Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence

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Recent advances in the phencyclidine model of schizophrenia

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Effect of COMT Val ^108/158 Met genotype on frontal lobe function and risk for schizophrenia

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Amyloid deposition as the central event in the aetiology of Alzheimer's disease

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A review of MRI findings in schizophrenia

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Schizophrenia as a Complex Trait

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Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders

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Glutamate Receptor Dysfunction and Schizophrenia

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The neuropathology of schizophrenia

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Meta-Analysis of Regional Brain Volumes in Schizophrenia

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Neuregulin 1 and Susceptibility to Schizophrenia

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Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia

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Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease

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Schizophrenia: a disconnection syndrome?

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Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison

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Enzymatic O-Methylation of Epinephrine and Other Catechols

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Disruption of two novel genes by a translocation co-segregating with schizophrenia

2000 • 1,250 citations

Proteomic analysis of NMDA receptor–adhesion protein signaling complexes

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Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia

2001 • 1,194 citations

Decrease in Reelin and Glutamic Acid Decarboxylase67 (GAD67) Expression in Schizophrenia and Bipolar Disorder

2000 • 1,189 citations

Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part II: Schizophrenia

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Kinetics of Human Soluble and Membrane-Bound Catechol O-Methyltransferase: A Revised Mechanism and Description of the Thermolabile Variant of the Enzyme

1995 • 1,152 citations

GTPase-Activating Proteins for Heterotrimeric G Proteins: Regulators of G Protein Signaling (RGS) and RGS-Like Proteins

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Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus

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Interactions between glutamatergic and monoaminergic systems within the basal ganglia-implications for schizophrenia and Parkinson's disease

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<scp>d</scp> -Serine is an endogenous ligand for the glycine site of the N -methyl- <scp>d</scp> -aspartate receptor

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DNA methylation in health and disease

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Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors.

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Neuregulins: functions, forms, and signaling strategies

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Reversal of Phencyclidine Effects by a Group II Metabotropic Glutamate Receptor Agonist in Rats

1998 • 1,002 citations

Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress

2004 • 924 citations

The reduced neuropil hypothesis: a circuit based model of schizophrenia

1999 • 918 citations

Oligodendrocyte dysfunction in schizophrenia and bipolar disorder

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Axonal Neuregulin-1 Regulates Myelin Sheath Thickness

2004 • 905 citations

Catechol O -methyltransferase val ¹⁵⁸ -met genotype and individual variation in the brain response to amphetamine

2003 • 900 citations

Convergent evidence for impaired AKT1-GSK3β signaling in schizophrenia

2004 • 898 citations

Twin studies of schizophrenia: From bow-and-arrow concordances to Star Wars Mx and functional genomics

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Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor

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Molecular Characterization of Schizophrenia Viewed by Microarray Analysis of Gene Expression in Prefrontal Cortex

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Prenatal developmental disturbances in the limbic allocortex in schizophrenics

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The Neurobiology of Slow Synaptic Transmission

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Brain abnormality in schizophrenia

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Catechol- O -methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior

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Genetic Variation in the 6p22.3 Gene DTNBP1, the Human Ortholog of the Mouse Dysbindin Gene, Is Associated with Schizophrenia

2002 • 842 citations

Genetic and physiological data implicating the new human gene G72 and the gene for <scp>d</scp> -amino acid oxidase in schizophrenia

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Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia

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White Matter Changes in Schizophrenia

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Neuronal nicotinic receptors in the human brain

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Regionally localized thinning of the cerebral cortex in schizophrenia

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Hippocampal Volume Reduction in Schizophrenia as Assessed by Magnetic Resonance Imaging

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Prefrontal neurons and the genetics of schizophrenia

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Impaired Repression at a 5-Hydroxytryptamine 1A Receptor Gene Polymorphism Associated with Major Depression and Suicide

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Schizophrenia and Affective Disorders—Cosegregation with a Translocation at Chromosome 1q42 That Directly Disrupts Brain-Expressed Genes: Clinical and P300 Findings in a Family

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Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia

1998 • 705 citations

A Highly Significant Association between a COMT Haplotype and Schizophrenia

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DARPP-32: An Integrator of Neurotransmission

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The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications

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Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia

1995 • 676 citations

Complexity of Prefrontal Cortical Dysfunction in Schizophrenia: More Than Up or Down

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Postnatal Neurodevelopmental Disorders: Meeting at the Synapse?

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Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: a magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins

1992 • 665 citations

Dopamine Uptake through the Norepinephrine Transporter in Brain Regions with Low Levels of the Dopamine Transporter: Evidence from Knock-Out Mouse Lines

2002 • 661 citations

Altered Distribution of Nicotinamide-Adenine Dinucleotide Phosphate—Diaphorase Cells in Frontal Lobe of Schizophrenics Implies Disturbances of Cortical Development

1993 • 660 citations

Schizophrenia as a Disorder of Developmentally Reduced Synaptic Connectivity

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Oligodendroglial density in the prefrontal cortex in schizophrenia and mood disorders: a study from the Stanley Neuropathology Consortium

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A polygenic theory of schizophrenia.

1967 • 622 citations

Reduced Neuronal Size and Glial Cell Density in Area 9 of the Dorsolateral Prefrontal Cortex in Subjects with Major Depressive Disorder

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An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis

2003 • 616 citations

A Functional Polymorphism in the COMT Gene and Performance on a Test of Prefrontal Cognition

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Genes for schizophrenia? Recent findings and their pathophysiological implications

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A Unitary Model of Schizophrenia

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Genes, dopamine and cortical signal-to-noise ratio in schizophrenia

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Executive Subprocesses in Working Memory

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Schizophrenia as an Anomaly of Development of Cerebral Asymmetry

1989 • 587 citations

The Regulator of G Protein Signaling Family

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The metabotropic glutamate receptors, MGLUR2 and MGLUR3, show unique postsynaptic, presynaptic and glial localizations

1996 • 584 citations

Glutamatergic Mechanisms in Schizophrenia

2002 • 579 citations

Dopamine Axon Varicosities in the Prelimbic Division of the Rat Prefrontal Cortex Exhibit Sparse Immunoreactivity for the Dopamine Transporter

1998 • 578 citations

The Origin and Neuronal Function ofIn VivoNonsynaptic Glutamate

2002 • 571 citations

From neuropathology to neurodevelopment

1995 • 569 citations

Genetics of Lactase Persistence and Lactose Intolerance

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Pronounced Reduction of Total Neuron Number in Mediodorsal Thalamic Nucleus and Nucleus Accumbens in Schizophrenics

1990 • 558 citations

Association of Neuregulin 1 with Schizophrenia Confirmed in a Scottish Population

2003 • 557 citations

Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21

1998 • 542 citations

METHYLATION PHARMACOGENETICS: Catechol O-Methyltransferase, Thiopurine Methyltransferase, and Histamine N-Methyltransferase

1999 • 541 citations

Neuronal and Glial Somal Size in the Prefrontal Cortex

1998 • 530 citations

PKB Binding Proteins

2002 • 528 citations

Location of a Major Susceptibility Locus for Familial Schizophrenia on Chromosome 1q21-q22

2000 • 528 citations

NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development

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Emerging principles of altered neural circuitry in schizophrenia

2000 • 520 citations

Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: An in situ hybridization study

1993 • 518 citations

Some Cytoarchitectural Abnormalities of the Entorhinal Cortex in Schizophrenia

1991 • 517 citations

How many diseases does it take to map a gene with SNPs?

2000 • 492 citations

Neuregulin and ErbB receptor signaling pathways in the nervous system

2001 • 490 citations

Electron microscopy of oligodendroglia in severe mental illness

2001 • 482 citations

Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia

2003 • 480 citations

A potential vulnerability locus for schizophrenia on chromosome 6p24–22: evidence for genetic heterogeneity

1995 • 465 citations

Structural Abnormalities in Frontal, Temporal, and Limbic Regions and Interconnecting White Matter Tracts in Schizophrenic Patients With Prominent Negative Symptoms

2001 • 454 citations

Distorted Distribution of Nicotinamide-Adenine Dinucleotide Phosphate—Diaphorase Neurons in Temporal Lobe of Schizophrenics Implies Anomalous Cortical Development

1993 • 449 citations

Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia

2001 • 448 citations

Association of Promoter Variants in the α7 Nicotinic Acetylcholine Receptor Subunit Gene With an Inhibitory Deficit Found in Schizophrenia

2002 • 446 citations

Glutamate, Dopamine, and Schizophrenia

2003 • 435 citations

Catechol-O-Methyltransferase Inhibition Improves Set-Shifting Performance and Elevates Stimulated Dopamine Release in the Rat Prefrontal Cortex

2004 • 422 citations

Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophrenia

2003 • 418 citations

Bringing Order to the Glutamate Chaos in Schizophrenia

2003 • 412 citations

Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia

2004 • 410 citations

Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia

2004 • 410 citations

Neuroimaging studies of the hippocampus in schizophrenia

2001 • 399 citations

Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse

2001 • 393 citations

Maldistribution of Interstitial Neurons in Prefrontal White Matter of the Brains of Schizophrenic Patients

1996 • 391 citations

Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia

2004 • 389 citations

Disrupted-in-Schizophrenia-1 (DISC-1): Mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth

2002 • 387 citations

Schizophrenia and Glutamatergic Transmission

1998 • 385 citations

Lamina-Specific Alterations in the Dopamine Innervation of the Prefrontal Cortex in Schizophrenic Subjects

1999 • 385 citations

Synaptic pathology in Alzheimer's disease: a review of ultrastructural studies

2003 • 384 citations

Stress activation of glutamate neurotransmission in the prefrontal cortex: implications for dopamine-associated psychiatric disorders

2002 • 377 citations

Differences between smokers and nonsmokers in regional gray matter volumes and densities

2003 • 377 citations

Association and linkage analyses of RGS4 polymorphisms in schizophrenia

2002 • 374 citations

DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation

2003 • 374 citations

Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles

1999 • 371 citations

Catechol O-methyltransferase mRNA expression in human and rat brain: evidence for a role in cortical neuronal function

2003 • 368 citations

Support for Association of Schizophrenia with Genetic Variation in the 6p22.3 Gene, Dysbindin, in Sib-Pair Families with Linkage and in an Additional Sample of Triad Families

2003 • 368 citations

Magnetic resonance imaging of brain in people at high risk of developing schizophrenia

1999 • 362 citations

Human Dysbindin (DTNBP1) Gene Expression inNormal Brain and in Schizophrenic Prefrontal Cortex and Midbrain

2004 • 358 citations

Ultrastructural Distribution of the α7 Nicotinic Acetylcholine Receptor Subunit in Rat Hippocampus

2001 • 358 citations

Structural Abnormalities of Subicular Dendrites in Subjects With Schizophrenia and Mood Disorders

2000 • 357 citations

Dopamine transporter immunoreactivity in monkey cerebral cortex: Regional, laminar, and ultrastructural localization

2001 • 355 citations

Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia

2004 • 353 citations

3‐Methoxytyramine Is the Major Metabolite of Released Dopamine in the Rat Frontal Cortex: Reassessment of the Effects of Antipsychotics on the Dynamics of Dopamine Release and Metabolism in the Frontal Cortex, Nucleus Accumbens, and Striatum by a Simple Two Pool Model

1994 • 349 citations

The relative importance of premortem acidosis and postmortem interval for human brain gene expression studies: selective mRNA vulnerability and comparison with their encoded proteins

1995 • 349 citations

Association Between a Functional Catechol O-Methyltransferase Gene Polymorphism and Schizophrenia: Meta-Analysis of Case-Control and Family-Based Studies

2003 • 348 citations

A Haplotype Implicated in Schizophrenia Susceptibility Is Associated with Reduced COMT Expression in Human Brain

2003 • 340 citations

Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites

2001 • 338 citations

Expression of the dopamine transporter gene is regulated by the 3′ UTR VNTR: Evidence from brain and lymphocytes using quantitative RT‐PCR

2002 • 337 citations

Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment

2003 • 335 citations

N‐Acetylaspartylglutamate

2000 • 332 citations

The dephosphins: dephosphorylation by calcineurin triggers synaptic vesicle endocytosis

2001 • 332 citations

Genomic organization of the human catechol O‐methyltransferase gene and its expression from two distinct promoters

1994 • 332 citations

Neurocognitive correlates of the COMT Val158Met polymorphism in chronic schizophrenia

2002 • 327 citations

Roles of serine/threonine phosphatases in hippocampel synaptic plasticity

2001 • 327 citations

The molecular genetics of schizophrenia: new findings promise new insights

2003 • 327 citations

The neuropathology of primary mood disorder

2002 • 326 citations

Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects

2003 • 325 citations

Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia

2002 • 322 citations

Catechol-O-Methyltransferase Genotype and Dopamine Regulation in the Human Brain

2003 • 321 citations

Smaller neuron size in schizophrenia in hippocampal subfields that mediate cortical-hippocampal interactions

1995 • 319 citations

Chromosome 1 loci in Finnish schizophrenia families

2001 • 315 citations

Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder

2004 • 313 citations

Single-nucleotide polymorphisms can cause different structural folds of mRNA

1999 • 313 citations

Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth

2003 • 312 citations

Smoking and mental illness

2001 • 309 citations

Molecular determinants of metabotropic glutamate receptor signaling

2001 • 307 citations

Dysbindin, a Novel Coiled-coil-containing Protein That Interacts with the Dystrobrevins in Muscle and Brain

2001 • 305 citations

Psychiatric Disturbances in Metachromatic Leukodystrophy

1992 • 302 citations

Reelin-mediated Signaling Locally Regulates Protein Kinase B/Akt and Glycogen Synthase Kinase 3β

2002 • 297 citations

Characterization and Implications of Estrogenic Down-Regulation of Human Catechol-O-Methyltransferase Gene Transcription

1999 • 297 citations

The gene encoding proline dehydrogenase modulates sensorimotor gating in mice

1999 • 293 citations

Schizophrenia and the brain: a prospective clinico-neuropathological study

1990 • 287 citations

Schizophrenia and velo-cardio-facial syndrome

2002 • 283 citations

Decreased protein level of nicotinic receptor α7 subunit in the frontal cortex from schizophrenic brain

1999 • 280 citations

Reduced number of mediodorsal and anterior thalamic neurons in schizophrenia

2000 • 279 citations

Oligodendrocytes Promote Neuronal Survival and Axonal Length by Distinct Intracellular Mechanisms: A Novel Role for Oligodendrocyte-Derived Glial Cell Line-Derived Neurotrophic Factor

2003 • 278 citations

Reduced Neuronal Size in Posterior Hippocampus of Schizophrenic Patients

1991 • 276 citations

Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophrenia

2003 • 275 citations

Polymorphisms at the G72/G30 Gene Locus, on 13q33, Are Associated with Bipolar Disorder in Two Independent Pedigree Series*

2003 • 270 citations

Pre‐and Postmortem Influences on Brain RNA

1993 • 269 citations

Oligodendrocytes promote neuronal survival and axonal length by distinct intracellular mechanisms: a novel role for oligodendrocyte-derived glial cell line-derived neurotrophic factor.

2003 • 266 citations

Left Hippocampal Volume as a Vulnerability Indicator for Schizophrenia

2002 • 264 citations

Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions

2004 • 264 citations

Neurotoxicity, Neuroplasticity, and Magnetic Resonance Imaging Morphometry

2002 • 262 citations

GABAergic local circuit neurons and prefrontal cortical dysfunction in schizophrenia

2000 • 257 citations

Decreased Somal Size of Deep Layer 3 Pyramidal Neurons in the Prefrontal Cortex of Subjects With Schizophrenia

2001 • 256 citations

Control of Synaptic Strength, a Novel Function of Akt

2003 • 255 citations

Neuronal Nicotinic Receptors in Dementia with Lewy Bodies and Schizophrenia

1999 • 252 citations

Subnucleus-specific loss of neurons in medial thalamus of schizophrenics

2000 • 250 citations

Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC , encoding the calcineurin gamma subunit

2003 • 248 citations

Inheritance of low erythrocyte catechol-o-methyltransferase activity in man.

1977 • 248 citations

Pathology of Layer V Pyramidal Neurons in the Prefrontal Cortex of Patients With Schizophrenia

2004 • 247 citations

A Genome-Wide Scan for Linkage to Chromosomal Regions in 382 Sibling Pairs With Schizophrenia or Schizoaffective Disorder

2002 • 244 citations

Association study of neuregulin 1 gene with schizophrenia

2003 • 241 citations

Support for genetic variation in neuregulin 1 and susceptibility to schizophrenia

2003 • 239 citations

Back signaling by the Nrg-1 intracellular domain

2003 • 237 citations

Quantification of frontal and temporal lobe brain-imaging findings in schizophrenia: a meta-analysis

2003 • 234 citations

Cis-acting variation in the expression of a high proportion of genes in human brain

2003 • 234 citations

Abnormal expression of two microtubule-associated proteins (MAP2 and MAP5) in specific subfields of the hippocampal formation in schizophrenia.

1991 • 234 citations

Comparison of the regional expression of nicotinic acetylcholine receptor ?7 mRNA and [125I]-?-bungarotoxin binding in human postmortem brain

1997 • 233 citations

Postmortem Assessment of Thalamic Nuclear Volumes in Subjects With Schizophrenia

2002 • 231 citations

Polymorphisms in the 3′-untranslated region of human and monkey dopamine transporter genes affect reporter gene expression

2002 • 231 citations

Structural Brain Abnormalities in Patients With Schizophrenia and Their Healthy Siblings

2000 • 229 citations

Hippocampal Deformities in Schizophrenia Characterized by High Dimensional Brain Mapping

2002 • 226 citations

The origin of schizophrenia: genetic thesis, epigenetic antithesis, and resolving synthesis

2004 • 225 citations

Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders

2003 • 224 citations

Neuropathological studies of synaptic connectivity in the hippocampal formation in schizophrenia

2001 • 221 citations

Mitochondrial dysfunction in schizophrenia: a possible linkage to dopamine

2002 • 218 citations

Promoter and intronic variants affect the transcriptional regulation of the human dopamine transporter gene

2003 • 218 citations

The α7-nicotinic acetylcholine receptor and the pathology of hippocampal interneurons in schizophrenia

2000 • 216 citations

Structural brain imaging in schizophrenia: a selective review

1999 • 214 citations

Neural Development of the Neuregulin Receptor ErbB4 in the Cerebral Cortex and the Hippocampus: Preferential Expression by Interneurons Tangentially Migrating from the Ganglionic Eminences

2003 • 211 citations

O-Methylation of Catechol Amines in Vivo

1958 • 210 citations

Expression of the human excitatory amino acid transporter 2 and metabotropic glutamate receptors 3 and 5 in the prefrontal cortex from normal individuals and patients with schizophrenia

1998 • 209 citations

The Human Brain Revisited Opportunities and Challenges in Postmortem Studies of Psychiatric Disorders

2002 • 209 citations

Total nerve cell number in neocortex in chronic schizophrenics and controls estimated using optical disectors

1993 • 208 citations

Meta-analysis of thalamic size in schizophrenia

2001 • 208 citations

Alzheimer's disease: one disorder, too many genes?

2004 • 207 citations

Ventricular Enlargement in Poor-Outcome Schizophrenia

1998 • 203 citations

Regionally Specific Neuronal Pathology in Untreated Patients with Schizophrenia: A Proton Magnetic Resonance Spectroscopic Imaging Study

1998 • 203 citations

Interstitial white matter neurons express less reelin and are abnormally distributed in schizophrenia: towards an integration of molecular and morphologic aspects of the neurodevelopmental hypothesis

2003 • 200 citations

Absence of Neurodegeneration and Neural Injury in the Cerebral Cortex in a Sample of Elderly Patients With Schizophrenia

1998 • 200 citations

Mitochondrial complex i subunits expression is altered in schizophrenia: a postmortem study

2004 • 199 citations

Genetic variation in the 22q11 locus and susceptibility to schizophrenia

2002 • 199 citations

The DTNBP1 (Dysbindin) Gene Contributes to Schizophrenia, Depending on Family History of the Disease

2003 • 198 citations

“Are We There Yet?”: Deciding When One Has Demonstrated Specific Genetic Causation in Complex Diseases and Quantitative Traits

2003 • 197 citations

Dendritic Spine Hypoplasticity and Downregulation of Reelin and GABAergic Tone in Schizophrenia Vulnerability

2001 • 197 citations

Identification in 2 Independent Samples of a Novel Schizophrenia RiskHaplotype of the Dystrobrevin Binding Protein Gene (DTNBP1)

2004 • 196 citations

Antipsychotic drugs and neuroplasticity: insights into the treatment and neurobiology of schizophrenia

2001 • 195 citations

Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons

2004 • 190 citations

Hippocampal Neuron Number in Schizophrenia

1991 • 188 citations

Developing a Neuronal Model for the Pathophysiology of Schizophrenia Based on the Nature of Electrophysiological Actions of Dopamine in the Prefrontal Cortex

1999 • 187 citations

Brain dystrophin, neurogenetics and mental retardation

2000 • 187 citations

Meta-analysis of association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia

2003 • 186 citations

Insight into the function of Group I and Group II metabotropic glutamate (mGlu) receptors: behavioural characterization and implications for the treatment of CNS disorders

2003 • 186 citations

Cortical regulation of subcortical dopamine systems and its possible relevance to schizophrenia

1993 • 186 citations

Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin

2004 • 185 citations

Replication of 1q42 linkage in Finnish schizophrenia pedigrees

2004 • 185 citations

Glial Cells Maintain Synaptic Structure and Function and Promote Development of the Neuromuscular Junction In Vivo

2003 • 182 citations

The absence of a major Ca ²⁺ signaling pathway in GABAergic neurons of the hippocampus

1998 • 181 citations

PRODH mutations and hyperprolinemia in a subset of schizophrenic patients

2002 • 180 citations

Brain catecholamine metabolism in catechol‐O‐methyltransferase (COMT)‐deficient mice

2002 • 178 citations

Volumetric analysis of frontal lobe regions in schizophrenia: relation to cognitive function and symptomatology

1999 • 177 citations

Size, shape, and orientation of neurons in the left and right hippocampus: investigation of normal asymmetries and alterations in schizophrenia

1997 • 176 citations

Association of the G1947A COMT (Val108/158Met) gene polymorphism with prefrontal P300 during information processing

2003 • 173 citations

Evidence for Decreased DARPP-32 in the Prefrontal Cortex of Patients With Schizophrenia

2002 • 173 citations

Laminar distribution of nicotinic receptor subtypes in cortical regions in schizophrenia

2001 • 173 citations

Reduced Gray Matter Volume in Schizophrenia

1999 • 171 citations

The Synaptic Hypothesis of Schizophrenia

2003 • 170 citations

Calcineurin regulation of neuronal plasticity

2003 • 163 citations

Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria

2004 • 162 citations

Schizophrenia

1979 • 161 citations

Yeast two-hybrid screens implicate DISC1 in brain development and function

2003 • 160 citations

Neuregulin induces GABA(A) receptor subunit expression and neurite outgrowth in cerebellar granule cells.

1999 • 160 citations

Neuregulin-1 (NRG-1) mRNA and protein in the adult human brain

2004 • 158 citations

Smaller Anterior Hippocampal Formation Volume in Antipsychotic-Naive Patients With First-Episode Schizophrenia

2003 • 156 citations

Identification of a novel neuregulin 1 at-risk haplotype in Han schizophrenia Chinese patients, but no association with the Icelandic/Scottish risk haplotype

2004 • 156 citations

Human catechol O-methyltransferase genetic variation: gene resequencing and functional characterization of variant allozymes

2004 • 155 citations

Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system

2004 • 154 citations

Interstitial white matter neurons express less reelin and are abnormally distributed in schizophrenia: towards an integration of molecular and morphologic aspects of the neurodevelopmental hypothesis

2003 • 154 citations

β-dystrobrevin, a member of the dystrophin-related protein family

1998 • 153 citations

Cerebral Gray Matter Volume Deficits in First Episode Psychosis

1998 • 151 citations

Reduced Spinophilin But Not Microtubule-Associated Protein 2 Expression in the Hippocampal Formation in Schizophrenia and Mood Disorders: Molecular Evidence for a Pathology of Dendritic Spines

2004 • 147 citations

Disturbed Gyrification of the Prefrontal Region in Male Schizophrenic Patients: A Morphometric Postmortem Study

2000 • 147 citations

Effects of catecholamine uptake blockers in the caudate-putamen and subregions of the medial prefrontal cortex of the rat

2002 • 147 citations

The axonal chemorepellant semaphorin 3A is increased in the cerebellum in schizophrenia and may contribute to its synaptic pathology

2003 • 145 citations

Polymorphisms in the 13q33.2 gene G72/G30 are associated with childhood-onset schizophrenia and psychosis not otherwise specified

2004 • 145 citations

Neuregulin 1 and schizophrenia

2004 • 145 citations

Volumes of association thalamic nuclei in schizophrenia: a postmortem study

2003 • 144 citations

Heregulin, but not ErbB2 or ErbB3, heterozygous mutant mice exhibit hyperactivity in multiple behavioral tasks

2000 • 144 citations

A Cysteine-Rich Isoform of Neuregulin Controls the Level of Expression of Neuronal Nicotinic Receptor Channels during Synaptogenesis

1998 • 143 citations

Circuit analysis of NMDAR hypofunction in the hippocampus, in vitro, and psychosis of schizophrenia†

2001 • 143 citations

Family-based linkage disequilibrium mapping using SNP marker haplotypes: application to a potential locus for schizophrenia at chromosome 22q11

2000 • 142 citations

Nicotinic α7 Receptor Clusters on Hippocampal GABAergic Neurons: Regulation by Synaptic Activity and Neurotrophins

2002 • 142 citations

The neuropathological effects of antipsychotic drugs

1999 • 142 citations

The G72/G30 Gene Complex and Cognitive Abnormalities in Schizophrenia

2006 • 139 citations

Confirming RGS4 as a susceptibility gene for schizophrenia

2003 • 138 citations

Identification of a high-risk haplotype for the dystrobrevin binding protein 1 (DTNBP1) gene in the Irish study of high-density schizophrenia families.

2003 • 137 citations

Schizophrenia: the cellular biology of a functional psychosis

1990 • 137 citations

Expression of disrupted-in-schizophrenia-1, a schizophrenia-associated gene, is prominent in the mouse hippocampus throughout brain development

2004 • 136 citations

Pathology of presynaptic proteins in Alzheimer's disease: more than simple loss of terminals

2003 • 135 citations

Support for RGS4 as a susceptibility gene for schizophrenia

2004 • 135 citations

Catechol O-Methyltransferase (COMT) mRNA Expression in the Dorsolateral Prefrontal Cortex of Patients with Schizophrenia

2003 • 135 citations

Schizophrenia: a disorder of neurodevelopment?

1997 • 134 citations

Linkage of schizophrenia with chromosome 1q loci in Taiwanese families

2003 • 132 citations

Intrinsic excitatory connections in the prefrontal cortex and the pathophysiology of schizophrenia

2000 • 131 citations

Neuregulin Induces GABA_AReceptor Subunit Expression and Neurite Outgrowth in Cerebellar Granule Cells

1999 • 130 citations

Confirmation and refinement of an ‘at-risk’ haplotype for schizophrenia suggests the EST cluster, Hs.97362, as a potential susceptibility gene at the Neuregulin-1 locus

2004 • 129 citations

The glial growth factors deficiency and synaptic destabilization hypothesis of schizophrenia

2002 • 128 citations

Meta-analysis identifies an association between the dopamine D2 receptor gene and schizophrenia

2003 • 128 citations

Preferential transmission of the high activity allele of COMT in schizophrenia

1996 • 127 citations

Identification of polymorphisms within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder

2001 • 127 citations

Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene ( GRM3 ) with schizophrenia

2003 • 127 citations

Mitochondrial pathology in human schizophrenic striatum: a postmortem ultrastructural study

1998 • 127 citations

Variants in the catechol-o-methyltransferase (COMT) gene are associated with schizophrenia in Irish high-density families

2004 • 126 citations

GSK-3 and the neurodevelopmental hypothesis of schizophrenia

2002 • 125 citations

Distribution of catechol-O-methyltransferase expression in human central nervous system

1998 • 125 citations

Increased density of microtubule associated protein 2-immunoreactive neurons in the prefrontal white matter of schizophrenic subjects

1996 • 124 citations

Entorhinal cortex pre-alpha cell clusters in schizophrenia: quantitative evidence of a developmental abnormality

2000 • 121 citations

Mitochondrial pathology in human schizophrenic striatum: a postmortem ultrastructural study

1999 • 121 citations

A Systematic Genomewide Linkage Study in 353 Sib Pairs with Schizophrenia

2003 • 119 citations

Interstitial cells of the white matter in the inferior parietal cortex in schizophrenia: An unbiased cell-counting study

1999 • 118 citations

Gray and White Matter Brain Abnormalities in First-Episode Schizophrenia Inferred From Magnetization Transfer Imaging

2003 • 114 citations

Chromosomal Location and Genomic Structure of the Human Translin-Associated Factor X Gene (TRAX; TSNAX) Revealed by Intergenic Splicing to DISC1, a Gene Disrupted by a Translocation Segregating with Schizophrenia

2000 • 113 citations

Cerebellar synaptic protein expression in schizophrenia

2001 • 113 citations

Higher scores of self reported schizotypy in healthy young males carrying the COMT high activity allele

2002 • 113 citations

Estimated Neuronal Populations and Volumes of the Hippocampus and Its Subfields in Schizophrenia

2002 • 110 citations

Reduced Pyramidal Cell Somal Volume in Auditory Association Cortex of Subjects with Schizophrenia

2002 • 108 citations

Catechol-O-methyltransferase polymorphisms and schizophrenia

1997 • 106 citations

The role of synaptic morphology in neural plasticity: structural interactions underlying synaptic power

2002 • 104 citations

Mitochondrial involvement in schizophrenia and other functional psychoses

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No evidence for linkage or association of neuregulin-1 (NRG1) with disease in the Irish study of high-density schizophrenia families (ISHDSF)

2004 • 104 citations

Expression and Intracellular Localization of Catechol O‐methyltransferase in Transfected Mammalian Cells

1997 • 103 citations

Cortical abnormality in schizophrenia: An in vivo application of the gyrification index

1997 • 103 citations

Stereological analysis of the mediodorsal thalamic nucleus in schizophrenia: Volume, neuron number, and cell types

2004 • 101 citations

A qualitative and quantitative analysis of the entorhinal cortex in schizophrenia

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Immunocytochemical localization of D-amino acid oxidase in rat brain.

1999 • 101 citations

The genetics of schizophrenia: glutamate not dopamine?

2003 • 101 citations

The Neuropathology of the Autism Spectrum Disorders: What Have We Learned?

2003 • 98 citations

No evidence for association of the dysbindin gene [DTNBP1] with schizophrenia in an Irish population-based study

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Polymorphisms in the 5′-untranslated region of the human serotonin receptor 1B (HTR1B) gene affect gene expression

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Cytoarchitecture of the entorhinal cortex in schizophrenia

1997 • 94 citations

Defining the course of brain structural change and plasticity in schizophrenia

1999 • 91 citations

Catechol‐o‐methyltransferase (COMT) and proline dehydrogenase (PRODH) mRNAs in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and major depression

2003 • 90 citations

Metabotropic glutamate receptor 3 (GRM3) gene variation is not associated with schizophrenia or bipolar affective disorder in the German population

2001 • 90 citations

The Role of ErbB2 Signaling in the Onset of Terminal Differentiation of OligodendrocytesIn Vivo

2003 • 89 citations

Genetic linkage and association between chromosome 1q and working memory function in schizophrenia

2002 • 88 citations

Comparison of polymorphisms in the α7 nicotinic receptor gene and its partial duplication in schizophrenic and control subjects

2003 • 87 citations

Meta-analysis of brain weight in schizophrenia

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Alternative splicing in the nervous system: an emerging source of diversity and regulation

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A postmortem study of the mediodorsal nucleus of the thalamus in schizophrenia

2003 • 83 citations

Population variation in linkage disequilibrium across the COMT gene considering promoter region and coding region variation

2002 • 83 citations

Nicotinic Receptors on Local Circuit Neurons in Dentate Gyrus: A Potential Role in Regulation of Granule Cell Excitability

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The activities of brain dopamine-?-hydroxylase and catechol-O-methyl transferase in schizophrenics and controls

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Rett Syndrome - an update

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Understanding the neurotransmitter pathology of schizophrenia: selective deficits of subtypes of cortical GABAergic neurons

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Up-regulation of the D1 Dopamine Receptor–Interacting Protein, Calcyon, in Patients With Schizophrenia

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Functional metabotropic glutamate receptors are expressed in oligodendrocyte progenitor cells

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Metabotropic glutamate receptor mRNA expression in the schizophrenic thalamus

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Regional expression of RGS4 mRNA in human brain^†

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DISC1 (Disrupted in Schizophrenia-1) is expressed in limbic regions of the primate brain

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Meta-analysis of the dopamine D3 receptor gene (DRD3) Ser9Gly variant and schizophrenia

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Density and distribution of white matter neurons in schizophrenia, bipolar disorder and major depressive disorder: no evidence for abnormalities of neuronal migration

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The amyloid hypothesis: let sleeping dogmas lie?

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Selective deficit of hippocampal N-acetylaspartate in antipsychotic-naive patients with schizophrenia

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A family-based study of the association between the G72/G30 genes and schizophrenia in the Chinese population

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Nicotinic modulation of mesoprefrontal dopamine neurons: pharmacologic and neuroanatomic characterization.

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Comparative analysis of group II metabotropic glutamate receptor immunoreactivity in Brodmann's area 46 of the dorsolateral prefrontal cortex from patients with schizophrenia and normal subjects

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Dynamic Expression ofRGS4in the Developing Nervous System and Regulation by the Neural Type-Specific Transcription Factor Phox2b

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N-acetylaspartate and N-Acetylaspartylglutamate deficits in superior temporal cortex in schizophrenia and bipolar disorder: a postmortem study

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Molecular characterization and localization of human metabotropic glutamate receptor type 3

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Immunohistochemical study of catechol-O-methyltransferase in the human mesostriatal system

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Protein and mRNA levels of nicotinic receptors in brain of tobacco using controls and patients with Alzheimer's disease

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Meta-analysis of postmortem studies of Alzheimer's disease-like neuropathology in schizophrenia [published erratum appears in Am J Psychiatry 1997 Aug;154(8):1180]

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Neuregulin-1 Isoforms Are Differentially Expressed in the Intact and Regenerating Adult Rat Nervous System

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Proton magnetic resonance spectroscopy in schizophrenia

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Alzheimer-associated C allele of the promoter polymorphism -22C&gt;T causes a critical neuron-specific decrease of presenilin 1 expression

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Detailed analysis of PRODH and PsPRODH reveals no association with schizophrenia

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Variability in the Human Entorhinal Region May Confound Neuropsychiatric Diagnoses

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Size of hippocampal pyramidal neurons in schizophrenia

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Opposite modulation of regulators of G protein signalling-2 (RGS2) and RGS4 expression by dopamine receptors in the rat striatum

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No increased incidence of Alzheimer's disease in elderly schizophrenics

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Differences in regional and subcellular localization of Gq/11 and RGS4 protein levels in Alzheimer's disease: Correlation with muscarinic M1 receptor binding parameters

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Cognitive Impairment in Elderly Schizophrenia: A Dementia (Still) Lacking Distinctive Histopathology

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Presynaptic Proteins and Schizophrenia

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A family-based association study of T1945C polymorphism in the proline dehydrogenase gene and schizophrenia in the Chinese population

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Decreased Thalamic Expression of the Homeobox Gene DLX1 in Psychosis

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Shape distortion of the hippocampus: a possible explanation of the pyramidal cell disarray reported in schizophrenia

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Atypical antipsychotics preferentially occupy caudate nucleus D2/D3 receptors within the striatum: A voxel-based analysis

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