Chromatin-based regulation of cytokine transcription in Th2 cells and mast cells

Interleukin-13: Central Mediator of Allergic Asthma

1998 • 2,642 citations

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

1997 • 2,317 citations

Requirement for IL-13 Independently of IL-4 in Experimental Asthma

1998 • 1,869 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

Mast cells in the development of adaptive immune responses

2005 • 1,252 citations

NUCLEASE HYPERSENSITIVE SITES IN CHROMATIN

1988 • 1,233 citations

MAST CELLS AS “TUNABLE” EFFECTOR AND IMMUNOREGULATORY CELLS: Recent Advances

2005 • 1,216 citations

Identification of a Coordinate Regulator of Interleukins 4, 13, and 5 by Cross-Species Sequence Comparisons

2000 • 793 citations

Modulation of Chromatin Structure Regulates Cytokine Gene Expression during T Cell Differentiation

1998 • 697 citations

The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4

1996 • 677 citations

Lineage commitment in the immune system: the T helper lymphocyte grows up

2000 • 627 citations

TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes

2002 • 517 citations

An epigenetic view of helper T cell differentiation

2003 • 429 citations

Genomic strategies to identify mammalian regulatory sequences

2001 • 389 citations

Neoplastic transformation of mast cells by Abelson-MuLV: abrogation of IL-3 dependence by a nonautocrine mechanism

1985 • 330 citations

PU.1 Regulates Expression of the Interleukin-7 Receptor in Lymphoid Progenitors

2002 • 316 citations

PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors

1998 • 296 citations

PU.1 Functions in a Cell-Autonomous Manner to Control the Differentiation of Multipotential Lymphoid–Myeloid Progenitors

1997 • 276 citations

Cell-Type-Restricted Binding of the Transcription Factor NFAT to a Distal IL-4 Enhancer In Vivo

2000 • 270 citations

Cooperative and Antagonistic Interplay between PU.1 and GATA-2 in the Specification of Myeloid Cell Fates

2002 • 268 citations

Regulation of the Th2 Cytokine Locus by a Locus Control Region

2003 • 222 citations

Deletion of a coordinate regulator of type 2 cytokine expression in mice

2001 • 196 citations

Identification of a Conserved GATA3 Response Element Upstream Proximal from the Interleukin-13 Gene Locus

2002 • 194 citations

Th2-Specific Chromatin Remodeling and Enhancer Activity in the Th2 Cytokine Locus Control Region

2004 • 188 citations

Mast cell clones: a model for the analysis of cellular maturation.

1982 • 174 citations

GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene.

1991 • 162 citations

Tissue-specific factors additively increase the probability of the all-or-none formation of a hypersensitive site.

1996 • 156 citations

The Cell Type-Specific Expression of the Murine IL-13 Gene Is Regulated by GATA-3

2001 • 152 citations

Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions

2004 • 152 citations

In Activated Mast Cells, IL-1 Up-Regulates the Production of Several Th2-Related Cytokines Including IL-9

2000 • 143 citations

Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region.

1998 • 139 citations

Computational and Biological Analysis of 680 kb of DNA Sequence from the Human 5q31 Cytokine Gene Cluster Region

1997 • 126 citations

PU.1 and GATA: components of a mast cell-specific interleukin 4 intronic enhancer.

1994 • 123 citations

A 3′ Enhancer in the IL-4 Gene Regulates Cytokine Production by Th2 Cells and Mast Cells

2002 • 117 citations

Deletion of a conserved Il4 silencer impairs T helper type 1–mediated immunity

2004 • 114 citations

MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells

2000 • 105 citations

Role of NFAT Proteins in IL13 Gene Transcription in Mast Cells

2004 • 98 citations

Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: A target for STAT6 but not GATA3

2004 • 94 citations

In vivoimmunological function of mast cells derived from embryonic stem cells: An approach for the rapid analysis of even embryonic lethal mutations in adult micein vivo

2000 • 91 citations

Nuclear Factor of Activated T Cells Is Associated with a Mast Cell Interleukin 4 Transcription Complex

1996 • 78 citations

A DNase I-hypersensitive site in the second intron of the murine IL-4 gene defines a mast cell-specific enhancer.

1992 • 78 citations

Bioinformatics for the 'bench biologist': how to find regulatory regions in genomic DNA

2004 • 76 citations

An Intron Transcriptional Enhancer Element Regulates IL-4 Gene Locus Accessibility in Mast Cells

2000 • 72 citations

T Cell Development

2002 • 61 citations

STAT6-independent production of IL-4 by mast cells

1999 • 45 citations

Characterization of the constitutive and inducible components of a T cell IL-4 activation responsive element.

1995 • 21 citations

Cutting Edge: IL-4 Production by Mast Cells Does Not Require c-maf

1999 • 20 citations