NFATc1 and NFATc2 Together Control Both T and B Cell Activation and Differentiation

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1991 • 1,054 citations

Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development

1995 • 800 citations

Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3

1997 • 754 citations

Defective Lymphoid Development in Mice Lacking Jak3

1995 • 650 citations

Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum

1998 • 639 citations

Defective T Cell Differentiation in the Absence of Jnk1

1998 • 590 citations

The transcription factor NF-ATc is essential for cardiac valve formation

1998 • 580 citations

Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3

1995 • 551 citations

Developmental defects of lymphoid cells in Jak3 kinase-deficient mice

1995 • 493 citations

Hyperproliferation and Dysregulation ofIL-4 Expression in NF-ATp-Deficient Mice

1996 • 456 citations

Multiple Myeloma

1997 • 389 citations

An Enhanced Immune Response in Mice Lacking the Transcription Factor NFAT1

1996 • 375 citations

The Transcription Factor NF-ATc1 Regulates Lymphocyte Proliferation and Th2 Cytokine Production

1998 • 340 citations

Inhibitory Function of Two NFAT Family Members in Lymphoid Homeostasis and Th2 Development

1998 • 325 citations

JNK is required for effector T-cell function but not for T-cell activation

2000 • 322 citations

Impaired NFATc Translocation and Failure of Th2 Development in Itk-Deficient CD4+ T Cells

1999 • 307 citations

Delayed Lymphoid Repopulation with Defects in IL-4–Driven Responses Produced by Inactivation of NF-ATc

1998 • 298 citations

Manipulating Immune Responses with Immunosuppressive Agents that Target NFAT

2000 • 279 citations

The Transcription Factor NFAT4 Is Involved in the Generation and Survival of T Cells

1998 • 271 citations

Requirement for Transcription Factor NFAT in Interleukin-2 Expression

1999 • 196 citations

Dok-3, a Novel Adapter Molecule Involved in the Negative Regulation of Immunoreceptor Signaling

2000 • 186 citations

Down-Regulation of IL-4 Gene Transcription and Control of Th2 Cell Differentiation by a Mechanism Involving NFAT1

1997 • 176 citations

A Role for the p38 MAP Kinase Pathway in the Nuclear Shuttling of NFATp

2000 • 156 citations

BASH, a novel signaling molecule preferentially expressed in B cells of the bursa of Fabricius.

1998 • 146 citations

The B Cell Antigen Receptor Activates the Akt (Protein Kinase B)/Glycogen Synthase Kinase-3 Signaling Pathway Via Phosphatidylinositol 3-Kinase

1999 • 133 citations

c-Jun NH₂-Terminal Kinase Inhibits Targeting of the Protein Phosphatase Calcineurin to NFATc1

2000 • 130 citations

Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4

1994 • 125 citations

Cyclosporin-a sensitive induction of NF-AT in murine B cells

1994 • 124 citations

GrpL, a Grb2-related Adaptor Protein, Interacts with SLP-76 to Regulate Nuclear Factor of Activated T Cell Activation

1999 • 121 citations

The role of membrane-associated adaptors in T cell receptor signalling

2000 • 111 citations

Cutting Edge: BASH, A Novel Signaling Molecule Preferentially Expressed in B Cells of the Bursa of Fabricius

1998 • 109 citations

A Novel B Lymphocyte–Associated Adaptor Protein, Bam32, Regulates Antigen Receptor Signaling Downstream of Phosphatidylinositol 3-Kinase

2000 • 94 citations

Inhibition of Signaling Through the B Cell Antigen Receptor by the Protooncogene Product, c-Cbl, Requires Syk Tyrosine 317 and the c-Cbl Phosphotyrosine-Binding Domain

1999 • 67 citations

Retarded thymic involution and massive germinal center formation in NF-ATp-deficient mice

1998 • 57 citations

NF-ATp plays a prominent role in the transcriptional induction of Th2-type lymphokines

1997 • 35 citations

The Jak Family Tyrosine Kinase Jak3 Is Required for IL-2 Synthesis by Naive/Resting CD4+ T Cells

1999 • 17 citations