protein Arginine N-Methyltransferase That Differs from PRMT1 in Its Oligomerization, Subcellular Localization, Substrate Specificity, and Regulation

1998 • 302 citations

The Human Homologue of the Yeast Proteins Skb1 and Hsl7p Interacts with Jak Kinases and Contains Protein Methyltransferase Activity

1999 • 276 citations

Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice

2003 • 273 citations

Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62

1992 • 271 citations

Arginine Methylation Inhibits the Binding of Proline-rich Ligands to Src Homology 3, but Not WW, Domains

2000 • 240 citations

Sam68 RNA Binding Protein Is an In Vivo Substrate for Protein ArginineN-Methyltransferase 1

2003 • 239 citations

Peptides with sequences similar to glycine, arginine-rich motifs in proteins interacting with RNA are efficiently recognized by methyltransferase(s) modifying arginine in numerous proteins

1993 • 236 citations

PABP1 identified as an arginine methyltransferase substrate using high‐density protein arrays

2002 • 223 citations

Lipopolysaccharide-induced Methylation of HuR, an mRNA-stabilizing Protein, by CARM1

2002 • 219 citations

Methylation of SPT5 Regulates Its Interaction with RNA Polymerase II and Transcriptional Elongation Properties

2003 • 217 citations

Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-κB-dependent gene expression

2004 • 212 citations

Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control

2005 • 210 citations

PRMT7, a New Protein Arginine Methyltransferase That Synthesizes Symmetric Dimethylarginine

2004 • 197 citations

Multiple Sclerosis

2003 • 195 citations

Control of CBP co-activating activity by arginine methylation

2002 • 195 citations

Methylation of Tat by PRMT6 Regulates Human Immunodeficiency Virus Type 1 Gene Expression

2004 • 193 citations

Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen‐independent status

2004 • 192 citations

Symmetrical dimethylarginine methylation is required for the localization of SMN in Cajal bodies and pre-mRNA splicing

2002 • 188 citations

PRMT7 Is a Member of the Protein Arginine Methyltransferase Family with a Distinct Substrate Specificity

2004 • 182 citations

A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor

1997 • 179 citations

Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1

2003 • 172 citations

A protective role for innate immunity in systemic lupus erythematosus

2004 • 171 citations

Automated Identification of Putative Methyltransferases from Genomic Open Reading Frames

2003 • 170 citations

Enzymatic methylation of protein fractions from calf thymus nuclei

1967 • 158 citations

The structure and oligomerization of the yeast arginine methyltransferase, Hmt1.

2000 • 158 citations

WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: The proline glycine and methionine-rich motif

1998 • 157 citations

PRMT3 is a ribosomal protein methyltransferase that affects the cellular levels of ribosomal subunits

2004 • 157 citations

Identification and Characterization of Two Putative Human Arginine Methyltransferases (HRMT1L1 and HRMT1L2)

1998 • 154 citations

A protein-domain microarray identifies novel protein–protein interactions

2002 • 152 citations

Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3)

2005 • 151 citations

Unusual Sites of Arginine Methylation in Poly(A)-binding Protein II and in Vitro Methylation by Protein Arginine Methyltransferases PRMT1 and PRMT3

1999 • 145 citations

A methylation-mediator complex in hormone signaling

2004 • 143 citations

Localization of Methylated Arginine in the A1 Protein from Myelin

1971 • 138 citations

Arginine methyltransferase affects interactions and recruitment of mRNA processing and export factors

2004 • 133 citations

Organellar Proteomics Reveals Golgi Arginine Dimethylation

2004 • 133 citations

Arginine Methylation of NIP45 Modulates Cytokine Gene Expression in Effector T Lymphocytes

2004 • 127 citations

Arginine Methylation of RNA Helicase A Determines Its Subcellular Localization

2004 • 119 citations

DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo

2004 • 116 citations

Loss of CARM1 Results in Hypomethylation of Thymocyte Cyclic AMP-regulated Phosphoprotein and Deregulated Early T Cell Development

2004 • 106 citations

Structure of SET domain proteins: a new twist on histone methylation

2003 • 106 citations

The Tudor Tandem of 53BP1

2004 • 100 citations

A Novel Pro-Arg Motif Recognized by WW Domains

2000 • 92 citations

Hepatitis Delta Virus Antigen Is Methylated at Arginine Residues, and Methylation Regulates Subcellular Localization and RNA Replication

2004 • 91 citations

Binding proteins for mRNA localization and local translation, and their dysfunction in genetic neurological disease

2004 • 85 citations

Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy

2002 • 84 citations

Genomic Organization, Physical Mapping, and Expression Analysis of the Human Protein Arginine Methyltransferase 1 Gene

2000 • 74 citations

Design of Allele-Specific Protein Methyltransferase Inhibitors

2001 • 73 citations

Characterization of the Drosophila protein arginine methyltransferases DART1 and DART4

2004 • 67 citations

Arginine Methylation of Scaffold Attachment Factor A by Heterogeneous Nuclear Ribonucleoprotein Particle-associated PRMT1

2004 • 67 citations

Nerve Growth Factor–specific Regulation of Protein Methylation during Neuronal Differentiation of PC12 Cells

1997 • 65 citations

Methylation of STAT6 Modulates STAT6 Phosphorylation, Nuclear Translocation, and DNA-Binding Activity

2004 • 65 citations

Identification of new drug sensitivity genes using genetic suppressor elements: protein arginine N-methyltransferase mediates cell sensitivity to DNA-damaging agents.

2003 • 61 citations

Nuclear Export of hnRNP Hrp1p and Nuclear Export of hnRNP Npl3p Are Linked and Influenced by the Methylation State of Npl3p

2004 • 50 citations

Detection of novel mutations in the SMN Tudor domain in type I SMA patients

2004 • 49 citations

In Vivo Posttranslational Modifications of the High Mobility Group A1a Proteins in Breast Cancer Cells of Differing Metastatic Potential

2004 • 48 citations

During Apoptosis of Tumor Cells HMGA1a Protein Undergoes Methylation: Identification of the Modification Site by Mass Spectrometry

2003 • 47 citations

Identification and phylogenetic analyses of the protein arginine methyltransferase gene family in fish and ascidians

2004 • 42 citations

Spliceosome Sm proteins D1, D3, and B/B′ are asymmetrically dimethylated at arginine residues in the nucleus

2004 • 40 citations

Arginine methylation signals mRNA export

2004 • 31 citations