Conditional deletion of Gata3 shows its essential function in TH1-TH2 responses

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.

1993 • 2,370 citations

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

1997 • 2,317 citations

The lineage decisions of helper T cells

2002 • 1,678 citations

THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions

1999 • 1,532 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

A Critical Role for Dnmt1 and DNA Methylation in T Cell Development, Function, and Survival

2001 • 1,215 citations

Distinct Effects of T-bet in T _H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells

2002 • 1,169 citations

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.

1996 • 1,124 citations

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1998 • 800 citations

Modulation of Chromatin Structure Regulates Cytokine Gene Expression during T Cell Differentiation

1998 • 697 citations

Stat6-Independent GATA-3 Autoactivation Directs IL-4-Independent Th2 Development and Commitment

2000 • 697 citations

Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene

1997 • 666 citations

Signaling and Transcription in T Helper Development

2000 • 635 citations

Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis

1995 • 619 citations

Transcription factor GATA-3 is required for development of the T-cell lineage

1996 • 614 citations

GATA3 haplo-insufficiency causes human HDR syndrome

2000 • 550 citations

Analysis of Type 2 Immunity In Vivo with a Bicistronic IL-4 Reporter

2001 • 460 citations

Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts

1987 • 453 citations

Identification and Characterization of a Constitutively Active STAT5 Mutant That Promotes Cell Proliferation

1998 • 426 citations

Interleukin 2 plays a central role in Th2 differentiation

2004 • 393 citations

Codon‐improved Cre recombinase (iCre) expression in the mouse

2002 • 384 citations

The Transcription Factor c-Maf Controls the Production of Interleukin-4 but Not Other Th2 Cytokines

1999 • 377 citations

Stat5 Activation Plays a Critical Role in Th2 Differentiation

2003 • 357 citations

GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells

2004 • 339 citations

An interleukin 4 (IL-4)-independent pathway for CD4⁺T cell IL-4 production is revealed in IL-4 receptor-deficient mice

1997 • 334 citations

Inhibition of Allergic Inflammation in a Murine Model of Asthma by Expression of a Dominant-Negative Mutant of GATA-3

1999 • 333 citations

Th2 Lineage Commitment and Efficient IL-4 Production Involves Extended Demethylation of the IL-4 Gene

2002 • 328 citations

Critical Roles for Transcription Factor GATA-3 in Thymocyte Development

2003 • 299 citations

Stat6 Is Necessary and Sufficient for IL-4’s Role in Th2 Differentiation and Cell Expansion

2001 • 281 citations

Cell-Type-Restricted Binding of the Transcription Factor NFAT to a Distal IL-4 Enhancer In Vivo

2000 • 270 citations

GATA-3 Suppresses Th1 Development by Downregulation of Stat4 and Not through Effects on IL-12Rβ2 Chain or T-bet

2003 • 266 citations

Single Cell Analysis Reveals That IL-4 Receptor/Stat6 Signaling Is Not Required for the In Vivo or In Vitro Development of CD4+ Lymphocytes with a Th2 Cytokine Profile

2000 • 252 citations

GATA-3 Expression Is Controlled by TCR Signals and Regulates CD4/CD8 Differentiation

2003 • 241 citations

Embryonic expression and cloning of the murine GATA-3 gene

1994 • 233 citations

Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3.

1998 • 228 citations

Growth Factor Independent-1 Induced by IL-4 Regulates Th2 Cell Proliferation

2002 • 207 citations

Stat6 Regulation of In Vivo IL-4 Responses

2000 • 194 citations

Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage

2001 • 172 citations

Cutting Edge: Differential Responsiveness of the IL-5 and IL-4 Genes to Transcription Factor GATA-3

1998 • 162 citations

The Cell Type-Specific Expression of the Murine IL-13 Gene Is Regulated by GATA-3

2001 • 152 citations

Cutting Edge: Chromatin Remodeling at the IL-4/IL-13 Intergenic Regulatory Region for Th2-Specific Cytokine Gene Cluster

2000 • 152 citations

Regulation of Expression of IL-4 Alleles

2001 • 147 citations

OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand

1996 • 138 citations

Activation of the Interleukin-5 Promoter by cAMP in Murine EL-4 Cells Requires the GATA-3 and CLE0 Elements

1995 • 137 citations

Induction of an IgE response in mice by Nippostrongylus brasiliensis: characterization of lymphoid cells with intracytoplasmic or surface IgE.

1983 • 89 citations

In TH2 cells theIl4gene has a series of accessibility states associated with distinctive probabilities of IL-4 production

2002 • 82 citations

Interleukin-13 Gene Expression Is Regulated by GATA-3 in T Cells

2002 • 75 citations

Protein Kinase A Regulates GATA-3-Dependent Activation of IL-5 Gene Expression in Th2 Cells

2003 • 47 citations