Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

Exploratory Data Analysis

1977 • 12,265 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods

1995 • 3,539 citations

Exploratory Data Analysis.

1978 • 2,890 citations

Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

1996 • 2,883 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

The Inverse Association Between Tuberculin Responses and Atopic Disorder

1997 • 1,305 citations

Noninvasive Measurement of Airway Responsiveness in Allergic Mice Using Barometric Plethysmography

1997 • 1,294 citations

Kidney Injury Molecule-1 (KIM-1), a Putative Epithelial Cell Adhesion Molecule Containing a Novel Immunoglobulin Domain, Is Up-regulated in Renal Cells after Injury

1998 • 1,189 citations

IMMUNOLOGIC BASIS OF ANTIGEN-INDUCED AIRWAY HYPERRESPONSIVENESS

1999 • 1,047 citations

Linkage Analysis of IL4 and Other Chromosome 5q31.1 Markers and Total Serum Immunoglobulin E Concentrations

1994 • 1,025 citations

SLAM (CDw150) is a cellular receptor for measles virus

2000 • 1,015 citations

A physical map of the human genome

2001 • 927 citations

Identification of a Coordinate Regulator of Interleukins 4, 13, and 5 by Cross-Species Sequence Comparisons

2000 • 793 citations

Mouse genetics: concepts and applications

1995 • 791 citations

Genetic Susceptibility to Asthma — Bronchial Hyperresponsiveness Coinherited with a Major Gene for Atopy

1995 • 774 citations

Bronchial responsiveness to histamine or methacholine in asthma: measurement and clinical significance

1981 • 764 citations

Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.

1992 • 762 citations

The Association of Atopy with a Gain-of-Function Mutation in the α Subunit of the Interleukin-4 Receptor

1997 • 743 citations

A genome-wide search for asthma susceptibility loci in ethnically diverse populations

1997 • 712 citations

Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological study

2000 • 697 citations

Allergen-specific Th1 cells fail to counterbalance Th2 cell–induced airway hyperreactivity but cause severe airway inflammation

1999 • 642 citations

LINKAGE BETWEEN IMMUNOGLOBULIN E RESPONSES UNDERLYING ASTHMA AND RHINITIS AND CHROMOSOME 11q

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Reproducibility and comparison of responses to inhaled histamine and methacholine.

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The health economics of asthma and rhinitis. I. Assessing the economic impact

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Cross sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis a virus

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Induction of Airway Mucus Production By T Helper 2 (Th2) Cells: A Critical Role For Interleukin 4 In Cell Recruitment But Not Mucus Production

1997 • 464 citations

The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1

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Genetic and Functional Relationships between MHC and NK Receptor Genes

2001 • 315 citations

Evidence for the Increase in Asthma Worldwide

2007 • 311 citations

Impaired NFATc Translocation and Failure of Th2 Development in Itk-Deficient CD4+ T Cells

1999 • 307 citations

Variation in the Interleukin 4–Receptor α Gene Confers Susceptibility to Asthma and Atopy in Ethnically Diverse Populations

2000 • 271 citations

The relationship of IL-4- and IFNγ-producing T cells studied by lineage ablation of IL-4-producing cells

1993 • 265 citations

DOES T4 TOXICOSIS EXIST ?

1975 • 252 citations

SAP controls T cell responses to virus and terminal differentiation of TH2 cells

2001 • 242 citations

The Human Homolog of HAVcr-1 Codes for a Hepatitis A Virus Cellular Receptor

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Cellular receptors for viruses: links to tropism and pathogenesis

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Evidence for Linkage Between Asthma/Atopy in Childhood and Chromosome 5q31-q33 in a Japanese Population

1997 • 187 citations

Negative regulation of airway responsiveness that is dependent on γδ T cells and independent of αβ T cells

1999 • 180 citations

Significant Evidence for Linkage of Mite-Sensitive Childhood Asthma to Chromosome 5q31–q33 near the Interleukin 12 B Locus by a Genome-wide Search in Japanese Families

2000 • 180 citations

Hypothesis

1963 • 155 citations

Computational and Biological Analysis of 680 kb of DNA Sequence from the Human 5q31 Cytokine Gene Cluster Region

1997 • 126 citations

Heat-KilledListeria monocytogenesas an Adjuvant Converts Established Murine Th2-Dominated Immune Responses into Th1-Dominated Responses

1998 • 125 citations

The Jackson Laboratory

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Antigen-specific B cells preferentially induce CD4+ T cells to produce IL-4.

1997 • 117 citations

Vaccination with Heat-KilledListeriaas Adjuvant Reverses Established Allergen-Induced Airway Hyperreactivity and Inflammation: Role of CD8+ T Cells and IL-18

2000 • 115 citations

Radiation hybrid map of the mouse genome

1999 • 111 citations

Genomic Approaches to Understanding Asthma

2000 • 91 citations

A BALB/c congenic strain of mice that carries a genetic locus (Ityr) controlling resistance to intracellular parasites

1983 • 91 citations

Identification of two genes on chromosome 4 that determine resistance to plasmacytoma induction in mice.

1994 • 84 citations

Antigen-Primed T Cells from B Cell-Deficient JHD Mice Fail to Provide B Cell Help

1998 • 83 citations

Sequence Polymorphisms in the Chemokines Scya1 (TCA-3), Scya2 (Monocyte Chemoattractant Protein (MCP)-1), and Scya12 (MCP-5) Are Candidates for eae7, a Locus Controlling Susceptibility to Monophasic Remitting/Nonrelapsing Experimental Allergic Encephalomyelitis

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IL-4 synthesis by in vivo primed keyhole limpet hemocyanin-specific CD4+ T cells. I. Influence of antigen concentration and antigen-presenting cell type.

1992 • 69 citations

Linkage and Allelic Association of Chromosome 5 Cytokine Cluster Genetic Markers with Atopy and Asthma Associated Traits

2001 • 63 citations

Ethnicity, childhood environment and atopic disorder

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The problem of atopic eczema: aetiological clues from the environment and lifestyles

1998 • 58 citations

Genomic interval engineering of mice identifies a novel modulator of triglyceride production

2000 • 44 citations

Genetic Mapping of 262 Loci Derived from Expressed Sequences in a Murine Interspecific Cross Using Single-Strand Conformational Polymorphism Analysis

1997 • 41 citations

Tpm1,a Locus Controlling IL-12 Responsiveness, Acts by a Cell-Autonomous Mechanism

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Mapping susceptibility genes for asthma and allergy

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Susceptibility of BALB/c mice carrying various DBA/2 genes to development of Friend murine leukemia virus-induced erythroleukemia.

1985 • 34 citations

Polymorphisms of the Hepatitis A Virus Cellular Receptor 1 in African Green Monkey Kidney Cells Result in Antigenic Variants That Do Not React with Protective Monoclonal Antibody 190/4

1998 • 34 citations