Neuregulins: functions, forms, and signaling strategies

Untangling the ErbB signalling network

2001 • 6,623 citations

NEW EMBO MEMBERS' REVIEW: The ErbB signaling network: receptor heterodimerization in development and cancer

2000 • 2,394 citations

Neuregulin 1 and Susceptibility to Schizophrenia

2002 • 1,654 citations

An Essential Role for Ectodomain Shedding in Mammalian Development

1998 • 1,607 citations

Control of Synapse Number by Glia

2001 • 1,327 citations

Requirement for neuregulin receptor erbB2 in neural and cardiac development

1995 • 1,272 citations

Multiple essential functions of neuregulin in development

1995 • 1,236 citations

Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia

2001 • 1,194 citations

Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor

1995 • 1,108 citations

Induction, assembly, maturation and maintenance of a postsynaptic apparatus

2001 • 1,003 citations

Identification of Heregulin, a Specific Activator of p185 ^erbB2

1992 • 963 citations

RefSeq and LocusLink: NCBI gene-centered resources

2001 • 899 citations

ErbB2 is essential in the prevention of dilated cardiomyopathy

2002 • 875 citations

The transcription factor Sox10 is a key regulator of peripheral glial development

2001 • 868 citations

Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions.

1996 • 772 citations

Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system

1993 • 744 citations

Severe neuropathies in mice with targeted mutations in the ErbB3 receptor

1997 • 721 citations

Cardiac Endothelial-Myocardial Signaling: Its Role in Cardiac Growth, Contractile Performance, and Rhythmicity

2003 • 654 citations

ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family

1993 • 612 citations

Multiple roles of eph receptors and ephrins in neural development

2001 • 611 citations

The ADAM gene family: surface proteins with adhesion and protease activity

2000 • 582 citations

Neu differentiation factor: A transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit

1992 • 579 citations

Association of Neuregulin 1 with Schizophrenia Confirmed in a Scottish Population

2003 • 557 citations

Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas.

1995 • 546 citations

Isolation of the NeuHER-2 stimulatory ligand: A 44 kd glycoprotein that induces differentiation of mammary tumor cells

1992 • 534 citations

Neuregulins Promote Survival and Growth of Cardiac Myocytes

1998 • 493 citations

Neuregulin and ErbB receptor signaling pathways in the nervous system

2001 • 490 citations

ADAMs: focus on the protease domain

1998 • 472 citations

Neuregulins and Their Receptors: A Versatile Signaling Module in Organogenesis and Oncogenesis

1997 • 471 citations

Patterning of Muscle Acetylcholine Receptor Gene Expression in the Absence of Motor Innervation

2001 • 463 citations

ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2- and heregulin-deficient mice

1997 • 462 citations

Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy

2002 • 461 citations

Transforming growth factor-alpha. A model for membrane-anchored growth factors.

1990 • 430 citations

Tumor Necrosis Factor-α Converting Enzyme (TACE) Regulates Epidermal Growth Factor Receptor Ligand Availability

2002 • 415 citations

Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases

1997 • 390 citations

Neuregulin-3 (NRG3): A novel neural tissue-enriched protein that binds and activates ErbB4

1997 • 385 citations

Isoform-specific expression and function of neuregulin

1997 • 384 citations

Neuregulin and erbB Receptors Play a Critical Role in Neuronal Migration

1997 • 381 citations

Regulation of Neuregulin Signaling by PSD-95 Interacting with ErbB4 at CNS Synapses

2000 • 376 citations

GGF/Neuregulin Is a Neuronal Signal That Promotes the Proliferation and Survival and Inhibits the Differentiation of Oligodendrocyte Progenitors

1996 • 374 citations

Binding specificities and affinities of egf domains for ErbB receptors

1999 • 370 citations

Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex

1997 • 366 citations

Axonal Control of Oligodendrocyte Development

1999 • 351 citations

The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system

1998 • 334 citations

Expression of Neuregulins and their Putative Receptors, ErbB2 and ErbB3, Is Induced during Wallerian Degeneration

1997 • 329 citations

Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2–ErbB3 receptors

2002 • 327 citations

Rescue of the Cardiac Defect in ErbB2 Mutant Mice Reveals Essential Roles of ErbB2 in Peripheral Nervous System Development

1999 • 321 citations

Survival and glial fate acquisition of neural crest cells are regulated by an interplay between the transcription factor Sox10 and extrinsic combinatorial signaling

2001 • 319 citations

Protein Translocation: Tunnel Vision

1998 • 312 citations

Cysteine-Rich Domain Isoforms of the Neuregulin-1 Gene Are Required for Maintenance of Peripheral Synapses

2000 • 309 citations

Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase

1999 • 307 citations

Schwann cells and their precursors emerge as major regulators of nerve development

1999 • 302 citations

Studies of Schwann cell proliferation. III. Evidence for the surface localization of the neurite mitogen.

1980 • 290 citations

Ligands for ErbB-family receptors encoded by a neuregulin-like gene

1997 • 288 citations

Modulation of Anthracycline-Induced Myofibrillar Disarray in Rat Ventricular Myocytes by Neuregulin-1β and Anti-erbB2

2002 • 285 citations

Schwann cell apoptosis at developing neuromuscular junctions is regulated by glial growth factor

1996 • 283 citations

Neuregulin, a factor with many functions in the life of a Schwann cell

2000 • 282 citations

ARIA: A Neuromuscular Junction Neuregulin

1997 • 279 citations

Neuregulins are concentrated at nerve-muscle synapses and activate ACh–receptor gene expression

1995 • 276 citations

Axon-induced mitogenesis of human Schwann cells involves heregulin and p185erbB2.

1995 • 273 citations

Maintenance of Acetylcholine Receptor Number by Neuregulins at the Neuromuscular Junction in Vivo

1997 • 272 citations

Neuregulin-β induces expression of an NMDA-receptor subunit

1997 • 261 citations

A Dual Role oferbB2in Myelination and in Expansion of the Schwann Cell Precursor Pool

2000 • 260 citations

Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development

1999 • 248 citations

Introducing RefSeq and LocusLink: curated human genome resources at the NCBI

2000 • 247 citations

CNS integrins switch growth factor signalling to promote target-dependent survival

2002 • 246 citations

Neuregulin-1 promotes formation of the murine cardiac conduction system

2002 • 244 citations

Remarkable roles of proteolysis on and beyond the cell surface

2000 • 235 citations

Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis

2000 • 230 citations

Differential expression of ARIA isoforms in the rat brain

1995 • 229 citations

Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development.

1996 • 228 citations

Structural and Functional Aspects of the Multiplicity of Neu Differentiation Factors

1994 • 220 citations

Targeting Transcription to the Neuromuscular Synapse

2001 • 201 citations

Neurotrophic and migratory properties of an olfactory ensheathing cell line

2001 • 190 citations

The formation of neuromuscular synapses

1998 • 189 citations

Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4

2000 • 183 citations

Aberrant development of motor axons and neuromuscular synapses in erbB2-deficient mice

2000 • 181 citations

Roles of Meltrin β/ADAM19 in the Processing of Neuregulin

2001 • 181 citations

Akt-Mediated Survival of Oligodendrocytes Induced by Neuregulins

2000 • 179 citations

Schwann cells as regulators of nerve development

2002 • 178 citations

Role of neuregulins in glial cell development

2000 • 175 citations

The bride of sevenless and sevenless interaction: Internalization of a transmembrane ligand

1992 • 172 citations

Evidence that Axon-Derived Neuregulin Promotes Oligodendrocyte Survival in the Developing Rat Optic Nerve

2000 • 171 citations

Sensory and Motor Neuron-derived Factor. A NOVEL HEREGULIN VARIANT HIGHLY EXPRESSED IN SENSORY AND MOTOR NEURONS

1995 • 170 citations

Normal Female Sexual Development Requires Neuregulin–erbB Receptor Signaling in Hypothalamic Astrocytes

2003 • 170 citations

Failure of spinal cord oligodendrocyte development in mice lacking neuregulin

1999 • 165 citations

Induction of cell fate in the Drosophila retina: the bride of sevenless protein is predicted to contain a large extracellular domain and seven transmembrane segments.

1990 • 164 citations

Neuregulin induces GABA(A) receptor subunit expression and neurite outgrowth in cerebellar granule cells.

1999 • 160 citations

Differential Shedding of Transmembrane Neuregulin Isoforms by the Tumor Necrosis Factor-α-Converting Enzyme

2000 • 159 citations

Glial Control of Neuronal Development

2001 • 159 citations

Neuregulin activation of ErbB receptors in vascular endothelium leads to angiogenesis

1999 • 158 citations

The neuregulin, glial growth factor 2, diminishes autoimmune demyelination and enhances remyelination in a chronic relapsing model for multiple sclerosis

1998 • 152 citations

A Role for a PDZ Protein in the Early Secretory Pathway for the Targeting of proTGF-α to the Cell Surface

1999 • 151 citations

Neuregulins increase alpha7 nicotinic acetylcholine receptors and enhance excitatory synaptic transmission in GABAergic interneurons of the hippocampus.

2001 • 151 citations

A Role for Neuregulin1 Signaling in Muscle Spindle Differentiation

2002 • 150 citations

Brain neurons and glial cells express Neu differentiation factor/heregulin: a survival factor for astrocytes.

1994 • 147 citations

Heregulin, but not ErbB2 or ErbB3, heterozygous mutant mice exhibit hyperactivity in multiple behavioral tasks

2000 • 144 citations

A Cysteine-Rich Isoform of Neuregulin Controls the Level of Expression of Neuronal Nicotinic Receptor Channels during Synaptogenesis

1998 • 143 citations

ErbB Tyrosine Kinases and the Two Neuregulin Families Constitute a Ligand-Receptor Network

1998 • 141 citations

Erbb transmembrane tyrosine kinase receptors are differentially expressed throughout the adult rat central nervous system

2001 • 133 citations

Neuregulin in Cardiac Hypertrophy in Rats With Aortic Stenosis

1999 • 130 citations

Ligand Discrimination in Signaling through an ErbB4 Receptor Homodimer

2000 • 128 citations

ARIA can be released from extracellular matrix through cleavage of a heparin-binding domain.

1995 • 128 citations

The glial growth factors deficiency and synaptic destabilization hypothesis of schizophrenia

2002 • 128 citations

The N-terminal Region of Neuregulin Isoforms Determines the Accumulation of Cell Surface and Released Neuregulin Ectodomain

2001 • 123 citations

NDF/heregulin induces persistence of terminal end buds and adenocarcinomas in the mammary glands of transgenic mice.

1996 • 123 citations

Neuregulin Signaling Regulates Neural Precursor Growth and the Generation of OligodendrocytesIn Vitro

2001 • 121 citations

Neuregulins and neuregulin receptors in neural development

1997 • 120 citations

A Novel Role of Neuregulin in Skeletal Muscle

2001 • 120 citations

Vascular Endothelial Growth Factor Up-regulation via p21-activated Kinase-1 Signaling Regulates Heregulin-β1-mediated Angiogenesis

2000 • 118 citations

Transmembrane transforming growth factor-alpha tethers to the PDZ domain-containing, Golgi membrane-associated protein p59/GRASP55

2000 • 114 citations

Characterization of a Neuregulin-Related Gene, Don-1, That Is Highly Expressed in Restricted Regions of the Cerebellum and Hippocampus

1997 • 114 citations

Regulation of Neuregulin Expression in the Injured Rat Brain and Cultured Astrocytes

2001 • 112 citations

The erbB2 gene is required for the development of terminally differentiated spinal cord oligodendrocytes

2001 • 111 citations

Nerve Terminal Withdrawal from Rat Neuromuscular Junctions Induced by Neuregulin and Schwann Cells

1997 • 111 citations

Neuregulins Signaling via a Glial erbB-2–erbB-4 Receptor Complex Contribute to the Neuroendocrine Control of Mammalian Sexual Development

1999 • 110 citations

Expression of multiple neuregulin transcripts in postnatal rat brains

1994 • 109 citations

GGF/Neuregulin Induces a Phenotypic Reversion of Oligodendrocytes

1999 • 105 citations

Influence of Glial Growth Factor and Schwann Cells in a Bioresorbable Guidance Channel on Peripheral Nerve Regeneration

2000 • 105 citations

Activity-dependent regulation of Neu differentiation factor/neuregulin expression in rat brain

1998 • 105 citations

Pathogenesis of Paget's Disease: Epidermal Heregulin- , Motility Factor, and the HER Receptor Family

2000 • 103 citations

Purification of multiple forms of glial growth factor.

1993 • 99 citations

Forced Transmembrane Orientation of Hydrophilic Polypeptide Segments in Multispanning Membrane Proteins

1998 • 98 citations

γ-Heregulin: a novel heregulin isoform that is an autocrine growth factor for the human breast cancer cell line, MDA-MB-175

1997 • 96 citations

Membrane-Bound Neuregulin1 Type III Actively Promotes Schwann Cell Differentiation of Multipotent Progenitor Cells

2002 • 94 citations

The breast proto-oncogene, HRGα regulates epithelial proliferation and lobuloalveolar development in the mouse mammary gland

2002 • 92 citations

Transmembrane Neuregulins Interact with LIM Kinase 1, a Cytoplasmic Protein Kinase Implicated in Development of Visuospatial Cognition

1998 • 92 citations

Domain-specific gene disruption reveals critical regulation of neuregulin signaling by its cytoplasmic tail

1998 • 92 citations

ErbB Signaling Regulates Lineage Determination of Developing Pancreatic Islet Cells in Embryonic Organ Culture

2002 • 92 citations

Expression patterns of transmembrane and released forms of neuregulin during spinal cord and neuromuscular synapse development

1999 • 89 citations

Biosynthetic Processing of neu Differentiation Factor

1995 • 89 citations

Differential Signaling by the Epidermal Growth Factor-like Growth Factors Neuregulin-1 and Neuregulin-2

1998 • 87 citations

The discovery of susceptibility genes for mental disorders

2002 • 86 citations

Neuregulin isoforms exhibit distinct patterns of ErbB family receptor activation

2002 • 86 citations

ARIA is concentrated in the synaptic basal lamina of the developing chick neuromuscular junction.

1995 • 86 citations

Neuregulin-Heparan-sulfate Proteoglycan Interactions Produce Sustained erbB Receptor Activation Required for the Induction of Acetylcholine Receptors in Muscle

2001 • 81 citations

Origin and early development of Schwann cells

1998 • 75 citations

Identification of a Region within the ErbB2/HER2 Intracellular Domain That Is Necessary for Ligand-independent Association

2002 • 74 citations

Neuregulin and erbB receptor expression in normal and diseased human white matter

1999 • 73 citations

The cytoplasmic carboxy-terminal amino acid determines the subcellular localization of proTGF-α and membrane type matrix metalloprotease (MT1-MMP)

1999 • 73 citations

Neuregulin: An Oligodendrocyte Growth Factor Absent in Active Multiple Sclerosis Lesions

2001 • 72 citations

A Novel Brain-Derived Member of the Epidermal Growth Factor Family That Interacts with ErbB3 and ErbB4

1997 • 72 citations

Cardiotoxicity in signal transduction therapeutics: ErbB2 antibodies and the heart

2001 • 71 citations

Cloning and neuronal expression of a type III newt neuregulin and rescue of denervated, nerve-dependent newt limb blastemas by rhGGF2

2000 • 71 citations

Neuregulin Stimulates Myogenic Differentiation in an Autocrine Manner

1999 • 70 citations

Mitogenic response of adult rat olfactory ensheathing glia to four growth factors

2001 • 69 citations

Neuregulin Expression in PNS Neurons: Isoforms and Regulation by Target Interactions

1997 • 68 citations

Colonic Epithelial Expression of ErbB2 Is Required for Postnatal Maintenance of the Enteric Nervous System

2003 • 68 citations

The Neuregulin Precursor proARIA Is Processed to ARIA after Expression on the Cell Surface by a Protein Kinase C-Enhanced Mechanism

1998 • 67 citations

The Catalytic Activity of the ErbB-2 Receptor Tyrosine Kinase Is Essential for Embryonic Development

2002 • 67 citations

Neuregulin-1 and Human Epidermal Growth Factor Receptors 2 and 3 Play a Role in Human Lung Development In Vitro

2000 • 65 citations

Growth Factor Control of CNS Myelination

2001 • 65 citations

Release of the Neuregulin Functional Polypeptide Requires Its Cytoplasmic Tail

1998 • 61 citations

Why are growth factors important in oligodendrocyte physiology?

2000 • 61 citations

Stimulation of cleavage of membrane proteins by calmodulin inhibitors

2000 • 60 citations

The role of heregulin-? as a motility factor and amphiregulin as a growth factor in wound healing

2002 • 54 citations

Role for ADAM-family proteinases as membrane protein secretases

1999 • 54 citations

Neuronal survival: Early dependence on Schwann cells

1998 • 54 citations

Heregulin enhances regenerative proliferation in postnatal rat utricular sensory epithelium after ototoxic damage.

1999 • 54 citations

Trastuzumab cardiotoxicity: Speculations regarding pathophysiology and targets for further study

2002 • 53 citations

β-Neuregulin-1 is required for the in vivo development of functional Ca ²⁺ -activated K ⁺ channels in parasympathetic neurons

2001 • 46 citations

Neuregulin in Neuron/Glial Interactions in the Central Nervous System

1999 • 44 citations

Expression of heregulin α, erbB2, and erbB3 and their influences on proliferation of gastric epithelial cells

1999 • 44 citations

Post-translational Processing of Membrane-associated neu Differentiation Factor Proisoforms Expressed in Mammalian Cells

1995 • 43 citations

Sensory and Motor Neuron-derived Factor Is a Transmembrane Heregulin That Is Expressed on the Plasma Membrane with the Active Domain Exposed to the Extracellular Environment

1998 • 40 citations

Primordial germ cell‐somatic cell partnership: A balancing cell signaling act

2001 • 39 citations

Fiber Apoptosis in Developing Rat Muscles Is Regulated by Activity, Neuregulin

1998 • 38 citations

rhGGF2 protects against cisplatin-induced neuropathy in the rat

2000 • 34 citations

γ-Heregulin: a fusion gene of DOC-4 and neuregulin-1 derived from a chromosome translocation

1999 • 33 citations

Members of the ErbB Receptor Tyrosine Kinases Are Involved in Germ Cell Development in Fetal Mouse Gonads

1999 • 27 citations

The Release of Acetylcholine Receptor Inducing Activity (ARIA) from Its Transmembrane Precursor in Transfected Fibroblasts

1999 • 25 citations

Hyperactive autocrine loop mediated by a NDF-related factor in neoplastic hamster embryo fibroblasts expressing an activated cph oncogene.

1995 • 23 citations

Effects of in Vivo Heregulin β1 Treatment in Wild-Type and ErbB Gene-Targeted Mice Depend on Receptor Levels and Pregnancy

2001 • 7 citations